Peptides et Protéines

D-Arg(28)-Semaglutide is a semaglutide impurity. The amino acid at position 28 has been replaced by the D-form of the amino acid D-arginine (D-Arg). Semaglutide impurities are structurally related compounds that arise during synthesis, purification, or storage of semaglutide, a long-acting GLP-1 receptor agonist for managing type 2 diabetes and obesity.

Applications Used as modulators of muscarinic receptors for treatment of CNS disorders.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Coghlan, M., et al.: J. Med. Chem., 44, 1627 (2001), Ashcroft, F., et al.: J. Clin. Invest., 115, 2047 (2005), Bryan, J., et al.: Curr. Pharm. Des., 11, 2699 (2005),

Stability Hygroscopic
Applications Lisinopryl impurity.
References Goa, K.L., et al.: Drugs, 52, 564 (1996), Cao, X.J., et al.: J. Pharm. Biomed. Anal., 39, 39 (2005),

Applications (S)-(-)-α-Methylbenzylamine (cas# 2627-86-3) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Lysipressin Acetic Acid Salt, is an analog of Vasopressin (A769550), a powerful vasopressor used to modulate blood pressure. An endogenous antidiuretic hormone in most mammalian species. It is released into the blood from nerve terminals in the posterior pituitary and median eminence. It is a neurotransmitter in the central nervous system and also implicated in a variety of physiological processes such as regulating water balance by antidiuretic action.
References Yamashita, K. et al.: Mol. Phylo., 67, 520 (2013); Hua F. et al.: J. Emerg. Med., 44, 434 (2013); Perucca, J. et al.: J. AM. Soc. Nephrol., 19, 1721 (2008); Toba, K. et al.: Prog. Brain Res., 119, 337 (1998); Berrada, K. et al.: J. Biol. Chem., 275, 27229 (2000);

Impurity Lopinavir EP Impurity R
Applications (αS)-3-[2-(2,6-Dimethylphenoxy)acetyl]-N-[(1S,3S,4S)-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide (Lopinavir EP Impurity R) is an impurity of Lopinavir (L469480), a selective HIV protease inhibitor.
References Chitturi, S.R., et al.: J. Pharma. Biomed. Anal., 48, 1430 (2008); Devi, A.S.L., et al.: Magnet. Reson. Chem., 45, 424 (2007);

Applications Trofinetide is a synthetic analogue of the endogenous N-terminus tripeptide, Glycine-Proline-Glutamate (GPE), that has shown to be neuroprotective in animal models of brain injury.
References Wei, H.H. et al.: J Neuroinflammation. 2009 Aug 5;6:19.

Applications 5-Oxo-L-proline-d5 is a labelled cyclized derivative of L-Glutamic Acid (G596960). The pyroglutamate core has potential application for synthesis of novel anti-bacterials.
References Mischo A. et al.: ChemBioChem., 13, 1421 (2012); Angelov P. et al.: Org. Biomol. Chem.: 10, 3472 (2012);

Applications Daptomycin Impurity B1-1 is an impurity of Daptomycin (D193350), cyclic lipopeptide antibiotic derived from a fermentation product of Streptomyces roseosporus; disrupts plasma membrane function in gram-positive bacteria. Antibacterial.
References Allen, N.E., et al.: Antimicrob. Agents Chemother., 31, 1093 (1987), Tully, F.P., et al.: Expert Opin. Invest. Drugs, 8, 1223 (1999),

Applications N(1-(3-Methylbutanamido) N(1-Des(boric Acid)) Bortezomib is an impurity of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer.
References Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl C.: Chem. and Eng. News, 87, 41 (2009);

Applications 1-nitrosopyrrolidine-2-carboxylic acid (cas# 2571-28-0) is a useful research chemical.

Applications Bortezomib (B675700) intermediate. A boronic acid dipeptide derivative as proteasome inhibitors.
References Kisselev, A., et al.: Chem. Biol., 8, 739 (2001), Kisselev, A., et al.: J. Biol. Chem., 278, 35869 (2003), Verdoes, M., et al.: Chem. Biol., 13, 1217 (2006),

Applications 9-(2,5-d|Dioxo-L-3-amino-1-pyrrolidineacetic acid)-10-deglycine Daptomycin is a stereoisomer of Daptomycin (D193350), cyclic lipopeptide antibiotic derived from a fermentation product of Streptomyces roseosporus; disrupts plasma membrane function in gram-positive bacteria. Antibacterial.
References Allen, N.E., et al.: Antimicrob. Agents Chemother., 31, 1093 (1987), Tully, F.P., et al.: Expert Opin. Invest. Drugs, 8, 1223 (1999),

Impurity Leuprolide Acetate EP Impurity B TFA salt
Applications Synthetic nonapeptide agonist analog of LH-RH. Antineoplastic (hormonal).
References Vilchez-Martinez, J.A., et al.: Biochem. Biophys. Res. Commun., 59, 1226 (1974), Sennello, L.T., et al.: J. Pharm. Sci., et al.: 75, 158 (1986), Wheeler, J.M., et al.: Am.J. Obstet. Gynecol., 167, 1367 (1992), Eri, L.M., et al.: J. Urol., 150, 359 (1993),

Applications A labelled NS3 serine protease inhibitor of hepatitis C virus. It is a COVID19-related research product.
References Malcolm, B., et al.: Antimicrob. Agents Chemother., 50, 1013 (2006); Cubero, M., et al.: Virology, 370, 237 (2008); Venkatraman, S., et al.: J. Med. Chem., 49, 6074 (2006);

Applications (αS)-α-Amino-N-[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]-benzenepropanamide Monohydrochloride is a Bortezomib (B675700) intermediate which is used in the evaluation of bone-targeted proteasome inhibitors for myeloma.
References Agyin, J.K., et al.: Bioorg. Med. Chem. Lett., 23, 6455 (2013); Traenckner, E., et al.: EMBO. J., 13, 5433 (1994)

Impurity Levothyroxine Acetamide Impurity
Applications 3,5,3',5'-Tetraiodo Thyroacetamide is a thyroid hormone analogue, a Thyroxine (T425600) impurity.
References Andre, M., et al.: J. Chromatogr., 741, 146 (1996),

Applications (S,S)-Hydroperoxy Des(boric Acid) Bortezomib is an impurity of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer.
References Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl C.: Chem. and Eng. News, 87, 41 (2009);

Stability Hygroscopic
Applications (R)-3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride is an important co-factor of mammalian mitochondrial energy metabolism. It is also a good active ingredient for dry-skin.
References Geier, David A., et al.: Neurochem. Res., 38(11), 2336-2341 (2013);Tanno, Osamu, et al.: Fragrance J., 33(8), 82-85 (2005);

Stability Hygroscopic
Applications (S)-4-Oxo-homophenylalanine Hydrochloride is a derivative of L-Homophenylalanine (H600500); an antitumor agent.
References Brunner, Henri., et al.: Eur. J. Med. Chem., 25, 35 (1990)

Applications (S)-2-((S)-4-Methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenylpropanoic Acid is an intermediate for Carfilzomib (C183460), which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
References Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);

Impurity Bortezomib USP Impurity L
Stability Unstable in Methanol
Applications (R)-Hydroperoxy Des(boric Acid) Bortezomib is an impurity of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer.
References Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl C.: Chem. and Eng. News, 87, 41 (2009);

Applications Polyoxyethylene (23) Lauric Acid is an intermediate in the synthesis of Bril L-23 Proline (LIFETC1), a polyethylene glycol derivative of Proline (P755995), an amino acid and precursor (with vitamin C) for collagen, the building block of the structure of tendons, ligaments, arteries, veins and muscles.
References Bondarenko, L.B., et al.: Int. J. Peptides., 2, 1687 (2012); Rimer, T., et al.: Biomacromolecules, 13, 2110 (2012);

Applications N-(1-Carboxy-3-phenylpropyl)-S-lisinopril (Mixture of diastereomers) is an impurity of lisinopril (L468985), an orally active angiotensin-converting enzyme (ACE) inhibitor.
References Shinde, V., et. al.: J. Pharm. Biomed. Anal., 43, 381 (2007); Goa, K.L., et al.: Drugs, 52, 564 (1996), Chaturvedi, N., et al.: Lancet, 351, 28 (1998)

Applications An impurity of Clomiphene (C587025).

Applications Linear Daptomycin Hydrochloride Salt is the hydrochloride salt of L466470, which is the open-conformation of Daptomycin (D193350), cyclic lipopeptide antibiotic derived from a fermentation product of Streptomyces roseosporus; disrupts plasma membrane function in gram-positive bacteria. Antibacterial. Daptomycin Impurity
References Allen, N.E., et al.: Antimicrob. Agents Chemother., 31, 1093 (1987), Tully, F.P., et al.: Expert Opin. Invest. Drugs, 8, 1223 (1999),

Applications t-Butyl 4-bromobutanoate is a useful research chemical for organic synthesis and other chemical and pharmaceutical processes.
References Brudeli, B., et al.: Bioorg. Med. Chem., 18, 8600 (2010); Colak, S., et al.: Macromolecules, 41, 8436 (2008)

Impurity Levothyroxine EP Impurity I; T4-Aldehyde (USP)
Applications 3,5,3',5'-Tetraiodo Thyroaldehyde (Levothyroxine EP Impurity I; T4-Aldehyde (USP)) is a Thyroid hormone analogue and a Thyroxine (T425600) analogue.
References Horst, C., et al.: Biochem. J., 261, 945 (1989), Kvetny, J., et al.: Horm. Metab. Res., 24, 322 (1992), Yamauchi, K., et al.: J. Biol. Chem., 274, 8460 (1999), Davis, P., et al.: J. Endocrinol. Invest., 25, 377 (2002),

Impurity Bortezomib USP Impurity J
Applications (S)-Hydroxy Des(boric Acid) Bortezomib is an impurity in the synthesis of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.
References Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl, C. et al.: Chem. and Eng. News, 87, 41 (2009)