Nucléosides et Nucléotides
Les nucléosides sont des composés formés par une base azotée liée à un sucre (ribose ou désoxyribose). Lorsqu’un groupe phosphate est ajouté au nucléoside, un nucléotide est formé. Ces composés sont essentiels en biologie cellulaire, car les nucléotides sont les blocs fondamentaux de l’ADN et de l’ARN, responsables du stockage et de la transmission de l’information génétique. Les nucléosides ont des applications dans le traitement des maladies virales, en tant qu’inhibiteurs de la réplication virale. Les nucléotides, en plus de leur rôle structurel dans les acides nucléiques, interviennent dans les processus énergétiques, comme la synthèse de l’ATP.
Chez CymitQuimica, nous proposons une large gamme de nucléosides et de nucléotides essentiels à la recherche en biologie moléculaire, virologie et pharmacologie.
3421 produits trouvés pour "Nucléosides et Nucléotides"
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N-Nitroso-N-(phosphonomethyl)glycine
CAS :<p>Applications N-Nitroso-N-(phosphonomethyl)glycine is used as herbicide.<br>References Khan, S.U., et al.: J. Agr. Food Chem., 27, 1398 (1979), Ambrus, A., et al.: Pure Appl. Chem., 75, 937 (2003),<br></p>Formule :C3H7N2O6PCouleur et forme :Off White SolidMasse moléculaire :198.07Adenine Hemisulfate
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Adenine Hemisulfate can be one of the factors that influence in vitro growth and shoot multiplication of pomegranate. It can be used in biological study along with varied levels of sucrose, light intensity, and MS medium hydrogen ion concentration where those factors can all significantly influence multiplication and growth of Punica granatum shoots.<br>References Singh, P., & Patel, R., M.: Bioscan, 9, 1031-1035 (2014)<br></p>Formule :C5H5N5·SO4H2Couleur et forme :NeatMasse moléculaire :368.33Etravirine-d8
CAS :Produit contrôlé<p>Applications A novel labelled HIV reverse transcriptase inhibitor useful in treatment of HIV infection.<br>References Scholler-Gyure, M., et al.: J. Clin. Pharmacol., 48, 322 (2008), Thakur, A., et al.: Eur. J. Med. Chem., 43, 471 (2008),<br></p>Formule :C202H6H9BrN6OCouleur et forme :NeatMasse moléculaire :441.31N,O-Diacetyllamivudine
CAS :Produit contrôléFormule :C12H15N3O5SCouleur et forme :Off-WhiteMasse moléculaire :313.335-Methyltetrahydrofolic Acid Calcium Salt Hydrate
CAS :Produit contrôléFormule :C20H23CaN7O6•xH2OCouleur et forme :White To BeigeMasse moléculaire :497.52Oxiracetam
CAS :Produit contrôlé<p>Applications Nootropic. Analog of Piracetam with psychostimulant activity.<br>References Son, J., et al.: J. Pharm. Biomed. Anal., 36, 657 (2004), Hlinak, Z., et al.: Behaviour. Brain Res., 161, 213 (2005),<br></p>Formule :C6H10N2O3Couleur et forme :NeatMasse moléculaire :158.16Melphalan Hydrochloride
CAS :Produit contrôlé<p>Stability Moisture Sensitive<br>Applications Melphalan Hydrochloride is used in combined intravitreal chemotherapy with topotecan hydrochloride for viable vitreous seeding from retinoblastoma. Also, it is an anti-cancer chemotherapy drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ghassemi, F., et al.: JAMA Ophthalmol., 132, 936-941 (2014); Gao, L. P., et al.: Adv. Mater. Res., 781-784, 993-998 (2013);<br></p>Formule :C13H18Cl2N2O2·ClHCouleur et forme :NeatMasse moléculaire :341.666-Thioinosine Phosphate (>85%)
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A metabolite of 6-Mercaptopurine.<br>References Parker, W., et al.: Cancer Res., 51, 2386 (1991) , Munagala, N., et al.: J. Biol. Chem., 275, 37072 (2000), Guddat, L., et al.: Protein Sci., 11, 1626 (2002), Pinkel, D., et al.: J. Clin. Oncol., 11, 1826 (1993), Tripathy, D., et al.: Oncologist, 12, 375 (2007),<br></p>Formule :C10H13N4O7PSDegré de pureté :>85%Couleur et forme :NeatMasse moléculaire :364.271-C-[4-Chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol
CAS :Produit contrôlé<p>Applications Open ring Dapagliflozin. Dapagliflozin (D185370) impurity.<br></p>Formule :C21H27ClO7Couleur et forme :NeatMasse moléculaire :426.888Ethoxy-5-fluoro-4(3H)-pyrimidinone
CAS :Produit contrôlé<p>Impurity Fluorouracil EP Impurity F<br>Applications Ethoxy-5-fluoro-4(3H)-pyrimidinone (Fluorouracil EP Impurity F) is a derivative of 5-fluorouracil (3C,15N2 labelled, F596002) which is a potent antineoplastic agent in clinical use.<br>References Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 221 (1973), Miyashita, O., et al.: Chem. Pharm. Bull., 29, 3181 (1981), Hansen, R.M., et al.: Cancer Invest., 9, 637 (1991),<br></p>Formule :C6H7FN2O2Couleur et forme :NeatMasse moléculaire :158.133-Methyl Cytidine Methosulfate
CAS :Produit contrôlé<p>Applications Cytidine derivative.<br>References Ueda, T., et al.: Chem. Pharmaceut. Bull., 22, 2377 (1974),<br></p>Formule :C10H16N3O5·CH3O4SCouleur et forme :NeatMasse moléculaire :369.35Acyclovir Monophosphate
CAS :<p>Stability Hygroscopic<br>Applications A nucleoside analog phosphates for topical use in the treatment of herpes virus infections. A topical treatment that seems to bypass a key mechanism responsible for resistance to Acyclovir.<br>References Furman, P., et al.: J. Virol., 32, 72 (1979), Darby, G., et al.: J. Gen. Virol., 48, 451 (1980),Prisbe, E., et al.: J. Med. Chem., 29, 671 (1986), Ellis, M., et al.: Antimicrob. Agents Chemother., 33, 304 (1989),<br></p>Formule :C8H12N5O6PCouleur et forme :Off-WhiteMasse moléculaire :305.18Stavudine
CAS :Produit contrôlé<p>Impurity Zidovudine EP Impurity A<br>Applications Stavudine (Zidovudine EP Impurity A) is used as an antiviral. A reverse transcriptase inhibitor.<br>References Mansuri, M.M., et al.: Antimicrob. Ag. Chemother., 34, 637 (1990), Cretton, E.M., et al.: Antimicrob. Ag. Chemother., 37, 1816 (1993), Browne, M.J., et al.: J. Infec. Dis., 167, 21 (1993)<br></p>Formule :C10H12N2O4Couleur et forme :WhiteMasse moléculaire :224.21Melamine-13C3,15N3
CAS :Produit contrôlé<p>Applications Isotope labelled Melamine (M208703), which forms synthetic resins with formaldehyde. It remains largely non-metabolized in male Wistar rats with 90% of the administered dose excreted in the urine (1,2) and thus acts as a non-protein nitrogen food additive found in milk (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Mast, R. et al.: Food Chem Toxicol. 1983 Dec;21(6):807-10.2. Smith, J. et al.: Toxicol Appl Pharmacol. 1994 Apr;125(2):296-308.3. Anirudhan, T. et al.: Food Chem. 2017 Jul 15;227:85-92.<br></p>Formule :C3H6N315N3Couleur et forme :NeatMasse moléculaire :132.082’,2’-Difluoro-2’-deoxyuridine-13C,15N2
CAS :Formule :C813CH10F215N2O5Couleur et forme :White To Off-WhiteMasse moléculaire :267.16Lamivudine Monophosphate Triethylammonium Salt
CAS :Produit contrôlé<p>Applications A metabolite of Lamivudine (L172500).<br>References Soudeyns, H., et al.: Antimicrob. Agents Chemother., 35, 1386 (1991), Denapoli, L., et al.: Nucleosides Nucleotides, 12, 21 (1993),<br></p>Formule :C8H12N3O6PSC6H15NDegré de pureté :>90%Couleur et forme :NeatMasse moléculaire :410.138891’-Epi Gemcitabine Hydrochloride
CAS :<p>Impurity Gemcitabine EP Impurity B<br>Applications 1’-Epi Gemcitabine Hydrochloride (Gemcitabine EP Impurity B) is an α-Anomer of Gemcitabine.<br>References Hertel, L.W., et al.: Cancer Res., 50, 4417 (1990), Abbruzzese, J.L., et al.: J. Clin. Oncol., 9, 491 (1991), Ruiz, V.W.T., et al.: Biochem. Pharmacol., 46, 762 (1993),<br></p>Formule :C9H12ClF2N3O4Couleur et forme :Off White SolidMasse moléculaire :299.669-Carboxymethoxymethylguanine-13C2,15N
CAS :<p>Stability Hygroscopic<br>Applications 9-Carboxymethoxymethylguanine-13C2,15N is the labelled analog of 9-Carboxymethoxymethylguanine (C179990) which is a metabolite of Acyclovir (A192400-an antiviral, orally active acyclic nucleoside with inhibitory activity towards several herpes viruses).<br>References Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979); Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988); Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992); Gunness, P., et al.: Transl. Res., 158, 290 (2011);<br></p>Formule :C2C6H915NN4O4Couleur et forme :Light Beige SolidMasse moléculaire :242.167Floxuridine
CAS :Produit contrôlé<p>Applications Floxuridine is an antiviral; antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Harris, M., et al.: Biophys. J., 4, 203 (1964),<br></p>Formule :C9H11FN2O5Couleur et forme :NeatMasse moléculaire :246.19Dapagliflozin Keto Impurity
CAS :<p>Applications Dapagliflozin Keto Impurity is an impurity of Dapagliflozin (D185370), a sodium-glucose transporter 2 inhibitor.<br>References Kasichayanula, S., et al.: Diabetes, Obesity and Metabolism 13, 47 (2011);<br></p>Formule :C21H23ClO7Couleur et forme :Off-WhiteMasse moléculaire :422.86Emtricitabine S-Oxide (Mixture of Diastereomers)
CAS :Produit contrôlé<p>Applications A metabolite of (-)-Emtricitabine (E525000).<br>References Schinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992); Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996); Feng, J.Y., et al.: FASEB J., 13, 1511 (1999); Molina, J.-M., et al.: J. Infec. Dis., 182, 599 (2000);<br></p>Formule :C8H10FN3O4SCouleur et forme :Off-WhiteMasse moléculaire :263.255-Azacytidine 2’,3’5’-O-triacetate
CAS :<p>Applications 5-Azacytidine 2’,3’5’-O-triacetate is a useful compound for the treatment and prevention of cancer and disorders related to abnormal cell proliferation, hematological disorders, and myelodysplastic syndromes (MDS). It can be also used to synthesize 2'3'5'triacetyl-5-azacytidine which is a prodrug for azacitidine. Azacitidine is a FDA-appproved DNA metnyltransferase (DNMT) inhibitor.<br>References Rajendiran, C., et al.: PCT Int. Appl. WO 2012135405 A1 20121004 (2012); Ziemba, A., et al.: Chemother Res Pract 965826, 9 (2011); Beisler, J. A., et al.: J. Carbohyd. Chem 4, 281 (1977)<br></p>Formule :C14H18N4O8Couleur et forme :White To Off-WhiteMasse moléculaire :370.31Canagliflozin hemihydrate
CAS :<p>Canagliflozin hemihydrate (TA 7284) treats type 2 diabetes by blocking SGLT2, leading to glucose excretion in urine.</p>Formule :C48H52F2O11S2Degré de pureté :99.42% - 99.96%Couleur et forme :SolidMasse moléculaire :907.053'-Azido-3'-deoxythymidine 5’-Monophosphate Sodium Salt
CAS :Produit contrôlé<p>Applications A metabolite of the potent and selective inhibitor of HIV-1 replication, AZT.<br>References Brehm, J., et al.: Biochem., 47, 14020 (2008), von Kleist, M., et al.: Eur. J. Pharm. Sci., 36, 532 (2009),<br></p>Formule :C10H13N5O7P·NaCouleur et forme :NeatMasse moléculaire :369.20Clofarabine
CAS :<p>Applications Second generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gandhi, V., et al.: Clin. Cancer Res., 9, 6335 (2003), Kantarjian, H., et al.: Blood, 102, 2379 (2003), Faderl, S., et al.: Cancer, 103, 1985 (2005),<br></p>Formule :C10H11ClFN5O3Couleur et forme :White To Off-WhiteMasse moléculaire :303.68Lobucavir
CAS :Produit contrôlé<p>Applications A nucleoside analog used in the treatment of viral infections, including those caused by human immunodeficiency virus, cytomegalovirus, and herpes virus.<br>References Faulds, D., et al.: Drugs, 39, 597 (1990), Greene, J., et al.: Fundam. Appl. Toxicol., 32, 140 (1996), Poirier, M., et al.: Toxicol. Appl. Pharmacol., 199, 151 (2004),<br></p>Formule :C11H15N5O3Couleur et forme :NeatMasse moléculaire :265.27(1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride
CAS :Produit contrôléFormule :C11H12ClN5O·ClHCouleur et forme :NeatMasse moléculaire :302.162,3’-Anhydrothymidine
CAS :Produit contrôlé<p>Applications An intermediate in the preparation of thymidine derivatives<br>References el Kouni, M., et al.: Biochem. Pharmacol., 51, 1687 (1996),<br></p>Formule :C10H12N2O4Couleur et forme :NeatMasse moléculaire :224.21Tegafur-13C,15N2
CAS :Produit contrôléFormule :CC7H9F15N2O3Couleur et forme :NeatMasse moléculaire :203.15Adenosine 5’-Diphosphate-13C5 Ammonium Salt Hydrate
CAS :Produit contrôlé<p>Stability Moisture Sensitive<br>Applications Adenosine 5’-Diphosphate-13C5 Ammonium Salt Hydrate is the isotope labelled analog of Adenosine 5’-Diphosphate Ammonium Salt Hydrate (A281700); a nucleoside diphosphate that interacts with a family of ADP receptors found on platelets (P2Y1, P2Y12 and P2X1), to induce platelet activation. ADP in the blood is converted to adenosine by the action of ecto-ADPases, inhibiting further platelet activation via adenosine receptors.<br>References Gamba, G. et al.: Haematologia, 58, 1215 (1973); Dejana, E. et al.: Thromb. Haemost., 39, 135 (1978)<br></p>Formule :C513C5H15N5O10P2xNH3xH2OCouleur et forme :NeatMasse moléculaire :432.16O,O'-Dipropanal Ganciclovir
CAS :Produit contrôlé<p>Impurity Ganciclovir EP Impurity I<br>Applications O,O'-Dipropanal Ganciclovir (Ganciclovir EP Impurity I) is derived from Ganciclovir (G235000), which is a nucleoside analog structurally related to Acyclovir (A192400). Ganciclovir is an antiviral.<br>References Halloran, P.J. and Fenton, R.G.: Cancer Res., 58, 3855 (1998), Rubsam, L.Z., et al.: Cancer Res., 59, 669 (1999), Yamasaki, H., et al.: C.R. Acad. Sci. III, 322, 151 (1999)<br></p>Formule :C15H21N5O6Couleur et forme :NeatMasse moléculaire :367.36N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-adenosine
CAS :Produit contrôlé<p>Applications N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-adenosine is used for developing platelet P2T receptor antagonists, which have potential applications for antithrombotic therapy.<br>References Ingall, A. H., et al.: J. Med. Chem. 42, 213 (1999)<br></p>Formule :C16H22F3N5O4S2Couleur et forme :NeatMasse moléculaire :469.56-Deoxypenciclovir hydrochloride
CAS :<p>Applications Hydrochloride salt metabolite of a metabolite of Famciclovir, an antiviral.<br>References Harnden, M.R., et al.: J. Med. Chem., 32, 1738 (1989)<br></p>Formule :C10H15N5O2·ClHCouleur et forme :White SolidMasse moléculaire :273.72UDP-3-O[R-3-Hydroxymyristoyl]-N-acetylglucosamine Tris Salt (90%)
CAS :Produit contrôlé<p>Applications UDP-3-O[R-3-Hydroxymyristoyl]-N-acetylglucosamine Tris Salt is a lipid A precursor for Escherichia coli.<br>References Anderson, M. S. et al.: Biochem., 27, 1908 (1988);<br></p>Formule :C35H64N4O22P2Degré de pureté :90%Couleur et forme :NeatMasse moléculaire :954.84N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-2-ethylbutyl Ester L-Alanine
CAS :Produit contrôlé<p>Applications N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-2-ethylbutyl Ester L-Alanine is used for the treatment of ebola and emerging viruses.<br>References Siegel, D., et al.: J. Med. Chem., 60, 1648-1661 (2017)<br></p>Formule :C21H27N2O7PCouleur et forme :NeatMasse moléculaire :450.422Desacetyl Famciclovir
CAS :Formule :C12H17N5O3Couleur et forme :White To Off-WhiteMasse moléculaire :279.30Adenosine
CAS :<p>Applications Adenosine is a nucleotide.<br>References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010); Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010);<br></p>Formule :C10H13N5O4Couleur et forme :NeatMasse moléculaire :267.24Melphalan-d8 Dihydrochloride
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ross, W.C.J., et al.: Biochem. Pharmacol., 13, 969 (1964); Donelli, M.G., et al.: J. Pharm. Pharmacol., 18, 760 (1966), Furner, R.L., et al.: Cancer Treat. Rep., 64, 559 (1980),<br></p>Formule :C13H12D8Cl4N2O2Couleur et forme :NeatMasse moléculaire :386.17Cytidine 5'-Monophosphate
CAS :<p>Applications A constituent of nucleic acids. It was isolated from yeast nucleic acid.<br>References Parrou, J., et al.: Anal. Biochem., 248, 186 (1997), Phipps, A., et al.: Xenobiotica, 28, 527 (1998), Mohler, R., et al.: Anal. Chem., 78, 2700 (2006),<br></p>Formule :C9H14N3O8PCouleur et forme :White CrystallineMasse moléculaire :323.20Cladribine 5’-Monophosphate Ammonium (>85%)
CAS :Produit contrôlé<p>Applications Cladribine 5’-Monophosphate Ammonium Salt can be used as an antiviral, antibacterial and antileukemic agent.<br>References Cook, P., et al.: U.S., US 4719295 A 19880112 (1988);<br></p>Formule :C10H16ClN6O6PDegré de pureté :>85%Couleur et forme :NeatMasse moléculaire :382.7Thymine
CAS :Produit contrôlé<p>Impurity Zidovudine EP Impurity C<br>Applications Thymine (Zidovudine EP Impurity C) is a nitrogenous base component in the nucleic acid of DNA.<br>References Keum, Y., et al.: App. Microbiol. Biotechnol., 80, 863 (2008); Redzic, Z., et al.: Neurochem. Res., 34, 566 (2009); Lanevskij, K., et al.: J. Pharm. Sci., 98, 122 (2009); Rajendar, B., et al.: Bioorg. Med. Chem., 17, 351 (2009);<br></p>Formule :C5H6N2O2Couleur et forme :WhiteMasse moléculaire :126.11Zanamivir Amine
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A synthetic precursor of Zanamivir.<br>References Gonzalez-Diaz, H., et al.: Bioorg. Med. Chem. Lett., 15, 1651 (2005), Bergmann, R., et al.: J. Med. Chem., 50, 2708 (2007), Lue, W., et al.: Eur. J. Med. Chem., 43, 569 (2008),<br></p>Formule :C11H18N2O7Couleur et forme :NeatMasse moléculaire :290.27Adenosine 5'-Diphosphate
CAS :Produit contrôlé<p>Applications Adenosine-5'-diphosphate (ADP) is a central component of energy storage, metabolism, and signal transduction in vivo. It serves as a precursor for ATP and, in this capacity, is utilized in a wide number of cellular processes, including respiration, biosynthetic reactions, motility, and cell division.<br>References Knowles, J.R., et al.: Annual Reviews of Biochemistry 49, 877-919 (1980); Klingenberg, M., et al.: Biochimica et Biophysica Acta, 1778(10), 1978-2021 (2008);<br></p>Formule :C10H15N5O10P2Couleur et forme :NeatMasse moléculaire :427.201,2-Ethylene Glycol (Ethylene Glycol)
CAS :Formule :C2H6O2Couleur et forme :NeatMasse moléculaire :62.07Gemcitabine Hydrochloride
CAS :<p>Applications An antineoplastic.<br>References Hertel, L.W., et al.: Cancer Res., 50, 4417 (1990), Abbruzzese, J.L., et al.: J. Clin. Oncol., 9, 491 (1991), Ruiz, V.W.T., et al.: Biochem. Pharmacol., 46, 762 (1993),<br></p>Formule :C9H11F2N3O4·ClHCouleur et forme :NeatMasse moléculaire :299.66Levomefolate Calcium
CAS :<p>Applications The calcium salt of L-5-methyltetrahydrofolic acid which belongs to the group of folate vitamins (Vitamin B9, Folacin). It is a coenzymated form of folic acid.<br>References Prinz-Langhebohi, R.: et al., Br. J. Pharmac., 158, 2014 (2009); Wright, A. et al.: Brit, J. Nutrit., 103, 724 (2010);<br></p>Formule :C20H23N7O6·CaCouleur et forme :Off-WhiteMasse moléculaire :497.526-Methylmercaptopurine
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Metabolite of 6-Mercaptopurine, an immunosuppressive drug used to treat leukemia.<br>References Chou, C., et al.: Biochem. Pharmacol., 75, 1601 (2008), Conejo-Garcia, A., et al.: Eur. J. Med. Chem., 43, 1742 (2008), Hawwa, A., et al.: Brit. J. Clin. Pharmacol., 66, 826 (2008), Askanase, A., et al.: J. Rheumatol., 36, 89 (2009),<br></p>Formule :C6H6N4SCouleur et forme :White To BeigeMasse moléculaire :166.20Cytarabine 5’-Monophosphate
CAS :Produit contrôlé<p>Stability Hygroscopic, Unstable in Solution<br>Applications A derivative of Cytarabine, a potent cytotoxic-antiviral nucleoside.<br>References Kufe, D., et al.: J. Biol. Chem., 255, 8997 (1980), Ross, D., et al.: Cancer Res., 50, 2658 (1990), Bhalla, K., et al.: Blood, 80, 2883 (1992), Tonetti, D., et al.: J. Biol. Chem., 269, 23230 (1994),<br></p>Formule :C9H14N3O8PCouleur et forme :NeatMasse moléculaire :323.204-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene
CAS :Produit contrôlé<p>Applications 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene is used as a reagent in the synthesis of Dapagliflozin (D185370); a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.<br>References Meng, W., et al.: J. Med. Chem., 51, 1145 (2008);<br></p>Formule :C15H14BrClOCouleur et forme :White To Off-WhiteMasse moléculaire :325.63Pteroic Acid (>85%)
CAS :Produit contrôlé<p>Impurity Methotrexate EP Impurity D N-Desmethyl Impurity<br>Applications Pteroic Acid (Methotrexate EP Impurity D N-Desmethyl Impurity) is a constituent as well as a degradation product of Folic Acid (F680300) formed via enzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutamate synthetase.<br>References Vickers, P.J. et al.: Can. J. Biochem. Cell Biol., 63, 777 (1985): Tafolla, W.H. et al.: J. Pharmac. Sci., 70, 1273 (1981); Iwai, K. et al.: J. Butrit. Sci. Vitaminol., 23, 95 (1977);<br></p>Formule :C14H12N6O3Degré de pureté :>85%Couleur et forme :NeatMasse moléculaire :312.28
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