Sels et Dérivés d’API
Les sels des Ingrédients Pharmaceutiques Actifs (API) sont des composés formés par la réaction d’un acide avec une base, aboutissant à un équilibre ionique. Ces sels améliorent souvent la solubilité et la stabilité des API, facilitant ainsi leur absorption par l’organisme. Les dérivés des API sont des variantes chimiques d’un principe actif qui peuvent présenter des propriétés améliorées ou modifiées afin d’optimiser leur efficacité thérapeutique. Les sels d’API sont utilisés dans la formulation de médicaments oraux, injectables et topiques. De plus, les dérivés d’API peuvent améliorer la pharmacocinétique des médicaments, notamment en permettant une libération contrôlée des substances actives.
Chez CymitQuimica, nous proposons des sels et dérivés d’API avec la pureté et la qualité requises pour la recherche et le développement de formulations pharmaceutiques.
79171 produits trouvés pour "Sels et Dérivés d’API"
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Bupropion 3,4-Dichloro Impurity Hydrochloride
CAS :Formule :C13H17Cl2NOHClMasse moléculaire :274.15:36.5Salbutamol EP Impurity C (Sulfate salt)
CAS :Formule :C13H21NO2H2O4SMasse moléculaire :223.32 : 98.07Bimatoprost Acid
CAS :Produit contrôlé<p>Applications Bimatoprost Acid is an impurity of the antiglaucoma agent Bimatoprost (B386820).Bimatoprost Acid is a metabolically stable analog of PGF2α (P838625) and is a potent agonist for the FP receptor.<br>References Balapure, A.K. et al.: Biochem. Pharmacol., 38, 2375 (1989); Hellberg, M.R. et al.: J. Ocular Pharmacol. Ther., 19, 97 (2003); Krishna, P.M. et al.: J. Pharm. res., 4, 2381 (2011);<br></p>Formule :C23H32O5Couleur et forme :White To Off-WhiteMasse moléculaire :388.504-Amino-6-ethoxy-5-[[4-[(4R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]azo]-α-[[4-[(4R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazono]-2-pyrimidineacetonitrile
CAS :<p>Applications 4-Amino-6-ethoxy-5-[[4-[(4R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]azo]-α-[[4-[(4R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazono]-2-pyrimidineacetonitrile is a levosimendan dimer impurity, which is a bioactive enantiomer of racemate, Simendan. Positive inotropic agent with vasodilating activity. Cardiotonic.<br>References Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995), Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996),<br></p>Formule :C30H30N12O3Couleur et forme :NeatMasse moléculaire :606.64O,O-Dimethyl Methylphosphonate
CAS :Produit contrôlé<p>Applications O,O-Dimethyl Methylphosphonate is a commercially used preignition additive for gasoline, anti-foaming agent, plasticizer, stabilizer and antistatic agents.<br>References Jang, S.H., et al.: J. Korean. Phy. Soc., 55, 294 (2009); Schneider, B.B., et al.: Int. J. Mass. Spectro., 298, 45 (2010);<br></p>Formule :C3H9O3PCouleur et forme :NeatMasse moléculaire :124.076trans R-138727, (Prasugrel Metabolite) -(>85%)(Mixture of Diastereomers)
CAS :Produit contrôléFormule :C18H20FNO3SCouleur et forme :White To Light YellowMasse moléculaire :349.42Scopoline Methobromide
CAS :<p>Applications Scopoline Methobromide is an impurity of Tiotropium (T444850), an muscarinic receptor antagonist and bronchodilator.<br>References Moffett, R.B.. et al.: J. Am. Chem. Soc., 77, 1245 (1955); Haddad, E.-B., et al.: Mol. Pharmacol., 45, 899 (1994); Donohue, J. F., et al.: Chest, 122, 47 (2002); Profita, M., et al.: Allergy, 60, 1361 (2005); Dusser, D., et al.: Eur. Respir. J., 27, 547 (2006)<br></p>Formule :C9H16NO2·BrCouleur et forme :White To Light GreyMasse moléculaire :250.13Ticagrelor Sulfoxide (Mixture of Diastereomers)
CAS :Produit contrôlé<p>Applications Ticagrelor Sulfoxide is an impurity of ticagrelor (T437700). Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>Formule :C23H28F2N6O5SCouleur et forme :NeatMasse moléculaire :538.57Desacetyl Rifampicin Quinone
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Desacetyl Rifampicin Quinone is an impurity of Rifampicin (R508000).<br>References Wilson, W.L. et al.: J. Chrom., 144, 270 (1977);<br></p>Formule :C41H54N4O11Couleur et forme :NeatMasse moléculaire :778.892-Oxo Clopidogrel Hydrochloride(Mixture of Diastereomers)
CAS :Produit contrôlé<p>Applications The essential intermediate metabolite from which the active metabolite of Clopidogel is formed.<br>References Feliste, R., et al.: Thromb. Res., 48, 403 (1987), Savi, P., et al.: Biochem. Pharmacol., 44, 527 (1992), Herbert, J., et al.: Cardiovasc Drug. Rev., 11, 180 (1993), Sugidachi, A., et al.: B. J. Pharmacol., 132, 47 (2001)<br></p>Formule :C16H17Cl2NO3SCouleur et forme :NeatMasse moléculaire :374.28Tacrolimus (FK506)
CAS :<p>Applications An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Asano, K., et al.: In Vivo, 10, 537 (1996), McCall, E., et al.: Circ. Res., 79, 1110 (1996), Raufman, J.P., et al.: J. Biol. Chem., 271, 19877 (1996), Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996), Knoll, G.A., and Bell, R.C.: Brit. Med. J., 318, 1104 (1999)<br></p>Formule :C44H69NO12Couleur et forme :NeatMasse moléculaire :804.02N1-Acetyl Triethylenetetramine Trihydrochloride
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications N1-Acetyl Triethylenetetramine is a monoacetylated metabolite of the selective CuII-chelator Triethylenetetramine (T776630).<br>References Murata, Y. et al.: Biomed. Res. Trace Elem., 4, 185 (1993): Lu, J. et al.: J. Clin. Pharmacol., 50, 647 (2010); Lu, J. et al.: J. Chrom. B Anal. Technol. Biomed. Life Sci., 859, 62 (2007);<br></p>Formule :C8H23Cl3N4OCouleur et forme :NeatMasse moléculaire :297.651-(3-Hydroxypropyl)theobromine
CAS :Produit contrôléFormule :C10H14N4O3Couleur et forme :White To Off-WhiteMasse moléculaire :238.243Apixaban-d3
CAS :Produit contrôlé<p>Applications Apixaban-d3 is labelled Apixaban (A726700) which is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.<br>References Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);<br></p>Formule :C25H22D3N5O4Couleur et forme :White To Off-WhiteMasse moléculaire :462.52A77 1726 (E/Z) Mixture
CAS :Produit contrôlé<p>Impurity Leflunomide USP Related Compound B<br>Applications rac A77 1726 is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme’s teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective than injectable interferon beta 1a (Rebif®). Leflunomide USP Related Compound B.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kirsch, B.M., et al.: Arthritis Research and Therapy, 7, 3, R694, (2005)<br></p>Formule :C12H9F3N2O2Couleur et forme :NeatMasse moléculaire :270.21Rivaroxaban-d4
CAS :Produit contrôléFormule :C19H14D4ClN3O5SCouleur et forme :White To Off-WhiteMasse moléculaire :439.911,1'-[(5E)-5-Methyl-7-oxo-5-undecene-1,11-diyl] Bis[Theobromine]
CAS :Formule :C26H34N8O5Couleur et forme :NeatMasse moléculaire :538.60Rivaroxaban
CAS :<p>Applications A novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Formule :C19H18ClN3O5SCouleur et forme :White To BeigeMasse moléculaire :435.88Tacrolimus Hydrate
CAS :<p>Applications Tacrolimus Hydrate is a disease-modifying antirheumatic drugs (DMARDs)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ogasawara, M., et al.: Mod. Rheumatol., 22, 831-836 (2012)<br></p>Formule :C44H69NO12·H2OCouleur et forme :NeatMasse moléculaire :822.03Febuxostat-d9
CAS :Produit contrôlé<p>Applications Labelled Febuxostat (F229000). Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),<br></p>Formule :C16D9H7N2O3SCouleur et forme :NeatMasse moléculaire :325.43Ethyl 2-Chloracetoacetate
CAS :<p>Applications Ethyl 2-Chloracetoacetate is used in the preparation of oxazoles and thiazoles as agonists for peroxisome proliferator-activated receptor δ. It is also used to synthesize dimethylimidazothiadiazolecarbohydrazides with anticancer activities.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sznaidman, M., et al.: Bioorg. Med. chem. Lett., 13, 1517 (2003); Terzioglu, N., et al.: Eur. J. Med. Chem., 38, 781 (2003)<br></p>Formule :C6H9ClO3Couleur et forme :NeatMasse moléculaire :164.59Ethyl 3-Amino-4-pyrazolecarboxylate
CAS :Produit contrôléFormule :C6H9N3O2Couleur et forme :White To BeigeMasse moléculaire :155.15Macitentan
CAS :Produit contrôlé<p>Applications Macitentan, is an orally active endothelin receptor antagonist used for pulmonary arterial hypertension.<br>References Emoto, N. Ensho to Men'eki, 20, 487 (2012);<br></p>Formule :C19H20Br2N6O4SCouleur et forme :White To Off-WhiteMasse moléculaire :588.27Ticagrelor
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>Formule :C23H28F2N6O4SCouleur et forme :WhiteMasse moléculaire :522.57Bisdionin C
CAS :Produit contrôlé<p>Applications Bisdionin C is the derivative of Theobromine (T343800), which is a metabolite of Caffeine.<br>References Suto, M., et al.: Anticancer Drug Des., 6, 107 (1991), Burkart, V., et al.: Nat. Med., 5, 314 (1999), Hassa, P., et al.: J. Biol. Chem., 278, 45145 2003), Veres, B., et al.: J. Pharmacol. Exp. Ther., 310, 247(2004)<br></p>Formule :C17H20N8O4Couleur et forme :NeatMasse moléculaire :400.39Edoxaban-d6
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Edoxaban-d6 is the isotope labelled analog of Edoxaban (E555520); an anticoagulant drug which acts as a direct factor Xa inhibitor.<br>References Ruff, C., et al.: Am. Heart J., 160, 635 (2010); Ogata, K., et al.: J. Clin. Pharm., 50, 73 (2010)<br></p>Formule :C24H24D6ClN7O4SCouleur et forme :Light Beige To Light BrownMasse moléculaire :554.09Ramiprilat-d5 (Mixture of Diastereomers)
CAS :Produit contrôlé<p>Applications A labelled metabolite of Ramipril (R111000).<br>References Teetz, V., et al.: Arzneim.-Forsch., 34, 1399 (1984), Ruggenenti, P., et al.: Lancet, 352, (1998), Bosch, J., et al.: Br. Med. J., 324, 1 (2002),<br></p>Formule :C212H5H23N2O5Couleur et forme :NeatMasse moléculaire :393.49Treprostinil Ethyl Ester
CAS :Produit contrôléFormule :C25H38O5Couleur et forme :NeatMasse moléculaire :418.566Ramipril-d5
CAS :Produit contrôlé<p>Applications A labelled antihypertensive. An angiotensin converting enzyme (ACE) inhibitor, converted to active, diacid metabolite.<br>References Teetz, V., et al.: Arzneim.-Forsch., 34, 1399 (1984), Ruggenenti, P., et al.: Lancet, 352, (1998), Bosch, J., et al.: Br. Med. J., 324, 1 (2002),<br></p>Formule :C23H27D5N2O5Couleur et forme :WhiteMasse moléculaire :421.54Bimatoprost
CAS :<p>Stability Light Sensitive<br>Applications Bimatoprost is an antiglaucoma agent. Bimatoprost is an synthetic prostamide; structurally related to prostaglandin F2α.<br>References Brandt, J.D., et al.: Ophthalmology, 108, 1023 (2001), Woodward, D.F., et al.: J. Pharmacol. Exp. Ther., 305, 772 (2003), Quinones, R., et al.: J. Ocul. Pharmacol. Ther., 20, 115 (2004),<br></p>Formule :C25H37NO4Couleur et forme :WhiteMasse moléculaire :415.57Iomeprol-d3
CAS :Produit contrôlé<p>Applications Diagnostic aid (radiopaque medium).<br>References Gallotti, A., et al.: Eur. J. Radiol., 18, Suppl 1 S1(1994), Morisetti, A., et al.: Eur. J. Radiol., 18, Suppl 1 S21(1994).<br></p>Formule :C17H19D3I3N3O8Couleur et forme :Off-WhiteMasse moléculaire :780.10Argatroban monohydrate
CAS :Produit contrôléFormule :C23H36N6O5S·H2OCouleur et forme :NeatMasse moléculaire :526.65Probenecid-d14
CAS :Produit contrôlé<p>Applications Uricosuric.<br>References McKinney, S.E., et al.: J. Pharmacol. Exp. Ther., 102, 208 (1951), Israili, Z.H., et al.: J. Med. Chem., 15, 709 (1972), Al-Badr, A.A., et al.: Anal. Profiles Drug Subs., 10, 639 (1981), Cunningham, R.F., et al.: Clin. Pharmacokinet., 6, 135 (1981),<br></p>Formule :C13D14H5NO4SCouleur et forme :NeatMasse moléculaire :299.455-Methylisoxazole-4-carboxylic Acid
CAS :Produit contrôléFormule :C5H5NO3Couleur et forme :NeatMasse moléculaire :127.10Apixaban PG Ester-I
CAS :Produit contrôlé<p>Applications Apixaban PG Ester-I is one of the multiple constituents extracted from Biebersteinia multifida, that exhibits inhibitory activity on acetylcholinesterase.<br>References Xiang, F., et al.: Faming Zhuanli Shenqing (2019), CN 109432093 A 20190308.<br></p>Formule :C28H30N4O6Couleur et forme :NeatMasse moléculaire :518.56Dofetilide N-Oxide
CAS :Produit contrôléFormule :C19H27N3O6S2Couleur et forme :NeatMasse moléculaire :457.56Ramipril (1 mg/mL in Methanol)
CAS :Formule :C23H32N2O5Couleur et forme :Single SolutionMasse moléculaire :416.51Brinzolamide
CAS :Produit contrôlé<p>Applications Carbonic anhydrase inhibitor. Antiglaucoma agent.<br>References Silver, L.H., et al.: Am. J. Ophthalmol., 126, 400 (1998), Davies, N., et al.: Clin. Exp. Pharmacol. Physiol., 27, 558 (2000), Stave, J., et al.: Ophthalmologe, 99, 276 (2002),<br></p>Formule :C12H21N3O5S3Couleur et forme :NeatMasse moléculaire :383.51Deferasirox Ferrate(III) Tripotassium Complex Methanoate Hydrate
CAS :<p>Applications A metal complex of Deferasirox (D228650) as oxidation catalysts. Coordination compound.<br>References Rouan, M., et al.: Biomed. Sci. Applic., 755, 203 (2001)<br></p>Formule :C44H36FeK3N6O12Couleur et forme :NeatMasse moléculaire :1013.93Diclofenac Levomenthol Ester
CAS :Produit contrôléFormule :C24H29Cl2NO2Couleur et forme :NeatMasse moléculaire :434.399Iopromide-d3
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Labelled Iopromide. Nonionic, injectable radio-contrast medium. Diagnostic aid (radiopaque medium).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Muetzel, W., et al.: Am.J. Neuroradiol., 4, 350 (1983), Dawson, P., et al.: Acta Radiol. Diagn., 25, 253 (1984),<br></p>Formule :C18H21D3I3N3O8Couleur et forme :White To Light YellowMasse moléculaire :794.13Tolvaptan
CAS :Produit contrôlé<p>Applications Tolvaptan is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).<br>References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000); Udelson, J., et al.: Circulation, 104, 2417 (2001); Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005); Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006);<br></p>Formule :C26H25ClN2O3Couleur et forme :White To Off-WhiteMasse moléculaire :448.94Riluzole-13C,15N2
CAS :Produit contrôléFormule :C713CH5F315N2OSCouleur et forme :Light Beige To Light YellowMasse moléculaire :237.18RO 2433
CAS :Produit contrôlé<p>Impurity Sofosbuvir Metabolite GS331007<br>Applications RO 2433 is the deaminated metabolite of β-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine, an effective inhibitor of hepatitis C virus (HCV) replication in vitro.<br>References Asif, G., et. al.: Antimicrob. Agents Ch., 51, 2877 (2007)<br></p>Formule :C10H13FN2O5Couleur et forme :NeatMasse moléculaire :260.221,2,3,4-Tetradehydro Argatroban
CAS :Produit contrôlé<p>Applications 1,2,3,4-Tetrahydro Argatroban is a metabolite of Argatroban (A769000); a synthetic thrombin inhibitor and antithrombotic.<br>References Abiko, Y., et al.: Thromb. Res., 24, 285 (1981); Kikumoto, R., et al.: Biochemistry, 23, 85 (1984)<br></p>Formule :C23H32N6O5SCouleur et forme :NeatMasse moléculaire :504.604-[4-[[(2R)-3-Chloro-2-hydroxypropyl]amino]phenyl]-3-morpholinone
CAS :Produit contrôlé<p>Impurity Rivaroxaban Impurity E<br>Applications 4-[4-[[(2R)-3-Chloro-2-hydroxypropyl]amino]phenyl]-3-morpholinone (Rivaroxaban Impurity E) is an impurity of Rivaroxaban (R538000), which is a antithrombotic agent and a FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Formule :C13H17ClN2O3Couleur et forme :NeatMasse moléculaire :284.74Hydroxy Brimonidine Trifluoroacetic Acid Salt
CAS :<p>Impurity Brimonidine EP Impurity G<br>Applications A possible metabolite of Brimonidine (B677520).<br></p>Formule :C11H12BrN5O·C2HF3O2Couleur et forme :NeatMasse moléculaire :424.1732Cyclosporin AM 1 (>80%)
CAS :Produit contrôlé<p>Applications A cyclosporine metabolite specifically inhibits growth of renal cells in culture.<br>References Schultz, J.C.; et al.: Biochem. Pharma., 42, 1403 (1991), Johnson, B., et al.: Drug Metab. Dispos., 34, 556 (2006), Westley, I.S., Drug Metab. Dispos., 36, 46 (2008).<br></p>Formule :C62H111N11O13Degré de pureté :>80%Couleur et forme :NeatMasse moléculaire :1218.61Diclofenac-d4
CAS :Produit contrôlé<p>Applications Labelled Diclofenac is a known nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kenny, J. R., et al.: J. Med. Chem., 47, 2816 (2004)<br></p>Formule :C142H4H7Cl2NO2Couleur et forme :White To Light PinkMasse moléculaire :300.17
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