Dérivés de Quinazoline et de Quinoléine
Les quinazolines et les quinoléines sont des composés hétérocycliques azotés à structure aromatique qui jouent un rôle clé dans la synthèse de médicaments à activité anticancéreuse, antimicrobienne et anti-inflammatoire. Leurs dérivés présentent des modifications structurelles qui optimisent leur biodisponibilité et leur sélectivité, permettant ainsi le développement de nouveaux principes actifs pour diverses applications thérapeutiques. Ces composés sont utilisés dans la fabrication d’API destinés au traitement du cancer, des infections, des maladies neurodégénératives et cardiovasculaires. De plus, les dérivés de quinazoline et de quinoléine sont essentiels dans la recherche d’inhibiteurs enzymatiques et dans la conception de molécules bioactives innovantes.
Chez CymitQuimica, nous proposons des dérivés de quinazoline et de quinoléine de haute pureté pour des applications en synthèse chimique, développement pharmaceutique et biotechnologie.
65615 produits trouvés pour "Dérivés de Quinazoline et de Quinoléine"
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5-(Ethoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic Acid
CAS :Produit contrôléFormule :C17H18N2O6Couleur et forme :NeatMasse moléculaire :346.334-Defluoro-4-(1H-1,2,4-triazol-1-yl) Fluconazole
CAS :Produit contrôlé<p>Impurity Fluconazole EP Impurity B / Fluconazole USP Related Compound A<br>Applications 4-Defluoro-4-(1H-1,2,4-triazol-1-yl) Fluconazole (Fluconazole EP Impurity B) is an impurity of the antifungal agent Fluconazole (F421000).<br>References Ramesh, B. et al.: J. Pharm. Res., 4, 1401 (2011); Al-Rimawi, F.: Jor. J. Chem., 4, 357 (2009);<br></p>Formule :C15H14FN9OCouleur et forme :NeatMasse moléculaire :355.339-Desmethyl endo-Granisetron Hydrochloride
CAS :Produit contrôlé<p>Impurity Granisetron USP Related Compound C<br>Stability Hygroscopic<br>Applications 9-Desmethyl endo-Granisetron hydrochloride (Granisetron USP Related Compound C) is an impurity in the synthesis of Granisetron HCl (G780000), a specific serotonin (5HT3) receptor antagonist. Used as an antiemetic.<br>References Kilpatrick, G.J., et al.: Nature, 330, 746 (1987), Durig, T., et al.: J. Pharm. Sci., 86, 1092 (1997), Yuasa, H., et al.: Chem. Pharm. Bull., 44, 1361 (1996),<br></p>Formule :C17H22N4O·ClHCouleur et forme :NeatMasse moléculaire :334.846-Des(diethanolamino)-6-chloro Dipyridamole
CAS :Produit contrôlé<p>Impurity Dipyridamole EP Impurity C<br>Applications 6-Des(diethanolamino)-6-chloro Dipyridamole (Dipyridamole EP Impurity C) is a Dipyridamole (D492625) impurity. An antitumor nucleoside pyrimido pyrimidine.<br>References Fontani, F., et al.: J. Chromatogr., 280, 181 (1983),<br></p>Formule :C20H30ClN7O2Couleur et forme :NeatMasse moléculaire :435.95(R)-Phenylephrine β-D-Glucuronide
Produit contrôlé<p>Stability Hygroscopic<br>Applications A metabolite of Phenylephrine (P320640).<br></p>Formule :C15H21NO8Couleur et forme :NeatMasse moléculaire :343.33N-Nitroso Amodiaquine
Produit contrôléFormule :C20H21ClN4O2Couleur et forme :NeatMasse moléculaire :384.8592,4-Difluorobenzoic Acid
CAS :Produit contrôlé<p>Applications 2,4-Difluorobenzoic Acid (cas# 1583-58-0) is a compound useful in organic synthesis.<br></p>Formule :C7H4F2O2Couleur et forme :NeatMasse moléculaire :158.10rac O-Acetyl Pseudoephedrine Hydrochloride
CAS :Produit contrôlé<p>Applications rac O-Acetyl Pseudoephedrine is a racemic O-acetylated analogue of the non-selective adrenergic agonist Pseudoephedrine (P839350).<br>References Snopek, J. et al.: J. Chrom., 438, 211 (1988);<br></p>Formule :C12H17NO2·ClHCouleur et forme :WhiteMasse moléculaire :243.73rac erythro-Dihydro Bupropion-d9
CAS :Produit contrôlé<p>Applications A labelled metabolite of the drug Bupropion (B689625).<br>References Hsyu, P-H., et al.: J. Clin. Pharmacol., 37, 737 (1997)<br></p>Formule :C13H11D9ClNOCouleur et forme :NeatMasse moléculaire :250.81Perphenazine-d8 Dihydrochloride Salt (1.0 mg/mL in Methanol)
CAS :Formule :C21H18D8ClN3OS·2HClCouleur et forme :ColourlessMasse moléculaire :484.93Desmethyl 7-Methoxycarbonyl Nintedanib (Nintedanib Impurity C)
Produit contrôlé<p>Applications Desmethyl 7-Methoxycarbonyl Nintedanib is an impurity of Intedanib (I666650), which is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases. it is an indolinone as triple angiokinase inhibitors and an antitumor agent.<br>References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)<br></p>Formule :C30H31N5O4Couleur et forme :NeatMasse moléculaire :525.5984-(2-Nitrophenyl)morpholin-3-one
CAS :Produit contrôlé<p>Applications 4-(2-Nitrophenyl)morpholin-3-one is an intermediate in the synthesis of 4-(2-Aminophenyl)-3-morpholinone (A625985). 4-(2-Aminophenyl)-3-morpholinone is a reagent used in the preparation of various Morpholine based pharmaceuticals.<br>References Mederski, W., et al.: Bioorg. Med. Chem. Lett., 14, 3763 (2004); Roehrig, S., et al.: J. Med. Chem., 48, 5900 (2005)<br></p>Formule :C10H10N2O4Couleur et forme :NeatMasse moléculaire :222.2Ethionamide Sulfoxide-D3
CAS :Produit contrôléFormule :C8D3H7N2OSCouleur et forme :NeatMasse moléculaire :185.26(2,5-Difluorophenyl)(piperidin-4-yl)methanone Hydrochloride
CAS :Produit contrôléFormule :C12H13F2NO·HClCouleur et forme :NeatMasse moléculaire :261.70Azilsartan Imidazole Carbonyl Dioxolene Ester
CAS :<p>Applications Azilsartan Imidazole Carbonyl Dioxolene Ester is an impurity of Azilsartan (A926900), an analgesic and antiinflammatory drugs containing angiotensin II antagonists.<br>References Kohara, Y., et al.: J. Med. Chem., 39, 5228 (1996), Plomgaard, P., et al.: Diabetes, 54, 2939 (2005), Fenton, C., et al.: Drugs, 2005, 65, 537,<br></p>Formule :C33H28N6O8Couleur et forme :NeatMasse moléculaire :636.612-Methylisoindole-1,3-dione
CAS :Produit contrôlé<p>Applications Photoreduction of N-methylphthalimide (NMP) with 2,3-dimethyl-2-butene h and the selective electroreduction of N-methylphthalimide to 3-hydroxy-2-methyl-isoindolin-1-one have been studied.<br>References Mazzocchi, P., et al.: J. Am. Chem. Soc., 106, 7567 (1984); Villagran, C., et al.: Ultrasonics Sonochemistry, 12, 423 (2005)<br></p>Formule :C9H7NO2Couleur et forme :NeatMasse moléculaire :161.163-Ethyl Haloperidol
CAS :Produit contrôléFormule :C23H27ClFNO2Couleur et forme :NeatMasse moléculaire :403.92N-Methylthiophene-2-carboxamide
CAS :Produit contrôléFormule :C6H7NOSCouleur et forme :NeatMasse moléculaire :141.19Methyl 4-Methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzoate
CAS :Produit contrôlé<p>Applications Methyl 4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzoate is an intermediate used in the synthesis of 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide (M326838), which is an impurity of Nilotinib (N465300), a possible agent in the treatment of chronic myelogenous leukemia.<br>References Corbin, A., et al.: J. Biol. Chem., 277, 32214 (2002); Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005); Gleixner, K., et al.: Blood, 107, 752 (2006); Nicolini, F., et al.: Leukemia, 20, 1061 (2006)<br></p>Formule :C18H16N4O2Couleur et forme :NeatMasse moléculaire :320.35(S)-N-[2-[2,3-Dihydro-6-hydroxy-7-(2-hydroxyethyl)-1H-inden-1-yl]ethyl]propanamide
CAS :Produit contrôlé<p>Applications Intermediate in the production of Ramelteon.<br>References Uchikawa, O., et al.: J. Med. Chem., 45, 4222 (2002),<br></p>Formule :C16H23NO3Couleur et forme :NeatMasse moléculaire :277.36Triciribine
CAS :Produit contrôlé<p>Applications Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is also a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO.<br>References Garrett, C.R. et al.: Invest. New Drugs, 29, 1381 (2011); Ptak, R.G. et al.: AIDS Res. Human Retrovir., 14, 1315 (1998); Bennett, L.L. et al.: BIochem. Pharmacol., 27, 233 (1978);<br></p>Formule :C13H16N6O4Couleur et forme :NeatMasse moléculaire :320.30Indomethacin Ethyl Ester
CAS :Produit contrôléFormule :C21H20ClNO4Couleur et forme :Off-WhiteMasse moléculaire :385.841-[1-(4-Chlorobenzoyl)-5-hydroxy-2-methyl-1H-indole-3-acetate]β-D-Glucopyranuronic Acid
CAS :Produit contrôlé<p>Stability Hygroscopic, Moisture Sensitive<br>Applications 1-[1-(4-Chlorobenzoyl)-5-hydroxy-2-methyl-1H-indole-3-acetate]β-D-Glucopyranuronic Acid is an analog of Indomethacin Acyl-β-D-glucuronide a metabolite of Indomethacin (I641000). Acyl glucuronides have been implicated in the toxicity of many xenobiotics and marketed drugs.<br>References Abid, A., et al.: Biochem. Pharmacol., 50, 557 (1995), Gamage, N., et al.: Toxicol. Sci., 90, 5 (2006), Cerveny, L., et al.: Drug Metab. Dispos., 35, 1032 (2007), Hayeshi, R., et al.: Eur. J. Pharm. Sci., 35, 383 (2008),<br></p>Formule :C24H22ClNO10Couleur et forme :NeatMasse moléculaire :519.895-Ethyl-5-phenyl-2-(1-phenylpropyl)dihydropyrimidine-4,6(1H,5H)-dione (Mixture of Diastereomers)
CAS :Produit contrôlé<p>Impurity Primidone EP Impurity F<br>Applications An impurity arising in the synthesis of Primidone.<br>References Pippenger, C.E., et al.: J. Anal. Toxicol., 1, 118 (1977),<br></p>Formule :C21H24N2O2Couleur et forme :NeatMasse moléculaire :336.43O-Desethyl Resiquimod-d6
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications O-Desethyl Resiquimod-d6 is the labelled analogue of O-Desethyl Resiquimod (D228575), which is derived from its parent compound Resiquimod (R144680), which is an imidazoquinoline derivative that acts as an immune response modifier. Resiquimod shows antitumor and antiviral activity and is used in the treatment of skin lesions such as herpes simplex virus. Resiquimod is a toll-like receptor 9 (TLR7) agonist.<br>References Wu, J.J. et al.: Antivir. Res., 64, 79 (2004); Fife, K.H. et al.: Antimicrob. Agents Chemother., 52, 477 (2008); Szeimies, R.M. et al.: Brit. J. Dermatol., 159, 205 (2008);<br></p>Formule :C15H12D6N4O2Couleur et forme :NeatMasse moléculaire :292.373-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one
CAS :Produit contrôlé<p>Applications 3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one is a reactant used in the synthesis of Zatebradine analogues as potential blockers od hyperpolarization-activated current.<br>References Romanelli, M. et al.: Bioorg. med. CHem., 13, 1211 (2005);<br></p>Formule :C15H18ClNO3Couleur et forme :NeatMasse moléculaire :295.764-[[3-[2-(3-Chlorophenyl)ethyl]-2-pyridinyl]carbonyl]-1-piperidinecarboxylic AcidEthyl Ester
CAS :Produit contrôlé<p>Applications Loratadine intermediate, as antiallergic agent.<br></p>Formule :C22H25ClN2O3Couleur et forme :NeatMasse moléculaire :400.90trans-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolane-4-methanol
CAS :Produit contrôlé<p>Applications trans-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolane-4-methanol is an impurity of Ketoconazole (K186000).<br>References Ryu, J., et al. Bull. Korean Chem. Soc., 24, 460 (2003)<br></p>Formule :C14H14Cl2N2O3Couleur et forme :NeatMasse moléculaire :329.18D 13223-d4 (Flupirtine Metabolite)
CAS :Produit contrôlé<p>Applications The major active labelled metabolite of Flupirtine in human plasma. A potassium channel opener<br>References Niebch, G., et al.: Arzneim.-Forsch., 42, 1343 (1992), Friedel, H., et al.: Drugs, 45, 548 (1993), Fu, I., et al.: J. Pharm. Biomed. Anal., 18, 347 (1998),<br></p>Formule :C14H12D4ClFN4OCouleur et forme :NeatMasse moléculaire :314.782,5-Bis(trifluoromethyl)aniline
CAS :Produit contrôlé<p>Applications 2,5-Bis(trifluoromethyl)aniline is a haloalkul substituted aniline used in the preparation of anti-benign prostatic hyperplasia drug, Dutasteride (D735000).<br>References Liang, Y. et al.: Jil. Dax. Xueb. Lixeub., 45, 1035 (2007);<br></p>Formule :C8H5F6NCouleur et forme :ColourlessMasse moléculaire :229.12(S)-Rivastigmine
CAS :<p>Applications S-Rivastigmine is an isomer of Rivastigmine ( an acetylcholinesterase inhibitor used in the treatment of neurological disorders such as Alzheimer’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Howes, L et al.: Drug. Safe., 37, 391 (2014); Shahar, O. et al.: Nucl. Acids Res., 42, 5869 (2014);<br></p>Formule :C14H22N2O2Couleur et forme :ColourlessMasse moléculaire :250.343,5-Bis(chloromethyl)pyridine Hydrochloride
CAS :Produit contrôlé<p>Stability Unstable in Aqueous Solution<br>Applications 3,5-BIS(CHLOROMETHYL)PYRIDINE HCL (cas# 1210824-61-5) is a useful research chemical.<br></p>Formule :C7H7Cl2N•HClCouleur et forme :NeatMasse moléculaire :212.5Hydroxy Varenicline N-Trifluoroacetic Acid Salt
CAS :Produit contrôlé<p>Applications Protected Varenicline metabolite.<br></p>Formule :C15H12F3N3O2Couleur et forme :NeatMasse moléculaire :323.27Desthiazolylmethyloxycarbonyl Ritonavir
CAS :Produit contrôléFormule :C32H45N5O3SDegré de pureté :>85%Couleur et forme :NeatMasse moléculaire :579.802-Des(5-methyl-1,3,4-oxadiazole-2-carboxamide) (E)-2-(N,N-Dimethylformimidamide) Raltegravir
CAS :Produit contrôlé<p>Applications 2-Des(5-methyl-1,3,4-oxadiazole-2-carboxamide) (E)-2-(N,N-Dimethylformimidamide) Raltegravir is an impurity of Raltegravir (R100300), a potent human immunodeficiency virus (HIV) integrase inhibitor. A novel anti-AIDS drug.<br>References Wade, K., et al.: J. Pharmacol. Biomed. Anal., 8, 401 (1990), Hazuda, D., et al.: Science, 287, 646 (2000), Williams, J., et al.: Drug Metab. Dispos., 32, 1201 (2004), Duckett, C., et al.: Xenobiotica, 36, 59 (2006), Miners, J., et al.: Biochem. Pharmacol., 71, 1531 (2006), Summa, V., et al.: J. Med. Chem., 49, 6646 (2006),<br></p>Formule :C19H24FN5O3Couleur et forme :NeatMasse moléculaire :389.42Indomethacin 1-Menthol ester
CAS :Produit contrôlé<p>Applications Indomethacin terpenoids' esters were synthesized and assessed both in vitro and in vivo as indomethacin dermal prodrugs.<br>References Bonina,, Francesco. , et al.: European Journal of Pharmaceutical Sciences, 14, 123 (2001),<br></p>Formule :C29H34ClNO4Couleur et forme :NeatMasse moléculaire :496.038Hydroxy Atrazine-d5
CAS :Produit contrôlé<p>Applications Labelled Hydroxy Atrazine (H828600). Hydroxy Atrazine is a major metabolite of Atrazine (A794600).<br>References Thurman, E., et al.: Environ. Sci. Technol., 26, 2440 (1992), Evgenidou, E., et al.: J. Agric. Food Chem., 50, 6423 (2002), Namiesnik, J., et al.: Anal. Bioanal. Chem., 381, 279 (2005), Hultgren, S., et al.: Anal. Bioanal. Chem., 393, 929 (2009),<br></p>Formule :C82H5H10N5OCouleur et forme :NeatMasse moléculaire :202.27Lodoxamide
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Lodoxamide is an antiallergic drug that acts as a mast cell stabilizer. It is effective in the treatment of allergic conjunctivitis and in decreasing vascular permeability.<br>References Ciprandi, G., et al.: Allergy, 51(12), 946-951 (1996); Bayer, Atilla., et al.: Ophthalmologica, 217(2), 119-123 (2003)<br></p>Formule :C11H6ClN3O6Couleur et forme :NeatMasse moléculaire :311.63Perampanel-d5
CAS :Produit contrôlé<p>Applications Perampanel-d5, is the labeled analogue of Perampanel (P285520), an antiepileptic drug.<br>References Shih, J., et al.: Therap. Clinical Risk Management, 9, 285 (2013); Rogawski, M. A., et al.: Epilepsy Curr., 11, 56 (2011);<br></p>Formule :C23D5H10N3OCouleur et forme :Light Orange Colour SolidMasse moléculaire :354.422-((3-Fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid
CAS :Produit contrôlé<p>Applications 2-((3-Fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid (cas# 1289942-66-0) is a useful research chemical.<br></p>Formule :C12H15FN2O3Couleur et forme :NeatMasse moléculaire :254.26(R,R)-Dihydro Bupropion β-D-Glucuronide
<p>Applications (R,R)-Dihydro Bupropion β-D-Glucuronide is a glucuronide metabolite of the drug Bupropion (B689625, HCl salt). Bupropion is a selective inhibitor of dopamine uptake.<br>References Soroko, F., et al.: J. Pharm. Pharmacol., 29, 769 (1977), Tucker, W.E., J. Clin. Psychiatry, 44, 60 (1983), Hsyu, P-H., et al.: J. Clin. Pharmacol., 37, 737 (1997), West, R., et al.: Expert Opin. Pharmacother., 4, 533 (2003),<br></p>Formule :C19H28ClNO7Couleur et forme :NeatMasse moléculaire :417.884-Fluoro-2-(hydroxymethyl)phenol
CAS :Produit contrôlé<p>Applications 4-Fluoro-2-(hydroxymethyl)phenol can be used in preparation of naphthyridine derivatives as chemokine receptor antagonists useful in the treatment of pain.<br>References Wang, X., et al.: PCT Int. Appl., WO 2013010453 A1 20130124 (2013)<br></p>Formule :C7H7FO2Couleur et forme :NeatMasse moléculaire :142.128Ethyl 2-Methoxy-5-sulfamoylbenzoate
CAS :Produit contrôlé<p>Impurity Sulpiride EPimpurity C<br>Applications ethyl 2-methoxy-5-sulfamoylbenzoate (cas# 33045-53-3) is a useful research chemical.<br></p>Formule :C10H13NO5SCouleur et forme :NeatMasse moléculaire :259.28(Z)-4-(2,4-Difluorobenzoyl)piperidine Oxime
CAS :Produit contrôlé<p>Applications Intermediate in the preparation of Risperidone (R525000) and it’s derivatives.<br></p>Formule :C12H14F2N2OCouleur et forme :NeatMasse moléculaire :240.2492(2S,4S)-Argatroban
CAS :Produit contrôlé<p>Applications Synthetic thrombin inhibitor. Antithrombotic.<br>References Abiko, Y., et al.: Thromb. Res., 24, 285 (1981), Kikumoto, R., et al.: Biochemistry, 23, 85 (1984),<br></p>Formule :C23H36N6O5SCouleur et forme :NeatMasse moléculaire :508.63DL-threo-Droxidopa-d3 Hydrochloride Salt Hydrate
CAS :Produit contrôlé<p>Applications DL-threo-Droxidopa-d3 Hydrochloride Salt Hydrate is an isotope labeled compound of DL-threo-Droxidopa (D689950), a synthetic amino acid precursor of Norepinephrine. An Antiparkinson.<br>References Bartholini, J., et al.: J. Pharmacol. Exp. Ther ., 193, 523 (1975), Kato, T., et al.: Biochem. Pharmacol., 36, 3051 (1987), Kawabata, A., et al.: Br J. Pharmacol., 111, 503 (1994)<br></p>Formule :C9H8D3NO5•HCl•x(H2O)Couleur et forme :NeatMasse moléculaire :216.2136461802(±)-Oxomemazine
CAS :Produit contrôléFormule :C18H22N2O2SCouleur et forme :NeatMasse moléculaire :330.44N-[(2Z)-Piperazin-2-ylidene]-2,2,2-trifluoroacetohydrazide
CAS :Produit contrôlé<p>Applications Sitagliptin intermediate.<br>References Sarges, R, et al.: J. Med. Chem., 33, 2240 (1990),<br></p>Formule :C6H9F3N4OCouleur et forme :NeatMasse moléculaire :210.16(3S)-1-[2-(3-Ethenyl-4-hydroxyphenyl)ethyl]-α,α-diphenyl-3-pyrrolidineacetamide
CAS :Produit contrôléFormule :C28H30N2O2Couleur et forme :NeatMasse moléculaire :426.553-Bromo-2-methylpropionic Acid
CAS :<p>Impurity Captopril EP Impurity D<br>Stability Hygroscopic<br>Applications 3-Bromo-2-methylpropionic Acid (Captopril EP Impurity D) is used in the preparation of captopril selenium analogs as antioxidants and ACE inhibitors used as antihypertensive drugs.<br>References Bhuyan, B. et al.: Org. Biomol. Chem., 9, 1356 (2011);<br></p>Formule :C4H7BrO2Couleur et forme :Colourless LiquidMasse moléculaire :167.00rac Pimobendan
CAS :Produit contrôlé<p>Applications Pimobendan is a cardiotonic agent. The study of the cardiotonic mechanism of Pimobendan using ventricular muscles from rabbits and guinea pigs suggests that Pimobendan acts by inhibiting phosphodiesterase III and potassium channel. The potent venodilating action of Pimobendan makes it a suitable treatment option for patients with congestive heart failure (CHF) as it also improves systemic vasoconstriction.<br>References Yokota, S. et al.: Yakuri Chiryo, 20, 1143 (1992); Yamamoto, M. et al.: Kank. Igaku Ken. Nenpo, 47, 155 (1996); Matsumoto, A. et al.: Cardiovas. Drugs Ther., 12, 595 (1998);<br></p>Formule :C19H18N4O2Couleur et forme :NeatMasse moléculaire :334.37R-Amisulpride
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications R-Amisulpride is an isomer of the antipsychotic Amisulpride (A633250). R-Amisulprideis a potential antidiabetic agent.<br>References Roix, J.J., et. al.: Diabetes Obesity Metab., 14, 329 (2012)<br></p>Formule :C17H27N3O4SCouleur et forme :NeatMasse moléculaire :369.482-(R)-[1-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-(S)-fluorophenylmorpholine[Aprepitant-M2]
CAS :Produit contrôlé<p>Applications A metabolite of Aprepitant.<br>References Ballard, T., et al.: Eur. J. Pharmacol., 412, 255 (2001), Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001), Severini, C., et al.: Pharmacol. Rev., 54, 285 (2002),<br></p>Formule :C20H18F7NO2Couleur et forme :NeatMasse moléculaire :437.35Ambrisentan-d10
CAS :Produit contrôlé<p>Applications Ambrisentan-d10, is the labeled analogue of Ambrisentan (A575860), a nonpeptide endothelin ETA receptor antagonist. Antihypertensive.<br>References Riechers, H., et al.: J. Med. Chem., 39, 2123 (1996), Billman, G.E., et al.: Curr. Opin. Invest. Drugs, 3, 1483 (2002), Vatter, H., et al.: Clin. Neuropharmacol., 26, 73 (2003),<br></p>Formule :C22H12D10N2O4Couleur et forme :NeatMasse moléculaire :388.48(alphaS)-N,N,α-Trimethyl-3-(4-nitrophenoxy)benzenemethanamine
CAS :Produit contrôlé<p>Applications (αS)-N,N,α-Trimethyl-3-(4-nitrophenoxy)benzenemethanamine is an impurity of Rivastigmine Tartrate (R541000). Rivastigmine Tartrate is a brain selective acetylcholinesterase inhibitor.<br>References Rosler, M., et al.: Brit. Med. J., 318, 633 (1999); Enz, A., et al.: Prog. Brain Res., 98, 431 (1993)<br></p>Formule :C16H18N2O3Couleur et forme :OrangeMasse moléculaire :286.334-Hydroxy-2-methyl- 1,1-dioxide-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide
CAS :Produit contrôléFormule :C8H8N2O4S2Couleur et forme :NeatMasse moléculaire :260.29Flumequine Ethyl Ester
CAS :Produit contrôlé<p>Applications Flumequine Ethyl Ester is an impurity of Flumequine (F445000), a quinolone antibacterial.<br>References Stilwell, G., et al.: Antimicrob. Agents Chemother., 7, 483 (1975), Rohlfing, S.R., et al.: J. Antimicrob. Chemother., 3, 615 (1977),<br></p>Formule :C16H16FNO3Couleur et forme :NeatMasse moléculaire :289.302-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride
CAS :Produit contrôlé<p>Impurity Omeprazole EP Impurity XI<br>Applications 2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride (Omeprazole EP Impurity XI) is an intermediate in the production of the antiulcer agent Omeprazole.<br>References Roma, G., et al.: J. Med. Chem., 50, 2886 (2007), Hoffmann, S., et al.: Toxicol. Lett., 180, 9 (2008),<br></p>Formule :C9H12ClNO·ClHCouleur et forme :WhiteMasse moléculaire :222.11N-Methyl Topiramate
CAS :Produit contrôlé<p>Impurity Topiramate N-methyl impurity<br>Applications N-Methyl Topiramate, is an impurity of Topiramate (T540250); which is an anticonvulsant (antiepilepsy) drug, that has been approved for weight loss by FDA.<br>References Maryanoff, B.E., et al.: J. Med. Chem., 30, 880 (1987), Bialer, M.: Clin. Pharmacokinet., 24, 441 (193),<br></p>Formule :C13H23NO8SCouleur et forme :NeatMasse moléculaire :353.39Carmustine-D8-Nitroso
Produit contrôléFormule :C5HD8Cl2N3O2Couleur et forme :NeatMasse moléculaire :193.1014,6-Dichloro-5-nitro-2-(propylthio)pyrimidine
CAS :<p>Stability Unstable in DMSO Solution<br>Applications 4,6-Dichloro-5-nitro-2-(propylthio)pyrimidine is used as a reactnat in the synthesis of carba-nucleosides as potent antagonists of ADP purinergic receptor P2Y12 on human platelets.<br>References Ye, H., et al.: ChemMedChem, 3, 732 (2008);<br></p>Formule :C7H7Cl2N3O2SCouleur et forme :NeatMasse moléculaire :268.120Methyl 4-Amino-3-methylbenzoate
CAS :Produit contrôlé<p>Applications Methyl 4-Amino-3-methylbenzoate is used in the synthesis of neuroprotective hydrazides used in the treatment of Alzheimer’s. It is also used in the research and development of diphenylamine-based retinoids.<br>References Chiruta, C. et al.: Bioorg. Med. Chem. Lett., 21, 2733 (2013); Ohta, K. et al.: Bioorg. Med. Chem. Lett., 23, 81 (2013);<br></p>Formule :C9H11NO2Couleur et forme :NeatMasse moléculaire :165.192,2'-Ethylenedianiline
CAS :Produit contrôlé<p>Applications 2,2'-Ethylenedianiline is used as a reagent to synthesize Oxcarbazepine (O869250), a broad-specturm, second-generation anticonvulsant drug that is used to treat partial and complex partial seizures in children and adults. 2,2'-Ethylenedianiline is also used as a reagent to prepare a series of triterpines (e.g. Lupeol [L474850]), compounds that have chemopreventative activity.<br>References Asmaa, M., et al.: Pac. J. Cancer Prevent., 15, 475 (2014); Kalis, M. & Huff, N.: Clin. Ther., 23, 680 (2001); Malke, S., et al.: Pharm. Sci., 69, 211 (2007); Schmidt, D. & Elger, C.: Epil. Beh., 5, 627 (2004)<br></p>Formule :C14H16N2Couleur et forme :NeatMasse moléculaire :212.29Hydroxynorketamine Hydrochloride
CAS :Produit contrôlé<p>Applications Hydroxynorketamine is a metabolite of Ketamine (K165300, HCl salt) which is a medication used mainly for starting and maintaining anesthesia.<br>References Adams, J., et al.: Biomed. Mass Spec., 11, 527 (1981); Sass, W.C., et al.: Anal. Profiles Drug Subs., 6, 297 (1977); Reich, D.L., et al.: Can. J. Anaesth., 36, 186 (1989)<br></p>Formule :C12H15Cl2NO2Couleur et forme :White To Off-WhiteMasse moléculaire :276.16N-Desmethyl N-Nitroso Olopatadine-d3
Produit contrôléFormule :C20D3H17N2O4Couleur et forme :NeatMasse moléculaire :355.4021-(6-Methylpyridin-3-yl)-2-((4-(2-(6-methylpyridin-3-yl)-2-oxoethyl)phenyl)sulfonyl)ethanone
CAS :Produit contrôléFormule :C22H20N2O4SCouleur et forme :NeatMasse moléculaire :408.473-(2-Chloroethyl)-2-methyl-9-(benzyloxy)-4H-pyrido[1,2a]pyrimidin-4-one
CAS :Produit contrôlé<p>Applications 3-(2-Chloroethyl)-2-methyl-9-(benzyloxy)-4H-pyrido[1,2a]pyrimidin-4-one (cas# 147687-17-0) is a compound useful in organic synthesis.<br></p>Formule :C18H17ClN2O2Couleur et forme :NeatMasse moléculaire :328.793-Chlorobenzyl Cyanide
CAS :Produit contrôlé<p>Applications 3-Chlorobenzyl Cyanide is a useful synthetic intermediate. It was used to design EGFR Tyrosine Kinase Inhibitors. It can also be used to synthesize imidoyl thioureas as non-nucleoside reverse transcriptase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Traxler, P., et al.: J. Med. Chem., 42, 1018 (1999); Ludovici, D., et al.: Bioorg. Med. Chem. Lett., 11, 2225 (2001)<br></p>Formule :C8H6ClNCouleur et forme :NeatMasse moléculaire :151.59(E)-Thiothixene
CAS :Produit contrôlé<p>Applications (E)-Thiothixene is an antipsychotic agent used in the treatment of psychological disorders.<br>References Andorn, A. et al.: Brain Res., 971, 66 (2003); Seeman, P. et al.: Mol. Pharmacol. 28, 391 (1985);<br></p>Formule :C23H29N3O2S2Couleur et forme :NeatMasse moléculaire :443.631,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid Diethyl Ester
CAS :Produit contrôléFormule :C19H22N2O6Couleur et forme :YellowMasse moléculaire :374.394-epi-Ritonavir
CAS :Produit contrôlé<p>Impurity Ritonavir EP Impurity O<br>Applications 4-epi-Ritonavir (Ritonavir EP Impurity O) is an isomer of Ritonavir (R535000), a selective HIV protease inhibitor. It is a COVID19-related research product.<br>References Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994), Ammaranond, P., et al.: J. Clin. Virol., 26, 153 (2003), Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005), Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788(2006)<br></p>Formule :C37H48N6O5S2Couleur et forme :NeatMasse moléculaire :720.942-Butyl-1,3-diazaspiro[4.4]non-1-en-4-one Hydrochloride
CAS :Produit contrôlé<p>Impurity Irbesartan Lactam Impurity<br>Applications 2-Butyl-1,3-diazaspiro[4.4]non-1-en-4-one is an intermediate of Irbesartan (Avapro) (I751000).<br>References Gillis, J., et al.: Drugs, 54, 885 (1997), Chando, T., et al.: Drug Metab. Disps., 26, 408 (1998), Hines, J., et al.: Eur. J. Pharmacol., 384, 81 (1999),<br></p>Formule :C11H18N2O·ClHCouleur et forme :NeatMasse moléculaire :230.73rac Desmethyl Citalopram-d4 Hydrobromide
CAS :Produit contrôlé<p>Applications rac Desmethyl Citalopram-d4 Hydrobromide is the labeled analogue of rac Desmethyl Citalopram Hydrobromide (D230870), a metabolite of Citalopram (C505000), an inhibitor of serotonin (5-HT) uptake. Used as an antidepressant.<br>References Gnerre, C., et al.: J. Pharm. Pharmacol., 53, 1125 (2001); Hagg, S., et al.: Br. J. Clin. Pharmacol., 51, 169 ( 2001); von Moltke, L., et al.: Drug Metab. Dispos., 29, 1102 (2001); Reis, M., et al.: Ther. Drug Monit., 27, 469 (2005)<br></p>Formule :C19H16D4BrFN2OCouleur et forme :NeatMasse moléculaire :395.3Homopiperazine
CAS :Produit contrôlé<p>Applications Homopiperazine acts as a corrosion inhibitor for iron. It has also been used in the preparation of potent H3 receptor antagonists for use as treatments for neurodegenerative conditions such as Alzheimer’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Granese, S. et al.: Corrosion., 44, 322 (1988); Pippel, D. et al.: Org. Proc. Res. Devel., 15, 638 (2011);<br></p>Formule :C5H12N2Couleur et forme :NeatMasse moléculaire :100.16Riociguat Nitroso Impurity 1
Produit contrôléFormule :C18H16FN9OCouleur et forme :NeatMasse moléculaire :393.151-Hydroxy-3,4-dihydroquinolin-2(1H)-one
CAS :Produit contrôléFormule :C9H9NO2Couleur et forme :NeatMasse moléculaire :163.17Haloperidol Decanoate N-Oxide
Produit contrôléFormule :C31H41ClFNO4Couleur et forme :NeatMasse moléculaire :546.11XL518
CAS :Produit contrôlé<p>Applications A potent, selective, orally bioavailable inhibitor of MEK1, a component of the RAS/RAF/MEK/ERK pathway. It inhibits proliferation and stimulates apoptosis in a variety of human tumor cell lines. In preclinical xenograft models, oral administration of XL518 results in sustained inhibition of pERK in tumor tissue, but not brain tissue, leading to tumor growth inhibition and regression at well tolerated doses.<br>References Rosen, L.S. et al.: J. Clin. Oncol., 26, 14585 (2008);<br></p>Formule :C21H21F3IN3O2Couleur et forme :White To Off-WhiteMasse moléculaire :531.314-[4-[(5R)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone Hydrochloride (>90%)
CAS :Produit contrôlé<p>Applications 4-[4-[(5R)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone Hydrochloride is an intermediate in the synthesis of ent-Rivaroxaban (R538005), the R-isomer of Rivaroxaban (R538000), which is a novel antithrombotic agent.<br>References Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Formule :C14H17N3O4·HClDegré de pureté :>90%Couleur et forme :White To Off-WhiteMasse moléculaire :291.31 + (36.46)1H-1-Ethyl Candesartan
CAS :Produit contrôlé<p>Applications Candesartan (C175575) impurity.<br></p>Formule :C26H24N6O3Couleur et forme :WhiteMasse moléculaire :468.51N-trifluoroacetyl Varenicline
CAS :Produit contrôlé<p>Applications 7,8,9,10-Tetrahydro-8-(trifluoroacetyl)-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine is used to prepare varenicline, which is a smoking cessation. It is a Varenicline protected impurity.<br>References Coe, J., et al.: J. Med. Chem., 48, 3474 (2005) ;<br></p>Formule :C15H12F3N3OCouleur et forme :NeatMasse moléculaire :307.27051,4-bis(7-Chloroquinolin-4-yl)piperazine
CAS :Produit contrôléFormule :C22H18Cl2N4Couleur et forme :NeatMasse moléculaire :409.31rac O-Desmethyl Naproxen-d3
CAS :Produit contrôléFormule :C13D3H9O3Couleur et forme :Dark RedMasse moléculaire :219.25Desmethyl-N-propyl Imiquimod
CAS :Produit contrôlé<p>Applications Desmethyl-N-propyl Imiquimod is a pharmacologically active compound related to Imiquimod (I475000), an immune response modifier. It stimulates the production of Interferon-a.<br>References Megyeri, K., et al.: Mol. Cell Biol., 15, 2207, (1995), Witt, P.L., et al.: Cancer Res., 53, 5176 (1993), Edwards, L., et al.: Arch. Dermatol., 134, 25 (1998); Gerster, J. et al.: J. Med. Chem., 48, 3481 (2005);<br></p>Formule :C13H14N4Couleur et forme :NeatMasse moléculaire :226.28N-Desmethyl Prochlorperazine-d8 Dimaleate
CAS :Produit contrôléFormule :C27H22D8ClN3O8SCouleur et forme :NeatMasse moléculaire :600.11Efavirenz 1-Desamine-1-oxy
Produit contrôlé<p>Applications Efavirenz 1-Desamine-1-oxy is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>Formule :C14H8ClF3O3Couleur et forme :NeatMasse moléculaire :316.663-O-Benzyl-4,5-O-(1-methylethyldiene)-β-D-fructopyranose
CAS :Produit contrôlé<p>Applications Intermediate in the preparation of 2,3-Desisopropylidene Topiramate, a metabolite of Topiramate<br></p>Formule :C16H22O6Couleur et forme :NeatMasse moléculaire :310.34Tadalafil-13C2,d3
CAS :Produit contrôlé<p>Applications Tadalafil-13C2,d3 is labelled Tadalafil (T004500) which is used for the treatment of erectile dysfunction. It is a phosphodiesterase 5 inhibitor.<br>References Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003), Doggrell, S.A., et al.: Expert Opin. Pharmacother., 6, 75 (2005), Forgue, S.T., et al.: Br. J. Clin. Pharmacol., 61, 280 (2005)<br></p>Formule :C2013C2H16D3N3O4Couleur et forme :White PowderMasse moléculaire :394.41(S)-5-Chloro-a-(cyclopropylethynyl)-2-[[(4-methoxyphenyl)methyl]amino]-a-(trifluoromethyl)benzenemethanol
CAS :Produit contrôlé<p>Applications (S)-5-Chloro-α-(cyclopropylethynyl)-2-[[(4-methoxyphenyl)methyl]amino]-α-(trifluoromethyl)benzenemethanol is the S enantiomer of rac-5-Chloro-α-(cyclopropylethynyl)-2-[[(4-methoxyphenyl)methyl]amino]-α-(trifluoromethyl)benzenemethanol (C365145). (S)-5-Chloro-α-(cyclopropylethynyl)-2-[[(4-methoxyphenyl)methyl]amino]-α-(trifluoromethyl)benzenemethanol is also an impurity of Efavirenz (E425000), an HIV-1 reverse transcriptase inhibitor.<br>References Pierce, M., et al.: J. Org. Chem., 63, 8536 (1998)<br></p>Formule :C21H19ClF3NO2Couleur et forme :NeatMasse moléculaire :409.83Resiquimod
CAS :<p>Applications Resiquimod is an imidazoquinoline derivative that acts as an immune response modifier. Resiquimod shows antitumor and antiviral activity and is used in the treatment of skin lesions such as herpes simplex virus. Resiquimod is a toll-like receptor 9 (TLR7) agonist.<br>References Wu, J.J. et al.: Antivir. Res., 64, 79 (2004); Fife, K.H. et al.: Antimicrob. Agents Chemother., 52, 477 (2008); Szeimies, R.M. et al.: Brit. J. Dermatol., 159, 205 (2008);<br></p>Formule :C17H22N4O2Couleur et forme :White SolidMasse moléculaire :314.384-(Diphenylmethyl)-1-nitrosopiperidine
CAS :Produit contrôléFormule :C18H20N2OCouleur et forme :NeatMasse moléculaire :280.37Denitro Tolcapone
CAS :Produit contrôléFormule :C14H12O3Couleur et forme :NeatMasse moléculaire :228.24Lacidipine Monomethyl Ester
CAS :Produit contrôlé<p>Applications Lacidipine Monomethyl Ester is an impurity of Lacidipine (L098000); a dihydropyridine calcium channel blocker. Antihypertensive.<br>References Mohan, Arivozhi., et al.: J. AOAC Int., 94(6), 1800-1806 (2011); Safar, M., et al.: Clin. Pharmacol. Ther., 46, 94 (1989); Kharat, V.R., et al.: J. Pharm. Biomed. Anal., 28, 789 (2002); McCormack, A.J., et al.: Drugs, 63, 2327 (2003)<br></p>Formule :C25H31NO6Couleur et forme :NeatMasse moléculaire :441.52(4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-2-(4-methoxyphenyl)-4-(trifluoromethyl)-2H-3,1-benzoxazine(Mixture of 2 Diastereomers)
CAS :Produit contrôlé<p>Applications An impurity arising in the synthesis of Efavirenz (E425000).<br>References Chen, C., et al.: Enantiomer, 4, 599 (1999), Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995),<br></p>Formule :C21H17ClF3NO2Couleur et forme :NeatMasse moléculaire :407.81(S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one
CAS :Produit contrôlé<p>Applications (S)-4-(4-(5-(AMINOMETHYL)-2-OXOOXAZOLIDIN-3-YL)PHENYL)MORPHOLIN-3-ONE (cas# 446292-10-0) is a useful research chemical.<br></p>Formule :C14H17N3O4Couleur et forme :White To Off-WhiteMasse moléculaire :291.30N-Nitroso-Vildagliptin carboxylic acid Impurity
Produit contrôléFormule :C17H25N3O5Couleur et forme :NeatMasse moléculaire :351.3971-(4-(4-(tert-Butyl)phenyl)-4-hydroxybutyl)-4-piperidinecarboxylic Acid Ethyl Ester
CAS :Produit contrôléFormule :C22H35NO3Couleur et forme :NeatMasse moléculaire :361.52N-Desmethyl 4-Benzyloxy Toremifene Hydrochloride
CAS :Produit contrôlé<p>Applications Toremifene (T547500) derivative. A triphenylalkene derivative with anti-estrogenic, and anti-tumor properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formule :C32H33Cl2NO2Couleur et forme :NeatMasse moléculaire :534.52Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro Dasatinib
CAS :Produit contrôlé<p>Applications Intermediate in the preparation of Dasatinib metabolite, used in the treatment of cancers and immune diseases. It is a COVID19-related research product.<br></p>Formule :C16H13Cl2N5O2SCouleur et forme :NeatMasse moléculaire :410.284-Chloro Perphenazine
CAS :Produit contrôlé<p>Applications 4-Chloro Perphenazine is an impurity of Perphenazine (P291100), an D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic.<br>References Briggs, K., et al.: Toxicology, 231, 113 (2007), Toga, T., et al.: J. Pharmacol. Sci., 105, 207 (2007),<br></p>Formule :C21H26ClN3OSCouleur et forme :NeatMasse moléculaire :403.97Diphenhydramine-d6 N-β-D-Glucuronide
CAS :Produit contrôlé<p>Applications A labelled glucuronide metabolite of Diphenhydramine (D486900) in humans.<br>References Breyer-Pfaff, U., et al.: Drug Metab. Dispos., 25, 340 (1997),<br></p>Formule :C23H23D6NO7Couleur et forme :NeatMasse moléculaire :437.52Loratadine Impurity F
CAS :Produit contrôlé<p>Impurity Loratadine EP Impurity F; Loratadine USP Related Compound G Impurity<br>Applications Loratadine Impurity F (Loratadine EP Impurity F; Loratadine USP Related Compound G Impurity) is a fluorinated analog of Loratadine (L469575), which is a nonsedating-type histamine H1-receptor.<br>References Bruttmann, G., et al.: J. Allergy Clin. Immunol., 83, 411 (1989), Haria, M., et al.: Drugs, 48, 617 (1994)<br></p>Formule :C22H24ClFN2O2Couleur et forme :White To Off-WhiteMasse moléculaire :402.895-Sulfosalicylic Acid Dihydrate
CAS :Produit contrôlé<p>Applications 5-Sulfosalicylic Acid Dihydrate is for reducing and fixation of proteins in agarose and polyacrylamide gels.<br></p>Formule :C7H6O6S·2H2OCouleur et forme :WhiteMasse moléculaire :254.21Bis(3-methylthien-2-yl)methanone
CAS :Produit contrôlé<p>Applications Bis(3-methylthien-2-yl)methanone is an impurity of Tiagabine (T436400), a GABA uptake inhibitor and nticonvulsant agent.<br>References Zhang, J.G., et al.: Chem. Res. Chin. Uni., 22, 351 (2006); Callen, G., et al.: Heterocycles., 39, 293 (1994);<br></p>Formule :C11H10OS2Couleur et forme :NeatMasse moléculaire :222.33Methylene-Bis Paroxetine Dihydrochloride
CAS :Produit contrôlé<p>Impurity Paroxetine EP Impurity F<br>Applications Methylene-Bis Paroxetine Dihydrochloride (Paroxetine EP Impurity F) is used in the chiral HPLC method for chiral purity determination of Paroxetine drug substance.<br>References Zukowski, J., et al.: Chirality, 15, 600 (2003),<br></p>Formule :C39H42Cl2F2N2O6Couleur et forme :NeatMasse moléculaire :743.66Indomethacin Acyl-β-D-glucuronide (>90%)
CAS :Produit contrôlé<p>Applications Indomethacin Acyl-β-D-glucuronide is a metabolite of Indomethacin (I641000). Acyl glucuronides have been implicated in the toxicity of many xenobiotics and marketed drugs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Abid, A., et al.: Biochem. Pharmacol., 50, 557 (1995), Gamage, N., et al.: Toxicol. Sci., 90, 5 (2006), Cerveny, L., et al.: Drug Metab. Dispos., 35, 1032 (2007), Hayeshi, R., et al.: Eur. J. Pharm. Sci., 35, 383 (2008),<br></p>Formule :C25H24ClNO10Couleur et forme :NeatMasse moléculaire :533.91ZK 159222
CAS :Produit contrôlé<p>Stability Light Sensitive, Temperature Sensitive<br>Applications ZK 159222 is a vitamin D receptor antagonist. It is a derivative of Vitamin D3 (V676045).<br>References Mizwicki, M., et al.: J. Bio. Chem., 284, 36292 (2009); Ochiai, E., et al.: Mol. Endocrinol., 19, 1147 (2005)<br></p>Formule :C32H48O5Couleur et forme :NeatMasse moléculaire :512.72Efavirenz 3-Desoxy
CAS :<p>Applications Efavirenz 3-Desoxy is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>Formule :C15H11ClF3NOCouleur et forme :Off White SolidMasse moléculaire :313.703’-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]propyl Domperidine (Domperidine Impurity F)
CAS :Produit contrôlé<p>Impurity Domperidone EP Impurity F<br>Applications An impurity of the gastrokinetic and antinauseant drug Domperidone (D531100(P)), which is a novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent.<br>References Baudry, M., et al.: Arch. Pharmacol., 308, 231 (1979), Ennis, C., et al.: J. Pharm. Pharmacol., 31, 14 (1979), Brogden, R.N., Drugs, 24, 360 (1982),<br></p>Formule :C37H42Cl2N8O3Couleur et forme :NeatMasse moléculaire :717.69Distigmine Bromide
CAS :Produit contrôlé<p>Stability Hygroscopic, Temperature Sensitive<br>Applications Distigmine Bromide is a cholinesterase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sugaya, K.,e t. al.: Int. J. Urology, 19, 480 (2012)<br></p>Formule :C22H32N4O4·2BrCouleur et forme :NeatMasse moléculaire :576.32N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide
CAS :Produit contrôlé<p>Applications N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide was used in the study to discover a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth. N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide is an impurity of Intedanib (I666650), which is an antitumor agent.<br>References Edupuganti, R., et al.: Bioorg. Med. Chem., 25, 2609 (2017); Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)<br></p>Formule :C29H31N5O2Couleur et forme :NeatMasse moléculaire :481.594,5-Dehydro Apixaban
CAS :Produit contrôlé<p>Applications 4,5-Dehydro Apixaban is an impurity of Apixaban (A726700), a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation<br>References Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011)<br></p>Formule :C25H23N5O4Couleur et forme :NeatMasse moléculaire :457.48rac-trans-7-Hydroxy Pramipexole
CAS :Produit contrôlé<p>Impurity Pramipexole Related Compound F<br>Applications Pramipexole derivative used for the preparation of (S)-Pramipexole via resolution of 2,6-diamino-7-hydroxy-4,5,6,7-tetrahydrobenzothiazole derivatives.<br>References Validation of a column liquid chromatographic method for the analysis of pramipexole and its 5 impurities. Journal of AOAC International (2010), 93(4), 1102-1112. Gegoe, Csaba Lehel; Fejes, Imre; Garaczi, Sandor; Kovacs, Imre; Lukacs, Ferenc; Majercsik, Orsolya; Schneider, Geza. Process for preparation of (S)-pramipexole via resolution of 2,6-diamino-7-hydroxy-4,5,6,7-tetrahydrobenzothiazole derivatives. Eur. Pat. Appl. (2008), 26pp. CODEN: EPXXDW EP 1878731<br></p>Formule :C10H17N3OSCouleur et forme :NeatMasse moléculaire :227.333-Chloro-1,2-propanediol-d5 (10 ug/mL in methanol)
CAS :Produit contrôléFormule :C32H5H2ClO2Couleur et forme :ColourlessMasse moléculaire :115.57N-[1-(4-Chlorophenyl)cyclobutylmethyl]-N,N-dimethylamine Hydrochloride
CAS :Produit contrôlé<p>Applications N-[1-(4-Chlorophenyl)cyclobutylmethyl]-N,N-dimethylamine Hydrochloride is an impurity of Sibutramine Hydrochloride (S422500), a serotonin and noradrenaline reuptake inhibitor.<br>References Hanotin, C., et al.: Int. J. Obesity, 22, 32 (1998)<br></p>Formule :C13H19Cl2NCouleur et forme :NeatMasse moléculaire :260.25-Ethoxy-2-pyrrolidone
CAS :Produit contrôlé<p>Applications 5-Ethoxy-2-pyrrolidone is an intermediate in the synthesis of rac-Vigabatrin (V253005), a novel antiepileptic drug. Antidepressant; antipsychotic; anxiolytic.<br>References Vajda, F., et al.: Clin. Neurosci., 7, 88 (2000), Beghi, E., et al.: Lancet. Neurol., 3, 618 (2004), Sagirli, O., et al.: J. Pharmaceut. Biomed., 42, 618 (2006),<br></p>Formule :C6H11NO2Degré de pureté :>90%Couleur et forme :NeatMasse moléculaire :129.16Efavirenz Amino Alcohol Ethyl Carbamate
CAS :Produit contrôlé<p>Applications Efavirenz Amino Alcohol Ethyl Carbamate is used in the synthesis of Efavirenz (E425000), a potent non-nucleoside HIV-1 reverse transcriptase inhibitor. Antiviral<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>Formule :C16H15ClF3NO3Couleur et forme :NeatMasse moléculaire :361.74Losartan Trityl Ether
CAS :<p>Impurity Losartan EP Impurity I<br>Applications Losartan Trityl Ether (Losartan EP Impurity I) is an impurity of Losartan.<br>References Duncia, J.V., et al.: J. Med. Chem., 33, 1312 (1990),<br></p>Formule :C41H37ClN6OCouleur et forme :NeatMasse moléculaire :665.23Lornoxicam-d4
CAS :Produit contrôlé<p>Applications Labelled Lornoxicam. Cyclooxygenase inhibitor; structurally similar to tenoxicam. Anti-inflammatory; analgesic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ankier, S.I., et al.: Postgrad. Med. J., 64, 752 (1988), Tricerri, M., et al.: Chem. Phys. Lipids, 71, 61 (1994), Santos, N., et al.: Biochemistry, 37, 8674 (1998), Pellicano, A., et al.: Infect. Immun., 75, 1738 (2007),<br></p>Formule :C132H4H6ClN3O4S2Couleur et forme :NeatMasse moléculaire :375.845-Methoxy-1-[4-(difluoromethyl)phenyl]-1-pentanone Oxime
CAS :Produit contrôlé<p>Applications Defluoro Fluvoxamine intermediate.<br></p>Formule :C13H17F2NO2Couleur et forme :NeatMasse moléculaire :257.28Haloperidol Decanoate
CAS :Produit contrôlé<p>Applications Antidyskinetic; antipsychotic.<br>References Janicki, C.A., et al.: Anal. Profiles Drug Subs., 9, 341 (1980), Beresford, R., et al.: Drugs, 33, 31 (1987)<br></p>Formule :C31H41ClFNO3Couleur et forme :NeatMasse moléculaire :530.112-Nitroso Riluzole
Produit contrôlé<p>Applications 2-Nitroso Riluzole is an impurity of Riluzole (R510000); is a neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant. Neuroprotective agent.<br>References Mizoule, J., et al.: Neuropharmacology, 24, 767 (1985), Wahl, F., et al.: Eur. J. Pharmacol., 230, 209 (1993) Bensimon, G., et al.: N. Engl. J. Med., 330, 585 (1994)<br></p>Formule :C8H3F3N2O2SCouleur et forme :Dark GreenMasse moléculaire :248.182Everolimus Isomer C (>60%, contains everolimus)
CAS :Produit contrôlé<p>Stability Unstable in solution, revert back to Everolimus<br>Applications Everolimus Isomer C is an isomer of Everolimus (E945400), a derivative of Rapamycin (R124000). Everolimus inhibits cytokine-mediated lymphocyte proliferation.<br>References Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001); Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001); Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002)<br></p>Formule :C53H83NO14Couleur et forme :NeatMasse moléculaire :958.22Lonafarnib
CAS :Produit contrôlé<p>Applications Lonafarnib is an orally bioavailable tricyclic inhibitor of farnesyl protein transferase. It inhibits Rheb farnesylation and mTOR signaling and enhances taxane and tamoxifen antitumor activity. Studies show that it induces CCAAT/enhancer-binding protein homologous protein-dependent expression of death receptor 5, leading to induction of apoptosis in human cancer cells<br>References Liu, M. et al.: Cancer Res., 58, 4947 (1998); Basso, A. et al.: J. Biol. Chem., 280, 31101 (2005); Sun, S. et al.: J. Biol. Chem., 282, 18800 (2007);<br></p>Formule :C27H31Br2ClN4O2Couleur et forme :NeatMasse moléculaire :638.824'-Nitro-3'-(trifluoromethyl)acetanilide
CAS :<p>Applications 4’-Nitro-3’-(trifluoromethyl)acetanilide is a metabolite of the nonsteroidal antiandrogen drug, Flutamide (F598850).<br>References Kang, P. et al.: Drug Metab. Dispos., 36, 1425 (2008); Takashima, E. et al.: Biol. Pharmac. Bull., 26, 1455 (2003); Katchen, B. et al.: J. Invest. Dermatol., 66, 379 (1976);<br></p>Formule :C9H7F3N2O3Couleur et forme :NeatMasse moléculaire :248.16α-Phenyl-2-pyridineacetamide
CAS :Produit contrôlé<p>Applications α-Phenyl-2-pyridineacetamide (cas# 7251-52-7) is a compound useful in organic synthesis.<br></p>Formule :C13H12N2OCouleur et forme :NeatMasse moléculaire :212.255,7-Difluorochroman-4-one
CAS :Produit contrôléFormule :C9H6F2O2Couleur et forme :NeatMasse moléculaire :184.14N-Ethyl-3-buteno-o-toluidide
CAS :Produit contrôléFormule :C13H17NOCouleur et forme :NeatMasse moléculaire :203.283-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Hydrochloride
CAS :<p>Applications Sitagliptin intermediate.<br>References Mohri, K., et al.: Chem. Pharm. Bull., 30, 3097 (1982), Sarges, R., et al.: J. Med. Chem., 33, 2240 (1990), Cameron, M., et al.: J. Pharm. Biomed. Anal., 28, 137 (2002),<br></p>Formule :C6H7F3N4·ClHCouleur et forme :WhiteMasse moléculaire :228.603-(2-Chloroethyl)-9-hydroxy-2-methyl-4H-Pyrido[1,2-a]pyrimidin-4-one Hydrochloride
CAS :Formule :C11H11ClN2O2·ClHCouleur et forme :NeatMasse moléculaire :275.13Zuclopenthixol (1 mg/mL In Methanol)
CAS :Formule :C22H25ClN2OSCouleur et forme :Single SolutionMasse moléculaire :400.962,2'-((6,6'-(2,4-Di(pyridin-2-yl)cyclobutane-1,3-diyl)bis(1H-indazole-6,3-diyl))bis(sulfanediyl))bis(N-methylbenzamide)
CAS :Produit contrôlé<p>Applications 2,2'-((6,6'-(2,4-Di(pyridin-2-yl)cyclobutane-1,3-diyl)bis(1H-indazole-6,3-diyl))bis(sulfanediyl))bis(N-methylbenzamide) is an impurity of Axitinib (A794650), a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.<br>References Wasser, K., et al.: Eur. Radiol., 13, 80 (2003), Park, J., et al.: Clin. Cancer Res., 8, 1172 (2002), Bergers, G., et al.: J. Clin. Invest., 111, 1287 (2003),<br></p>Formule :C44H36N8O2S2Couleur et forme :BeigeMasse moléculaire :722.94Atazanavir-d9
CAS :Produit contrôlé<p>Applications Atazanavir-d9 is the deuterated analog of Atazanavir (A790051), a azapeptide HIV protease inhibitor derivative. Atazanavir have been investigated as potential treatment of human immunodeficiency virus (HIV) and for anticancer purposes.<br>References Musial, B.L., et al.: Am. J. Health Syst. Pharm., 61, 1365 (2004), Wood, R., et al.: J. Acquir. Immune Defic. Syndr., 36, 684 (2004),<br></p>Formule :C382H15H37N6O7Couleur et forme :NeatMasse moléculaire :719.95Valdecoxib Sulfonic Acid
CAS :Produit contrôlé<p>Applications Valdecoxib Sulfonic Acid is a metabolite of the potent and specific inhibitor of cyclooxygenase-2, Valdecoxib (V090000).<br>References Zhang, J.I. et al.: Drug Metab. Dispos., 31, 491 (2003); Yuan, J.J. et al.: Drug Metab. Dispos., 30, 1013 (2002);<br></p>Formule :C16H13NO4SCouleur et forme :White To Off-WhiteMasse moléculaire :315.34N-(4-Methoxybenzyl)-4-chloro-2-(trifluoroacetyl)aniline
CAS :Produit contrôléFormule :C16H13ClF3NO2Couleur et forme :NeatMasse moléculaire :343.73rac N-Desmethyl Mephenytoin-D5 (Major)
CAS :Produit contrôlé<p>Applications An anticonvulsant, hypnotic. A labelled metabolite of Mephentoin.A representative lot was 85% d5; 15% d4 1% d3 with no detectable d0.<br>References Karlaganis, G., et al.: Drug Metab. Dispos., 8, 173 (1980), Knabe, J., et al.: Arch. Phar., 313, 538 (1980),<br></p>Formule :C112H5H7N2O2Couleur et forme :NeatMasse moléculaire :209.265-(2-Fluorophenyl)-5-oxovaleric Acid
CAS :Produit contrôlé<p>Applications 5-(2-Fluorophenyl)-5-oxovaleric Acid is used as a reagent in the preparation of indole derivatives which act as cell protective agents. It is also used as a reagent in the catalytic N-nitroso aldol reaction of γ,δ-unsaturated δ-lactones.<br>References Yamamoto, I., et al.: Preparation of indole derivatives as cell protective agents, WO Patent 9745410, Dec 4, 1997; Yanagisawa, A., et al.: Org. Lett., 14, 2434 (2012);<br></p>Formule :C11H11FO3Couleur et forme :NeatMasse moléculaire :210.2(S)-(-)-Felodipine
CAS :Produit contrôlé<p>Applications A dihydropyridine calcium channel blocker. Enantiomer S of Felodipine.<br>References Berntsson, P.B., et al.: Acta Pharm. Suec., 18, 221 (1981), Kratochwil, N., et al.: Biochem. Pharmacol., 64, 1355 (2002), O'Brien, S., et al.: J. Med. Chem., 48, 1287 (2005), Castilho, M., et al.: Bioorg. Med. Chem., 14, 516 (2006),<br></p>Formule :C18H19Cl2NO4Couleur et forme :White To Off-WhiteMasse moléculaire :384.25rac Dropropizine
CAS :Produit contrôlé<p>Applications Dropropizine is a cough suppressant and central sedative therapeutic agent.<br>References Bakken, G., et al.: J. Med. Chem., 43, 4534 (2000), Salunkhe, M., et al.: Enz. Microb. Technol., 28, 333 (2001), Atul, B., et al.: J. Pharm. Sci., 91, 2067 (2002),<br></p>Formule :C13H20N2O2Couleur et forme :WhiteMasse moléculaire :236.314-Ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydro-imidazo[5,1-f][1,2,4]-triazin-2-yl)benzene-sulfonyl Chloride
CAS :Produit contrôlé<p>Applications Vardenafil Intermediate.<br>References Terrett, N.K., et al.: Bioorg. Med. Chem. Lett., 6, 1819, (1996)<br></p>Formule :C17H19ClN4O4SCouleur et forme :NeatMasse moléculaire :410.885-Methyl-1,3-benzenediacetonitrile
CAS :<p>Impurity Anastrozole 1,3-Dicyanomethyl Impurity<br>Applications 5-Methyl-1,3-benzenediacetonitrile is an Anastrozole intermediate. Anastrozole 1,3-Dicyanomethyl Impurity. Anastrozole is an aromatase inhibitor and used as an antineoplastic.<br>References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)<br></p>Formule :C11H10N2Couleur et forme :NeatMasse moléculaire :170.21Ethyl 2-[N-[(2'-Cyanobiphenyl-4-yl)methyl]amino]-3-nitrobenzoate
CAS :<p>Applications Ethyl 2-[N-[(2'-Cyanobiphenyl-4-yl)methyl]amino]-3-nitrobenzoate is a useful reagent in synthesis of candesartan cilexitil.<br>References Zhu, Y., et al.: Zhongguo Yaowu Huaxue Zazhi, 13, 31 (2003); Cao, R., et al.: Zhongguo Yiyao Gongye Zazhi, 34, 425 (2003);<br></p>Formule :C23H19N3O4Couleur et forme :NeatMasse moléculaire :401.41Rotigotine Hydrochloride
CAS :<p>Applications It is a non-ergot dopamine agonist drug and is indicated for the treatment of Parkinson’s disease.<br>References Loschmann, P., et al.: Eur. J. Pharmacol., 166, 373 (1989), Edgar, D., et al.: J. Pharmacol. Exp. Ther., 283, 757 (1997), Ferreira, J., et al.: Lancet, 355, 1333 (2000), Arnulf, I., et al.: Neurology, 58, 1019 (2002), Wisor, J., et al.: Neuroscience, 132, 1027 (2005),<br></p>Formule :C19H25NOS·ClHCouleur et forme :White To Off-WhiteMasse moléculaire :351.935-Chloro-N-methylthiophene-2-carboxamide
CAS :Produit contrôlé<p>Applications 5-Chloro-N-methylthiophene-2-carboxamide is an impurity of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Formule :C6H6ClNOSCouleur et forme :NeatMasse moléculaire :175.64Deshydroxymethyl Losartan Trifluoroacetic Acid Salt
CAS :Produit contrôlé<p>Applications Losartan Impurity C.<br>References Duncia, J.V., et al.: J. Med. Chem., 33, 1312 (1990),<br></p>Formule :C21H21ClN6·C2HF3O2Couleur et forme :White To Off-WhiteMasse moléculaire :506.916-Hydroxy-7-methoxy-4(1H)-quinazolinone
CAS :Produit contrôlé<p>Applications 6-Hydroxy-7-methoxy-4(1H)-quinazolinone is a reactant used in the preparation of 4-anilinoquinazoline derivatives that have shown antitumor activities. 6-Hydroxy-7-methoxy-4(1H)-quinazolinone was also used as a reactant in the synthetic preparation of 2-arylbenzothiazoles as kinase inhibitors.<br>References Chandregowda, V., et al.: Eur. J. Med. Chem., 44, 3046 (2009); Tasler, S., et al.: Bioorg. Med. Chem. Lett., 17, 6728 (2009);<br></p>Formule :C9H8N2O3Couleur et forme :BeigeMasse moléculaire :192.172,5-Bis-(3,4-dihydroxyphenyl)piperazine Dihydrochloride
Produit contrôléFormule :C16H18N2O4•2(HCl)Couleur et forme :BrownMasse moléculaire :302.33236462-Thiopheneacetic Acid
CAS :Produit contrôléFormule :C6H6O2SCouleur et forme :NeatMasse moléculaire :142.181-Ethyl-2-[(methylamino)methyl]pyrrolidine
CAS :<p>Applications 1-Ethyl-2-[(methylamino)methyl]pyrrolidine is an intermediate of the neuroleptic drug Amisulpride (A633250).<br>References Tahara, T., et al.: Chem. Pharmaceut. Bull., 38, 1609 (1990);<br></p>Formule :C8H18N2Couleur et forme :Colourless OilyMasse moléculaire :142.242(6S)-N6-[3-[[(6S)-2-Amino-4,5,6,7-tetrahydro-6-benzothiazolyl]amino]-1-ethyl-2-methylpropyl]-4,5,6,7-tetrahydro-2,6-benzothiazolediamine
CAS :<p>Stability Hygroscopic<br>Applications (6S)-N6-[3-[[(6S)-2-Amino-4,5,6,7-tetrahydro-6-benzothiazolyl]amino]-1-ethyl-2-methylpropyl]-4,5,6,7-tetrahydro-2,6-benzothiazolediamine can be obtained from (-)-2-Amino-6-propionamido-tetrahydrobenzothiazole (A628150) and is the byproduct of process for the preparation of pramipexole and salts thereof by reductive amination of (diamino)tetrahydrobenzothiazole with propanal. It is also a Pramaxo Impurity C.<br>References Deo, K., et al.: Indian Pat. Appl. (2015), IN 2013MU02843 A<br></p>Formule :C20H32N6S2Degré de pureté :>80%Couleur et forme :NeatMasse moléculaire :420.6383Nilotinib 3-Imidazolyl N-oxide
CAS :Produit contrôlé<p>Applications 4-Methyl-3-(4-pyridin-3-yl)pyrimidin-2-yl]amino-N-(5-(3-oxo-4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamine is an impurity compound of Nilotinib (N465300), useful in the treatment of chronic myelogenous leukemia. It is a COVID19-related research product.<br>References Wei-Sheng H., et al.: Synthesis, 14, 2121 (2007); Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),<br></p>Formule :C28H22F3N7O2Couleur et forme :NeatMasse moléculaire :545.522-Nitrodeamino Fingolimod
CAS :Produit contrôlé<p>Applications An impurity of Fingolimod (F805000, HCl salt), a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),<br></p>Formule :C19H31NO4Couleur et forme :NeatMasse moléculaire :337.45Loxapine, Succinate
CAS :Produit contrôlé<p>Applications A D2/D4-Dopamine receptor antagonist. A serotonergic receptor antagonist. A dibenzoxazepine antipsychotic agent.<br>References Shen, Y., et al.: J. Biol. Chem., 268, 18200 (1993), Fiorella, D., et al.: Psychopharmacology, 121, 347 (1995), Glusa, E., et al.: Br. J. Pharmacol., 130, 692 (2000)<br></p>Formule :C18H18ClN3O·C4H6O4Couleur et forme :WhiteMasse moléculaire :445.902-[[(3aR,4S,6R,6aS)-6-[[5-Amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol
CAS :Produit contrôlé<p>Applications 2-[[(3aR,4S,6R,6aS)-6-[[5-Amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol is used as a reagent in the synthesis of Ticagrelor (T437700) derivatives as antiplatelet agents.<br>References Zhang, H., et al.: Bioorg. Med. Chem. Lett., 22, 3598 (2012)<br></p>Formule :C17H27ClN4O4SCouleur et forme :NeatMasse moléculaire :418.942-Hydroxy Nevirapine-d3
CAS :Produit contrôlé<p>Applications A labelled metabolite of Nevirapine (N391275).<br>References Rettie, A., et al.: J. Biol. Chem., 263, 13733 (1988), Lamson, M., et al.: Biopharm. Drug Dispos., 20, 285 (1999), Guengerich, F., et al.: Chem. Res. Toxicol., 14, 611 (2001), Lu, W., et al.: Drug Metab. Dispos., 36, 1624 (2008),<br></p>Formule :C15H11D3N4O2Couleur et forme :NeatMasse moléculaire :285.32Sitagliptin N-Sulfate Sodium Salt
CAS :Produit contrôlé<p>Applications A metabolite of Sitagliptin.<br>References Beconi, M.G. , et al.: Drug Metab. Dispos., 35, 525 (2007),<br></p>Formule :C16H15F6NaN5O4SCouleur et forme :NeatMasse moléculaire :509.363-(Dibenzo[b,e]oxepin-11(6H)yl)-N,N-dimethylpropan-1-amine Hydrochloride
CAS :Produit contrôlé<p>Applications 3-(Dibenzo[b,e]oxepin-11(6H)yl)-N,N-dimethylpropan-1-amine Hydrochloride is an impurity of Doxepin (D550000), which is used clinically to treat anxiety and depression and is classified as an antidepressant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ribbentrop, A., et al.: Arzneim.-Forsch., 15, 863 (1965); Hobbs, D.C., et al.: Biochem. Pharmacol., 18, 1941 (1969); Pinder, R.M., et al.: Drugs, 13, 161 (1977); Shrivastava, R.K., et al.: Clin. Ther., 7, 181 (1985)<br></p>Formule :C19H23NO•(HCl)Couleur et forme :NeatMasse moléculaire :281.393646Isopropyl 4-Hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-Dioxide (Piroxicam Impurity I)
CAS :Produit contrôlé<p>Impurity Piroxicam EP Impurity I<br>Applications Piroxicam impurity I.<br>References Lombardino, J., et al.: J. Med. Chem., 14, 1171 (1971), Turck, D., et al.: Clin. Drug Invest., 9, 270 (1995),<br></p>Formule :C12H13NO5SCouleur et forme :NeatMasse moléculaire :283.3Valdecoxib Sulfonyl Chloride
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Valdecoxib Sulfonyl Chloride is an impurity in the preparation of the cyclooxygenase-2 inhibitor, Valdecoxib (V090000) and its metabolites.<br>References Erdelyi, P. et al.: Bioorg. Med. Chem., 16, 5322 (2008);<br></p>Formule :C16H12ClNO3SCouleur et forme :NeatMasse moléculaire :333.79Apatinib-d8 25-N-Oxide Dihydrochloride
CAS :Produit contrôlé<p>Applications Labelled Apatinib 25-N-Oxide (A726160). Apatinib 25-N-Oxide is a metabolite of the antiangiogenic agent and selective VEGFR2 inhibitor Apatinib (A726150).<br>References Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);<br></p>Formule :C24H15D8N5O2•2HClCouleur et forme :NeatMasse moléculaire :421.52236467,7'-[1,4-Piperazinediylbis(4,1-butanediyloxy)]bis-2(1H)-quinolinone
CAS :Produit contrôléFormule :C30H36N4O4Couleur et forme :NeatMasse moléculaire :516.632-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-3,3-diphenyl-2-propenoic Acid
CAS :Produit contrôlé<p>Impurity Ambrisentan Impurity E<br>Applications 2-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-3,3-diphenyl-2-propenoic Acid is an acrylic acid derivative that can be used as an endothelin receptor antagonist useful for treating hypertension or pulmonary artery hypertension. Ambrisentan Impurity E<br>References Zhang, D., et al.: Faming Zhuanli Shenqing. CN 102093286 A 20110615. Jun 15, 2011<br></p>Formule :C21H18N2O3Couleur et forme :White To Off-WhiteMasse moléculaire :346.38(Z)-4-Hydroxy Tamoxifen O-β-D-Glucuronide (~90%)
CAS :Produit contrôlé<p>Applications (Z)-4-Hydroxy Tamoxifen O-β-D-Glucuronide is an active metabolite of Tamoxifen (T006000).<br>References Ogura, K. et al.: Biochem. Pharmacol., 71, 1358 (2006); Nishiyama, T. et al.: Biochem. Pharmacol., 63, 1817 (2002); McCague, R. et al.: Biochem. Pharmacol., 39, 1459 (1990);<br></p>Formule :C32H37NO8Degré de pureté :~90%Couleur et forme :NeatMasse moléculaire :563.646,8-Dioxo Apalutamide
CAS :Produit contrôlé<p>Applications 6,8-Dioxo Apalutamide is an impurity of Apalutamide (A726120). Apalutamide is a second-generation antiandrogen used in the treatment of prostate cancer.<br>References Li, Huifang, et al.: J. of Chem. Info. and Model., 53(1), 123-130 (2013);Joseph, James D., et al.: Cancer Disc., 3(9), 1020-1029 (2013)<br></p>Formule :C21H15F4N5O3Couleur et forme :NeatMasse moléculaire :461.38(3Z)-2,3-Dihydro-3-[[[4-(methylamino)phenyl]amino]phenylmethylene]-2-oxo-1H-Indole-6-carboxylic Acid Methyl Ester
CAS :Produit contrôléFormule :C24H21N3O3Couleur et forme :NeatMasse moléculaire :399.44OPC 3930
CAS :Produit contrôlé<p>Applications A metabolite of Cilostazol (C441500), used as internal standard.<br>References Akiyama, H., et al.: Arzneim.-Forsch./Drug Res., 35, 1133 (1985), Akiyama, H., et al.: J. Chromatogr., 338, 456 (1985),<br></p>Formule :C19H23N5O2Couleur et forme :NeatMasse moléculaire :353.42rac 4-(3-Aminobutyl)phenol
CAS :Produit contrôlé<p>Applications A metabolite of the antihypertensive agent, Labetalol (L096500).<br>References Gal, J., et al.: Res. Comm. Chem. Pathol. Pharmacol., 62, 3 (1988),<br></p>Formule :C10H15NOCouleur et forme :NeatMasse moléculaire :165.23Fluphenazine β-D-Glucuronide
CAS :Produit contrôléFormule :C28H34F3N3O7SCouleur et forme :NeatMasse moléculaire :613.65N-Sulfamoylethyl Naratriptan Pyridinium Chloride
CAS :Produit contrôlé<p>Impurity Naratriptan Impurity F<br>Stability Hygroscopic<br>Applications 4-[1,5-Bis-(2-methylsulfamoylethyl)-1H-indol-3-yl]-1-methylpyridinium Chloride is an impurity of Naratriptan (N378730).<br></p>Formule :C20H27ClN4O4S2Couleur et forme :NeatMasse moléculaire :487.04Rilmazafone Hydrochloride
CAS :<p>Applications Rilmazafone Hydrochloride can be used in biological study of nitrazepam or rilmazafone hydrochloride combined with ethanol effects on human memory. It is also used as sleep aid medication.<br>References Suzuki, M., et al.: Neurosciences (Okayama, Japan), 20, 43 (1994)<br></p>Formule :C21H20Cl2N6O3·HClCouleur et forme :NeatMasse moléculaire :475.33 + (36.46)Fenbutrazate
CAS :Produit contrôlé<p>Applications Fenbutrazate is a derivative of Phenmetrazine (P314500). Fenbutrazate is a psychostimulant used as an anorexigen (appetite suppressant).<br>References Betbeder, A. et al.: Bull. Soc. Pharm. Bord., 121, 125 (1982); Hengen, O.: Arzneim.-Forsch., 7, 524 (1957);<br></p>Formule :C23H29NO3Couleur et forme :NeatMasse moléculaire :367.48Iso Fluconazole
CAS :Produit contrôlé<p>Impurity Fluconazole EP Impurity A<br>Applications Iso Fluconazole (Fluconazole EP Impurity A) is an impurity of Fluconazole (F421000). Fluconazole USP impurity A.<br>References Rogers, T., et al.: Antimicrob. Agents Chemother., 30, 418 (1986), Itoh, H., et al.: Chem. Pharmaceut. Bull., 48, 1148 (2000),<br></p>Formule :C13H12F2N6OCouleur et forme :Off-WhiteMasse moléculaire :306.27Ofloxacin Isopropyl Ester
CAS :Produit contrôléFormule :C21H26FN3O4Couleur et forme :NeatMasse moléculaire :403.45Desmethyl Nintedanib Carboxylic Acid (Nintedanib Impurity A)
Produit contrôlé<p>Applications Desmethyl Nintedanib Carboxylic Acid is an impurity of Intedanib (I666650), which is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases. it is an indolinone as triple angiokinase inhibitors and an antitumor agent.<br>References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)<br></p>Formule :C29H29N5O5Couleur et forme :NeatMasse moléculaire :527.574-Hydroxy Phenylbutazone
CAS :<p>Applications Impurity in the production of Phenylbutazone (P319570)<br>References Fricoteaux, R., et al.: J. Pharm. Biomed. Anal., 7, 1585 (1989), Segrestaa, J., et al.: Chem. Pharm. Bull., 50, 744 (2002),<br></p>Formule :C19H20N2O3Couleur et forme :White To Off-WhiteMasse moléculaire :324.372-Acetylbutyrolactone
CAS :Produit contrôlé<p>Applications An intermediate in the synthesis of 2,4-disubstituted pyridines. A fluorogenic reagent for the spectrofluorimetric determination of primary amines.<br>References Toche, R.B. et al.: H. Heterocyclic Chem., 45, 1711 (2008); Sabry, S.M., J. Pharm. Biomed. Anal., 40, 1057 (2006);<br></p>Formule :C6H8O3Couleur et forme :NeatMasse moléculaire :128.13Quetiapine Dimer Impurity-d8
CAS :Produit contrôlé<p>Applications An impurity of labelled Quetiapine.<br>References Xu, H., et al.: J. Pharm. Biomed. Anal., 47, 658 (2008), Stolarczyk, E., et al.: Pharm. Develop. Technol., 14, 27 (2009),<br></p>Formule :C30H16D8N4S2Couleur et forme :NeatMasse moléculaire :512.724,6-Dichloro-2-(propylthio)pyrimidin-5-amine
CAS :Produit contrôlé<p>Applications Intermediate in the preparation of Ticagrelor (T437700) and reversible P2Y12 receptor antagonists.<br>References Zhang, H. et al.; Bioorg. Med. Chem. Lett. 22, 3598 (2012); Springthorpe, B. et al.; Bioorg. Med. Chem. Lett. 17, 6013 (2007)<br></p>Formule :C7H9Cl2N3SCouleur et forme :NeatMasse moléculaire :238.14(S)-(-)-O-Desmethyl Carvedilol
CAS :Produit contrôlé<p>Applications An optically active metabolite of Carvedilol (C184625), a nonselective ß-adrenergic blocker with α1-blocking activity. [α]D= -18.7 (c= 0.1 methanol)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., et al.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Clohs, L., et al.: J. Pharm. Biomed. Anal., 31, 407 (2003),<br></p>Formule :C23H24N2O4Couleur et forme :NeatMasse moléculaire :392.45Omeprazole Sodium Salt
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Omeprazole Sodium Salt is the salt analogue of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983); Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>Formule :C17H18N3O3S·Na·H2OCouleur et forme :Off-WhiteMasse moléculaire :385.413-Aminobenzotrifluoride
CAS :Produit contrôlé<p>Applications 3-Aminobenzotrifluoride is a known human toxin that can cause bacterial mutation and hepatocyte unscheduled DNA synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Reinhold, D., et al.: T. ASAE, 49, 2077 (2006); Thompson, C., et al.: Environ. Mutagen., 5, 803 (1983)<br></p>Formule :C7H6F3NCouleur et forme :YellowMasse moléculaire :161.12Solifenacin EP Impurity A Nitroso Impurity
Produit contrôléFormule :C15H14N2OCouleur et forme :NeatMasse moléculaire :238.295-Amino-4-(4-nitro-1-oxoisoindolin-2-yl)-5-oxopentanoic Acid
CAS :Produit contrôléFormule :C13H13N3O6Couleur et forme :Off-WhiteMasse moléculaire :307.2592-Methylthieno[2,3-d]isothiazol-3(2H)-one 1,1-Dioxide
CAS :Produit contrôléFormule :C6H5NO3S2Couleur et forme :NeatMasse moléculaire :203.244-[[3-(4-Methylphenyl)-3-oxo-1-(trifluoromethyl)propylidene]amino]benzenesulfonamide
CAS :Produit contrôlé<p>Applications 4-[[3-(4-Methylphenyl)-3-oxo-1-(trifluoromethyl)propylidene]amino]benzenesulfonamide, is an impurity of Celecoxib (C251000), which is a selective cyclooxygenase-2 (COX-2) inhibitor, an anti-inflammatory agent. It is also used in treatment of familial adenomatous polyposis.<br>References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998), Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000), Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000),<br></p>Formule :C17H15F3N2O3SCouleur et forme :YellowMasse moléculaire :384.372,2’-Methylene Bis[Ranitidine]
CAS :Produit contrôlé<p>Impurity Ranitidine EP Impurity I<br>Stability Light Sensitive, Temperature Sensitive<br>Applications 2,2’-Methylene Bis[Ranitidine] (Ranitidine EP Impurity I) is an impurity of histamine H2-receptor antagonist Ranitidine (R120000).<br>References Jones, M.D. et al.: J. Sep. Sci., 29, 2409 (2006); Kelly, M.A. et al.: J. Chrom. A, 798, 297 (1998);<br></p>Formule :C27H44N8O6S2Couleur et forme :NeatMasse moléculaire :640.82Anagrelide-13C3
CAS :Produit contrôléFormule :C713C3H7Cl2N3OCouleur et forme :NeatMasse moléculaire :259.07Hydroxy Ebastine-d5
CAS :Produit contrôlé<p>Applications A labelled metabolite of Ebastine.<br>References Hashizume, T., et al.: Drug Metab. Dispos., 29, 798 (2001), Hashizume, T., et al.: J. Pharmacol. Exp. Ther., 300, 298 (2002), Matsumoto, S., et al.: Xenobiotica, 33, 615 (2003), Chaikin, P., et al.: Br. J. Clin. Pharmacol., 59, 346 (2005),<br></p>Formule :C32H34D5NO3Couleur et forme :NeatMasse moléculaire :490.691-(2,4-Bis(benzyloxy)phenyl)ethanone
CAS :Produit contrôlé<p>Applications 1-(2,4-Bis(benzyloxy)phenyl)ethanone is a useful research chemical for organic synthesis and other chemical processes.<br>References Chen, D., et al.: Eur. J. Med. Chem., 87, 765 (2014); Malik, N., et al.: Tetrahedron Lett., 54, 4121 (2013)<br></p>Formule :C22H20O3Couleur et forme :NeatMasse moléculaire :332.39Dacomitinib
CAS :Produit contrôlé<p>Applications Dacomitinib is an Erb-inhibitor, or an inhibitor of the members of the epidermal growth factor receptor family. Used as an ant-cancer agent due to observation of over-expressed epidermal growth factor receptor in nearly all cases of squamous cell carcinoma in the head and neck.<br>References Williams, J. et al.: PLoS., 9, e98557 (2014); Peters, S. et al.: Canc. Treatment Rev., 40, 917 (2014);<br></p>Formule :C24H25ClFN5O2Couleur et forme :NeatMasse moléculaire :469.94Famotidine Acetaldehyde Adduct Maleate
CAS :Produit contrôléFormule :C10H17N7O2S3·C4H4O4Couleur et forme :NeatMasse moléculaire :479.554-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone
CAS :Produit contrôléFormule :C21H21N3O5Couleur et forme :NeatMasse moléculaire :395.41Nitrofurantoin Monohydrate
CAS :Produit contrôlé<p>Applications 1-(((5-Nitrofuran-2-yl)methylene)amino)-imidazolidine-2,4-dione hydrate (CAS# 17140-81-7) is a useful research chemical compound.<br></p>Formule :C8H8N4O6Couleur et forme :YellowMasse moléculaire :256.181-Nitroso-1-(2-Hydroxyethyl)-3-(2-chloroethyl)urea
CAS :Produit contrôléFormule :C5H10ClN3O3Couleur et forme :Off-WhiteMasse moléculaire :195.64-Isobutylamino-3-aminoquinoline
CAS :Produit contrôlé<p>Applications 4-Isobutylamino-3-aminoquinoline is a pharmacologically active compound related to Imiquimod (I475000), an immune response modifier. It stimulates the production of Interferon-a.<br>References Megyeri, K., et al.: Mol. Cell Biol., 15, 2207, (1995), Witt, P.L., et al.: Cancer Res., 53, 5176 (1993), Edwards, L., et al.: Arch. Dermatol., 134, 25 (1998); Gerster, J. et al.: J. Med. Chem., 48, 3481 (2005);<br></p>Formule :C13H17N3Couleur et forme :NeatMasse moléculaire :215.29
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