Dérivés de Quinazoline et de Quinoléine
Les quinazolines et les quinoléines sont des composés hétérocycliques azotés à structure aromatique qui jouent un rôle clé dans la synthèse de médicaments à activité anticancéreuse, antimicrobienne et anti-inflammatoire. Leurs dérivés présentent des modifications structurelles qui optimisent leur biodisponibilité et leur sélectivité, permettant ainsi le développement de nouveaux principes actifs pour diverses applications thérapeutiques. Ces composés sont utilisés dans la fabrication d’API destinés au traitement du cancer, des infections, des maladies neurodégénératives et cardiovasculaires. De plus, les dérivés de quinazoline et de quinoléine sont essentiels dans la recherche d’inhibiteurs enzymatiques et dans la conception de molécules bioactives innovantes.
Chez CymitQuimica, nous proposons des dérivés de quinazoline et de quinoléine de haute pureté pour des applications en synthèse chimique, développement pharmaceutique et biotechnologie.
65644 produits trouvés pour "Dérivés de Quinazoline et de Quinoléine"
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(E)-4-Methoxy-N-(2-(2-(pyridin-4-yl)vinyl)phenyl)benzenesulfonamide
CAS :Degré de pureté :97.0%Masse moléculaire :366.440002441406255-(CHLOROMETHYL)-3-(3-PHENOXYPYRIDIN-4-YL)-1,2,4-OXADIAZOLE
Degré de pureté :95.0%Masse moléculaire :287.70001220703125Ivacaftor Carboxylic Acid
CAS :<p>Applications Ivacaftor Carboxylic Acid is an impurity of Ivacaftor (I940600); a drug used in the treatment of cystic fibrosis.<br>References Clancy, J. et al.: Am. J. Resp. Crit. Care. Med., 186, 593 (2012)<br></p>Formule :C24H26N2O5Couleur et forme :NeatMasse moléculaire :422.47p-Nicorandil
CAS :<p>Applications A positional isomeric impurity of the antianginal Nicorandil (N398500).<br>References Fedorov, B.S. et al.: Pharmac. Chem. J., 43, 134 (2009); Tatyanenko, L.V. et al.: Biomed. Khim., 52, 174 (2006);<br></p>Formule :C8H9N3O4Couleur et forme :BeigeMasse moléculaire :211.174-(Benzo[d]thiazol-2-ylthio)morpholine
CAS :Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :252.35000610351562(E)-3-(3-(3,4-dimethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)acrylic acid
CAS :Degré de pureté :98%Masse moléculaire :350.37399291992194-piperazin-1-ylquinazoline
CAS :Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :214.272003173828124-Chloro-2-methyl-5-(thiophen-2-yl)thieno[2,3-d]pyrimidine
CAS :Degré de pureté :95%Masse moléculaire :266.7600097656251-[3-Chloro-5-(trifluoromethyl)pyrid-2-yl]-1,4-diazepane
CAS :Degré de pureté :98.0%Couleur et forme :LiquidMasse moléculaire :279.690002441406251-(3-Carboxypropyl)-3,7-dimethylxanthine
CAS :Produit contrôlé<p>Applications A metabolite of Pentoxifylline (P276500).<br>References Yamaoka, K., et al.: J. Pharmacokin. Biopharm., 6, 165 (1978), Cottam, H.B., et al.: J. Med. Chem., 39, 2 (1996), Janvilisri, T., et al.: J. Biol. Chem., 278, 20645 (2003),<br></p>Formule :C11H14N4O4Couleur et forme :NeatMasse moléculaire :266.25N-(4-Aminobenzoyl)-β-alanine
CAS :Produit contrôlé<p>Impurity Balsalazide Aminobenzoyl Impurity<br>Applications N-(4-aminobenzoyl)-β-Alanine is a metabolite of BX661A, a therapeutic agent used in the treatment of ulcerative colitis, chemotaxis and reactive oxygen species production in polymorphonuclear leukocyctes. Inhibits lipid peroxidation in large intestinal mucosa after mesenteric ischemia/reperfusion.<br>References Kimura, I. et al.: Arzneimittelforschung., 48, 1007 (1998); Kumamoto, T. et al.: Jpn. J. Pharmacol., 75, 187 (1997);<br></p>Formule :C10H12N2O3Couleur et forme :NeatMasse moléculaire :208.21OSI-420, Free Base (Desmethyl Erlotinib)
CAS :Produit contrôléFormule :C21H21N3O4Couleur et forme :NeatMasse moléculaire :379.41Ofloxacin
CAS :<p>Applications Ofloxacin is a fluorinated quinolone antibacterial.This compound is a contaminant of emerging concern (CECs).<br>References Monk, J.P., et al.: Drugs, 33, 346 (1987); Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990);<br></p>Formule :C18H20FN3O4Couleur et forme :Off-WhiteMasse moléculaire :361.37Risperidone N-Oxide
CAS :Produit contrôlé<p>Applications Risperidone (R525000) impurity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References El-Sherif, Z., et al.: J. Pharm. Biomed. Anal., 36, 975 (2005), Sattanathan, P., et al.: J. Pharm. Biomed. Anal., 40, 598 (2006),<br></p>Formule :C23H27FN4O3Couleur et forme :WhiteMasse moléculaire :426.484-phenyl-3-(2-thienyl)-1,2,4-triazoline-5-thione 98%
CAS :Degré de pureté :98.0%Masse moléculaire :259.35000610351563-[6-(Trifluoromethyl)pyridin-3-yl]propanoic acid
CAS :Formule :C9H8F3NO2Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :219.1635-Hydroxy Omeprazole (~5% Triethylamine as stabilizer)
CAS :<p>Stability Hygroscopic, Temperature Sensitive<br>Applications 5-Hydroxy Omeprazole is the main metabolite of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983); Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>Formule :C17H19N3O4SCouleur et forme :NeatMasse moléculaire :361.42Clofedanol Hydrochloride
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A centrally-acting cough suppressant. It has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses.<br>References Yuizono, T., et al.: Yakugaku Zasshi, 87, 915 (1967), Nomura, A., et al.: Oyo Yakuri, 8, 119 (1974),<br></p>Formule :C17H20ClNO·ClHCouleur et forme :White To Off-WhiteMasse moléculaire :326.265-p-Tolyl-1H-pyrazole-3-carboxylic acid methyl ester
CAS :Degré de pureté :95.0%Masse moléculaire :216.24000549316406Retigabine N-β-D-Glucuronide Sodium Salt
CAS :Produit contrôlé<p>Applications Sodium salt of Retigabine N-β-D-Glucuronide is the major metabolite of the antiepileptic drug Retigabine (R189050) that is produced via N-glucuronidation in humans.<br>References Hiller, A. et al.: Drug Metab. Dispos., 27, 605 (1999); Borlak, J. et al.: Metab. Clin. Exp., 55, 711 (2006); McNeilly, P.P. et al.: Zenobiotica, 27, 431 (1997);<br></p>Formule :C22H25FN3NaO8Couleur et forme :NeatMasse moléculaire :501.44Famotidine Acid
CAS :Produit contrôlé<p>Impurity Famotidine EP Impurity F<br>Stability Light Sensitive<br>Applications Famotidine impurity.<br>References Junnarkar, G., et al.: Pharm. Res., 12, 599 (1995), Singh, S., et al.: J. Pharm. Sci., 91, 253 (2002),<br></p>Formule :C8H12N4O2S2Couleur et forme :NeatMasse moléculaire :260.345-Chloro-2-thiophenecarboxylic Acid
CAS :Produit contrôlé<p>Applications 5-Chloro-2-thiophenecarboxylic Acid is a metabolite of Rivaroxaban (R538000).<br>References Brickner, S., et al.: J. Med. Chem., 39, 673 (1996), Sato, K., et al.: Eur. J. Pharmacol., 347, 231 (1998), Chang, P., et al.: IDrugs, 7, 50 (2004), Weinz, C., et al.: Drug Metab. Dispos., 37, 1056 (2009)<br></p>Formule :C5H3ClO2SCouleur et forme :NeatMasse moléculaire :162.59Semicarbazide-13C,15N2 Hydrochloride
CAS :Produit contrôlé<p>Applications A labelled metabolite of Nitrofuran.Environmental contaminants; Food contaminants; Heat processing contaminants<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Elliott, J., et al.: J. Pharm. Pharmacol., 41, 37 (1989), Tribalat, L., et al.: Anal. Bioanal. Chem., 386, 2168 (2006), Chu, P., et al.: J. Agric. Food Chem., 55, 2129 (2007),<br></p>Formule :CH515N2NO·ClHCouleur et forme :NeatMasse moléculaire :114.51(S)-Lansoprazole
CAS :Produit contrôlé<p>Applications The S-enantiomer of Lansoprazole; a gastric proton pump inhibitor. An antiulcerative.<br>References Figgitt, D., et al.: Drugs, 60, 925 (2000), Katsuki, H., et al.: Eur. J. Clin. Pharmacol., 57, 709 (2001), Barradell, L.B., et al.: Drugs, 44, 225 (1992), Kim, K., et al.: Clin. Pharmacol. Ther., 72, 90 (2002), Niioka, T., et al.: Ther. Drug Monit., 28, 321 (2006),<br></p>Formule :C16H14F3N3O2SCouleur et forme :NeatMasse moléculaire :369.36Dolutegravir Sodium
CAS :<p>Applications Dolutegravir is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.<br>References Kobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al.: Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011)<br></p>Formule :C20H18F2N3O5·NaCouleur et forme :NeatMasse moléculaire :441.36Levofloxacin-d3 Sodium Salt
CAS :Produit contrôlé<p>Applications Levofloxacin-d3 Sodium Salt, is the labeled analogue of Levofloxacin (L360000), an antibiotic used against gram-negative organisms.<br>References Kato, M., et al.: Arzneim.-Forsch., 42, 365 (1992), North, D.S., et al.: Pharmacotherapy, 18, 915 (1998), Hwang, D.G., et al.: Br. J. Ophthalmol., 87, 1004 (2003),<br></p>Formule :C18H16D3FN3NaO4Couleur et forme :NeatMasse moléculaire :386.37Diminazene-13C2,15N4 Dihydrochloride (major)
CAS :<p>Applications Labelled Diminazene (D479550). Antiprotozoal (Trypanosoma, Babesia).<br>References Braithwaite, A.W.<br></p>Formule :C1213C2H17Cl2N315N4Couleur et forme :Yellow To Dark YellowMasse moléculaire :360.24-Chloro-2-(4-chlorobenzoyl)-1-(4-methoxyphenyl)hydrazide Benzoic Acid
CAS :<p>Applications An impurity of the anti-inflammatory drug indomnethacin (I641000). Indomethacin inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). A clinically useful NAISD.<br>References Salari, H., et al.: Prostagland. Leukotrienes Med., 13, 53 (1984), Lehmann, J.M., et al.: J. Biol. Chem., 272, 3406 (1997)<br></p>Formule :C21H16Cl2N2O3Couleur et forme :NeatMasse moléculaire :415.27Ioversol
CAS :Produit contrôlé<p>Applications Nonionic, low osmolality, radiographic contrast agent. Diagnostic aid (radiopaque medium).<br>References Wilkins, R.A., et al.: Invest. Radiol., 24, 781 (1989), Kaufman, A.J., et al.: Urol. Radiol., 12, 56 (1990),<br></p>Formule :C18H24I3N3O9Couleur et forme :Off-WhiteMasse moléculaire :807.11ETHYL 2-(3-METHYL-4-OXO-3,4-DIHYDROPHTHALAZIN-1-YL)ACETATE
CAS :Degré de pureté :95.0%Masse moléculaire :246.266006469726562-(4-Benzyl-morpholin-2-ylmethyl)-isoindole-1,3-dione
CAS :Degré de pureté :95.0%Masse moléculaire :336.3909912109375Nepafenac
CAS :<p>Applications A non-steroidal anti-inflammatory with analgesic activity; selective COX-2 inhibitor. Prodrug of Amfenac.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Walsh, D.A., et al.: J. Med. Chem., 33, 2296 (1990), Gamache, D.A., et al.: Inflammation, 24, 357 (2000), Lindstrom, R., et al.: Curr. Med. Res. Opin., 22, 397 (2006),<br></p>Formule :C15H14N2O2Couleur et forme :NeatMasse moléculaire :254.28Bis[(1S)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinyl]-methanone
CAS :Produit contrôlé<p>Applications Bis[(1S)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinyl]-methanone is a possible impurity of solifenacin (S676700) which is a muscarinic M3 receptor antagoinst. Solifenacin is used in treatment of urinary incontinence.<br>References Ikeda K., et al.: Arch. Pharmacol., 366, 97, (2002); Chapple, C.R., et al.: Br. J. Urol., 93, 303 (2004); Ohtake, A., et al.: Eur. J. Pharmacol., 492, 243 (2004); Brunton, S., et al.: Curr. Med. Res. Opin., 21, 71 (2005); Habb, F., et al.: Eur. Urol. 47, 376 (2005); Payne, C.K., et al.: Drugs, 66, 175 (2006)<br></p>Formule :C31H28N2OCouleur et forme :NeatMasse moléculaire :444.57Sitagliptin
CAS :Produit contrôlé<p>Applications Sitagliptin (cas# 486460-32-6) is a useful research chemical.<br></p>Formule :C16H15F6N5OCouleur et forme :Off-WhiteMasse moléculaire :407.31(S)-9-Hydroxy Risperidone
CAS :Produit contrôlé<p>Applications The S-enantiomer metabolite of Risperidone, a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tiberghien, F., et al.: Anticancer Drugs, 7, 568 (1996), Kansy, M., et al.: J. Med. Chem., 41, 1007 (1998), Kerns, E., et al.: J. Pharm. Sci., 90, 1838 (2001), Kerr, K., et al.: J. Biol. Chem., 276, 8657 (2001), Doran, A., et al.: Drug Metab. Dispos., 33, 165 (2005),<br></p>Formule :C23H27FN4O3Couleur et forme :NeatMasse moléculaire :426.48N-(2-chloro-4-methylpyridin-3-yl)-2-(cyclopropylamino)nicotinamide
CAS :Degré de pureté :98%Masse moléculaire :302.760009765625Dolutegravir-d4
CAS :Produit contrôlé<p>Applications Isotope labelled Dolutegravir is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.<br>References Kobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al.: Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011);<br></p>Formule :C20H15D4F2N3O5Degré de pureté :>80%Couleur et forme :NeatMasse moléculaire :423.402-(5-amino-3-methyl-1H-pyrazol-1-yl)-6-phenylpyrimidin-4(3H)-one
CAS :Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :267.2919921875N-Mesyldronedarone
CAS :Produit contrôlé<p>Applications N-Mesyldronedarone is an impurity of Dronedarone (D679445, HCl); a drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.<br>References Singh, B., et al.: J. Cardiovas. Pharmacol., 52, 300 (2008); Hoy, S., et al.: Drugs, 69, 1647 (2009); Hohnloser, S., et al.: New Eng. J. Med., 360, 668 (2009); Mahender, M., et al.: Org. Process Res. Dev., 18, 157 (2014)<br></p>Formule :C32H46N2O7S2Couleur et forme :NeatMasse moléculaire :634.85Tilidine Impurity D Hydrochloride
CAS :Produit contrôlé<p>Applications Tilidine Impurity D Hydrochloride is an imourity of Tilidine, which is a controlled substance (opiate). Analgesic. It is used in clinical trial in comparison with Nefopam. Tilidine is one of the most widely used narcotics in Germany and Belgium.<br>References Vollmer, K.-O., et al.: Arzneim.-Forsch., 20, 990 (1970), Abeloos, J., et al.: Acta Anaesthesiol. Belg., 34, 283 (1983), Van Cauwenberge, H., et al.: Int. J. Clin. Pharmacol. Res., 12, 1 (1992),<br></p>Formule :C13H19NO2·ClHCouleur et forme :NeatMasse moléculaire :257.76Trimetazidine Dihydrochloride
CAS :Produit contrôlé<p>Applications Coronary vasodilator. Antianginal.<br>References Fujita, et al.: Jpn. J. Pharmacol., 17, 19 (1967), Harpey, C., et al.: Cardiovasc. Drug Rev., 6, 292 (1989),<br></p>Formule :C14H22N2O3·2ClHCouleur et forme :Off WhiteMasse moléculaire :339.262,3,4,5-Tetrahydro-3-(trifluoroacetyl)-1,5-methano-1H-3-benzazepine-7,8-diamine
CAS :Produit contrôlé<p>Applications Varenicline intermediate.<br>References Coe, J., et al.: J. Med. Chem., 48, 3474 (2005),<br></p>Formule :C13H14F3N3OCouleur et forme :NeatMasse moléculaire :285.26Lansoprazole Sulfone
CAS :<p>Impurity Lansoprazole USP Related Compound A<br>Applications A metabolite of Lansoprazole, as gastric pump inhibitor. Lansoprazole USP Related Compound A.<br>References De Morais, S., et al.: Mol. Pharmacol., 46, 594 (1994), Spencer, C., et al.: Drugs, 48, 404 (1994), Pearce, R., et al.: J. Pharmacol. Exp. Ther., 277, 805 (1996), Tassaneeyakul, W., et al.: Br. J. Clin. Pharmacol., 49, 139 (2000),<br></p>Formule :C16H14F3N3O3SCouleur et forme :NeatMasse moléculaire :385.36Hydroxymethoxy-N-desmethyl Toremifene
Formule :C26H28ClNO3Degré de pureté :>80%Couleur et forme :NeatMasse moléculaire :437.963-(5-azetidin-3-yl-1,2,4-oxadiazol-3-yl)pyridine dihydrochloride
CAS :Degré de pureté :95.0%Masse moléculaire :275.1300048828125
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