Composés Organométalliques

Iron(III) chloride hexahydrate, 97+% (ACS)

Applications Gadodiamide is an apoptosis inducing agent used in chondrocytes. It is primarily used in muscoskeletal diagnosis as a contrast agent.
References Greisberg, J. et al.: Mag. Res. Imag., 19, 731 (2001); Hemmingsson, A. et al.: Mag. Res. Mat. Phys. Biol. Med., 12, 96 (2001);

Applications Analog of Cisplatin with reduced nephrotoxicity. Antineoplastic.
References Harland, S.J., et al.: Cancer Res., 44, 1693 (1984), Smith, I.E., et al.: Cancer Treat. Rep., 69, 43 (1985), Lygidakis, N.J., et al.: Interferon Cytokine Res., 15, 467 (1995),

Stability Hygroscopic
Applications N-Acetyl Cyclized Iodixanol is an impurity of Iodixanol (I667200) which is a nonionic, dimeric x-ray contrast medium.
References Svaland, M.G., et al.: Invest. Radiol., 27, 130 (1992), Palmers, Y., et al.: Eur. J. Radiol., 17, 203 (1993), Conroy, R.M., et al.: Clin. Radiol., 49, 337 (1994)

Stability Hygroscopic
Applications Cyclic Iodixanol is an impurity of Iodixanol (I667200) which is a nonionic, dimeric x-ray contrast medium.
References Svaland, M.G., et al.: Invest. Radiol., 27, 130 (1992), Palmers, Y., et al.: Eur. J. Radiol., 17, 203 (1993), Conroy, R.M., et al.: Clin. Radiol., 49, 337 (1994)

Stability Hygroscopic
Applications Caldiamide Sodium is an analog of Gadodiamide (G125710) which is an apoptosis inducing agent used in chondrocytes. Gadodiamide is primarily used in muscoskeletal diagnosis as a contrast agent.
References Greisberg, J. et al.: Mag. Res. Imag., 19, 731 (2001); Hemmingsson, A. et al.: Mag. Res. Mat. Phys. Biol. Med., 12, 96 (2001)

Applications [SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-κN,κN')diiodoplatinum is a potential antitumor agent. Impurity of Oxiplatin (O845075), third generation platinum complex. An antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA. Antineoplastic.
References Kidani, Y. et al.: Biomed. Pharmacther., 43, 261 (1989); Noji, M. et al.: J. Med. Chem., 24, 508 (1981); Kidani, Y., et al.: J. Med. Chem., 21, 1315 (1978), Kizu, R., et al.: Cancer Chemother. Pharmacol., 31, 475 (1993), Levi, F., et al.: Eur. J. Cancer, 29A, 1280 (1993), Simpson, D., et al.: Drugs, 63, 2127 (2003),

Applications 1,1-Cyclobutanedicarboxylic Acid is used in the design, studies and structural model of antitumor dicycloplatin a clinical cancer drug. Hydrolysis mechanism of second-generation anticancer drug carboplatin.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yang, X. Q., et al.: Science China: Chemistry, 53, 1346 (2010); Pavelka, M., et al.: Chem. Eur. J., 13, 10108 (2007)

Applications Oxaliplatin-d10, is the labeled analogue of Oxaliplatin (O845075), which is platinum-based antineoplastic agent that is used in cancer chemotherapy.
References Kidani, Y., et al.: J. Med. Chem., 21, 1315 (1978), Kizu, R., et al.: Cancer Chemother. Pharmacol., 31, 475 (1993), Levi, F., et al.: Eur. J. Cancer, 29A, 1280 (1993), Simpson, D., et al.: Drugs, 63, 2127 (2003),

Applications Potassium Trichloroammineplatinate is the degradation product of Cisplatin (C499500), an antitumor compound which exhibits mutagenic activity.
References Peer, R.L., et al.: Enivron. Mutagen., 3, 555 (1981); Macquet, J.P., et al.: Develop. Oncol., 17, 27 (1984); Macquet, J.P., et al.: J. Clin. Hematol. Oncol., 7, 469 (1997);

Applications 2-Fluoro-3-methoxyphenylboronic acid

Applications Gadoteric Acid is used for magnetic resonance imaging.
References Gheuens, E., et al.: Invest. Radiol., 49, 505-508 (2014)

Applications The (S,S) Oxaliplatin isomer. Third generation platinum complex. An antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA. Antineoplastic.
References Kidani, Y., et al.: J. Med. Chem., 21, 1315 (1978), Kizu, R., et al.: Cancer Chemother. Pharmacol., 31, 475 (1993), Levi, F., et al.: Eur. J. Cancer, 29A, 1280 (1993), Simpson, D., et al.: Drugs, 63, 2127 (2003),

Impurity Iohexol EP Impurity K
Applications 5-Amino-2,4,6-triiodoisophthalic Acid (Iohexol EP Impurity K) is an intermediate for nonionic iodinated X-ray contrast agents.

Applications Third generation platinum complex. An antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA. Antineoplastic.
References Kidani, Y., et al.: J. Med. Chem., 21, 1315 (1978), Kizu, R., et al.: Cancer Chemother. Pharmacol., 31, 475 (1993), Levi, F., et al.: Eur. J. Cancer, 29A, 1280 (1993), Simpson, D., et al.: Drugs, 63, 2127 (2003),

Impurity Oxaliplatin EP Impurity E
Stability Light Sensitive
Applications A dimeric impurity of Oxaliplatin (O845075) with neoplasm-inhibiting activity.
References Gill, D.: Dev. Oncol., 17, 267 (1984);

Applications 13-oxo-1,4,7,10-Tetraazabicyclo[8.2.1]tridecane-4,7-diacetic Acid is an impurity in the synthesis of Gadoteridol, an MRI contrast chelating agent.
References Petersein, J. et al.: Am. J. Roentgenol., 165, 1167 (1995);

Stability Hygroscopic
Applications Bifunctional DOTA conjugates to peptides and has become an established strategy for constructing target-specific metal containing agents including targeted MRI contrast agents and diagnostic and therapeutic radiopharmaceuticals.
References Lewis, M., et al.: Bioconjug. Chem., 9, 72 (1998), Chappell, L., et al.: Bioorg. Med. Chem., 7, 2313 (1999), Prantner, A., et al.: Mol. Imaging, 2, 333 (2003), Allen, M., et al.: Chem. Biol., 11, 301 (2004), Weiner, R., et al.: BioDrugs, 19, 145 (2005), Breeman, W., et al.: Radionuclide Peptide Cancer Therapy, 119 (2006),

Applications: Gadopentetic Acid is a magnetic resonance contrast agent being used to develop a new platform for the delivery of therapeutic and imaging agents simultaneously to the colon.
References Jin, M., et al.: Mol. Pharm, 13, 2457-2465 (2016)

Impurity Iohexol USP Related Compound C
Applications N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide is used in the preparation of X-ray contrast agents.
References Haavaldsen, J. et al.: Acta Pharmac. Sue., 20, 219 (1983);

Applications Transplatin is the trans stereoisomer impurity of Cisplatin (C499500), an antineoplastic used in the treatment of sarcomas, some carcinomas, lymphomas, and germ cell tumors. Transplatin binds to DNA but does not exhibit the same useful pharmacological effect as its cis stereoisomer.
References Cersosimo, R.J.: Cancer Treat. Rev., 16, 195 (1989); Takeiri, A. et al.: Genes Environ., 29, 89 (2007); Giraud-Panis, M.-J. et al.: Pharmacol. Therap., 85, 175 (2000);

Applications An Oxaliplatin (O845075) derivative. An orally active antitumor cyclohexanediamine-Pt(IV) complex. Oxaliplatin impurity C as per EP.
References Yamashita, T., et al.: Biol. Pharma. Bull., 16, 1014 (1993),

Stability Hygroscopic
Applications An intermediate used in the synthesis of imaging agents such as Iohexol (I729500).
References Priebe, H., et al.: J. Clin. Pharm. Ther., 24, 227 (1999),

Stability Hygroscopic
Applications Deuterated Iohexol. Imaging agent.
References Wolf, G.L., et al.: Invest. Radiol., 16, 320 (1981), Mancini, G.B.J., et al.: Am. J. Cardiol., 51, 1218 (1983), Bettmann, M.A., et al.: Radiology, 153, 583 (1984), Sullivan, I.D., et al.: Br. Heart J.,51, 643 (1984),

Applications Nonionic, dimeric x-ray contrast medium. Diagnostic aid (radiopaque medium).
References Svaland, M.G., et al.: Invest. Radiol., 27, 130 (1992), Palmers, Y., et al.: Eur. J. Radiol., 17, 203 (1993), Conroy, R.M., et al.: Clin. Radiol., 49, 337 (1994),

Applications Imaging agent.
References Wolf, G.L., et al.: Invest. Radiol., 16, 320 (1981), Mancini, G.B.J., et al.: Am. J. Cardiol., 51, 1218 (1983), Bettmann, M.A., et al.: Radiology, 153, 583 (1984), Sullivan, I.D., et al.: Br. Heart J.,51, 643 (1984),

Stability Hygroscopic
Applications Used as an intermediate in the industrial preparation of non-ionic X-ray contrast agents such as Iohexol (I729500), Ioversol (I737000), Ioxilan (I737500), Iopamidol (I735600).
References Rongved, P., et al.: Carbohydrate Res., 297, 325 (1997),

1,1'-Bis{(S)-4,5-dihydro-3H-binaphtho[1,2-c:2',1'-e]phosphino}ferrocene, min. 98% (S,S)-f-Binaphane