Dérivés des Purines et Pyrimidines
Les purines possèdent une structure bicyclique, composée d’un cycle à six membres fusionné avec un cycle à cinq membres, tous deux contenant des atomes d’azote à des positions clés. Les dérivés des purines, tels que l’adénine et la guanine, sont essentiels à la formation de l’ADN et de l’ARN. Ces composés ont des applications thérapeutiques dans le traitement du cancer et des maladies virales en inhibant la réplication cellulaire. Les pyrimidines, quant à elles, possèdent une structure monocyclique à six membres avec deux atomes d’azote. Leurs dérivés, tels que la cytosine, la thymine et l’uracile, sont également des composants essentiels de l’ADN et de l’ARN et sont utilisés en chimiothérapie et dans les traitements antiviraux.
Chez CymitQuimica, nous proposons des dérivés des purines et pyrimidines pour la recherche en biologie moléculaire, génomique et le développement de thérapies innovantes.
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5,6-Dihydro Uracil-13C,15N2
CAS :<p>Applications Isotope Labelled 5,6-Dihydro Uracil is a degradation product of DNA and was used in mass spectrometric studies of cellular DNA damage.<br>References Nelson, V.C., et al.: J. Label. Com. Radiopharma., 38, 713 (1996)<br></p>Formule :C313CH615N2O2Couleur et forme :Off-White To BeigeMasse moléculaire :117.08TERT-BUTYL 2-(6-AMINO-9H-PURIN-9-YL)ACETATE
CAS :Degré de pureté :95.0%Masse moléculaire :249.2740020751953O-Desisobutyl-O-n-propyl Febuxostat
CAS :Formule :C15H14N2O3SCouleur et forme :NeatMasse moléculaire :302.352-(3-Bromophenyl)-4,6-diphenylpyrimidine
CAS :Degré de pureté :95.0%Masse moléculaire :387.27999877929694-(TERT-BUTYL)-N-(6-(2-HYDROXYETHOXY)-5-(2-METHOXYPHENOXY)-[2,2'-BIPYRIMIDIN]-4-YL)BENZENESULFONAMIDE
CAS :Degré de pureté :95%Masse moléculaire :551.619995117188Ref: 10-F802473
1gÀ demander2gÀ demander5gÀ demander50mgÀ demander100mgÀ demander250mgÀ demander500mgÀ demander(6-Benzhydryloxycarbonylamino-purin-9-yl)-acetic acid
CAS :Degré de pureté :97.0%Couleur et forme :SolidMasse moléculaire :403.39801025390625Acetaldehyde 2,4-Dinitrophenylhydrazone
CAS :<p>Stability Hygroscopic<br>Applications Acetaldehyde 2,4-Dinitrophenylhydrazone is a dinitrophenylhydrazone (DNPH) derivative of an aliphatic alldehyde found in mainstream cigarette smoke. Dyes and metabolites.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zwiener, C. et al.: Anal. Bioanal. Chem., 372, 615 (2002); Delgado, B. et al.: J. Liq. Chrom. Rel. Technol., 31, 361 (2008); Miller, J.H. et al.: J. Chrom. Sci., 48, 12 (2010);<br></p>Formule :C8H8N4O4Couleur et forme :YellowMasse moléculaire :224.174-(5-methylfuran-2-yl)-6-(3,4,5-trimethoxyphenyl)pyrimidin-2-amine
CAS :Degré de pureté :95.0%Masse moléculaire :341.367004394531252-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl] Sumatriptan (>90%)
CAS :Produit contrôlé<p>Impurity Sumatriptan EP Impurity A<br>Stability Light Sensitive<br>Applications 2-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl] Sumatriptan Succinate (Sumatriptan EP Impurity A) is an impurity of Sumatriptan (S810000), a serotonin 5HT-1-receptor agonist.<br>References Skwierawska, A.. et al.: Poish. J. Chem., 77, 329 (2003);<br></p>Formule :C27H37N5O2SCouleur et forme :Off White SolidMasse moléculaire :495.68Methotrexate-d3 Diglutamate Trifluoroacetate
CAS :Produit contrôlé<p>Applications Methotrexate-d3 Diglutamate is the isotope labelled analog of Methotrexate Diglutamate (M260720); a metabolite of Methotrexate (M260675) which is a folic acid antagonist, antineoplastic, and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)<br></p>Formule :C25H26D3N9O8•x(C2HF3O2)•xH2SO4Couleur et forme :NeatMasse moléculaire :586.58114029813-[(Dimethylamino)methyl]-1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one Hydrochloride
CAS :Produit contrôlé<p>Impurity Ondansetron EP Impurity A/ Ondansetron USP Related Compound A<br>Applications 3-[(Dimethylamino)methyl]-1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron EP Impurity A) is an impurity of Ondansetron (O655000), an antiemetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mackinnon, J.W.M., et al.: Eur. J. Cancer Clin. Oncol., 25, 61 (1989);<br></p>Formule :C16H20N2O·ClHCouleur et forme :NeatMasse moléculaire :292.801-Propyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
CAS :Degré de pureté :98%Masse moléculaire :154.16900634765625N-Formyl Memantine
CAS :Produit contrôlé<p>Applications N-Formyl Memantine is an impurity of Memantine (M218000). Memantine impurity E per USP.<br>References Gerzon, K., et al.: J. Med. Chem., 6, 760 (1963),<br></p>Formule :C13H21NOCouleur et forme :WhiteMasse moléculaire :207.312-Chloro-4,6-diphenylpyrimidine
CAS :Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :266.73001098632815-Diazoimidazole-4-carboxamide
CAS :Produit contrôlé<p>Impurity Temozolomide USP Related Compound A<br>Applications Temozolomide USP Related Compound A<br></p>Formule :C4H3N5OCouleur et forme :NeatMasse moléculaire :137.103,4-Dihydro Naratriptan Oxalate
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications 3,4-Dihydro Naratriptan Oxalate is the basic form of 3,4-Dihydro Naratriptan(D449205); it is an impurity of Naratriptan (N378730), It is a triptan drug and is used for the treatment of migraine headaches.<br>References Dulery, B.D., et al.: J. Pharm. Biomed. Anal., 15, 1009 (1997), Havanka, H., et al.: Clin. Ther., 22, 970 (2000),<br></p>Formule :C17H23N3O2S·C2H2O4Couleur et forme :White To Light YellowMasse moléculaire :333.45 + 90.03N-(4-((4-Chloro-6-((5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)thio)phenyl)cyclopropanecarboxamide
CAS :Degré de pureté :95.0%Masse moléculaire :400.89001464843756,6'-Binicotinic Acid
CAS :Produit contrôlé<p>Applications A Nicotinic acid (N429250) derivative for treatment of hypercholesterolemia and hyperlipidemia and cardiovascular disease.<br>References Hales, N.J., et al.: J. Med. Chem., 36, 3853 (1993),<br></p>Formule :C12H8N2O4Couleur et forme :NeatMasse moléculaire :244.204-(3,4-dimethylphenyl)-6-(thiophen-2-yl)pyrimidin-2-amine
CAS :Degré de pureté :95.0%Masse moléculaire :281.3800048828125Allopurinol-d2
CAS :Produit contrôlé<p>Applications Labelled xanthine oxidase inhibitor; decreases uric acid production. Used in treatment of hyperuricemia and chronic gout. Antiurolithic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Benezra, S.A., et al.: Anal. Profiles Drug Subs., 7, 1, (1978), Dalbeth, N., et al.: Rheumatology, 44, 1090 (2005), Dinarello, C., et al.: J. Exp. Med., 201, 1355 (2005),<br></p>Formule :C52H2H2N4OCouleur et forme :Light BrownMasse moléculaire :138.121,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one
CAS :<p>Impurity Ondansetron EP Impurity C<br>Applications 1,2,3,9-Tetrahydro-9-(methyl-d3)-4H-carbazol-4-one (Ondansetron EP Impurity C) is used in the preparation of 5-HT3 modulators useful in the treatment and prevention of 5-HT3 receptor-mediated diseases. 1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one is an impurity of Ondansetron (O655000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Huang, W. et al.: Zhong. Yao. Dax. Xueb., 30, 1 (1999); Kim, M. et al.: Heterocycles, 45, 2041 (1997); Feng, R. et al.: Zhong. Yaox. Zaz., 46, 1436 (2011);<br></p>Formule :C13H13NOCouleur et forme :Off-WhiteMasse moléculaire :199.255-((tert-Butoxycarbonyl)amino)pyrimidine-2-carboxylic acid
CAS :Degré de pureté :95%Masse moléculaire :239.2310028076172Uridine-3'-monophosphate disodium salt
CAS :Degré de pureté :99.0%Couleur et forme :SolidMasse moléculaire :368.14498901367196,6’-Methylenebis[(3RS)-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one(Ondansetron Impurity B)
CAS :<p>Impurity Ondansetron EP Impurity B<br>Applications Ondansetron EP Impurity B.<br></p>Formule :C37H38N6O2Couleur et forme :NeatMasse moléculaire :598.742-[3-(Aminocarbonyl)-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid
CAS :Produit contrôlé<p>Applications 2-[3-(Aminocarbonyl)-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid is an impurity of Febuxostat (F229000), an xanthine oxidase/xanthine dehydrogenase inhibitor used for the treatment of hyperuricemia and chronic gout.<br>References Kadivar, M.H., et al.: J. Pharma. Biomed. Anal., 56, 749 (2011);<br></p>Formule :C16H18N2O4SCouleur et forme :White To Off-WhiteMasse moléculaire :334.39Zolmitriptan
CAS :Produit contrôlé<p>Applications Zolmitriptan is a serotonin 5HTID-receptor agonist and used to treat migraine (1,2,3).<br>References (1) Glen, R.C., et al.: J. Med. Chem., 38, 3566 (1995)(2) Seaber, E., et al.: Brit. J. Clin. Pharmacol., 41, 141 (1996)(3) Tepper, S.J., et al.: Curr. Med. Res. Opin., 15, 254 (1999)<br></p>Formule :C16H21N3O2Couleur et forme :NeatMasse moléculaire :287.364,6-diphenyl-1,2-dihydropyrimidin-2-one
CAS :Degré de pureté :98%Masse moléculaire :248.285003662109381-phenyl-5-[(pyrimidin-2-ylsulfanyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid
CAS :Degré de pureté :95.0%Masse moléculaire :313.33999633789064-Hydroxythiobenzamide
CAS :<p>Applications 4-Hydroxythiobenzamide is used in the synthesis of PPARα agonists used in increasing HDLc levels. Also used in the synthesis of potent CDK5 inhibitors in the treatment of Alzheimer’s disease.<br>References Sierra, M. et al.: J. Med. Chem., 50, 685 (2007); Zhong, W. et al.: Bioorg. Med. Chem. Lett., 17, 5384 (2007);<br></p>Formule :C7H7NOSCouleur et forme :NeatMasse moléculaire :153.2Iso Rizatriptan
CAS :Produit contrôlé<p>Impurity Rizatriptan EP Impurity C<br>Applications Iso Rizatriptan (Rizatriptan EP Impurity C) is a potential impurity of Rizatriptan. A regioisomer of Rizatriptan.<br>References Dill, K., et al.: J. Phys. Chem., 91, 1980 (1987), Cole, L., et al.: Anal. Chem., 64, 1317 (1992), Street, L., et al.: J. Med. Chem., 1995, 38, 1799<br></p>Formule :C15H19N5Couleur et forme :NeatMasse moléculaire :269.344-(6-BROMOINDOLIN-1-YL)PYRIMIDIN-2-AMINE HCL
Degré de pureté :95.0%Masse moléculaire :327.6099853515625Methyl 4-((6-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-yl)oxy)benzoate
CAS :Degré de pureté :97.0%Masse moléculaire :324.3399963378906N,N'-Di-Boc-guanidine
CAS :Degré de pureté :99.0%Couleur et forme :Solid, Crystalline Powder or PowderMasse moléculaire :259.30599975585945-Amino-2-chloropyrimidine-4-carboxylic acid
CAS :Degré de pureté :97%Masse moléculaire :173.559997558593753-TERT-BUTYL-1-CYCLOHEXYL-1-(6-HYDROXYHEXYL)UREA
Degré de pureté :95.0%Masse moléculaire :298.471008300781253-Amino-4-carbamoylpyrazole Hemisulfate
CAS :Produit contrôlé<p>Impurity Allopurinol EP Impurity A / Allopurinol USP Related Compound A<br>Stability Hygroscopic<br>Applications 3-Amino-4-carbamoylpyrazole Hemisulfate (Allopurinol EP Impurity A) is an impurity of Allopurinol (A547300), a pyrazole derivative that has been shown to induce neoplasm immunogenicity.<br>References Nicolin, A. et al.: Cancer, Chemother. Rep., 57, 3 (1973); Bonmassar, E. et al.: Cancer Res., 35, 1957 (1975);<br></p>Formule :C4H6N4O·H2O4SCouleur et forme :White To Light BrownMasse moléculaire :350.313,5-Dimethyl-1-adamantanol
CAS :Produit contrôlé<p>Impurity Memantine USP Related Compound B (3,5-Dimethyladamantane-1-ol)<br>Applications 3,5-Dimethyl-1-adamantanol is an impurity of Memantine (M218000). Memantine impurity B. Memantine USP Related Compound B (3,5-Dimethyladamantane-1-ol).<br>References England, P., et al.: Biochemistry, 43, 11623 (2004), Schousboe, A., et al.: Eur. J. Pharmacol., 500, 281 (2004), Horvat, S., et al.: J. Med. Chem., 49, 3136 (2006),<br></p>Formule :C12H20OCouleur et forme :WhiteMasse moléculaire :180.296-(4-Methoxyphenyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
CAS :Formule :C11H10N2O2SDegré de pureté :95.0%Masse moléculaire :234.27Ethyl 2-(2-(methylamino)pyrimidin-4-yl)-1H-indole-5-carboxylate
CAS :Degré de pureté :95.0%Couleur et forme :Liquid, No data available.Masse moléculaire :296.32998657226566-METHYL-N1-(3-METHYL-1-(6-(METHYLAMINO)PYRIMIDIN-4-YL)-1H-PYRAZOL-5-YL)BENZENE-1,3-DIAMINE
CAS :Degré de pureté :95.0%Masse moléculaire :309.377014160156254-(2,3-dimethoxyphenyl)-6-(5-methylfuran-2-yl)pyrimidin-2-amine
CAS :Degré de pureté :95.0%Masse moléculaire :311.341003417968752,4,5,6-Tetraaminopyrimidine Sulfate
CAS :Produit contrôlé<p>Applications Intermediate in the production of Methotrexate<br>References Chiosis, G., et al.: Bioorg. Med. Chem., 10, 3555 (2002), Palanki, M., et al.: J. Med. Chem., 50, 4279 (2007), Zav'yalov, S., et al.: Pharm. Chem. J., 42, 51 (2008),<br></p>Formule :C4H8N6·H2O4SCouleur et forme :NeatMasse moléculaire :238.224-(2-fluorophenyl)-6-(thiophen-2-yl)pyrimidin-2-amine
CAS :Degré de pureté :95.0%Masse moléculaire :271.309997558593753-Nitropyridine
CAS :Produit contrôlé<p>Applications Used in the novel synthesis of biologically active nitro heterocyclic compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pawar, N., et al.: Eur. J. Pharm. Sci., 21, 115 (2004), Badgujar, D., et al.: J. Sci. Ind. Res., 66, 250 (2007),<br></p>Formule :C5H4N2O2Couleur et forme :NeatMasse moléculaire :124.103-(2-CHLOROPYRIMIDIN-4-YL)-1-(CYCLOPROPYLSULFONYL)-1H-INDOLE
Degré de pureté :95.0%Masse moléculaire :333.7900085449219N-benzyl-7H-purin-6-amine hydrochloride
CAS :Degré de pureté :98%Masse moléculaire :261.7099914550781N'-Methyl-N,N-diphenylurea
CAS :<p>Impurity Temozolomide USP Related Compound B<br>Applications N'-Methyl-N,N-diphenylurea is used in the stabilization of thermal propellants. Temozolomide USP Related Compound B.<br>References Bohn, M. et al.: Prop. Exp. Pyro.,et al.: 19, 266 (1994); Muthurajan, H. et al.: J. Hazard. Mat., 133, 30 (2006);<br></p>Formule :C14H14N2OCouleur et forme :NeatMasse moléculaire :226.27
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