Dérivés de Quinazoline et de Quinoléine
Les quinazolines et les quinoléines sont des composés hétérocycliques azotés à structure aromatique qui jouent un rôle clé dans la synthèse de médicaments à activité anticancéreuse, antimicrobienne et anti-inflammatoire. Leurs dérivés présentent des modifications structurelles qui optimisent leur biodisponibilité et leur sélectivité, permettant ainsi le développement de nouveaux principes actifs pour diverses applications thérapeutiques. Ces composés sont utilisés dans la fabrication d’API destinés au traitement du cancer, des infections, des maladies neurodégénératives et cardiovasculaires. De plus, les dérivés de quinazoline et de quinoléine sont essentiels dans la recherche d’inhibiteurs enzymatiques et dans la conception de molécules bioactives innovantes.
Chez CymitQuimica, nous proposons des dérivés de quinazoline et de quinoléine de haute pureté pour des applications en synthèse chimique, développement pharmaceutique et biotechnologie.
65630 produits trouvés pour "Dérivés de Quinazoline et de Quinoléine"
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1-(6-Chloro-9H-carbazol-2-yl)ethanone
CAS :<p>1-(6-Chloro-9H-carbazol-2-yl)ethanone is a chemical substance that belongs to the class of synthetic drugs. It is used as a pharmaceutical intermediate in the production of other chemical substances, including antibiotics and antihypertensives. 1-(6-Chloro-9H-carbazol-2-yl)ethanone has been shown to be metabolized by cytochrome P450 enzymes and by glucuronidases or esterases. This product can also be used as an impurity standard for HPLC analyses of fluoroquinolones.</p>Formule :C14H10ClNODegré de pureté :Min. 95%Masse moléculaire :243.69 g/molLumateperone
CAS :<p>Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).</p>Formule :C24H28FN3ODegré de pureté :99.68% - 99.91%Couleur et forme :SolidMasse moléculaire :393.511,11'-(1,4-Piperazinediyl)bis-dibenzo[b,f][1,4]thiazepine
CAS :<p>11,11'-(1,4-Piperazinediyl)bis-dibenzo[b,f][1,4]thiazepine is a molecule that inhibits the replication of DNA and RNA in viruses. The structure of 11,11'-(1,4-Piperazinediyl)bis-dibenzo[b,f][1,4]thiazepine has been determined by X-ray crystallography. Hepatocyte cells were used for this study because they are important for the metabolism of drugs. This molecule binds to serine proteases and prevents them from functioning properly. It also inhibits the replication of hepatitis C virus and human immunodeficiency virus type 1 (HIV-1). 11,11'-(1,4-Piperazinediyl)bis-dibenzo[b,f][1,4]thiazepine can be used as a template for designing other molecules with antiviral</p>Formule :C30H24N4S2Degré de pureté :Min. 95%Couleur et forme :Yellow SolidMasse moléculaire :504.67 g/mol2-Amino-5,6-dichloro-3(4H)-quinazoline acetic acid
CAS :<p>This is a synthetic, impurity standard for 2-Amino-5,6-dichloro-3-(4H)-quinazoline acetic acid (CAS No. 1159977-03-3) that can be used in the drug product development process. This product is available as a custom synthesis and as an analytical standard for HPLC. It is also available as a pharmacopoeia grade material. The compound has been shown to have niche applications in metabolism studies and natural products research.</p>Formule :C10H9Cl2N3O2Degré de pureté :Min. 95%Masse moléculaire :274.1 g/molRuDiOBn
CAS :<p>RuDiOBn exhibits low antioxidant activity by scavenging DPPH and ABTS free radicals with scavenging rates of 13.2% and 5.9% at a concentration of 100 μg/mL. It inhibits collagen glycation and reduces the formation of advanced glycation end-products (AGE) with an IC50 of 2.45 μg/mL. RuDiOBn also enhances fibroblast proliferation and migration, stimulates collagen synthesis, and aids in skin repair and regeneration while inhibiting collagenase.</p>Formule :C29H22O7Couleur et forme :SolidMasse moléculaire :482.481Rodatristat
CAS :<p>Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively).</p>Formule :C27H27ClF3N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :561.98SD-7300
CAS :<p>SD-7300 (SC-81490) functions as an orally active inhibitor targeting MMP-2, MMP-9, and MMP-13, exhibiting potent inhibition with K_i values of 0.03, 0.01, and 0.03 nM, respectively. By inhibiting these metalloproteinases, SD-7300 effectively reduces extracellular matrix degradation by tumor cells, thereby curbing their invasion and metastasis. Additionally, this compound acts as a dose-dependent inhibitor of mouse corneal angiogenesis and prevents interleukin-1-induced degradation of bovine cartilage. SD-7300 is applicable in the study of breast cancer.</p>Formule :C21H30F3N3O7SCouleur et forme :SolidMasse moléculaire :525.54UK-370106
CAS :<p>UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-</p>Formule :C35H44N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :572.73Indinavir monohydrate
CAS :<p>Indinavir monohydrate is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability.</p>Formule :C36H49N5O5Couleur et forme :SolidMasse moléculaire :631.82PNU-248686A
CAS :<p>PNU-248686A is an inhibitor of matrix metalloproteinase (MMP).</p>Formule :C22H18ClNaO5S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :484.95Macitentan (n-butyl analogue)
CAS :<p>Macitentan n-butyl analogue, an oral ETA/ETB receptor blocker, may treat IPF and PAH.</p>Formule :C20H21Br2N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :587.29Faldaprevir
CAS :Faldaprevir is an orally effective, selective, non-covalent HCV NS3/4A protease inhibitor with high inhibitory activity against HCV 1a and 1b genotype.Formule :C40H49BrN6O9SDegré de pureté :99.04% - 99.19%Couleur et forme :SolidMasse moléculaire :869.82UK 356618
CAS :<p>UK 356618 is a potent and selective inhibitor of matrix metalloprotease-3 (IC50: 5.9 nM).</p>Formule :C34H43N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :557.72Lisuride
CAS :<p>Lisuride: an oral D2 dopamine agonist, ergot derivative, used in Parkinson's, migraine, and high prolactin research.</p>Formule :C20H26N4OCouleur et forme :SolidMasse moléculaire :338.45Finafloxacin
CAS :Finafloxacin is a pH-activated fluoroquinolone, most effective at pH 5.0-6.0, targeting bacterial topoisomerases, used for UTIs and H. pylori infections.Formule :C20H19FN4O4Couleur et forme :SolidMasse moléculaire :398.39ZK159222
CAS :<p>ZK159222 is an effective 1α,25-(OH)2D3 receptor (VDR) agonist. ZK159222 has a partial agonistic character.</p>Formule :C32H48O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :512.72Neptinib
CAS :<p>Neptinib (NEP010), a derivative of Afatinib, exhibits enhanced antitumor properties and improved pharmacokinetics when administered orally. It demonstrates a notable suppression of tumor expansion in mouse models of non-small cell lung cancer harboring various EGFR mutations. Furthermore, Neptinib effectively inhibits the EGFR kinase family, exhibiting IC 50 values of 0.24 nM for EGFR wt, 7.25 nM for EGFR L858R/T790M, 0.46 nM for EGFR L858R, and 1.79 nM for EGFR T790M.</p>Formule :C22H23ClFN5O2Couleur et forme :SolidMasse moléculaire :443.90HU-308
CAS :<p>HU-308, a synthetic cannabinoid analogue, is a highly selective agonist of the CB2 receptor. It demonstrates an affinity for the CB2 receptor that is over 440 times greater than its affinity for the CB1 receptor, which are predominantly found in immune cells. This compound plays a crucial role in modulating the immunosuppressive effects of the endocannabinoid system (ECS). Additionally, HU-308 possesses anti-inflammatory and neuroprotective properties, and it regulates the function of microglia. Its potential applications include research into neuroinflammation and retinal diseases.</p>Formule :C27H42O3Couleur et forme :SolidMasse moléculaire :414.62Tezosentan
CAS :<p>Tezosentan is an antagonist of the endothelin receptor (pA2s: 9.5, 7.7 for ETA and ETB receptors, respectively).</p>Formule :C27H27N9O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :605.63Arterolane
CAS :<p>Arterolane is an antimalarial compound. For against P. falciparum Ro73 and W2, the IC50s are both 1.1 nM.</p>Formule :C22H36N2O4Couleur et forme :SolidMasse moléculaire :392.53Thioquinapiperifil dihydrochloride
CAS :<p>Thioquinapiperifil dihydrochloride is a potent, selective PDE-5 inhibitor (IC50: 0.074 nM) for research.</p>Formule :C24H29ClN6OSDegré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :485.05OncoFAP
CAS :<p>OncoFAP is an ultra-high affinity fibroblast activating protein (FAP) ligand with potential tumour targeting.</p>Formule :C21H19F2N5O5Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :459.40Beloranib
CAS :<p>Beloranib is a fumagillin anticancer drug. Beloranib belongs to an angiogenesis inhibitor.</p>Formule :C29H41NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :499.643-Aminobenzene-1,2-diol
CAS :<p>3-Aminobenzene-1,2-diol (compound C8) is an inhibitor of matrix metalloproteinases (MMP), with IC50 values of 20, 26, 16, and 16.3 μM against MMP-2, MMP-8, MMP-9, and MMP-14, respectively.</p>Formule :C6H7NO2Couleur et forme :SolidMasse moléculaire :125.13SD-2590 HCl
CAS :<p>SD-2590 HCl is an MMP-2,-3, -9, -8, 13, and -14 inhibitor.</p>Formule :C22H26ClF3N2O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :554.96Quinagolide Free Base
CAS :<p>Quinagolide Free Base is a non-ergot dopamine D(2)-agonist.</p>Formule :C20H33N3O3SCouleur et forme :SolidMasse moléculaire :395.56Vibegron
CAS :<p>Vibegron (MK-4618) is an effective and selective Beta 3 adrenergic receptor agonist, used to treat overactive bladder (OAB).</p>Formule :C26H28N4O3Couleur et forme :SolidMasse moléculaire :444.53Tofogliflozin
CAS :Tofogliflozin specifically inhibits SGLT2; IC50s are 2.9 nM (human), 14.9 nM (rat), 6.4 nM (mouse).Formule :C22H26O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :386.44Quinapril
CAS :<p>Quinapril is an orally active, non-peptide, and non-thiol angiotensin-converting enzyme (ACE) inhibitor. It primarily blocks the conversion of angiotensin I to angiotensin II in both plasma and tissues. Upon enzymatic hydrolysis, Quinapril is converted into the pharmacologically active Quinaprilat and is effective in hypertension models.</p>Formule :C25H30N2O5Couleur et forme :SolidMasse moléculaire :438.516BAY-7598
CAS :<p>BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).</p>Formule :C28H31N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :505.56COTI-219
CAS :<p>COTI-219 is an oral inhibitor of KRAS with antitumor properties [1].</p>Formule :C17H18N6SCouleur et forme :SolidMasse moléculaire :338.43(3S,4R)-Tofacitinib
CAS :(3S,4R)-Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib is a JAK3 inhibitor(IC50 : 1 nM).Formule :C16H20N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :312.37Aclidinium
CAS :<p>Aclidinium, a dual-action compound, serves as a long-acting muscarinic antagonist and a β2-adrenoceptor (β2-AR) agonist, exhibiting bronchodilator properties. It effectively reduces lung hyperinflation, enhances lung function, and prolongs exercise endurance time. This compound is commonly utilized in studies focusing on chronic obstructive pulmonary disease (COPD).</p>Formule :C26H30NO4S2Couleur et forme :SolidMasse moléculaire :484.65CM-352
CAS :<p>CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage.</p>Formule :C24H29N3O6SDegré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :487.57Tipelukast
CAS :<p>Tipelukast (KCA 757), an oral drug for asthma research, blocks leukotrienes and fights inflammation and fibrosis.</p>Formule :C29H38O7SDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :530.67RJF02215
CAS :RJF02215, an MMP-9 inhibitor, exhibits growth inhibitory activity against the ovarian cancer cell line SKOV3. It is utilized in tumor research.Formule :C17H12ClN3OS3Couleur et forme :SolidMasse moléculaire :405.95Aleglitazar
CAS :<p>Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively.</p>Formule :C24H23NO5SDegré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :437.51Vecabrutinib
CAS :<p>Vecabrutinib (SNS-062) is a potent and noncovalent BTK and ITK inhibitor (Kd: 0.3 nM and 2.2 nM, respectively). Vecabrutinib displays an IC50 of 24 nM for ITK.</p>Formule :C22H24ClF4N7O2Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :529.92Obicetrapib
CAS :<p>Obicetrapib (AMG-899) is an inhibitor of cholesteryl ester transfer protein.</p>Formule :C32H31F9N4O5Degré de pureté :99.26% - >99.99%Couleur et forme :SolidMasse moléculaire :722.6(S)-Rasagiline
CAS :<p>(S)-Rasagiline is rasagiline S-isomer, and is an agent of anti-Parkinson.</p>Formule :C12H13NCouleur et forme :SolidMasse moléculaire :171.24Ezetimibe 2-Fluorobenzene Isomer ((3R,4S)-1-(4-fluorophenyl)-3-((S)-3-(2-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one)
CAS :Lactams, nesoiFormule :C24H21F2NO3Couleur et forme :White Off-White SolidMasse moléculaire :409.14895Ezetimibe Ketone ((3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)azetidin-2-one)
CAS :Lactams, nesoiFormule :C24H19F2NO3Couleur et forme :White SolidMasse moléculaire :407.1333N-Acetyl-L-Leucine (Acetyl-L-leucine)
CAS :Acyclic amides (including acyclic carbamates) and their derivatives and salts thereof, nesoiFormule :C8H15NO3Couleur et forme :White PowderMasse moléculaire :173.10519Everolimus System Suitability Mixture (This is a mixture of Everolimus, Everolimus oxepane isomer and 9-O-Hydroxyethyl Sirolimus)
Diagnostic or lab reagents on a backing, prepared diagnostic or lab reagents whether or not on a backing, whether or not in the form of kits, nesoiCouleur et forme :White Yellow PowderDasatinib
CAS :Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structureFormule :C22H26ClN7O2S·H2OMasse moléculaire :505.16629Rivaroxaban Open Ring ((R)-5-chloro-N-(2-hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)thiophene-2-carboxamide)
CAS :Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormule :C18H20ClN3O4SCouleur et forme :Off-White SolidMasse moléculaire :409.0863Chlorothiophene carboxylic acid (5-chlorothiophene-2-carboxylic acid)
CAS :Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormule :C5H3ClO2SCouleur et forme :Off-White Pale Yellow SolidMasse moléculaire :161.95423Ezetimibe Tetrahydropyran Analog ((2R,3R,6S)-N,6-bis(4-fluorophenyl)-2-(4-hydroxyphenyl)tetrahydro-2H-pyran-3-carboxamide)
CAS :Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoiFormule :C24H21F2NO3Couleur et forme :White Off-White SolidMasse moléculaire :409.14895Dasatinib Related Compound A
CAS :Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structureFormule :C22H26ClN7O3SMasse moléculaire :503.15064(4-Methylbenzoyl)trifluoroacetone (1,1,1-Trifluoro-4-hydroxy-4-(4-methylphenyl)-3-buten-2-one)
CAS :Ketones and quinones, w/not with other oxygen function,and their halogenated,sulfated,nitrated,or nitrosated derivatives, nesoiFormule :C11H9F3O2Couleur et forme :White SolidMasse moléculaire :230.05546Methylbis(2-pyridylethyl)amine Hydrochloride (N-Methyl-N,N-bis(2-pyridin-2-yl-ethyl)amine trihydrochloride)
CAS :Compounds containing an unfused pyridine ring in the structure, nesoiFormule :C15H19N3·3HClCouleur et forme :Light Brown PowderMasse moléculaire :241.1579Desmethoxy Omeprazole (2-(((3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-5-methoxy-1H-benzo[d]imidazole; 2-[(RS)-[(3,5-Dimethylpyridin-2-yl)methyl]sulfinyl]-5-methoxy-1H-benzimidazole) (DISCONTINUED)
CAS :Compounds containing an unfused pyridine ring in the structure, nesoiFormule :C16H17N3O2SCouleur et forme :White Off-White SolidMasse moléculaire :315.10415Ezetimibe Desfluoroaniline Analog ((3R,4S)-3-[(S)-3-(4-Fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-1-phenylazetidin-2-one)
CAS :Lactams, nesoiFormule :C24H22FNO3Couleur et forme :White Off-White PowderMasse moléculaire :391.15837Levetiracetam acid ((S)-2-(2-oxopyrrolidin-1-yl)butanoic acid)
CAS :Lactams, nesoiFormule :C8H13NO3Couleur et forme :Off-White SolidMasse moléculaire :171.08954Methoxyamiodarone ([2-[(1RS)-1-Methoxybutyl]benzofuran-3-yl][4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone) (DISCONTINUED)
CAS :Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoiFormule :C26H31I2NO4Couleur et forme :Colorless GelMasse moléculaire :675.03425Atazanavir Benzylidenehydrazine Carbamate (Methyl [(S)-1-{[(2S,3S)-3-hydroxy-1-phenyl-4-{1-[4-(pyridin-2-yl)benzyl]-2-[4-(pyridin-2-yl)benzylidene]hydrazinyl}butan-2-yl]amino}-3,3-dimethyl-1-oxobutan-2-yl]carbamate)
CAS :Compounds containing an unfused pyridine ring in the structure, nesoiFormule :C42H46N6O4Couleur et forme :Light Yellow SolidMasse moléculaire :698.35805Acetyl Rotigotine Hydrochloride ((S)-6-(propyl(2-(thiophen-2-yl)ethyl)amino)-5,6,7,8-tetrahydronaphthalen-1-yl acetate hydrochloride)
CAS :Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormule :C21H28ClNO2SCouleur et forme :Off-White SolidMasse moléculaire :393.15293(-)-3,4-Dihydroxynorephedrine
CAS :Formule :C9H13NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :183.2044Irbesartan Impurity 17-d4
CAS :Formule :C25H23D4N7O2Couleur et forme :White To Off-White SolidMasse moléculaire :461.56Balsalazide Impurity 6
CAS :Formule :C20H19N6O6·ClCouleur et forme :Dark Orange SolidMasse moléculaire :439.41 35.45Tadalafil Impurity 97
CAS :Formule :C23H22N4O4Couleur et forme :White To Off-White SolidMasse moléculaire :418.45
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