Nucléosides et Nucléotides
Les nucléosides sont des composés formés par une base azotée liée à un sucre (ribose ou désoxyribose). Lorsqu’un groupe phosphate est ajouté au nucléoside, un nucléotide est formé. Ces composés sont essentiels en biologie cellulaire, car les nucléotides sont les blocs fondamentaux de l’ADN et de l’ARN, responsables du stockage et de la transmission de l’information génétique. Les nucléosides ont des applications dans le traitement des maladies virales, en tant qu’inhibiteurs de la réplication virale. Les nucléotides, en plus de leur rôle structurel dans les acides nucléiques, interviennent dans les processus énergétiques, comme la synthèse de l’ATP.
Chez CymitQuimica, nous proposons une large gamme de nucléosides et de nucléotides essentiels à la recherche en biologie moléculaire, virologie et pharmacologie.
3428 produits trouvés pour "Nucléosides et Nucléotides"
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Adefovir Dipivoxyl Impurity I
CAS :<p>Adefovir Dipivoxyl Impurity I is a white crystalline powder with a melting point of 232–234 °C. It is soluble in water, and insoluble in organic solvents. Adefovir Dipivoxyl Impurity I is used as an impurity standard for Adefovir Dipivoxyl and has been shown to be metabolized by CYP3A4 and UGT1A9. This impurity also has the potential to inhibit DNA synthesis in cells.</p>Formule :C21H34N5O9PDegré de pureté :Min. 95%Masse moléculaire :531.5 g/molDecitabine impurity 13
CAS :<p>Decitabine is a drug product that is being developed for the treatment of cancer. It has been shown to inhibit the proliferation of human tumor cells in vitro and to induce apoptosis in prostate cancer cells. Decitabine is metabolized to an active form, dideoxycitidine (DDC), which binds to DNA and inhibits the enzyme DNA polymerase alpha, leading to inhibition of DNA synthesis. Impurity 13 is a by-product of the synthesis process and can be used as an analytical standard. It can also be used as a research and development impurity standard or as a pharmacopoeia impurity standard.</p>Formule :C4H6N6O2Degré de pureté :Min. 95%Masse moléculaire :170.13 g/mol2'-Deoxy-2',2'-difluorocytidine 5'-monophosphate
CAS :<p>2'-Deoxy-2',2'-difluorocytidine 5'-monophosphate (CDFMP) is a potent antitumor agent that has been shown to have a strong anti-angiogenic effect. It inhibits the cancer cell's production of microvessels and interferes with the formation of new blood vessels from pre-existing ones, which can be used to deliver chemotherapy drugs to the tumor. CDFMP is synthesized by reacting 2'-deoxy-2',2'-difluorocytidine with phosphoric acid and then converting it into the monophosphate form using phosphorus oxychloride. This drug is also resistant to platinum-based chemotherapy agents, making it a promising drug for patients who are resistant to other treatments.</p>Formule :C9H12F2N3O7PDegré de pureté :Min. 97 Area-%Couleur et forme :PowderMasse moléculaire :343.18 g/molRemdesivir impurity 10
CAS :<p>Remdesivir impurity 10 is a synthetic chemical compound that has been synthesized for research and development. It is an impurity standard of remdesivir, which is not present in any drug product. The purity of this product is high, and it can be used as a pharmacopoeia or drug development standard. It can also be used as an analytical standard to measure the concentration of metabolites in animal studies or metabolism studies.</p>Formule :C27H35N6O8PDegré de pureté :Min. 95%Masse moléculaire :602.58 g/molRemdesivir Related Compound 4
CAS :<p>Remdesivir Related Compound 4 is a synthetic compound that is structurally related to remdesivir. It has been shown to have anti-HIV activity in vitro. Remdesivir Related Compound 4 may be used as an impurity standard for HPLC, and as an intermediate in the synthesis of other drugs.</p>Formule :C32H32N4O5Degré de pureté :Min. 95%Masse moléculaire :552.62 g/molRemdesivir impurity 6
CAS :<p>Remdesivir impurity 6 is an impurity standard for a research and development drug product. It is a synthetic compound that has been custom synthesized for use in pharmacopoeia drug products. The purity of this compound is high and it has been shown to have no toxic effects on metabolism studies. Remdesivir impurity 6 is a metabolite of remdesivir, which is used as an antiviral agent for the treatment of HIV infection.</p>Formule :C15H24NO5PDegré de pureté :Min. 95%Masse moléculaire :329.33 g/molRemdesivir impurity 13
CAS :<p>Remdesivir impurity 13 is a metabolite of remdesivir, which is a drug product that is custom synthesized by us. This compound has been shown to be natural and can be found in the human body. Remdesivir impurity 13 has been studied extensively for its metabolic pathway and as a potential impurity standard for HPLC analysis.</p>Formule :C27H35N6O8PDegré de pureté :Min. 95%Masse moléculaire :602.58 g/molMethyl 2-deoxy-3,5-di-O-(4-chlorobenzoyl)-a-D-ribofuranoside
CAS :<p>Methyl 2-deoxy-3,5-di-O-(4-chlorobenzoyl)-a-D-ribofuranoside is a research and development impurity standard for the synthesis of drug products. This chemical is used as a metabolite in the study of metabolic pathways and can be converted to Methyl 3,5-di-O-(4-chlorobenzoyl)-a-D-ribofuranoside by hydrolysis with dilute acid. Methyl 2-deoxy-3,5-di-O-(4-chlorobenzoyl)-a-D ribofuranoside has been shown to be a synthetic molecule and is listed in pharmacopoeia. CAS No. 7818564 5.</p>Formule :C22H24O6Degré de pureté :Min. 95%Masse moléculaire :384.42 g/mol1-β-D-Ribofuranosyl-3-guanylurea picrate
CAS :Produit contrôlé<p>1-beta-D-Ribofuranosyl-3-guanylurea picrate is also known as 1-(diaminomethylene)-3-(beta-D-ribofuranosyl)urea picrate, 1-amidino-3-b-D-ribofuranosylurea monopicrate and Azacitidine Related Compound C. 1-beta-D-Ribofuranosyl-3-guanylurea picrate is an impurity generated from the hydrolysis of the drug Azacitidine, available on the market with the trade name Vidaza. Azacitidine is a chemical analogue of cytidine and is used in the treatment of myelodysplastic syndrome.</p>Formule :C7H14N4O5•C6H3N3O7Degré de pureté :Min. 95.0 Area-%Couleur et forme :PowderMasse moléculaire :463.31 g/molDecitabine impurity 11
CAS :<p>Decitabine is a drug product that is used as an anti-cancer drug. It is a synthetic, natural, and research and development (R&D) metabolite with the CAS No. 909402-26-2. Decitabine has shown anticancer activity in vitro and in vivo against leukemia cells. This compound is an impurity of the API decitabine that is manufactured by a chemical synthesis process. The analytical impurities are 11 compounds that have been identified from the HPLC standard of this API. The metabolites of these compounds are also included in this standard. High purity decitabine should be obtained for pharmacopoeia studies and niche applications such as HPLC standards, pharmaceuticals, or research purposes.</p>Formule :C9H13N3O5Degré de pureté :Min. 95%Masse moléculaire :243.22 g/molAcyclovir acetate
CAS :<p>Acyclovir is an antiviral agent that prevents the growth of herpes simplex virus. Acyclovir is a prodrug, which is converted to acycloguanosine 5'-triphosphate (ACV-TP) in vivo. ACV-TP inhibits viral DNA polymerase and thereby prevents viral genome replication, replication. The molecular structure of Acyclovir was determined by X-ray crystallography at 3.2 Å resolution. It has been shown that ACV-TP can be activated by chloride ions and it has been suggested that this activation may be the result of an interaction with a ligand.<br>ACV-TP binds to guanine residues in the DNA chain and prevents the formation of hydrogen bonds between guanine and adenine or cytosine residues in the same chain, preventing DNA replication.</p>Formule :C10H13N5O4Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :267.24 g/molDapagliflozin Impurity 30
CAS :<p>Dapagliflozin Impurity 30 is a natural impurity found in the drug Dapagliflozin. It is an analytical standard used for HPLC quantification of dapagliflozin, and it can be used as a pharmacopoeia reference material or research and development material. Dapagliflozin Impurity 30 is synthesized by using a custom synthesis protocol. The CAS number for this compound is 1373321-04-0.</p>Formule :C21H25ClO6Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :408.9 g/molβ-lactamase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO)
<p>Beta-lactamase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) is expressed in E.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :56.7 kDa (predicted)β-lactamase Protein, E. coli, Recombinant (His & SUMO)
<p>This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :52.5 kDa (predicted)3’-O-(5’-Deoxy-β-D-ribofuranosyl) Capecitabine
CAS :Produit contrôlé<p>Impurity Capecitabine 3-O-BDR Impurity (USP)<br>Applications Capecitabine (C175650) impurity. Capecitabine 3-O-BDR Impurity (USP).<br></p>Formule :C20H30FN3O9Couleur et forme :NeatMasse moléculaire :475.471,2,3,5-Tetra-O-acetyl b-D-Ribofuranose
CAS :Produit contrôlé<p>Applications Used in the synthesis of 3-(β-D-ribofuranosyl)-2,3-dihydro-6H-1,3-oxazine-2,6-dione, a new pyrimidine nucleoside analog related to uridine.<br>References Chwang, T.-L., et al.: J. Med. Chem., 19, 643 (1976),<br></p>Formule :C13H18O9Couleur et forme :NeatMasse moléculaire :318.28Diethylamine
CAS :Produit contrôlé<p>Applications Diethylamine, can be used for the preparation of alkali metal diethylamides, generated with n-BuLi or NaH, have been used for the cleavage of ethers. Also, in combination with Lithium aluminum hydride, generates lithium tris(diethylamino)aluminum hydride, which is a useful selective reducing agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cha, J.S., et al.: J. Org. Chem., 52, 5030 (1987); Tetrahedron Lett., 32, 6903 (1991);<br></p>Formule :C4H11NCouleur et forme :ColourlessMasse moléculaire :73.14Stavudine Triphosphate Triethylammonium Salt
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Stavudine Triphosphate Trisodium Salt has a free acid of Stavudine Triphosphate. Stavudine Triphosphate inhibits HIV-1 RT (reverse transcriptase). Stavudine Triphosphate Trisodium Salt is a metabolite of Stavudine.<br>References Vaccaro, J.A., Parnell K.M., Terezakis S.A., Anderson, K.S.: Antimicrob. Agents Ch., 44, 217 (2000)<br></p>Formule :C10H15N2O13P3•x(EtN)Couleur et forme :NeatMasse moléculaire :464.152,3,5-Tri-O-acetyl-6-chloropurine-9-β-D-ribofuranoside (~90%)
CAS :Produit contrôlé<p>Applications 2,3,5-Tri-O-acetyl-6-chloropurine-9-β-D-ribofuranoside is a nucleoside compound with inhibitory activity on a rho-GTPase cell protein.<br>References Mounetou., et al.: J. Med. Chem., 40, 2902 (1997), Panero, J., et al.: Biotech. Lett., 28, 1077 (2006),<br></p>Formule :C16H17ClN4O7Degré de pureté :>90%Couleur et forme :NeatMasse moléculaire :412.78(2R,5S)-L-Menthol-5-(acetyloxy)-1,3-oxathiolane-2-carboxylate
CAS :Produit contrôlé<p>Applications Lamivudine intermediate.<br>References Chang, C., et al.: J. Biol. Chem., 267, 13938 (1992), Jeong, L., et al.: J. Med. Chem., 36, 181 (1993).<br></p>Formule :C16H26O5SCouleur et forme :WhiteMasse moléculaire :330.44
