Stéroïdes et Dérivés
Les stéroïdes sont des composés organiques possédant une structure de quatre cycles fusionnés, connue sous le nom de noyau stéroïdien. Ce noyau peut être associé à divers groupes fonctionnels modifiant leurs propriétés et leurs fonctions biologiques. Les stéroïdes jouent un rôle clé dans la régulation des processus métaboliques et hormonaux. Ils sont utilisés en médecine pour traiter les troubles inflammatoires, les maladies auto-immunes et les déséquilibres hormonaux. De plus, certains dérivés stéroïdiens possèdent de puissantes propriétés anti-inflammatoires, comme les corticostéroïdes. Dans certaines thérapies spécifiques, ils sont utilisés pour réduire l’inflammation et soulager la douleur dans diverses maladies.
Chez CymitQuimica, nous proposons une variété de stéroïdes et de leurs dérivés pour la recherche et le développement pharmaceutique.
4949 produits trouvés pour "Stéroïdes et Dérivés"
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25-Hydroxy Cholesterol-d6
CAS :Produit contrôlé<p>Applications 25-Hydroxy Cholesterol-d6, is the labeled analogue of 25-Hydroxy Cholesterol (H918030), which is an oxygenated derivative of Cholesterol (C432501); an oxysterol. An inhibitor of human immunodeficiency virus replication in vitro. It also induces apoptosis in human monocytic cell lines as well as inducing apoptosis in CEM cells associated with negative regulation of c-Myc.<br>References Aupeix, K. et al.: Immunobiology, 194, 415 (1995); Moog, C. et al.: Antivir. Chem, Chemother., 9, 491 (1998); Ayala-Torres, S. et al.: Exp. Cell Res., 246, 193 (1999);<br></p>Formule :C272H6H40O2Couleur et forme :NeatMasse moléculaire :408.69Betamethasone 21-Phosphate Biotin (>85%)
Produit contrôléFormule :C34H49FN3O10PSDegré de pureté :>85%Couleur et forme :NeatMasse moléculaire :741.81Estradiol 17-Valerate-d9
CAS :Produit contrôlé<p>Applications Labelled Estradiol (E888000) derivative. An estrogen.<br>References Salole, E.G., et al.: Anal. Profiles Drug Subs., 15, 283 (1986), Lievertz, R.W., et al.: Am. J. Obstet. Gynecol., 156, 1289 (1987),<br></p>Formule :C23H23D9O3Couleur et forme :NeatMasse moléculaire :365.5517α-Methyl-4-[(phenylthio)methyl]testosterone
CAS :Produit contrôlé<p>Applications Testosterone (T155000) derivative.<br></p>Formule :C27H36O2SCouleur et forme :NeatMasse moléculaire :424.64Prednicarbate
CAS :Produit contrôlé<p>Applications Topical anti-inflammatory agent. Glucocorticoid.<br>References Stache, U., et al.: Arzneim.-Forsch., 35, 1753 (1985),<br></p>Formule :C27H36O8Couleur et forme :Off-WhiteMasse moléculaire :488.57Betamethasone 21-Mesylate (>90%)
CAS :Produit contrôléFormule :C23H31FO7SDegré de pureté :>90%Couleur et forme :NeatMasse moléculaire :470.552-Methyl Ethynyl Estradiol
CAS :Produit contrôlé<p>Impurity Ethinylestradiol EP Impurity M<br>Applications 2-Methylethynylestradiol (Ethinylestradiol EP Impurity M) is a 17α-ethynyl steroid. 2-Methylethynylestradiol is an impurity of Ethynylestradiol (E685100).<br></p>Formule :C21H26O2Couleur et forme :NeatMasse moléculaire :310.43Testosterone Cypionate-d3 (1 mg/ml in Acetonitrile)
CAS :Produit contrôléFormule :C27D3H37O3Couleur et forme :Single SolutionMasse moléculaire :415.626α-Hydroxy Testosterone-d3
CAS :Produit contrôléFormule :C19H25D3O3Couleur et forme :NeatMasse moléculaire :307.446b-Hydroxylevonorgestrel
CAS :<p>Impurity Levonorgestrel EP Impurity H<br>Applications 6β-Hydroxylevonorgestrel (Levonorgestrel EP Impurity H) is an impurity from the synthesis of Levonorgestrel (N689510), an oral contraceptive.<br>References Hu. S.H., et al.: Steroids., 63, 88 (1998); Nash, H.A., et al.: J. Pharma. Sci., 93, 2420 (2004); Choudhary, M.I., et al.: Natural. Prod. Res., 20, 1074 (2006);<br></p>Formule :C21H28O3Couleur et forme :White To Light YellowMasse moléculaire :328.45a-Epoxyabiraterone Acetate
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications α-Epoxyabiraterone Acetate is an impurity of Abiraterone (A108490), a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.<br>References Denis, L., et al.: Cancer, 72, 3888 (1993); Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al.: Nat. Rev., 2, 389(2002); Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005)<br></p>Formule :C26H33NO3Couleur et forme :NeatMasse moléculaire :407.55Testosterone 17-O-Acetate-d3 (1mg/ml in Acetonitrile)
CAS :Produit contrôléFormule :C21H27D3O3Couleur et forme :ColourlessMasse moléculaire :333.48Dexamethasone Phosphate Bisulfate Adduct Sodium Salt
CAS :Formule :C22H32FO11PS•xNaCouleur et forme :NeatMasse moléculaire :554.5222983β-Hydroxy Tibolone (1mg/ml in Acetonitrile)
CAS :Produit contrôléFormule :C21H30O2Couleur et forme :Single SolutionMasse moléculaire :314.4620β-Dihydrocortisone
CAS :Produit contrôlé<p>Applications 20β-Dihydrocortisone is a metabolite of Cortisol (H714615), a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.<br>References Reach, G., et. al.: Steroids, 30, 621 (1977); Vigore, L., et al.: Cancer Ther., 6, 699 (2008); Puurunen, J., et al.: J. Clin. Endocrinol. Metab., 94, 1973 (2009); Lemos, D., et al.: J. Endocrinol., 201, 275 (2009); Chen, S., et al.: Am. J. Physiol., 296 (2009)<br></p>Formule :C21H30O5Couleur et forme :NeatMasse moléculaire :362.462-Hydroxy Estradiol 6-N3-Adenine
CAS :Produit contrôlé<p>Applications 2-Hydroxy Estradiol 6-N3-Adenine is a depurinating adduct that is created by the interaction of specific metabolites of estrogens in the body with DNA. Unfortunately, these adducts are endogeneous initiators of various human cancers, such as breast & prostate.<br>References Yang, L., et al.: Prostate, 69, 41 (2009); Zahid, M., et al.: Chem. Res. Toxicol., 19, 164 (2006); Zhang, Y., et al.: Metabol. Clin. Exp., 56, 887 (2007)<br></p>Formule :C23H27N5O3Couleur et forme :NeatMasse moléculaire :421.49Carbenoxolone
CAS :Produit contrôlé<p>Applications Carbenoxolone<br></p>Formule :C34H50O7Couleur et forme :NeatMasse moléculaire :570.76Fluocinolone Acetonide-13C3
CAS :Produit contrôléFormule :C2113C3H30F2O6Couleur et forme :NeatMasse moléculaire :455.476α-Chloro-17-acetoxy Progesterone
CAS :<p>Applications Progesterone (P755900) impurity.<br>References Liang, T., et al.: Biol. Chem., 256, 7998 (1981), Bratoeff, E., et al.: J. Steroid Biochem. Mol. Biol., 111, 275 (2008),<br></p>Formule :C23H31ClO4Couleur et forme :NeatMasse moléculaire :406.943Dutasteride-13C6
CAS :Produit contrôlé<p>Applications Labelled Dutasteride (D735000). Dutasteride is a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia.<br>References Bakshi, R.K., et al.: J. Med. Chem., 38, 3189 (1995), Gisleskog, P.O., et al.: Brit. J. Clin. Pharmacol., 47, 53 (1999), Djavan, B., et al.: Expert Opin. Pharmacother., 6, 311 (2005),<br></p>Formule :C2113C6H30F6N2O2Couleur et forme :NeatMasse moléculaire :534.491,2-Dihydro-Betamethasone 17,21-Dipropionate
CAS :<p>Stability Hygroscopic<br>Applications A degradation product of Betamethasone (B327000).<br>References Andersson, P., et al.: J. Pharm. Pharmacol., 36, 763 (1984), Wurthwein, G., et al.: Biopharm. Drug Dispos., 11, 381 (1990), Samtani, M., et al.: J. Pharm. Sci., 93, 726 (2004), Samtani, M., et al.: Drug Metab. Dispos., 33, 1124 (2005),<br></p>Formule :C28H39FO7Couleur et forme :NeatMasse moléculaire :506.604-Methylestrone
CAS :Produit contrôlé<p>Applications 4-Methylestrone is an intermediate in the synthesis of 4-substituted estrone and estradiol derivatives with inhibitory activities towards steroid sulfatase as a target for therapeutic intervention of treating breast cancer.<br>References Numazawa, M., et al.: J. Steroid. Biochem. Molec. Biol., 96, 51 (2005);<br></p>Formule :C19H24O2Couleur et forme :NeatMasse moléculaire :284.39Fluticasone-d3 17β-Carboxylic Acid
CAS :Produit contrôléFormule :C21H23D3F2O5Couleur et forme :NeatMasse moléculaire :399.44Estratetraenol
CAS :Produit contrôlé<p>Applications A steroid produced by females having pheromone activities.<br>References Kotiyan, P., et al.: J. Pharm. Biomed. Anal., 22, 667 (2000), Bensafi, M., et al.: Behaviour. Brain Res., 152, 11 (2004), Zhu, B., et al.: Endocrinol., 147, 4132 (2006), Bellavance, E., et al.: J. Med. Chem., 52, 7488 (2009),<br></p>Formule :C18H22OCouleur et forme :NeatMasse moléculaire :254.37Desogestrel
CAS :Produit contrôlé<p>Applications A progestogen with low androgenic potency.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Viinikka, L., et al.: Eur. J. Clin. Pharmacol., 15, 349 (1979), Bergink, E.W., et al.: J. Steroid Biochem., 14, 175 (1981)<br></p>Formule :C22H30OCouleur et forme :White To Off-WhiteMasse moléculaire :310.47Finasteride Carboxaldehyde
CAS :Produit contrôlé<p>Applications A metabolite of Finasteride (F342000) in human bile (M2 metabolite).<br>References Faller, B., et al.: Biochemistry, 32, 5705 (1993), Carlin, J.R., Drug Metab. Dispos., 25, 100 (1997), Bergman, E., et al.: Eur. J. Pharm. Sci., 29, 205 (2006),<br></p>Formule :C23H34N2O3Couleur et forme :NeatMasse moléculaire :386.53Dexamethasone Oxetanone
CAS :Produit contrôlé<p>Applications Dexamethasone Oxetanone is a potent antiglucocorticoid.<br>References Lamontagne, N., et al.: Endocrinology, 114, 2252 (1984);<br></p>Formule :C22H27FO4Couleur et forme :NeatMasse moléculaire :374.4517a-Hydroxy-17a-methyl-D-homoandrost-4-ene-3,17-dione
CAS :Produit contrôléFormule :C21H30O3Couleur et forme :NeatMasse moléculaire :330.461,2-Dihydro Triamcinolone
CAS :Produit contrôlé<p>Applications 1,2-Dihydro Triamcinolone is a derivative of Triamcinolone (T767165), a glucocorticoid, antiasthmatic (inhalant); antiallergic (nasal).<br>References Florey, K., et al.: Anal. Profiles Drug Subs., 1, 397 (1972); Bernstein, I.L., et al.: Chest, 81, 20 (1982);<br></p>Formule :C21H29FO6Couleur et forme :NeatMasse moléculaire :396.452,5-Bis(trifluoromethyl)aniline
CAS :Produit contrôlé<p>Applications 2,5-Bis(trifluoromethyl)aniline is a haloalkul substituted aniline used in the preparation of anti-benign prostatic hyperplasia drug, Dutasteride (D735000).<br>References Liang, Y. et al.: Jil. Dax. Xueb. Lixeub., 45, 1035 (2007);<br></p>Formule :C8H5F6NCouleur et forme :ColourlessMasse moléculaire :229.129-Chloro Triamcinolone Acetonide 21-Acetate
CAS :Produit contrôlé<p>Applications Triamcinolone Acetonide (T767165) impurity.<br></p>Formule :C26H33ClO7Couleur et forme :WhiteMasse moléculaire :492.989(5α)-17,17-Dimethyl-18-nor-2-oxaandrost-13-en-3-one
CAS :Produit contrôlé<p>Applications (5α)-17,17-Dimethyl-18-nor-2-oxaandrost-13-en-3-one is metabolite and impurity of the anabolic steroid Oxandrolone (O845050).<br>References Fragkaki, A.G. et al.: J. Steroid Biochem. Mol. Biol., 115, 44 (2009); Bi, H. et al.: J. Steroid Biochem. Mol. Biol., 42, 533 (1992);<br></p>Formule :C19H28O2Couleur et forme :White To Off-WhiteMasse moléculaire :288.42[1S-(1α,3aBeta,4β,7aAlpha)]-4-[2-(2,5-Dihydroxyphenyl)ethyl]octahydro-1-hydroxy-7a-methyl-5H-inden-5-one
CAS :Produit contrôléFormule :C18H24O4Couleur et forme :NeatMasse moléculaire :304.38(E/Z)-17-Deacetylnorgestimate
CAS :Produit contrôléFormule :C21H29NO2Couleur et forme :NeatMasse moléculaire :327.46δ6-Gestodene
Produit contrôlé<p>Applications Δ6-Gestodene, is an impurity of Gestodene (G368250), an orally active gestogen with progesterone-like profile of activity. Used in combination with estrogen as oral contraceptive.<br>References Duesterberg, B., et al.: Contraception, 24, 673 (1981); Duesterberg, B., et al.: Seroids, 43, 43 (1984); Losert, W., et al.: Arzneim.-Forsch., 35, 459 (1985);<br></p>Formule :C21H24O2Couleur et forme :NeatMasse moléculaire :308.41Equilenin-d3
CAS :Produit contrôlé<p>Applications Isotope labelled Equilenin (E592400), which is a naturally occuring estrogenic steroidal hormone (1,2) isolated from urine of pregnant mares (3). Not found in human urine. Component of conjugated estrogenic hormones. Estrogen. This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Corbellini, A. et L.: Farmaco Sci. 1964 Nov;19:913-22.2. Stein, R. et al.: Tetrahedron 1970 Apr;26(8):1917-33.<br></p>Formule :C182H3H15O2Couleur et forme :White To Light BrownMasse moléculaire :269.35Betamethasone 21-Acetate
CAS :Produit contrôlé<p>Applications Betamethasone acetate (BA) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties which can be used in treatment of asthma and itching.<br>References Kerns, E., et al.: J. Pharm. Sci., 90, 1838 (2001), Seidler, J., et al.: J. Med. Chem., 46, 4477 (2003), Alsenz, J., et al.: J. Pharm. Sci., 96, 1748 (2007),<br></p>Formule :C24H31FO6Couleur et forme :WhiteMasse moléculaire :434.504-Hydroxy Estradiol 1-N3-Adenine
CAS :Produit contrôlé<p>Applications 4-Hydroxy Estradiol 1-N3-Adenine is an estrogen metabolite formed with DNA which can lead to the mutations that initiate breast, prostate, and other types of cancer. The N3Ade depurinating adducts could serve as biomarkers to predict the risk of breast cancer.<br>References Chakravarti, D., et al.: Mutat. Res., 456, 17 (2000), Liehr, J., et al.: Endocr. Rev., 21, 4054 (2000), Chakravarti, D., et al.: Oncogene, 20, 7945 (2001), Cavalieri, E., et al.: Chem. Res. Toxicol., 14, 1041 (2002),<br></p>Formule :C23H27N5O3Couleur et forme :NeatMasse moléculaire :421.4913-Ethyl-18,19-dinor-17α-pregn-4-en-20-yn-17-ol (~90%) (Levo Norgestrel Impurity)
CAS :Produit contrôlé<p>Impurity Levonorgestrel EP Impurity D<br>Applications 13-Ethyl-18,19-dinor-17α-pregn-4-en-20-yn-17-ol (Levonorgestrel EP Impurity D) is an impurity of Levonorgestrel.<br>References McGinty, D., et al.: Endocrinology, 24, 829 (1939), Belanger, A., et al.: Steroids, 37, 361 (1981), Nieman, L., et al.: J. Clin. Endocrinol. Metab., 61, 536 (1985), Klebe, G., et al.: J. Med. Chem., 37, 4130 (1994),<br></p>Formule :C21H30OCouleur et forme :NeatMasse moléculaire :298.46Equilin-d4
CAS :Produit contrôléFormule :C182H4H16O2Couleur et forme :White SolidMasse moléculaire :272.376β-Hydroxymethylandrosta-1,4-diene-3,17-dione
CAS :Produit contrôléFormule :C20H26O3Couleur et forme :White To Off-WhiteMasse moléculaire :314.42(3aR,4R,5R,6aS)-4-((S,E)-3-Hydroxy-5-phenylpent-1-enyl)hexahydro-2H-cyclopenta[b]furan-2,5-diol (Bimatoprost Impurity)
CAS :Produit contrôléFormule :C18H24O4Couleur et forme :NeatMasse moléculaire :304.38Tasimelteon
CAS :<p>Applications Tasimelteon is a novel drug, used in the treatment of non-24 hour sleep-wake disorder. It helps to correct the circadian rhythm disorder often seen in patients who are visually impaired.<br>References Lahon, J. et al.: World. J. Pharm. Res., 3, 1521 (2014);<br></p>Formule :C15H19NO2Couleur et forme :NeatMasse moléculaire :245.31695,6-Dehydro-17β-dutasteride
CAS :<p>5,6-Dehydro-17beta-dutasteride is a synthetic drug product that is used as an analytical standard for the determination of metabolites and impurities in pharmaceuticals. It also has been used as a natural metabolite, which can be found in human urine. 5,6-Dehydro-17beta-dutasteride is a metabolite of dutasteride, which is an antiandrogen medication for the treatment of benign prostatic hyperplasia (BPH). It is also known to inhibit the metabolism of other drugs such as ketoconazole and metoprolol.</p>Formule :C27H28F6N2O2Degré de pureté :Min. 95%Masse moléculaire :526.51 g/molBIBB 515
CAS :<p>BIBB 515 inhibits OSC, reducing cholesterol in hamsters by up to 25% with specific dosing.</p>Formule :C22H21ClN2O2Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :380.87Fluticasone furoate EP impurity G
CAS :<p>Fluticasone furoate is a synthetic corticosteroid that has anti-inflammatory and immunosuppressive properties. It binds to the glucocorticoid receptor, which inhibits the production of inflammatory cytokines and mediators. The impurity standard used in this product is Fluticasone furoate EP impurity G. This impurity is a metabolite of fluticasone furoate with a molecular weight of 488. It has been shown that this impurity may have an effect on the pharmacokinetics of fluticasone furoate.</p>Formule :C27H29ClF2O6SDegré de pureté :Min. 95%Masse moléculaire :555.03 g/molAtorvastatin 3-deoxyhept-2-enoic acid
CAS :<p>Atorvastatin is a potent inhibitor of the enzyme HMG-CoA reductase, which is responsible for the conversion of HMG-CoA to mevalonate. This inhibition reduces the production of cholesterol and other lipids in the liver. Metabolism studies have shown that atorvastatin undergoes extensive presystemic metabolism by cytochrome P450 enzymes, primarily CYP3A4 and CYP2C9. The drug is converted to inactive metabolites that are eliminated primarily through renal excretion. Atorvastatin has not been found to inhibit any of the following: cytochrome P450 1A1/2, 2C8/9, 2D6, 2E1, 3A4/5 or glucuronidases.</p>Formule :C33H33FN2O4Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :540.62 g/mol(betaR,deltaR)-2,3-Bis(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt
CAS :<p>(betaR,deltaR)-2,3-Bis(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt is an impurity that is used in the production of a drug product. This product is metabolized to (betaR,deltaR)-2,3-bis(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-4-[(phenylamino)carbonyl]-1H-pyrrole 1 heptanoic acid which is used as an analytical standard for HPLC.</p>Formule :C66H66CaF4N4O10Degré de pureté :Min. 95%Masse moléculaire :1,193.34 g/molDexamethasone Impurity A
<p>Impurity A is an impurity of the drug product, dexamethasone. The impurity is a natural metabolite of dexamethasone that is found in the urine of patients taking this medication. Impurity A is chemically identified using HPLC and its purity verified using GC-MS and LC-MS. This impurity can be used as a reference standard for analytical purposes and as an impurity standard for pharmacopoeia testing.</p>Formule :C22H29FO5Degré de pureté :Min. 95 Area-%Couleur et forme :White Off-White PowderMasse moléculaire :392.46 g/molFluticasone Impurity D
CAS :<p>Fluticasone Impurity D is a sulfoxide that is found in the drug fluticasone. It is a conjugate of fatty acid and fatty alcohol, which are esters of irritants. Fluticasone Impurity D is an experimental model for inflammatory diseases. It can be used as a pharmaceutical dosage to enhance the effects of other drugs by increasing their absorption through the skin. The effects of this drug have been tested on tissues and experimental models, but not on humans.</p>Degré de pureté :Min. 95%
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