Dérivés des Purines et Pyrimidines
Les purines possèdent une structure bicyclique, composée d’un cycle à six membres fusionné avec un cycle à cinq membres, tous deux contenant des atomes d’azote à des positions clés. Les dérivés des purines, tels que l’adénine et la guanine, sont essentiels à la formation de l’ADN et de l’ARN. Ces composés ont des applications thérapeutiques dans le traitement du cancer et des maladies virales en inhibant la réplication cellulaire. Les pyrimidines, quant à elles, possèdent une structure monocyclique à six membres avec deux atomes d’azote. Leurs dérivés, tels que la cytosine, la thymine et l’uracile, sont également des composants essentiels de l’ADN et de l’ARN et sont utilisés en chimiothérapie et dans les traitements antiviraux.
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3-(Formylamino)-1H-pyrazole-4-carboxylic Acid Ethyl Ester
CAS :<p>Impurity Allopurinol EP Impurity E / Allopurinol USP Related Compound E<br>Applications 3-(Formylamino)-1H-pyrazole-4-carboxylic Acid Ethyl Ester (Allopurinol EP Impurity E) is an impurity of Allopurinol (A547300), a pyrazole derivative that has been shown to induce neoplasm immunogenicity.<br>References Nicolin, A. et al.: Cancer, Chemother. Rep., 57, 3 (1973); Bonmassar, E. et al.: Cancer Res., 35, 1957 (1975)<br></p>Formule :C7H9N3O3Couleur et forme :WhiteMasse moléculaire :183.165-Nitro Nicotinic Acid
CAS :Produit contrôlé<p>Applications An intermediate in the synthesis of nicotinamide with potential anticoccidial activity.<br>References Morisawa, Y. et al.: J. Med. Chem., 20, 129 (1977);<br></p>Formule :C6H4N2O4Couleur et forme :NeatMasse moléculaire :168.11Memantine Hydrochloride
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Used as an antiparkinsonian and antispasmodic.<br>References Rohde, H., et al.: Fortschr. Med., 100, 2023 (1982), Kornhuber, J., et al.: Eur. J. Pharmacol., 166, 589 (1989), Gortelmeyer, R. and Erbler, H.: Arzneimittel-Forsch., 42, 904 (1992)<br></p>Formule :C12H21N·ClHCouleur et forme :White To Off-WhiteMasse moléculaire :215.76Methotrexate-Cadaverine-Biotin Conjugate
Produit contrôlé<p>Applications Methotrexate-Cadaverine-Biotin Conjugate is biotin labelled Methotrexate. Methotrexate (M260675) is a folic acid antagonist and it is used as a antineoplastic and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Formule :C35H48N12O6SDegré de pureté :>85%Couleur et forme :NeatMasse moléculaire :764.93-Nitro-L-tyrosine-d3
CAS :Produit contrôlé<p>Applications A labelled marker for peroxynitrite. Oxidant and cytotoxic agent.<br>References Sekiguchi, M., et al.: Brain Res., 978, 228 (2003), van den Tweel, E., et al.: J. Neurobiol., 167, 64 (2005), Shirakura, T., et al.: Biol. Pharm. Bull., 28, 1658 (2005),<br></p>Formule :C9D3H7N2O5Couleur et forme :NeatMasse moléculaire :229.24-(furan-2-yl)-6-[4-(propan-2-yl)phenyl]pyrimidin-2-amine
CAS :Degré de pureté :95.0%Masse moléculaire :279.3429870605469Tenofovir Disoproxil Isopropoxycarbonyl
CAS :<p>Stability Hygroscopic<br>Applications Tenofovir Disoproxil derivative as antiviral and antitumor agent.<br></p>Formule :C23H36N5O12PCouleur et forme :White SolidMasse moléculaire :605.53Tenofovir Alafenamide-d5 (Diastereomers)
CAS :Produit contrôléFormule :C212H5H24N6O5PCouleur et forme :NeatMasse moléculaire :481.507-Methyl Memantine Hydrochloride
CAS :<p>Stability Hygroscopic<br>Applications 7-Methyl Memantine is an impurity of Memantine (HCl salt, M218000) which is used as an antiparkinsonian and antispasmodic.<br>References Rohde, H., et al.: Fortschr. Med., 100, 2023 (1982), Kornhuber, J., et al.: Eur. J. Pharmacol., 166, 589 (1989), Gortelmeyer, R. and Erbler, H.: Arzneimittel-Forsch., 42, 904 (1992)<br></p>Formule :C13H23N·ClHCouleur et forme :White SolidMasse moléculaire :229.79Tenofovir Isopropyl Ethyl Diester
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Tenofovir Disopropyl Ethyl Diester is an impurity of Tenofovir (T018500), an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),<br></p>Formule :C18H28N5O10PCouleur et forme :NeatMasse moléculaire :505.42Formaldehyde 2,4-Dinitrophenylhydrazone
CAS :<p>Stability Shock Sensitive<br>Applications Formaldehyde 2,4-Dinitrophenylhydrazone is a dinitrophenylhydrazone (DNPH) derivative of an aliphatic aldehyde found in mainstream cigarette smoke.<br>References Delgado, B. et al.: J. Liq. Chrom. Rel. Technol., 31, 361 (2008); Miller, J.H. et al.: J. Chrom. Sci., 48, 12 (2010);<br></p>Formule :C7H6N4O4Couleur et forme :NeatMasse moléculaire :210.15Zeatin
CAS :<p>Applications Zeatin belongs to the family of plant-growth hormones called cytokinins and it can be used for agricultural use as agrochemicals for increasing crop yields and regulate various aspects of plant growth and development.<br>References Koprna, R., et al.: Bioorgan. Med. Chem., 24, 484-492 (2016)<br></p>Formule :C10H13N5OCouleur et forme :White To Off-WhiteMasse moléculaire :219.24Methotrexate-d3 Heptaglutamate Trifluoroacetate
CAS :Produit contrôléFormule :C50H61D3N14O23xC2HF3O2Couleur et forme :NeatMasse moléculaire :1232.142N-(6-Amino-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetamide
CAS :<p>Applications N-(6-Amino-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetamide is an intermediate in synthesizing 5-Acetylamino-6-formylamino-3-methyluracil (A168210), which is a metabolite of Caffeine (C080100).<br>References Grant, D.M., et al.: Clin. Pharm. and Ther., 33, 591 (1983),<br></p>Formule :C7H10N4O3Couleur et forme :Off White SolidMasse moléculaire :198.18Pemetrexed-13C5 Disodium Heptahydrate
CAS :Produit contrôlé<p>Applications Pemetrexed-13C5 Disodium Salt, is the labeled analogue of Pemetrexed Disodium (P219500), used as Antineoplastic agent.<br>References McDonald, A.C., et al.: Clin. Cancer Res., 4, 605 (1998), John, W., et al.: Cancer, 88, 1807 (2000), Miller, K.D., et al.: Ann. Oncol., 11, 101 (2000),<br></p>Formule :C1513C5H19N5Na2O6•7(H2O)Couleur et forme :Off-WhiteMasse moléculaire :476.3471802N2-ISOBUTYRYL-2'-O-METHYL-GUANOSINE
CAS :Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :367.361999511718755,6-Dihydro Uracil-13C,15N2
CAS :<p>Applications Isotope Labelled 5,6-Dihydro Uracil is a degradation product of DNA and was used in mass spectrometric studies of cellular DNA damage.<br>References Nelson, V.C., et al.: J. Label. Com. Radiopharma., 38, 713 (1996)<br></p>Formule :C313CH615N2O2Couleur et forme :Off-White To BeigeMasse moléculaire :117.08DAMPA-d3
CAS :Produit contrôlé<p>Applications Labelled Methotrexate (M260675) analog. DAMPA is an antitumor agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Martinelli, J.E., et al.: J. Med. Chem., 22, 869 (1979);<br></p>Formule :C152H3H12N7O2Couleur et forme :Dark OrangeMasse moléculaire :328.341-Methyl Xanthine-d3
CAS :Produit contrôlé<p>Applications A labelled metabolite of Theophylline.<br>References ottrup, A., et al.: Pharmacol. Toxicol., 67, 340 (1990), El-Kadi, A., et al.: Drug Metab. Dispos., 28, 1112 (2000), Kim, S., et al.: J. Med. Chem., 45, 2131 ( 2002), Hansel, T., et al.: Drugs Today, 40, 55 (2004),<br></p>Formule :C62H3H3N4O2Couleur et forme :NeatMasse moléculaire :169.16Tetrabenazine-d6
CAS :Produit contrôlé<p>Applications Labelled Tetrabenazine. Dopamine depleting agent. An antidyskinetic; antipsychotic.<br>References Schwartz, et al.: Biochem. Pharmacol., 15, 645 (1966), Janovic, J., et al.: Ann. Neurol., 11, 41 (1982), Janovic, J., et al.: Neurology, 38, 391 (1988),<br></p>Formule :C19H21D6NO3Couleur et forme :NeatMasse moléculaire :323.46Methotrexate-d3 Diglutamate Trifluoroacetate
CAS :Produit contrôlé<p>Applications Methotrexate-d3 Diglutamate is the isotope labelled analog of Methotrexate Diglutamate (M260720); a metabolite of Methotrexate (M260675) which is a folic acid antagonist, antineoplastic, and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)<br></p>Formule :C25H26D3N9O8•x(C2HF3O2)•xH2SO4Couleur et forme :NeatMasse moléculaire :586.58114029814-Hydroxyphenylpyruvic Acid
CAS :Formule :C9H8O4Couleur et forme :Light Yellow To OrangeMasse moléculaire :180.164-(3-Aminophenyl)-2-methylpyrimidine
CAS :Formule :C11H11N3Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :185.23Iopamidol-d8
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Labelled Iopamidol, a nonionic radiocontrast medium. Diagnostic aid (radiopaque medium).<br>References Drayer, B., et al.: Am. J. Neuroradiol., 3, 59 (1982); Molyneux, A.J., et al.: Br. J. Radiol., 55, 117 (1982); Sovak, M., et al.: Radiology, 142, 115 (1982); Felder, E., et al.: Anal. Profiles Drug Subs., 17, 115 (1988);<br></p>Formule :C17H14D8I3N3O8Couleur et forme :NeatMasse moléculaire :785.132-[3-(Aminocarbonyl)-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid
CAS :Produit contrôlé<p>Applications 2-[3-(Aminocarbonyl)-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid is an impurity of Febuxostat (F229000), an xanthine oxidase/xanthine dehydrogenase inhibitor used for the treatment of hyperuricemia and chronic gout.<br>References Kadivar, M.H., et al.: J. Pharma. Biomed. Anal., 56, 749 (2011);<br></p>Formule :C16H18N2O4SCouleur et forme :White To Off-WhiteMasse moléculaire :334.39Sumatriptan Succinate
CAS :Produit contrôlé<p>Applications Sumatriptan Succinate is a selective 5-HT1B/1D-receptor agonist with anticonvulsant properties (1,2). Sumatriptan Succinate is used for migraine relief (2).<br>References (1) Razzaque, Z., et al.: Br J Clin Pharmacol. 47, 75 (1999) (2) Cady, R. K., et al.: J Headache Pain. 18, 17 (2017)<br></p>Formule :C14H21N3O2S·C4H6O4Couleur et forme :White To Off-WhiteMasse moléculaire :413.492-Hydrazino Adenosine
CAS :Produit contrôlé<p>Stability Moisture Sensitive<br>Applications A useful synthetic intermediate for making potent and selective coronary vasodilators.<br>References Niiya, K., et al.: J. Med. Chem., 35, 4557 (1992)<br></p>Formule :C10H15N7O4Couleur et forme :NeatMasse moléculaire :297.273-Amino-4-carbamoylpyrazole Hemisulfate
CAS :Produit contrôlé<p>Impurity Allopurinol EP Impurity A / Allopurinol USP Related Compound A<br>Stability Hygroscopic<br>Applications 3-Amino-4-carbamoylpyrazole Hemisulfate (Allopurinol EP Impurity A) is an impurity of Allopurinol (A547300), a pyrazole derivative that has been shown to induce neoplasm immunogenicity.<br>References Nicolin, A. et al.: Cancer, Chemother. Rep., 57, 3 (1973); Bonmassar, E. et al.: Cancer Res., 35, 1957 (1975);<br></p>Formule :C4H6N4O·H2O4SCouleur et forme :White To Light BrownMasse moléculaire :350.313,5-Dimethyl-1-adamantanol
CAS :Produit contrôlé<p>Impurity Memantine USP Related Compound B (3,5-Dimethyladamantane-1-ol)<br>Applications 3,5-Dimethyl-1-adamantanol is an impurity of Memantine (M218000). Memantine impurity B. Memantine USP Related Compound B (3,5-Dimethyladamantane-1-ol).<br>References England, P., et al.: Biochemistry, 43, 11623 (2004), Schousboe, A., et al.: Eur. J. Pharmacol., 500, 281 (2004), Horvat, S., et al.: J. Med. Chem., 49, 3136 (2006),<br></p>Formule :C12H20OCouleur et forme :WhiteMasse moléculaire :180.292,4,5,6-Tetraaminopyrimidine Sulfate
CAS :Produit contrôlé<p>Applications Intermediate in the production of Methotrexate<br>References Chiosis, G., et al.: Bioorg. Med. Chem., 10, 3555 (2002), Palanki, M., et al.: J. Med. Chem., 50, 4279 (2007), Zav'yalov, S., et al.: Pharm. Chem. J., 42, 51 (2008),<br></p>Formule :C4H8N6·H2O4SCouleur et forme :NeatMasse moléculaire :238.22L-Monapterin
CAS :Produit contrôlé<p>Applications L-Monapterin is the major pterin compound extracted from Escherichia coli (E.coli) and is used in its detection and identification.<br>References Sugimoto, T. et al.: Hetero., 54, 283 (2001); Ikawa, M. et al.: Phytochem., 38, 1229 (1995);<br></p>Formule :C9H11N5O4Couleur et forme :Light OrangeMasse moléculaire :253.21N-benzyl-7H-purin-6-amine hydrochloride
CAS :Degré de pureté :98%Masse moléculaire :261.7099914550781N-(2-Hydroxy-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
CAS :Degré de pureté :95+%Masse moléculaire :469.55999755859375N'-Methyl-N,N-diphenylurea
CAS :<p>Impurity Temozolomide USP Related Compound B<br>Applications N'-Methyl-N,N-diphenylurea is used in the stabilization of thermal propellants. Temozolomide USP Related Compound B.<br>References Bohn, M. et al.: Prop. Exp. Pyro.,et al.: 19, 266 (1994); Muthurajan, H. et al.: J. Hazard. Mat., 133, 30 (2006);<br></p>Formule :C14H14N2OCouleur et forme :NeatMasse moléculaire :226.27Zolmitriptan-d6 (Major)
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A Serotonin 5HTID-receptor agonist.<br>References Glen, R.C., et al.: J. Med. Chem., 38, 3566 (1995), Seaber, E., et al.: Brit. J. Clin. Pharmacol., 41, 141 (1996), Tepper, S.J., et al.: Curr. Med. Res. Opin., 15, 254 (1999)<br></p>Formule :C16H15D6N3O2Couleur et forme :NeatMasse moléculaire :293.39Methotrexate γ-Methyl Ester
CAS :Produit contrôlé<p>Impurity Methotrexate EP Impurity H<br>Applications Methotrexate γ-methyl ester is an impurity of Methotrexate (M260675), a folic acid antagonist. Used as a antineoplastic and antirheumatic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Formule :C21H24N8O5Couleur et forme :NeatMasse moléculaire :468.47Regadenoson
CAS :Produit contrôlé<p>Applications Regadenoson is a selective and potent A2A adenosine receptor agonist (1). The adenosine A2A receptor is a G-protein-coupled receptor and a key therapeutic target for oncologic, inflammatory, Parkinson's and cardiovascular diseases (2). In rodent studies, it has been shown that co-administration of Regadenoson with Temozolomide (T017775) can increase Temozolomide concentration in the brain (3).<br>References (1) Gao, Z., et al.: J Pharmacol Exp Ther. 298, 209 (2001) (2) Yuan, G., et al.: Expert Opin Drug Discov. 10, 63 (2015) (3) Jackson, S., et al.: J Neurooncol. 126, 433 (2016)<br></p>Formule :C15H18N8O5Couleur et forme :Off WhiteMasse moléculaire :390.35Sumatriptan-d6
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A serotonin 5HT1-receptor agonist. Antimigraine.<br>References Humphrey, P.P.A., et al.: Br. J. Pharmacol., 94, 1123 (1988),<br></p>Formule :C14H15D6N3O2SCouleur et forme :NeatMasse moléculaire :301.44LY-338979
CAS :<p>Applications LY 338979 is a metabolite of the antifolate Pemetrexed (P219500).<br>References Woodland, J.M. et al.: Drug Metab. Dispos., 25, 693 (1997);<br></p>Formule :C20H21N5O7Couleur et forme :NeatMasse moléculaire :443.41Methopterine (>90%)
CAS :Produit contrôlé<p>Impurity Methotrexate EP Impurity C; Methotrexate USP Related Compound C<br>Applications Methopterine (Methotrexate EP Impurity C) is a Folic acid (F680300) analogue. Methopterine is effective in the treatment of ectopic pregnancy. Methotrexate USP Related Compound C<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References McNamara, P., et al.: Drug Metab. Dispos., 20, 302 (1992), Soldin, O., et al.: Ther. Drug Monit., 24, 1 (2002), Nicoli, S., et al.: J. Pharm. Biomed. Anal., 41, 994 (2006),<br></p>Formule :C20H21N7O6Degré de pureté :>90%Couleur et forme :NeatMasse moléculaire :455.42(S)-Tenofovir
CAS :Produit contrôlé<p>Applications (S)-Tenofovir is an S-enatiomeric derivative of Tenofovir (T018500). (S)-Tenofovir displays virucidal activity against herpes, visna virus and retrovirus. The S enantiomer of Tenofovir (T018500) is less effective against HIV than their (R)-enantiomeric counterparts.<br>References Balzarini, J. et al: Biochem. Biophys. Res. Comm., 219, 337 (1996); Balzarini, J. et al.: Antimicrob. Agents. Ch., 37, 332 (1993); Thormar, H. et al.: Antimicorb. Agents. Ch., 37, 2540 (1993)<br></p>Formule :C9H14N5O4PCouleur et forme :NeatMasse moléculaire :287.21Sulbutiamine
CAS :Produit contrôlé<p>Applications Sulbutiamine (isobutyryl thiamine disulfide) is a lipophilic derivative of thiamine used for the treatment of asthenia and other related pathological conditions. Sulbutiamine is available over-the-counter in several countries as a component of nutritional supplements.<br>References Micheau, J., et al.: Pharmacol. Biochem. Behav., 23, 195 (1985), Bettendorff, L., et al.: Biochem. Pharmacol., 40, 2557 (1990), van Reeth, O., et al.: Drugs Today, 35, 187 (1999),<br></p>Formule :C32H46N8O6S2Couleur et forme :Off WhiteMasse moléculaire :702.89N10-Methyl Pteroic Acid
CAS :<p>Impurity Methotrexate EP Impurity D<br>Applications N10-Methyl Pteroic Acid (Methotrexate EP Impurity D) is a Methotrexate (M260675) impurity D.<br>References Cramer, S., et al.: Cancer Res. 1984, 44, 1843 (1984), Hendel, J., et al.: Eur. J. Clin. Pharmacol., 26, 103 (1984),<br></p>Formule :C15H14N6O3Couleur et forme :Orange To Dark RedMasse moléculaire :326.31
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