Dérivés de Quinazoline et de Quinoléine
Les quinazolines et les quinoléines sont des composés hétérocycliques azotés à structure aromatique qui jouent un rôle clé dans la synthèse de médicaments à activité anticancéreuse, antimicrobienne et anti-inflammatoire. Leurs dérivés présentent des modifications structurelles qui optimisent leur biodisponibilité et leur sélectivité, permettant ainsi le développement de nouveaux principes actifs pour diverses applications thérapeutiques. Ces composés sont utilisés dans la fabrication d’API destinés au traitement du cancer, des infections, des maladies neurodégénératives et cardiovasculaires. De plus, les dérivés de quinazoline et de quinoléine sont essentiels dans la recherche d’inhibiteurs enzymatiques et dans la conception de molécules bioactives innovantes.
Chez CymitQuimica, nous proposons des dérivés de quinazoline et de quinoléine de haute pureté pour des applications en synthèse chimique, développement pharmaceutique et biotechnologie.
65578 produits trouvés pour "Dérivés de Quinazoline et de Quinoléine"
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Teneligliptin Sulfoxide (Mixture of Diastereomers)
Produit contrôlé<p>Applications Teneligliptin Sulfoxide, is an impurity of Teneligliptin (T018300) which is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used to treat type 2 diabetes. Tenegliptin is eliminated from the via excretion, and has a half-life of 24.2 hours in the human body.<br>References Goda, M. & Kadowaki, T.: Drugs Today, 49, 615 (2013); Kishimoto, M.: Diabetes Metab. Syndr. Obes., 6, 187 (2012)<br></p>Formule :C22H30N6O2SCouleur et forme :NeatMasse moléculaire :442.583-(4-Fluorophenyl)-1-phenyl-1H-pyrazole-4-carboxaldehyde
CAS :Degré de pureté :95.0%Masse moléculaire :266.27499389648445,5',5''-((1,3,5-Triazine-2,4,6-triyl)tris(azanediyl))triisophthalic acid
CAS :Degré de pureté :97%Masse moléculaire :618.47100830078123-(3-([1,1'-biphenyl]-4-yl)-1-phenyl-1h-pyrazol-4-yl)acrylic acid
CAS :Degré de pureté :97%Masse moléculaire :366.422-(4-Phenylpiperazin-1-yl)quinolin-8-ol
CAS :Degré de pureté :95.0%Masse moléculaire :305.38101196289062-((2R,3R)-3-(tert-butyl)-4-methoxy-2,3-dihydrobenzo[d][1,3]oxaphosphol-2-yl)pyridine
CAS :Degré de pureté :95%,99%eeMasse moléculaire :301.325988769531252,4,6-Tris(4-carboxyphenoxy)-1,3,5-triazine
CAS :Degré de pureté :97%Masse moléculaire :489.39599609375N”Nitrosoketamine
CAS :Produit contrôléFormule :C13H15ClN2O2Couleur et forme :White To Light YellowMasse moléculaire :266.7231-Isopropenyl-2-benzimidazolidinone
CAS :Produit contrôlé<p>Applications 1-Isopropenyl-2-benzimidazolidinone (cas# 52099-72-6) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formule :C10H10N2OCouleur et forme :NeatMasse moléculaire :174.20Tert-butyl (3S)-3-(1H-pyrazol-5-yl)azepane-1-carboxylate
CAS :Degré de pureté :98%Masse moléculaire :265.35699462890625Prochlorperazine Sulfoxide-d3
CAS :Produit contrôlé<p>Applications A labelled metabolite of Prochlorperazine.<br>References Finn, A., et al.: J. Clin. Pharmacol., 45, 1383 (2005),<br></p>Formule :C202H3H21ClN3OSCouleur et forme :Off WhiteMasse moléculaire :392.96rac Metanephrine Hydrochloride Salt
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A metabolite of Epinephrine (E588585). A naturraly occurring derivative of Epinephrine, found in urine and in certain tissues.<br>References Eisenhofer, G., et al.: J. Clin. Endocrinol. Metab., 82, 3864 (1997), Akiyama, T., et al.: Cardiovasc. Res., 49, 78 (2001), Burke, W., et al.: Brain Res., 891, 218 (2001),<br></p>Formule :C10H15NO3·ClHCouleur et forme :White To GreyMasse moléculaire :233.69Ethyl 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate
CAS :Degré de pureté :95.0%Masse moléculaire :351.459991455078110-Methyl-10H-phenothiazine-3,7-dicarbaldehyde
CAS :Degré de pureté :98%Masse moléculaire :269.32000732421875Omeprazole-d3 Sulfone
CAS :Produit contrôléFormule :C17H16D3N3O4SCouleur et forme :NeatMasse moléculaire :364.43Doravirine
CAS :<p>Applications Doravirine is a novel non-nucleoside inhibitor of HIV-1 reverse transcriptase with potent activity against wild-type virus.<br>References Feng, M., et al.: Antimicrob Agents Chemother, 60, 2241-7 (2016); Lai, M.T., et al.: Antimicrob Agents Chemother, 58, 1652-63 (2014); Anderson, M.S., et al.: Antivir Ther., 20, 397-405 (2015);<br></p>Formule :C17H11ClF3N5O3Couleur et forme :NeatMasse moléculaire :425.75Azasetron-d3 Hydrochloride
CAS :Produit contrôlé<p>Applications A 5-HT3 receptor antagonist. Used as an antiemetic.<br>References Sato, N., et al.: Japan J. Pharmacol., 59, 443 (1992), Haga, K., et al.: Japan J. Pharmacol., 63, 377 (1993)<br></p>Formule :C172H3H17ClN3O3·ClHCouleur et forme :NeatMasse moléculaire :389.29Gefitinib-d3
CAS :Produit contrôlé<p>Applications Labelled Gefitinib (G304000). Gefitinib is an antineoplastic.<br>References Anderson, N.G., et al.: Int. J. Cancer, 94, 774 (2001), Hirata, A., et al.: Cancer Res., 62, 2554 (2002), Kris, M.G., et al.: J. Am. Med. Assoc., 290, 2149 (2003), Tamura, K., et al.: Expert Opin. Pharmacother., 6, 985 (2005),<br></p>Formule :C22H21D3ClFN4O3Couleur et forme :NeatMasse moléculaire :449.92Adrafinil
CAS :Produit contrôléFormule :C15H15NO3SCouleur et forme :Off-White Light Orange ColourMasse moléculaire :289.354-(3-Aminophenyl)-3-morpholinone
CAS :Produit contrôlé<p>Applications 4-(3-Aminophenyl)-3-morpholinone is an intermediate during the preparation of imidazothiazoles as protein kinase inhibitors for treating cancers.<br>References Bamaung, N., et al.: PCT Int. Appl. (2009), WO 2009070516 A1 20090604.<br></p>Formule :C10H12N2O2Couleur et forme :NeatMasse moléculaire :192.214N-Nitro-1,2,3,4-tetradehydro Argatroban Ethyl Ester
CAS :<p>Applications N-Nitro-1,2,3,4-tetradehydro Argatroban Ethyl Ester is an intermediate in the preparation of Argatroban (A769000).<br></p>Formule :C25H35N7O7SCouleur et forme :Off White SolidMasse moléculaire :577.65N’-(1-Methylazepan-4-yl)benzohydrazine Monohydrochloride Salt
CAS :Produit contrôlé<p>Impurity Azelastine EP Impurity B/Azelastine USP Related Compound B<br>Stability Hygroscopic<br>Applications An intermediate in the preparation of Azelastine (A808250(P)), which is an orally active H1-hystamine receptor antagonist and an antihistaminic.<br>References Scheffler, G. et al.: Arch. Pharm., 321, 205 (1988); Tasaka, K., et al.: Arzneim.-Forsch., 29, 488 (1979); Chand, N., et al.: Int. J. Immunopharmacol., 7, 833 (1985)<br></p>Formule :C14H21N3O·ClHCouleur et forme :Light Yellow To Dark YellowMasse moléculaire :283.80Lansoprazole Sulfone-d4
CAS :Produit contrôléFormule :C16H10D4F3N3O3SCouleur et forme :NeatMasse moléculaire :389.381,2:4,5-bis-O-(1-Methylethylidene)-β-D-Fructopyranose
CAS :Produit contrôlé<p>Applications 1,2:4,5-bis-O-(1-Methylethylidene)-β-D-Fructopyranose is a reagent in the synthesis of antibacterial/antifungal monosaccaride esters. Also used in the synthesis of antihyperlipidemic novel compounds involving glycosyl fructose derivatives.<br>References Shen, Y. et al.: Molecules, 17, 8661 (2012); Tiwari, P. et al.: Bioorg. Med. Chem. Lett., 16, 6028 (2006);<br></p>Formule :C12H20O6Couleur et forme :NeatMasse moléculaire :260.289’-Desmethyl Granisetron
CAS :Produit contrôlé<p>Impurity Granisetron EP Impurity C<br>Applications An impurity in the synthesis of Granisetron Hydrochloride.<br>References Nishikawa, M., et al.: Drug Metab. Pharmacokin., 19, 280 (2004), Firkusny, L., et al.: Biochem. Pharmacol., 49, 1777 (1995), Sanwald, P., et al.: Drug Metab. Dispos., 24, 602 (1996), Vanderstreene, et al.: J. Labelled Comp. Radiopharm., XLI, 3, 71 (1997),<br></p>Formule :C17H22N4OCouleur et forme :White To Light YellowMasse moléculaire :298.383,6-Bis(5-bromothiophen-2-yl)-2,5-dioctylpyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione
CAS :Degré de pureté :95%Masse moléculaire :682.5700073242188(2R)-Vildagliptin
CAS :<p>Applications (2R)-Vildagliptin is an oral anti-hyperglycemic agent that inhibit dipeptidyl peptidase 4 (DPP-4) which can act as a serine exopeptidase. Aside from there use in type 2 diabetes, gliptins have positive cardiovascular and anti-inflammtatory effects. Antidiabetic.<br>References Ahren, B., et al.: J. Clin. Endocrinol. Metab., 89, 2078 (2004), Ahren, B., et al.: Diabetes Care, 27, 2874 (2004), Barlocco, D., et al.: Curr. Opin. Invest. Drugs, 5, 1094 (2004),<br></p>Formule :C17H25N3O2Couleur et forme :Off-White To Light BeigeMasse moléculaire :303.402-(4-Chlorophenoxy)aniline
CAS :Produit contrôlé<p>Applications Amoxapine impurity.<br>References Matsuo, M., et al.: Chem. Pharma. Bull., 33, 4409 (1985),<br></p>Formule :C12H10ClNOCouleur et forme :NeatMasse moléculaire :219.67Cyanuric Acid-13C3
CAS :<p>Applications Useful for diagnostic determination of Melamine and related compounds in kidney tissue.<br>References Mast, R., et al.: Food Chem. Toxicol., 21, 807 (1983), Yokley, R., et al.: J. Agric. Food Chem., 48, 3352 (2000), Ehling, S., et al.: Food Addit. Contam., 24, 1319 (2007), Vail, T., et al.: J. Anal. Toxicol., 31, 304 (2007),<br></p>Formule :C3H3N3O3Couleur et forme :NeatMasse moléculaire :132.05(S)-(-)-Thalidomide
CAS :Produit contrôlé<p>Applications Optically active isomer of Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative.<br>References D’Amato, r.J., et al.: Proc. Natl. Acad. Sci. USA, 91, 4082 (1994), Makonkawkeyoon, S., et al.: Proc. Natl. Acad. Sci. USA, 90, 5974 (1993), Schumacher, H., et al.: J. Pharmacol. Exp. Therap., 160, 189 (1968)<br></p>Formule :C13H10N2O4Couleur et forme :White To Off-WhiteMasse moléculaire :258.23Ebastine-d5
CAS :Produit contrôlé<p>Applications A nonsedating type histamine H1-receptor antagonist. Antihistaminic.<br>References Vincent, J., et al.: Brit. J. Clin. Pharmacol., 26, 497 (1988)<br></p>Formule :C32H34D5NO2Couleur et forme :NeatMasse moléculaire :474.69Diazoxide
CAS :Produit contrôlé<p>Applications Diazoxide reduces status epilepticus neuron damage in diabetes. A potassium channel opener<br>References Baba, A., et al.: J. Neurosci., 23, 7737 (2003), Bancila, V., et al.: J. Neurochem., 90, 1243 (2004), Bancila, V., et al.: J. Biol. Chem., 280, 8793 (2005),<br></p>Formule :C8H7ClN2O2SCouleur et forme :NeatMasse moléculaire :230.67Pyrazinamide-15N,d3
CAS :Produit contrôlé<p>Applications Antibacterial (tuberculostatic).<br>References Weiner, I.M., et al.: J. Pharmacol. Exp. Ther., 180, 411 (1972), Feldner, E., et al.: Anal. Profiles Drug Subs., 12, 433 (1983)<br></p>Formule :C5H2D3N215NOCouleur et forme :White Crystalline PowderMasse moléculaire :127.12[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]methanol
CAS :Degré de pureté :95.0%Masse moléculaire :284.7399902343752-FLUORO-5-((4-OXO-3,4-DIHYDROPHTHALAZIN-1-YL)METHYL)BENZONITRILE
CAS :Degré de pureté :95.0%Masse moléculaire :279.27398681640625(trans)-4-Morpholin-4-yl-cyclohexylamine; dihydrochloride
CAS :Degré de pureté :%Masse moléculaire :184.157563262-Chloromethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine, Hydrochloride
CAS :Produit contrôléFormule :C9H9ClF3NO·ClHCouleur et forme :NeatMasse moléculaire :276.08N-Desmethyl Sildenafil Hemicitrate
CAS :Produit contrôlé<p>Applications N-Desmethyl Sildenafil Hemicitrate is an impurity of Sildenafil (S435000), an orally active selective type 5 cGMP phosphodiesterase inhibitor.<br>References Terrett, N.K., et al.: Bioorg. Med. Chem. Lett., 6, 1819 (1996); Goldstein, I., et al.: N. Engl. J. Med., 338, 1397 (1998)<br></p>Formule :C48H64N12O15S2Couleur et forme :NeatMasse moléculaire :1113.22Sulindac Sulfone-d6
CAS :Produit contrôlé<p>Applications Labelled analogue of Sulindac Sulfone, an active metabolite of Sulindac. Inducer of apoptosis independent of cyclooxygenase inhibition. Inhibits cell growth by inducing apoptosis.<br>References Piazza, G.A. et al.: Cancer Res., 55, 3310 (1995);<br></p>Formule :C20H11D6FO4SCouleur et forme :NeatMasse moléculaire :378.45N-Cyano-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]-carbamimidic Acid Methyl Ester
CAS :Produit contrôlé<p>Impurity Cimetidine EP Impurity B<br>Applications N-Cyano-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]-carbamimidic Acid Methyl Ester which is an impurity of Cimetidine (C441650), which acts as a competitive histamine H2-receptor antagonist which inhibits gastric acid secretion and reduces pepsin output (1).<br>References 1. Brimblecombe, R. et al.: J. Int. Med. Res. 1975 Mar:3(2) 86-92<br></p>Formule :C10H15N5OSCouleur et forme :White To Off-WhiteMasse moléculaire :253.32Aripiprazole
CAS :Produit contrôlé<p>Applications Aripiprazole is an agonist at the dopamine autoreceptor and an antagonist at the postsynaptic D2 receptor (1,2,3,4). Aripiprazole is an antipsychotic and a potential drug candidate for treating psychoses such as schizophrenia.<br>References (1) Canive, J.M., et al.: Psychopharmacol. Bull., 34, 101 (1998)(2) Shiokawa, M., et al.: Eur.J.Pharmacol. 570, 108 (2007)(3) Oshiro, Y., et al.: J. Med. Chem. 41, 658 (1998)(4) Ozdemir, V., et al.: Curr Opin Investig Drugs. 3, 113 (2002)<br></p>Formule :C23H27Cl2N3O2Couleur et forme :NeatMasse moléculaire :448.39Levosimendan Cyanoacetamide Hydrazone Impurity
CAS :Produit contrôlé<p>Applications Levosimendan Cyanoacetamide Hydrazone Impurity is an impurity of Levosimendan (L378000) which is a bioactive enantiomer of racemate, Simendan. It is a positive inotropic agent with vasodilating activity and also cardiotonic.<br>References Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995); Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996)<br></p>Formule :C14H14N6O2Couleur et forme :Off-White To Dark OrangeMasse moléculaire :298.3Propylthiouracil
CAS :Produit contrôlé<p>Applications Antihyperthyroid. Has been used to promote fattening. This substance is reasonably anticipated to be a human carcinogen.<br>References Aboul-Enein, H.Y., et al.: Anal. Profiles Drug Subs., 6, 457 (1977), Cooper, D.S., et al.: N. Engl. J. Med., 311, 1353 (1984),<br></p>Formule :C7H10N2OSCouleur et forme :White To Off-WhiteMasse moléculaire :170.234-Hydroxy Phenobarbital-d5
CAS :Produit contrôléFormule :C122H5H7N2O4Couleur et forme :NeatMasse moléculaire :253.27Levofloxacin-d8
CAS :Produit contrôlé<p>Applications Labelled S-(-)-Form of Ofloxacin. An antibiotic used against gram-negative organisms.<br>References Kato, M., et al.: Arzneim.-Forsch., 42, 365 (1992), North, D.S., et al.: Pharmacotherapy, 18, 915 (1998), Hwang, D.G., et al.: Br. J. Ophthalmol., 87, 1004 (2003),<br></p>Formule :C18H12D8FN3O4Couleur et forme :Light Yellow SolidMasse moléculaire :369.421,2,3,4-Tetrahydro-2-[2-(4-hydroxyphenyl)-1-methylethyl]-4,6,8-isoquinolinetriol
CAS :Produit contrôléFormule :C18H21NO4Couleur et forme :NeatMasse moléculaire :315.361-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic Acid
CAS :Formule :C25H24N4O5Couleur et forme :Light Orange ColourMasse moléculaire :460.484-[4-(4-Chlorophenyl)-3,6-dihydro-1(2H)-pyridinyl]-1-(4-fluorophenyl)-1-butanone
CAS :<p>Applications 4-[4-(4-Chlorophenyl)-3,6-dihydro-1(2H)-pyridinyl]-1-(4-fluorophenyl)-1-butanone is a dehydrated metabolite of haloperidol that can be biotransfomed by humans to Haloperidol pyridinium (HPP+), a potential neurotoxic found in the brain.<br>References Usuki, E., et. al.: Neurotoxicity Res., 4, 51 (2002)<br></p>Formule :C21H21ClFNOCouleur et forme :NeatMasse moléculaire :357.857-Hydroxy Loxapine-D8
CAS :Produit contrôlé<p>Applications 7-Hydroxy Loxapine-D8 is a labelled analogue of 7-Hydroxy Loxapine (H943790).<br>References Kapur, S., et al.: Am. J. Psychiatry, 154, 1525 (1997); Rivers-Bulkeley, N. & Hollender, M.: Am. J. Psychiat., 139, 1345 (1982)<br></p>Formule :C18H10D8ClN3O2Couleur et forme :Dark YellowMasse moléculaire :351.86
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