Dérivés de Quinazoline et de Quinoléine
Les quinazolines et les quinoléines sont des composés hétérocycliques azotés à structure aromatique qui jouent un rôle clé dans la synthèse de médicaments à activité anticancéreuse, antimicrobienne et anti-inflammatoire. Leurs dérivés présentent des modifications structurelles qui optimisent leur biodisponibilité et leur sélectivité, permettant ainsi le développement de nouveaux principes actifs pour diverses applications thérapeutiques. Ces composés sont utilisés dans la fabrication d’API destinés au traitement du cancer, des infections, des maladies neurodégénératives et cardiovasculaires. De plus, les dérivés de quinazoline et de quinoléine sont essentiels dans la recherche d’inhibiteurs enzymatiques et dans la conception de molécules bioactives innovantes.
Chez CymitQuimica, nous proposons des dérivés de quinazoline et de quinoléine de haute pureté pour des applications en synthèse chimique, développement pharmaceutique et biotechnologie.
65630 produits trouvés pour "Dérivés de Quinazoline et de Quinoléine"
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3-(3-Nitrophenyl)-1H-pyrazole-4-carbaldehyde
CAS :Degré de pureté :95.0%Masse moléculaire :217.18400573730476-Bromo-3-hydroxyquinoline-4-carboxylic acid
CAS :Degré de pureté :95+%Masse moléculaire :268.0660095214844Famotidine Amide Impurity Hydrochloride
CAS :<p>Applications Famotidine impurity.<br>References Junnarkar, G., et al.: Pharm. Res., 12, 599 (1995), Singh, S., et al.: J. Pharm. Sci., 91, 253 (2002),<br></p>Formule :C8H14ClN5OS2Couleur et forme :White SolidMasse moléculaire :295.811-Acetyl-4-(4-hydroxyphenyl)piperazine
CAS :Produit contrôlé<p>Applications 1-Acetyl-4-(4-hydroxyphenyl)piperazine is an intermediate used to prepare Ketoconazole (K186000) which inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo.<br>References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986), Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989), Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988), Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)<br></p>Formule :C12H16N2O2Couleur et forme :WhiteMasse moléculaire :220.27Nicorandil-d4
CAS :Produit contrôlé<p>Stability Unstable in Solution<br>Applications An antianginal.<br>References Yoneyama, F., et al.: Cardiovasc. Drugs Ther., 4, 1119 (1990), Purcell, H., et al.: Brit. J. Clin. Pract., 47, 150 (1993)<br></p>Formule :C82H4H5N3O4Couleur et forme :NeatMasse moléculaire :215.20A77 1726 (E/Z) Mixture
CAS :Produit contrôlé<p>Impurity Leflunomide USP Related Compound B<br>Applications rac A77 1726 is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme’s teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective than injectable interferon beta 1a (Rebif®). Leflunomide USP Related Compound B.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kirsch, B.M., et al.: Arthritis Research and Therapy, 7, 3, R694, (2005)<br></p>Formule :C12H9F3N2O2Couleur et forme :NeatMasse moléculaire :270.215-Amino-1-cyclopropyl-6,7-difluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
CAS :Degré de pureté :95+%Masse moléculaire :294.257995605468752-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzamide
CAS :Degré de pureté :95.0%Masse moléculaire :297.28900146484375Firocoxib-d4
CAS :Produit contrôlé<p>Applications Labelled Firocoxib (F356002). A selective cyclooxygenase-2-(COX-2) inhibitor. Anti-inflammatory; analgesic.<br>References McCann, M.E., et al.: Am. J. Vet. Res., 65, 503 (2004),<br></p>Formule :C172H4H16O5SCouleur et forme :NeatMasse moléculaire :340.43Benzocaine
CAS :Produit contrôlé<p>Applications Benzocaine is used as an anesthetic (local).<br>References Kholod, Y., et al.: Environ. Sci. Technol., 43, 9208 (2009), Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Perez-Garrido, Alfonso; Helguera, A., et al.: J. Pharm. Sci., 98, 4557 (2009), Onoue, S., et al.: J. Pharm. Sci., 98, 3647 (2009),<br></p>Formule :C9H11NO2Couleur et forme :NeatMasse moléculaire :165.19Leflunomide
CAS :Produit contrôlé<p>Applications An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therapeutically as a antirheumatic (Merck Index).This compound is suitable for dihydroorotate dehydrogenase (DHODH) related research.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Vrenken, T., et al.: J. Hepatol., 49, 799 (2008), Mazzucco, G., et al.: Clin. Nephrol., 70, 163 (2008), Davies, M., et al.: J. Med. Chem., 52, 2683 (2009),<br></p>Formule :C12H9F3N2O2Couleur et forme :NeatMasse moléculaire :270.21Methomyl
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Methomyl is a carbamate insecticide. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Armes, N., et al.: Bull. Entomol. Res., 86, 499 (1996); Shono, T., et al.: Pest. Biochem. Physiol., 75, 1 (2003)<br></p>Formule :C5H10N2O2SCouleur et forme :ColourlessMasse moléculaire :162.211-(4-Pyridyl)piperazine
CAS :Formule :C9H13N3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :163.224MDV 3100-d6 (Enzalutamide-d6)
CAS :Produit contrôlé<p>Applications Isotope labelled MDV 3100 is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer.<br></p>Formule :C21H10D6F4N4O2SCouleur et forme :NeatMasse moléculaire :470.482,5-Bis(2,2,2-trifluoroethoxy)benzoic Acid
CAS :Produit contrôlé<p>Impurity Flecainide EP Impurity D<br>Applications Flecainide Acetate Impurity D.<br>References Banitt, E., et al.: J. Med. Chem., 18, 1130 (1975),<br></p>Formule :C11H8F6O4Couleur et forme :White To Off-WhiteMasse moléculaire :318.172-(4-Hydroxybenzyl)-N,5-bis-(4-fluorophenyl)-5-hydroxypentanamide
CAS :<p>Applications 2-(4-Hydroxybenzyl)-N,5-bis-(4-fluorophenyl)-5-hydroxypentanamide is an ring-opened impurity of Ezetimibe (E975000).<br>References Raman, B. et al.: J. Pharmac. Biomed. Anal., 52, 73 (2010);<br></p>Formule :C24H23F2NO3Couleur et forme :WhiteMasse moléculaire :411.44(N-Methyl-O-(10H-phenothiazine-10-carbonyl)hydroxylamine hydrochloride
CAS :Degré de pureté :95%Masse moléculaire :308.77999877929691-[[2-[(2-Aminophenyl)amino]-5-methyl-3-thienyl]carbonyl]-4-methyl-piperazine
CAS :Produit contrôlé<p>Applications 1-[[2-[(2-Aminophenyl)amino]-5-methyl-3-thienyl]carbonyl]-4-methyl-piperazine is an impurity of Olanzapine (O253750), a serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic activity.<br>References Moore, N.A., et al.: Curr. Opin Invest. Drugs, 2, 281 (1993), Baldwin, D.S. and Montgomery, S.A.: Int. Clin. Psychopharmacol., 10, 239 (1995), Tohen, M., et al.: Am. J. Psychiatry, 156, 702 (1999)<br></p>Formule :C17H22N4OSCouleur et forme :NeatMasse moléculaire :330.452-(3,4-Dichlorobenzoyl)-5-(1,3-dioxolan-2-yl)thiophene
CAS :Degré de pureté :97.0%Masse moléculaire :329.190002441406252,7-Bis(pyridin-4-ylmethyl)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone
CAS :Degré de pureté :95%Masse moléculaire :448.43798828125Riluzole Dimer Impurity
Produit contrôlé<p>Applications Riluzole Dimer Impurity is an impurity of Rifuzole (R510000), a neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant. Neuroprotective agent.<br>References Mizoule, J., et al.: Neuropharmacology, 24, 767 (1985), Wahl, F., et al.: Eur. J. Pharmacol., 230, 209 (1993) Bensimon, G., et al.: N. Engl. J. Med., 330, 585 (1994)<br></p>Formule :C17H10F6N4O2S2Couleur et forme :NeatMasse moléculaire :480.41N-Nitrosocarvedilol
CAS :Produit contrôléFormule :C24H25N3O5Couleur et forme :NeatMasse moléculaire :435.4727-chloro-4-methoxy-N-(pyridin-3-ylmethyl)benzo[d]thiazol-2-amine
CAS :Degré de pureté :95.0%Masse moléculaire :305.77999877929691-(4-Methylphenyl)-4,4,4-trifluorobutane-1,3-dione
CAS :<p>Applications A Celecoxib (Celebrex) intermediate.<br>References Kujubu, D., et al.: J. Biol. Chem., 266, 12866 (1991), Penning, T., et al.: J. Med. Chem., 40, 1347 (1997), Prasit, P., et al.: Bioorg. Med. Chem. Lett., 9, 1773 (1999), Sorbera, L., et al.: Drugs Future, 26, 346 (2001),<br></p>Formule :C11H9F3O2Couleur et forme :White SolidMasse moléculaire :230.18Carvedilol-d3
CAS :Produit contrôléFormule :C242H3H23N2O4Couleur et forme :Off WhiteMasse moléculaire :409.49N-Boc-L-cis-4,5-Methanoprolineamide
CAS :Produit contrôlé<p>Applications N-Boc-L-cis-4,5-Methanoprolineamide is an intermediate used to prepare methanoprolinenitrile-contg. dipeptide mimetics as DPP-IV inhibitors and as antidiabetic agents.<br>References Magnin, D., et al.: J. Med. Chem., 47, 2587 (2004)<br></p>Formule :C11H18N2O3Couleur et forme :NeatMasse moléculaire :226.272Thioacetic Acid
CAS :Produit contrôlé<p>Stability Light Sensitive<br>Applications Thiacetic Acid is a commonly used reagent in organic synthesis for the introduction of thiol groups in molecules.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chapman, J.H. et al.: J. Chem. Soc., 579 (1950); Hoque, A., et al.: Bioorg. Med. Chem. Lett., 22, 6770 (2012)<br></p>Formule :C2H4OSCouleur et forme :NeatMasse moléculaire :76.12Riluzole
CAS :<p>Applications A neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant. Neuroprotective agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mizoule, J., et al.: Neuropharmacology, 24, 767 (1985), Wahl, F., et al.: Eur. J. Pharmacol., 230, 209 (1993) Bensimon, G., et al.: N. Engl. J. Med., 330, 585 (1994)<br></p>Formule :C8H5F3N2OSCouleur et forme :NeatMasse moléculaire :234.20Cyclohexylmethyl 5-(1,3-dioxolan-2-yl)-2-thienyl ketone
CAS :Degré de pureté :97.0%Masse moléculaire :280.38000488281253,5-Bis-benzyloxypyridine-2-carboxylic acid
CAS :Degré de pureté :95.0%Masse moléculaire :335.3590087890625N-(2,6-Dimethylphenyl)-1-piperazineacetamide
CAS :Formule :C14H21N3OCouleur et forme :NeatMasse moléculaire :247.34(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester
CAS :Produit contrôlé<p>Applications (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate used to prepare dipeptidyl peptidase IV (DPP-IV) inhibitors.<br>References Yoshida, T., et al.: Bioorg. Med. Chem., 20, 5705 (2012); Sakashita, H., et al.: Bioorg. Med. Chem., 15, 641 (2007)<br></p>Formule :C13H20N2O4SCouleur et forme :NeatMasse moléculaire :300.37Bupivacaine Hydrochloride Monohydrate
CAS :<p>Applications Sodium channel blocker, local anesthetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wilson, T.D., et al.: Anal. Profiles Drug Subs., 19, 59 (1990), McClellan, K.J., et al.: Drugs, 56, 355 (1998),<br></p>Formule :C18H28N2O·ClH·H2OCouleur et forme :WhiteMasse moléculaire :324.891,3-Diphenyl-1 H -pyrazole-4-carboxylic acid
CAS :Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :264.283996582031255-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is used as a reagent in the synthesis of N-(2-acylaminobenzyl or 2-acylaminoheterocyclylmethyl)thiophene-2-carboxamide derivatives as antithrombotics. It is also used as a reagent in the synthesis of diamide derivatives as FXa inhibitors. 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is an intermediate for Edoxaban (E555520).<br>References Mochizuki, A., et al.: Jpn. Kokai Tokkyo Koho. JP 2010120852 A 20100603. Jun 3, 2010; Mochizuki, A., et al.: PCT Int. Appl. WO 2008123017 A1 20081016. Oct 16, 2008<br></p>Formule :C8H11ClN2O2SCouleur et forme :Light BrownMasse moléculaire :234.7Keto Bisoprolol Hydrochloride
CAS :Produit contrôlé<p>Impurity Bisoprolol EP Impurity J<br>Applications An impurity of Bisoprolol (B510500). Bisoprolol ester Impurity<br>References Tattersfield, A.E., et al.: Br. J. Clin. Pharmacol., 18, 343 (1984); Kohli, R.S., et al.: Eur. Heart J., 6, 845 (1985); Zachariah, P.K., et al.: Clin. Ther., 15, 779 (1993);<br></p>Formule :C18H30ClNO5Couleur et forme :Off WhiteMasse moléculaire :375.891,2-Deshydro Praziquantel
CAS :Produit contrôlé<p>Impurity Praziquantel USP Related Compound B<br>Applications 1,2-Deshydro Praziquantel is a related compound to Praziquantel (P702095), anthelmintic, effective against flatworms. Praziquantel USP Related Compound B.<br>References Kuhn, I., et al.: Bioorg. Med. Chem., 18, 7900 (2010), Wang, W., et al.: Parasitol., 137, 1905 (2010),<br></p>Formule :C19H22N2O2Couleur et forme :Off-White To BeigeMasse moléculaire :310.394-Fluoro-3-(((5-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)methyl)amino)-N-(3-(trifluoromethoxy)phenyl)benzamide
CAS :Degré de pureté :97.0%Masse moléculaire :485.442993164062511-Hydroxy-N-methyl Dihydro Loratadine
CAS :<p>Impurity Loratadine USP Related Compound D<br>Stability Hygroscopic<br>Applications 11-Hydroxy-N-methyl Dihydroloratadine (Loratadine USP Related Compound D) is an impurity of Loratadine (L469575).<br>References Zhong, D., et al.: Pharmazie, 49, 736 (1994), Squella, J., et al.: Talanta, 43, 2029 (1996), Ruperez, F., et al.: J. Pharm. Biomed. Anal., 29, 35 (2002),<br></p>Formule :C20H23ClN2OCouleur et forme :White To YellowMasse moléculaire :342.864-Cyanopyridine
CAS :Produit contrôlé<p>Applications 4-Cyanopyridine is a reagent for the synthesis of 1-tolyl-5-benzylthiotetrazole and 2-hexylthio-4-pyridinecarbonitrile, an antituberculotics. Preparation of the antihypertensive agent Pinacidil using the chemoselective and green oxidative rearrangement of an amidine and addition of an amine to a guanidine as the key step. Structure-based discovery of human L-xylulose reductase inhibitors from database screening and molecular docking. Human L-xylulose reductase (XR) is an enzyme of the glucuronic acid/uronate cycle of glucose metabolism with the possible target for treatment of the long-term complications of diabetes.<br>References Waisser, K., et al.: Folia Pharmaceutica Universitatis Carolinae, 18, 31 (1995); Carbone, V., et al.: Bioorg. Med. Chem., 13, 301 (2004); Baeten, M., et al.: Adv. Synth. Catal., 358, 826 (2016)<br></p>Formule :C6H4N2Couleur et forme :WhiteMasse moléculaire :104.11Ambrisentan Acyl β-D-Glucuronide
CAS :Produit contrôlé<p>Applications A glucuronide metabolite of Ambrisentan (A575860).<br></p>Formule :C28H30N2O10Couleur et forme :NeatMasse moléculaire :554.55Prothipendyl-d6 Hydrochloride
CAS :Produit contrôlé<p>Applications A labelled Phenothiazine (P318040) analog. Antipsychotic.<br>References Sartorelli, A.C., et al.: Experientia, 21, 457 ( 1965),<br></p>Formule :C16H13D6N3S•HClCouleur et forme :NeatMasse moléculaire :291.4436462-(Pyridin-3-yl)-1H-benzo[d]imidazole
CAS :Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :195.225006103515624'-[(2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-[1,1'-Biphenyl]-2-carbonitrile
CAS :Produit contrôlé<p>Impurity Irbesartan Cyano Impurity<br>Applications A butyldiazaspirononenone derivative used in the preparation of acetylcholinesterase inhibitors. An impurity found in Irbesartan (I751000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kavitha, C.V. et al.: Bioorg. Med. Chem., 15, 7391 (2007);<br></p>Formule :C25H27N3OCouleur et forme :NeatMasse moléculaire :385.50Nitrendipine Propyl Ester
CAS :Produit contrôlé<p>Applications Nitrendipine Propyl Ester is an analogue of the antihypertensive drug Nitrendipine (N490150). Also, Nitrendipine Propyl Ester is an impurity of antihypertensive Lercanidipine (L179000). Lercanidipine impurity A.<br>References Ashimori, A., et al.: Chem. Pharm. Bull., 39, 108 (1991), Baindur, N., et al.: J. Med. Chem., 36, 3743 (1993), Zhang, B., et al.: Bioorg. Med. Chem. Lett., 20, 805 (2010),<br></p>Formule :C19H22N2O6Couleur et forme :NeatMasse moléculaire :374.394-Hydroxy Moxonidine
CAS :Produit contrôléFormule :C9H13N5O2Couleur et forme :NeatMasse moléculaire :223.23
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