Nucléosides et Nucléotides
Les nucléosides sont des composés formés par une base azotée liée à un sucre (ribose ou désoxyribose). Lorsqu’un groupe phosphate est ajouté au nucléoside, un nucléotide est formé. Ces composés sont essentiels en biologie cellulaire, car les nucléotides sont les blocs fondamentaux de l’ADN et de l’ARN, responsables du stockage et de la transmission de l’information génétique. Les nucléosides ont des applications dans le traitement des maladies virales, en tant qu’inhibiteurs de la réplication virale. Les nucléotides, en plus de leur rôle structurel dans les acides nucléiques, interviennent dans les processus énergétiques, comme la synthèse de l’ATP.
Chez CymitQuimica, nous proposons une large gamme de nucléosides et de nucléotides essentiels à la recherche en biologie moléculaire, virologie et pharmacologie.
3427 produits trouvés pour "Nucléosides et Nucléotides"
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Cidofovir dihydrate
CAS :<p>Cidofovir dihydrate: Injectable anti-CMV; suppresses CMV by inhibiting viral DNA polymerase; treats CMV retinitis in AIDS.</p>Formule :C8H18N3O8PDegré de pureté :99.44%Couleur et forme :SolidMasse moléculaire :315.22Fludarabine Phosphate
CAS :<p>Fludarabine Phosphate (NSC 312887 Phosphate) is a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine with antineoplastic activity.</p>Formule :C10H13FN5O7PDegré de pureté :99.25% - 99.78%Couleur et forme :SolidMasse moléculaire :365.21Hibifolin
CAS :<p>Hibifolin is a flavonol glycoside natural product,is a potential inhibitor of adenosine deaminase (Ki of 49.92 μM).</p>Formule :C21H18O14Degré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :494.361,5-Isoquinolinediol
CAS :<p>1,5-Isoquinolinediol, a PARP1 inhibitor (IC50: 0.39 μM), is used in DNA repair and cell death studies.</p>Formule :C9H7NO2Degré de pureté :98.29% - 99.35%Couleur et forme :Of White To White PowderMasse moléculaire :161.16Dilazep dihydrochloride
CAS :<p>Dilazep dihydrochloride inhibits adenosine uptake, ischemia, nucleoside transport, platelet aggregation, and acts as a vasodilator.</p>Formule :C31H46Cl2N2O10Degré de pureté :98.39%Couleur et forme :SolidMasse moléculaire :677.61Remdesivir
CAS :<p>Remdesivir (GS-5734) is a nucleoside analog, a broad-spectrum antiviral compound that exerts its activity by inhibiting the RNA-dependent RNA polymerase of</p>Formule :C27H35N6O8PDegré de pureté :97.62% - 99.98%Couleur et forme :SolidMasse moléculaire :602.58Uridine
CAS :<p>Uridine (Uridin) is a nucleoside compound, a base that makes up RNA, that replaces thymine in DNA during transcriptione. Cost-effective and quality-assured.</p>Formule :C9H12N2O6Degré de pureté :99.08% - 99.82%Couleur et forme :White To Off-White Crystalline PowderMasse moléculaire :244.2Adenosine monophosphate
CAS :<p>AMP is a purine nucleotide, vital in cell signaling and energy regulation, and inhibits EC 3.1.3.11 and 3.1.3.1, also an A1 receptor agonist.</p>Formule :C10H14N5O7PDegré de pureté :99.59% - 99.84%Couleur et forme :Crystals From Water + Acetone SolidMasse moléculaire :347.22GKT136901
CAS :<p>GKT136901 (AK120765) is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite</p>Formule :C19H15ClN4O2Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :366.8NADPH tetrasodium salt
CAS :<p>NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate, which acts as an electron donor in a variety of</p>Formule :C21H26N7Na4O17P3Degré de pureté :97.15% - >99.99%Couleur et forme :SolidMasse moléculaire :833.35NADPH tetracyclohexanamine
CAS :<p>NADPH tetracyclohexanamine (NADPH (tetracyclohexanamine)) is a cofactor and biological reducing agent.</p>Formule :C45H82N11O17P3Degré de pureté :98.73% - 99.05%Couleur et forme :SolidMasse moléculaire :1142.12Thiamine pyrophosphate chloride
CAS :<p>Thiamine pyrophosphate, a vitamin B1 derivative, is a coenzyme in transketolase studies for decarboxylation in biology.</p>Formule :C12H19ClN4O7P2SDegré de pureté :98.29% - 99.72%Couleur et forme :SolidMasse moléculaire :460.76ASP-9521
CAS :<p>ASP-9521 is a selective, potent and orally active indole-based AKR1C3 inhibitor with an IC50 of 11 nM for human AKR1C3.Cost-effective and quality-assured.</p>Formule :C19H26N2O3Degré de pureté :95.11% - 96.96%Couleur et forme :SolidMasse moléculaire :330.42Rabeprazole sodium
CAS :<p>Rabeprazole sodium treats stomach ulcers and Zollinger-Ellison syndrome, blocking ATPase in gastric cells.</p>Formule :C18H20N3NaO3SDegré de pureté :98% - 99.912%Couleur et forme :White Or Off White Crystalline PowderMasse moléculaire :381.42Ganciclovir sodium
CAS :<p>Ganciclovir sodium, a sodium salt with anti-CMV and HSV-1 antiviral properties.</p>Formule :C9H13N5NaO4Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :278.22Didanosine
CAS :<p>Didanosine (ddI) is a nucleoside reverse transcriptase inhibitor analog of adenosine (IC50: 0.49 μM).</p>Formule :C10H12N4O3Degré de pureté :99.64%Couleur et forme :White Crystalline PowderMasse moléculaire :236.23Cytosine
CAS :<p>Cytosine is a pyrimidine nucleic acid base; its deamination can cause mutations in leukemia and cancer.</p>Formule :C4H5N3ODegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :111.1Sofosbuvir
CAS :<p>Sofosbuvir (GS 7977) is a uridine monophosphate analog inhibitor of hepatitis C virus (HCV) polymerase NS5B that is used as an antiviral agent in the treatment</p>Formule :C22H29FN3O9PDegré de pureté :99.77% - 99.82%Couleur et forme :SolidMasse moléculaire :529.45Cytidine 5'-monophosphate
CAS :<p>Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide, one of the basic units that make up RNA.</p>Formule :C9H14N3O8PDegré de pureté :98.78% - 99.10%Couleur et forme :SolidMasse moléculaire :323.20N2-Nitroso Folinic Acid (N2-Nitroso (6RS)-Calcium Levofolinate EP Impurity H, N2-Nitroso Leucovorin)
Formule :C20H22N8O8Masse moléculaire :502.442’-Deoxycytidine 5'-Monophosphate Hydrate
CAS :Produit contrôlé<p>Applications A phosphorylated metabolite of the deoxyribonucleoside 2’-Deoxycytidine. A constituent of Deoxyribonucleic acid. Studies show that it increases influenza virus antigen-induced immune cell proliferation.<br>References Holen, E. et al.: Nutrition, 21, 1003 (2005); Alexandre, J.A. et al.: Nucleosides Nucleotides Nucelic Acids, 26, 1375 (2007);<br></p>Formule :C9H14N3O7P·xH2OCouleur et forme :White To Off-WhiteMasse moléculaire :307.20 + x(18.02)Gemcitabine-13C,15N2 Hydrochloride
CAS :<p>Stability Hygroscopic<br>Applications Labelled Gemcitabine, an antineoplastic.<br>References Hertel, L.W., et al.: Cancer Res., 50, 4417 (1990), Abbruzzese, J.L., et al.: J. Clin. Oncol., 9, 491 (1991), Ruiz, V.W.T., et al.: Biochem. Pharmacol., 46, 762 (1993),<br></p>Formule :C813CH12ClF2N15N2O4Couleur et forme :Off-WhiteMasse moléculaire :302.64cis 5-Fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2,4(1H,3H)- pyrimidinedione
CAS :Produit contrôlé<p>Applications Antiviral nucleoside analog, also an impurity found in emtricitabine (E525000).<br>References Jeong, L., et al.: J. Med. Chem., 36, 181 (1993),<br></p>Formule :C8H9FN2O4SCouleur et forme :Off-WhiteMasse moléculaire :248.23Adenosine-13C5
CAS :<p>Stability Hygroscopic<br>Applications Labelled nucleotide.<br>References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010), Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010),<br></p>Formule :C513C5H13N5O4Couleur et forme :White To Off-WhiteMasse moléculaire :272.20Folic Acid-13C5
CAS :<p>Applications A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.<br>References Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),<br></p>Formule :C5C14H19N7O6Couleur et forme :Dark Yellow To Dark BrownMasse moléculaire :446.362-Oxa-1,4-butanediol diacetate
CAS :Produit contrôléFormule :C7H12O5Couleur et forme :NeatMasse moléculaire :176.17trans-Abacavir Dihydrochloride
CAS :Produit contrôlé<p>Applications trans-Abacavir Dihydrochloride is an impurity of Abacavir. Abacavir (A104990) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br>References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)<br></p>Formule :C14H18N6O·2HClCouleur et forme :NeatMasse moléculaire :359.25Adenosine 5’-Monophosphoramidate Sodium Salt
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Used in the characterization and elucidation of coordination requirements of adenine nucleotides complexes with Fe(II) ions.<br>References Richter, Y., et al.: Nucleos. Nucleot. Nucleic Acids, 22, 1757 (2003),<br></p>Formule :C10H14N6O6P·NaCouleur et forme :NeatMasse moléculaire :368.22O-Benzoyllamivudine
CAS :Produit contrôléFormule :C15H15N3O4SCouleur et forme :Off-WhiteMasse moléculaire :333.362α-Decitabine-3',5'-bis(4-chlorobenzoate)
CAS :Produit contrôléFormule :C22H18Cl2N4O6Couleur et forme :White To Off-WhiteMasse moléculaire :505.3085-Fluoro Cytosine
CAS :Produit contrôlé<p>Applications 5-FC is a toxic antifungal/antimicrobial agent.<br>References Gopinath, P., et al.: Biotechnol. Lett., 30, 1913 (2008), Kalkanci, A., et al.: Microbiol Immunol., 52, 435 (2008), Dubeau, M., et al.: App. Env. Microbiol., 75, 1211 (2009),<br></p>Formule :C4H4FN3OCouleur et forme :White To Off-WhiteMasse moléculaire :129.09Penciclovir
CAS :<p>Applications An antiviral.<br>References Weinberg, A., et al.: Antimicrob. Ag. Chemother., 36, 2037 (1992), McMeekin, J.R., et al.: Anal. Proc., 29, 178 (1992),<br></p>Formule :C10H15N5O3Couleur et forme :NeatMasse moléculaire :253.26N2-Acetyl Acyclovir
CAS :Produit contrôlé<p>Impurity Aciclovir EP Impurity F<br>Applications N2-Acetyl Acyclovir (Aciclovir EP Impurity F) is an impurity of Acyclovir (A192400).<br>References Balon, K., et al.: Pharm. Res., 16, 882 (1999),<br></p>Formule :C10H13N5O4Couleur et forme :BeigeMasse moléculaire :267.245-Fluoro ent-Lamivudine Acid D-Menthol Ester
CAS :Produit contrôlé<p>Applications Intermediate in the synthesis of ent-Emtricitabine (E525005).<br></p>Formule :C18H26FN3O4SCouleur et forme :NeatMasse moléculaire :399.486-Deoxypenciclovir
CAS :Produit contrôlé<p>Applications A metabolite of Famciclovir, an antiviral.<br>References Harnden, M.R., et al.: J. Med. Chem., 32, 1738 (1989)<br></p>Formule :C10H15N5O2Couleur et forme :Off White SolidMasse moléculaire :237.26Canagliflozin 2-Glucuronide
CAS :Produit contrôlé<p>Applications Canagliflozin 2-glucuronide is a derivative of Canagliflozin (C175190). Canagliflozin is a sodium-glucose cotransporter 2 inhibitor that is used to treat patients with type 2 diabetes. Canagliflozin lowers blood glucose by increasing the amount of glucose that exits the body through urinary excretion.<br>References Devineni, D., et al.: Diab. Obes. Metab., 14, 539 (2012); Nicolle, L., et al.: Curr. Med. Res. Opin., 28, 1167 (2012)<br></p>Formule :C30H33FO11SCouleur et forme :NeatMasse moléculaire :620.641R-Dapagliflozin
CAS :Produit contrôlé<p>Applications 1R-Dapagliflozin is an isomer of Dapagliflozin (D185370), which is a sodium-glucose transporter 2 inhibitor.<br>References Kasichayanula, S. et al.: Diabetes, Obesity and Metabolism 13, 47 (2011)<br></p>Formule :C21H25ClO6Couleur et forme :NeatMasse moléculaire :408.88Viaminate
CAS :Produit contrôlé<p>Applications Viaminate is a pharmaceutical used to treat severe acne and other keratinization disorders. Viaminate can be taken orally, or topically in prepared gels and creams.<br>References Zhang, H.; et al.: Am. J. Med. Sci., 356, 84 (2018); Lu, J.; et al.: Zhongguo Yaofang, 22, 155 (2011); Li, G.: Zhonghua Yiyao Zazhi, 7, 536 (2007).<br></p>Formule :C29H37NO3Couleur et forme :Light YellowMasse moléculaire :447.613'-Deoxyinosine
CAS :Produit contrôlé<p>Impurity Didanosine EP Impurity D<br>Applications 3'-Deoxyinosine (Didanosine EP Impurity D) is an Inosine (I661000) analog with potential use as an antileishmanial drug. Used as an inhibiting agent in studies of Trypanosoma cruzi growth inside host cells in vitro. An impurity of the antiviral drug 2’,3’-Dideoxyinosine (D440950).<br>References Morishige, K. et al.: Exp. Parasitol., 80, 665 (1995); Aoki, T. et al.: Adv. Exp. Med. Biol., 370, 499 (1994);<br></p>Formule :C10H12N4O4Couleur et forme :NeatMasse moléculaire :252.23α-Decitabine
CAS :Produit contrôlé<p>Applications α-Decitabine is shown to inhibit DNA methylation resulting in an effective anticancer agent.<br>References Hajek, M. et al.: Biochem. Pharm., 75, 965 (2008); Rogstad, D. et al.: Chem. Res. Toxicol., 22, 1194 (2009);<br></p>Formule :C8H12N4O4Couleur et forme :NeatMasse moléculaire :228.21
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