Dérivés de Quinazoline et de Quinoléine
Les quinazolines et les quinoléines sont des composés hétérocycliques azotés à structure aromatique qui jouent un rôle clé dans la synthèse de médicaments à activité anticancéreuse, antimicrobienne et anti-inflammatoire. Leurs dérivés présentent des modifications structurelles qui optimisent leur biodisponibilité et leur sélectivité, permettant ainsi le développement de nouveaux principes actifs pour diverses applications thérapeutiques. Ces composés sont utilisés dans la fabrication d’API destinés au traitement du cancer, des infections, des maladies neurodégénératives et cardiovasculaires. De plus, les dérivés de quinazoline et de quinoléine sont essentiels dans la recherche d’inhibiteurs enzymatiques et dans la conception de molécules bioactives innovantes.
Chez CymitQuimica, nous proposons des dérivés de quinazoline et de quinoléine de haute pureté pour des applications en synthèse chimique, développement pharmaceutique et biotechnologie.
65630 produits trouvés pour "Dérivés de Quinazoline et de Quinoléine"
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4-(Benzo[d]thiazol-2-ylthio)morpholine
CAS :Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :252.35000610351562Ivacaftor Carboxylic Acid
CAS :<p>Applications Ivacaftor Carboxylic Acid is an impurity of Ivacaftor (I940600); a drug used in the treatment of cystic fibrosis.<br>References Clancy, J. et al.: Am. J. Resp. Crit. Care. Med., 186, 593 (2012)<br></p>Formule :C24H26N2O5Couleur et forme :NeatMasse moléculaire :422.474-Dechloro-4-hydroxy Diclazuril
CAS :<p>Applications 4-Dechloro-4-hydroxy Diclazuril is an impurity of Diclazuril (D436200), a nucleotide analog with broad-spectrum anticoccidial activity.<br>References Fodey, T.L., et al.: J. Immunol. Meth., 323, 31 (2007);<br></p>Formule :C17H10Cl2N4O3Couleur et forme :NeatMasse moléculaire :389.19Acetyl Isoniazid-d4
CAS :Produit contrôlé<p>Applications A labelled metabolite of Isoniazid (I821450) in plasma.<br>References Peloquin, C., et al.: Antimicrob. Agents Chemother., 41, 2670 (1997), Peloquin, C., et al.: Drugs, 62, 2169 (2002),<br></p>Formule :C8H5D4N3O2Couleur et forme :Off-WhiteMasse moléculaire :183.2Norneo Vardenafil
CAS :Produit contrôlé<p>Applications Norneo Vardenafil is a related compound of Vardenafil (V098001) as phosphodiesterase inhibitor.<br></p>Formule :C18H20N4O4Couleur et forme :Off White SolidMasse moléculaire :356.38N-Nitrosoephedrine
CAS :Produit contrôléFormule :C10H14N2O2Couleur et forme :NeatMasse moléculaire :194.23Nilotinib-d3
CAS :Produit contrôlé<p>Applications Labelled analog of Nilotinib (AMN1O7), which might be useful in treatment of chronic myelogenous leukemia. It is a COVID19-related research product.<br>References Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),<br></p>Formule :C282H3H19F3N7OCouleur et forme :Off-White To Light YellowMasse moléculaire :532.53p-Nicorandil
CAS :<p>Applications A positional isomeric impurity of the antianginal Nicorandil (N398500).<br>References Fedorov, B.S. et al.: Pharmac. Chem. J., 43, 134 (2009); Tatyanenko, L.V. et al.: Biomed. Khim., 52, 174 (2006);<br></p>Formule :C8H9N3O4Couleur et forme :BeigeMasse moléculaire :211.17AMOZ-d5
CAS :Produit contrôlé<p>Applications A labelled metabolite of Nitrofuran.Environmental contaminants; Food contaminants; Heat processing contaminants<br>References Tribalat, L., et al.: Anal. Bioanal. Chem., 386, 2168 (2006), Chu, P., et al.: J. Agric. Food Chem., 55, 2129 (2007),<br></p>Formule :C82H5H10N3O3Couleur et forme :NeatMasse moléculaire :206.25(S)-Linagliptin
CAS :<p>Applications (S)-Linagliptin is a novel potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with potential use in the treatment of type 2 diabetes.<br>References Prabavathy, N. et al.: Int. J. Pharm. Bio. Sci., 2, 438 (2011); Deacon, C.F.: Diab. Obes. Metab., 13, 7 (2011);<br></p>Formule :C25H28N8O2Couleur et forme :NeatMasse moléculaire :472.54TEMPO
CAS :Produit contrôlé<p>Applications TEMPO is a stable radical prepared through the oxidation of 2,2,6,6-tetramethylpiperidine. TEMPO has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin resonance spectroscopy. TEMPO can also be used as a mediator in free radical polymerization.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Seaton, T.A. et al.: Brain Res., 777, 110 (1997); Tanielyan, S.K. et al.: Top. Catal., 55, 556 (2012); Wolinska-Grabczyk, A. et al.: Polymer, 46, 2461 (2005); Keoshkerian, B. et al.: Polym. Prep., 35, 675 (1994);<br></p>Formule :C9H18NOCouleur et forme :NeatMasse moléculaire :156.256-Methyl Risperidone
CAS :Produit contrôlé<p>Impurity Risperidone EP Impurity E<br>Applications 6-Methyl Risperidone (Risperidone EP Impurity E) is a Risperidone (R525000) impurity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formule :C24H29FN4O2Couleur et forme :Light YellowMasse moléculaire :424.512,2,2-Trifluoroethyl 2,5-Bis(2,2,2-trifluoroethoxy)benzoate
CAS :Produit contrôlé<p>Applications Intermediate in the production of antiarrhythmic N-(Piperidylalkyl)trifluoroethoxybenzamides. Possible Flecainide impurity.<br>References Banitt, E., et al.: J. Med. Chem., 20, 821 (1977),<br></p>Formule :C13H9F9O4Couleur et forme :NeatMasse moléculaire :400.19(S) FTY720 Phosphate
CAS :<p>Applications FTY720 is a sphingosine 1-phosphate receptor modular, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration. FTY720 Phosphate is the active metabolite of FTY720-phosphate.<br>References Chiba, K., et al.: J. Immunol., 160, 5037 (1998), Brinkmann, V., et al.: J. Biol. Chem., 277, 21453 (2002), Kiuchi, M., et al.: Bioorganic & Medicinal Chemistry, 13, 425 (2005<br></p>Formule :C19H34NO5PCouleur et forme :WhiteMasse moléculaire :387.45Ethyl 2-Chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
CAS :Produit contrôlé<p>Applications Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate (cas# 27143-07-3) is a useful research chemical.<br></p>Formule :C11H13N2O3ClCouleur et forme :NeatMasse moléculaire :256.68Valsartan Benzyl Ester
CAS :<p>Impurity Valsartan USP Related Compound C<br>Applications Valsartan (V095750) intermediate. Valsartan USP Related Compound C.<br>References Cramer., et al.: J. Med. Chem., 42, 3919 (1999),<br></p>Formule :C31H35N5O3Couleur et forme :NeatMasse moléculaire :525.644-(4-Nitrophenyl)-3-morpholinone
CAS :Produit contrôléFormule :C10H10N2O4Couleur et forme :NeatMasse moléculaire :222.20(4S)-Brivaracetam
CAS :Produit contrôléFormule :C11H20N2O2Couleur et forme :NeatMasse moléculaire :212.2893-(4-CHLOROPHENYL)-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE
CAS :Degré de pureté :95.0%Masse moléculaire :282.7300109863281Darunavir
CAS :<p>Applications Second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product.<br>References Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003), Arasteh, K., et al.: AIDS, 19, 943 (2005), Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005),<br></p>Formule :C27H37N3O7SCouleur et forme :BeigeMasse moléculaire :547.662-Benzylacrylic Acid
CAS :Produit contrôlé<p>Stability Light Sensitive<br>Applications 2-Benzylacrylic Acid (cas# 5669-19-2) is a compound useful in organic synthesis.<br></p>Formule :C10H10O2Couleur et forme :NeatMasse moléculaire :162.192-Nitrobenzotrifluoride
CAS :Produit contrôlé<p>Applications 2-Nitrobenzotrifluoride can be used for self-repairing polyimide based on dynamic imine bond.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lei, X., et.al., Faming Zhuanli Shenqing, 15, (2019);<br></p>Formule :C7H4F3NO2Couleur et forme :NeatMasse moléculaire :191.107N-Cyano-N’-[2-[(4-methyl-5-imidazolyl)methylthio]ethyl]-S-methylisothiourea
CAS :Produit contrôléFormule :C10H15N5S2Couleur et forme :NeatMasse moléculaire :269.39N-Formyl Apixaban
CAS :Produit contrôlé<p>Applications N-Formyl Apixaban is derived from Apixaban (A726700) which is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.<br>References Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);<br></p>Formule :C26H25N5O5Couleur et forme :NeatMasse moléculaire :487.51(R)-(+)-Thalidomide
CAS :Produit contrôlé<p>Applications Optically active isomer of Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative.<br>References D’Amato, r.J., et al.: Proc. Natl. Acad. Sci. USA, 91, 4082 (1994), Makonkawkeyoon, S., et al.: Proc. Natl. Acad. Sci. USA, 90, 5974 (1993), Schumacher, H., et al.: J. Pharmacol. Exp. Therap., 160, 189 (1968)<br></p>Formule :C13H10N2O4Couleur et forme :NeatMasse moléculaire :258.23Thiazolylmethyl-4-nitrophenylcarbonate
CAS :Produit contrôlé<p>Applications Retinovir intermediate.<br>References Randad, R., et al.: Bioorg. Med. Chem. Lett., 4, 1247 (1994), Scholz, et al.: J. Med. Chem., 37, 3079 (1994), Vacca, J., et al.: Bioorg. Med. Chem. Lett., 4, 499 (1994),<br></p>Formule :C11H8N2O5SCouleur et forme :Light YellowMasse moléculaire :280.26Desethylene Aripiprazole
CAS :<p>Impurity Aripiprazole Desethylene Impurity<br>Applications Desethylene Aripiprazole is an Aripiprazole derivative. Aripiprazole Desethylene Impurity<br></p>Formule :C21H25Cl2N3O2Couleur et forme :NeatMasse moléculaire :422.351-Chloro-2-nitrobenzene
CAS :Produit contrôlé<p>Applications 1-Chloro-2-nitrobenzene is a useful synthetic intermediate. It was used in the synthesis of 1-hydroxybenzotriazole derivatives. Reaction of 1-chloro-2-nitrobenzene with dinitrogen pentoxide in dichloromethane is strongly catalysed by H-Faujasite-720.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fathalla, M., et al.: J. Chem. Soc. Pak., 33, 324 (2011); Claridge, R., et al.: J. Chem. Soc. Perkin Trans. II, 9, 1815, (1999)<br></p>Formule :C6H4ClNO2Couleur et forme :NeatMasse moléculaire :157.55Desmethyl Ofloxacin
CAS :Produit contrôlé<p>Impurity Ofloxacin EP Impurity E<br>Applications Desmethyl Ofloxacin (Ofloxacin EP Impurity E) is a metabolite of Ofoxacin (O245750), a fluorinated quinolone antibacterial.<br>References Leysen, D., et al.: Antimicrob. Agents Chemother., 33, 1 (1989); Polk, R., et al.: J. Antimicrob. Chemother., 27, 17 (1991); Todo, Y., et al.: Chem. Pharm. Bull., 42, 2049 (1994); Furuhata, K., et al.: Biol. Pharm. Bull., 21, 456 (1998); Monk, J.P., et al.: Drugs, 33, 346 (1987); Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990)<br></p>Formule :C17H18FN3O4Couleur et forme :White To Light BeigeMasse moléculaire :347.34Thalidomide-d4
CAS :Produit contrôléFormule :C132H4H6N2O4Couleur et forme :NeatMasse moléculaire :262.25N-cyclopropyl-2-(piperazin-1-yl)nicotinamide
CAS :Degré de pureté :97%Masse moléculaire :246.31399536132812N-Formyl Lenalidomide
CAS :Produit contrôléFormule :C14H13N3O4Couleur et forme :NeatMasse moléculaire :287.27Domperidone N-Oxide
CAS :Produit contrôlé<p>Impurity Domperidone EP Impurity C<br>Stability Hygroscopic<br>Applications Domperidone N-Oxide (Domperidone EP Impurity C) is an oxygenated metabolite of the gastrokinetic and antinauseant drug Domperidone (D531100).<br>References Van Vaeck, L. et al.: Biomed. Env. Mass Spec., 16, 121 (1988);<br></p>Formule :C22H24ClN5O3Couleur et forme :White To Off-WhiteMasse moléculaire :441.91[1,1'-Biphenyl]-4-yl(phenyl)methanol
CAS :Produit contrôlé<p>Impurity Bifonazole EP Impurity A<br>Applications [1,1'-Biphenyl]-4-yl(phenyl)methanol (Bifonazole EP Impurity A) is a Bifonazole (B383400), an anti-fungal agent used in the treatment of skin diseases. Causes an increase in Ca2+ concentration and triggers cell death in PC3 human prostate cancer cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cheng, J. et al.: J. Recep. Sign. Transduct., 34, 493 (2014); Chen, Z. et al.: Mol. Pharm., 12, 590 (2015);<br></p>Formule :C19H16OCouleur et forme :NeatMasse moléculaire :260.33(R)-3-Chloro-1-phenyl-1-(2-methylphenoxy)propane
CAS :Produit contrôléFormule :C16H17ClOCouleur et forme :NeatMasse moléculaire :260.761-(4-Chlorophenyl)-5-[6-[[4-[(4-chlorophenyl)amino]-6-[(1S,2R,3R,4R)-1,2,3,4,5-pentahydroxypentyl]-1,3,5-triazin-2-yl]amino]hexyl]biguanide D-Gluconic Acid
CAS :Produit contrôléFormule :C28H38Cl2N10O5•C6H12O7Couleur et forme :NeatMasse moléculaire :665.57196163,7-Dihydro-3-methyl-1,7-bis(5-oxohexyl)-1H-purine-2,6-dione
CAS :Formule :C18H26N4O4Couleur et forme :NeatMasse moléculaire :362.42Tazarotenic Acid
CAS :Produit contrôlé<p>Applications Tazarotenic acid is the major active metabolite of Tazarotene (T010050).<br>References Nagpal, S., et al.: J. Biol. Chem., 270, 923 (1995), Madhu, C., et al.: J. Pharm. Sci., 86, 972 (1997), Attar, M., et al.: Drug Metab. Dispos., 31, 476 (2003),<br></p>Formule :C19H17NO2SCouleur et forme :NeatMasse moléculaire :323.41Hydrolyzed Pomalidomide M11
CAS :Produit contrôléFormule :C13H13N3O5Couleur et forme :NeatMasse moléculaire :291.26rac-trans-Ketoconazole
CAS :Produit contrôlé<p>Impurity Ketoconazole EP Impurity C<br>Applications rac-trans-Ketoconazole (Ketoconazole EP Impurity C) is a Ketoconazole (K186000) analog. The trans isomer of Ketoconazole.<br>References Kan, P.B., et al.: J. Steroid Biochem., 23, 1023 (1985),<br></p>Formule :C26H28Cl2N4O4Couleur et forme :Off-WhiteMasse moléculaire :531.43Tazarotene Thiochromane Dimer
CAS :<p>Applications Tazarotene Thiochromane DImer is an impurity of Tazarotene (T010050), an acetylenic retinoid prodrug converted to the active metabolite, Tazarotenic acid, with selective affinity for retinoic acid receptors RARβ and RARγ.<br>References Tang-Liu, D.D.-S., et al.: Clin. Pharmacokinet., 37, 273 (1999), Roeder, A., et al.: Skin Pharmacol. Physiol., 17, 111 (2004),<br></p>Formule :C26H26S2Couleur et forme :NeatMasse moléculaire :402.6146Valsartan Ethyl Ester
CAS :Produit contrôlé<p>Applications Valsartan Ethyl Ester is an impurity of Valsartan (V095750), a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993); Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)<br></p>Formule :C26H33N5O3Couleur et forme :White To Light BeigeMasse moléculaire :463.57Cobicistat
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Cobicistat is a HIV protease inhibitor and has been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer, significantly increasing their plasma concentrations.<br>References Von, H., Exp. Rev. Clin. Pharmacol., 5, 557 (2012); Lepist, E.I., et al.: Antimicrob. Agent. Chemother., 56, 5409 (2012); Orr, S.T.M., et al.: J. Med. Chem., 55, 4896 (2012);<br></p>Formule :C40H53N7O5S2Couleur et forme :NeatMasse moléculaire :776.02Amantadine
CAS :Produit contrôlé<p>Applications Amantadine is useful in biology studies. Particularly it has been used for solid-state NMR and membrane protein studies.<br>References Shigeta, A., et al.: New Developments in NMR, 20, 457 (2019)<br></p>Formule :C10H17NCouleur et forme :White To Off-WhiteMasse moléculaire :151.25(S)-Lisinopril Dimer
CAS :Produit contrôlé<p>Applications (S)-Lisinopril (L468985) impurity. Lisinopril Impurity G (Dimer Impurity)<br></p>Formule :C42H60N6O9Couleur et forme :WhiteMasse moléculaire :792.96Maraviroc-d6
CAS :Produit contrôlé<p>Applications Potent, non-competitive CCR5 receptor antagonist; inhibits binding of HIV viral coat protein gp120. Antiviral.<br>References Fumero, E., et al.: Clin. Microbiol. Infect., 9, 1077 (2003), Walker, D.K., et al.: Drug Metab. Dispos., 33, 587 (2005), Wood, A., et al.: Prog. Med. Chem., 43, 239 (2005),<br></p>Formule :C29D6H35F2N5OCouleur et forme :NeatMasse moléculaire :519.70Dechloro-Rivaroxaban
CAS :Produit contrôlé<p>Applications Dechloro-Rivaroxaban is an impurity of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Formule :C19H19N3O5SCouleur et forme :NeatMasse moléculaire :401.444-Nitro Lenalidomide
CAS :Produit contrôlé<p>Impurity Lenalidomide impurity<br>Applications Lenalidomide (L328000) analog. Lenalidomide impurity; Lenalidomide intermediate.<br>References Hashimoto, Y., et al.: Bioorg. Med. Chem., 10, 461 (2002),<br></p>Formule :C13H11N3O5Couleur et forme :NeatMasse moléculaire :289.24
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