Sels et Dérivés d’API
Les sels des Ingrédients Pharmaceutiques Actifs (API) sont des composés formés par la réaction d’un acide avec une base, aboutissant à un équilibre ionique. Ces sels améliorent souvent la solubilité et la stabilité des API, facilitant ainsi leur absorption par l’organisme. Les dérivés des API sont des variantes chimiques d’un principe actif qui peuvent présenter des propriétés améliorées ou modifiées afin d’optimiser leur efficacité thérapeutique. Les sels d’API sont utilisés dans la formulation de médicaments oraux, injectables et topiques. De plus, les dérivés d’API peuvent améliorer la pharmacocinétique des médicaments, notamment en permettant une libération contrôlée des substances actives.
Chez CymitQuimica, nous proposons des sels et dérivés d’API avec la pureté et la qualité requises pour la recherche et le développement de formulations pharmaceutiques.
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(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane Hydrochloride
CAS :Produit contrôléFormule :C12H17NO2·ClHCouleur et forme :NeatMasse moléculaire :243.73Disalicylimide
CAS :<p>Applications Disalicylimide is an impurity of Deferasirox (D228650), an orally active tridentate iron chelator.<br>References Hershko, C., et al.: Blood, 97, 1115 (2001), Galanello, R., et al.: J. Clin. Pharmacol., 43, 565 (2003), Nick, H., et al.: Curr. Med. Chem., 10, 1065 (2003),<br></p>Formule :C14H11NO4Couleur et forme :NeatMasse moléculaire :257.25Deferasirox Ethyl Ester
CAS :Produit contrôlé<p>Applications Deferasirox Ethyl Ester is a derivative of Deferasirox (D228650); an orally active tridentate iron chelator.<br>References Hershko, C., et al.: Blood, 97, 1115 (2001); Galanello, R., et al.: J. Clin. Pharmacol., 43, 565 (2003); Nick, H., et al.: Curr. Med. Chem., 10, 1065 (2003)<br></p>Formule :C23H19N3O4Couleur et forme :White To Light YellowMasse moléculaire :401.41Dehydro Ivabradine
CAS :Produit contrôléFormule :C27H34N2O5Couleur et forme :Light Yellow To Dark BrownMasse moléculaire :466.57FK-506 3’-Methyl Ether
CAS :Produit contrôlé<p>Applications It is a fermentation process impurity. It is formed during Tacrolimus ((F370000) fermentation using Strain of Streptomyces Tsukubaensis.<br></p>Formule :C45H71NO12Couleur et forme :NeatMasse moléculaire :818.044-[4-[(5S)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone Hydrochloride
CAS :Produit contrôléFormule :C14H17N3O4·ClHCouleur et forme :NeatMasse moléculaire :327.763”-O-Demethyl Ivermectin
CAS :<p>Applications 3”-O-Demethyl Ivermectin is an impurity of Ivermectin (I940800), an antiparasitic drug that is active against a wide variety of nematode and arthropod parasites and is used to treat scabies and lice in humans. An invitro inhibitor of SARS-CoV-2/ Covid-19.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Campbell, W., et al.: Science, 221, 823 (1983); Glaziou, P., et al.: Trop. Med. Parasitol., 45, 253 (1994); Meinking, T., et al.: New Engl. J. Med., 333, 26 (1995); Caly, L., et al.: Antivir. Res., 178<br></p>Formule :C47H72O14Couleur et forme :NeatMasse moléculaire :861.072-Chloro-N-(2,6-dichlorophenyl)-N-phenylacetamide
CAS :Produit contrôlé<p>Impurity Diclofenac Impurity<br>Applications 2-Chloro-N-(2,6-dichlorophenyl)-N-phenylacetamide is used as a reactant in the preparation of 1-(2,6-dichlorophenyl)-3-methylene-1,3-dihydro-indol-2-one derivatives with in vitro cytotoxic activity on SW620 colon cancer cell lines.<br>References Virsodia, V., et. al.: Eur. J. Med. Chem., 44, 1355 (2009)<br></p>Formule :C14H10Cl3NOCouleur et forme :WhiteMasse moléculaire :314.59Argatroban Ethyl Ester
Produit contrôléFormule :C25H40N6O5SCouleur et forme :NeatMasse moléculaire :536.687Bimatoprost 13,14-Epoxide
<p>Applications Bimatoprost 13,14-Epoxide is the impurity of Bimatoprost (B386800), which is an antiglaucoma agent. Bimatoprost is an synthetic prostamide; structurally related to prostaglandin F2α.<br>References Brandt, J.D., et al.: Ophthalmology, 108, 1023 (2001), Woodward, D.F., et al.: J. Pharmacol. Exp. Ther., 305, 772 (2003), Quinones, R., et al.: J. Ocul. Pharmacol. Ther., 20, 115 (2004)<br></p>Formule :C25H37NO5Couleur et forme :ColourlessMasse moléculaire :431.56(E/Z)-3-[(2-Cyano-3-ethoxy-3-oxo-1-propenyl)amino]-1H-Pyrazole-4-carboxylic Acid Ethyl Ester
CAS :<p>Applications Impurity of Allopurinol (A547300), an xanthine oxidase inhibitor used in treatment of hyperuricemia and chronic gout. Antiurolithic.<br>References Benezra, S.A., et al.: Anal. Profiles Drug Subs., 7, 1, (1978), Dalbeth, N., et al.: Rheumatology, 44, 1090 (2005), Dinarello, C., et al.: J. Exp. Med., 201, 1355 (2005),<br></p>Formule :C12H14N4O4Couleur et forme :NeatMasse moléculaire :278.27(E/Z)-FK-506 26,28-Allylic Ester Rearrangement Impurity (>90%)
CAS :Formule :C44H69NO12Couleur et forme :White To Light YellowMasse moléculaire :804.02N-Desmethyl Riociguat
CAS :Produit contrôlé<p>Applications N-Desmethyl-riociguat, is a complex that is part affiliated with potent oral stimulator for the treatment of pulmonary hypertension.<br>References Mittendorf, J., et al.: ChemMedChem., 4, 853 (2009)<br></p>Formule :C19H17FN8O2Couleur et forme :NeatMasse moléculaire :408.39Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
CAS :<p>Applications Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.<br>References Vallu, V., et. al.: Anal. Chem. Indian J., 14, 339 (2014); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)<br></p>Formule :C18H20N2O3SCouleur et forme :NeatMasse moléculaire :344.43S(+)-N-(2-(2-Thienyl)ethyl)-2-chlorophenyl Glycine Methyl Ester Hydrochloride
CAS :Produit contrôlé<p>Applications S(+)-N-(2-(2-Thienyl)ethyl)-2-chlorophenyl Glycine Methyl Ester Hydrochloride is an impurity from Clopidogrel (C587250) which acts as an anti-platelet agent.<br>References Zhu, Y. et al.: ACS. Med. Chem. Lett., 4, 349 (2013); Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)<br></p>Formule :C15H16ClNO2S·ClHCouleur et forme :NeatMasse moléculaire :346.27Ivermectin B1b
CAS :Produit contrôléFormule :C47H72O14Couleur et forme :Off WhiteMasse moléculaire :861.0661-(4-Aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridinone
CAS :Produit contrôlé<p>Applications 1-(4-Aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridinone is an intermediate in the synthesis of Apixaban (A726700), A potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.<br>References Nevuluri, N. et al.: Monat. fuer Chem., 148, 1477 (2017);<br></p>Formule :C15H19N3O2Couleur et forme :NeatMasse moléculaire :273.334-Bromo Riluzole
CAS :Produit contrôlé<p>Applications 4-Bromo Riluzole is an impurity of Riluzole (R510000); a benzothiazole derivative that is used to treat amyotrophic lateral sclerosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ahamed, A., et al.: J. Pharm. Res., 3, 1028 (2010); Satyanarayana, B., et al.: ARKIVOC, no vol., 109 (2008)<br></p>Formule :C8H4BrF3N2OSCouleur et forme :NeatMasse moléculaire :313.09N-Nitroso Propafenone (2,2,3,3,3-Propyl-D5)
Produit contrôléFormule :C21D5H21N2O4Couleur et forme :NeatMasse moléculaire :375.4731,1’-Methylene Bis[Theobromine]
CAS :Produit contrôléFormule :C15H16N8O4Couleur et forme :NeatMasse moléculaire :372.344,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-Pyrazolo[3,4-c]pyridine-3-carboxylic Acid Methyl Ester
CAS :Produit contrôléFormule :C26H26N4O5Couleur et forme :NeatMasse moléculaire :474.508Ticagrelor Acetonide
CAS :<p>Stability Hygroscopic<br>Applications 2-[[(3aS,4R,6S,6aa)-4-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-6-yl]oxy]ethanol is an intermediate in the synthesis of Ticagrelor (T437700) which is an anticoagulant.<br>References Qiao, D., et al.: Preparation of anticoagulant Ticagrelor, China Patent 104592237, May 6, 2015;<br></p>Formule :C26H32F2N6O4SCouleur et forme :NeatMasse moléculaire :562.63Deferasirox Methyl Ester
CAS :Produit contrôlé<p>Applications Deferasirox Methyl Ester is a derivative of Deferasirox (D228650); an orally active tridentate iron chelator.<br>References Hershko, C., et al.: Blood, 97, 1115 (2001); Galanello, R., et al.: J. Clin. Pharmacol., 43, 565 (2003); Nick, H., et al.: Curr. Med. Chem., 10, 1065 (2003)<br></p>Formule :C22H17N3O4Couleur et forme :White To BeigeMasse moléculaire :387.39Levosimendan Cyanoacetamide Hydrazone Impurity
CAS :Produit contrôlé<p>Applications Levosimendan Cyanoacetamide Hydrazone Impurity is an impurity of Levosimendan (L378000) which is a bioactive enantiomer of racemate, Simendan. It is a positive inotropic agent with vasodilating activity and also cardiotonic.<br>References Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995); Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996)<br></p>Formule :C14H14N6O2Couleur et forme :Off-White To Dark OrangeMasse moléculaire :298.35-Desbromo, 5-Chloro Brimonidine
CAS :Produit contrôlé<p>Impurity Brimonidine EP Impurity H<br>Applications UK 14819 is a quinoxalinyl imidazolidine α2-adrenoceptor agonist and is structurally related to Brimonidine (B677520).<br>References Thaina, P., et al.: J. Auton. Pharmacol., 19, 185 (1999)<br></p>Formule :C11H10ClN5Couleur et forme :Light Yellow To YellowMasse moléculaire :247.6836N-Mesyldronedarone
CAS :Produit contrôlé<p>Applications N-Mesyldronedarone is an impurity of Dronedarone (D679445, HCl); a drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.<br>References Singh, B., et al.: J. Cardiovas. Pharmacol., 52, 300 (2008); Hoy, S., et al.: Drugs, 69, 1647 (2009); Hohnloser, S., et al.: New Eng. J. Med., 360, 668 (2009); Mahender, M., et al.: Org. Process Res. Dev., 18, 157 (2014)<br></p>Formule :C32H46N2O7S2Couleur et forme :NeatMasse moléculaire :634.854-(4-Nitrophenyl)-3-morpholinone
CAS :Produit contrôléFormule :C10H10N2O4Couleur et forme :NeatMasse moléculaire :222.209-Hydroxy Ramipril Diketopiperazine
CAS :Formule :C23H30N2O5Couleur et forme :NeatMasse moléculaire :414.49Riluzole 5-Trifluoromethoxy Isomer
CAS :Produit contrôlé<p>Stability Toxic<br>Applications Riluzole 5-Trifluoromethoxy Isomer is an impurity of Riluzole (R510000); a neuroprotective agent. Riluzole modulates glutamatergic transmission. It is a glutamate release inhibitor and an anticonvulsant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gunakkunru, A., et al.: Asian J. Chem., 19, 2843 (2007); Mizoule, J., et al.: Neuropharmacology, 24, 767 (1985); Wahl, F., et al.: Eur. J. Pharmacol., 230, 209 (1993); Bensimon, G., et al.: N. Engl. J. Med., 330, 585 (1994)<br></p>Formule :C8H5F3N2OSCouleur et forme :NeatMasse moléculaire :234.2L-(2S,3aS,7aS)-Octahydroindole-2-carboxylic Acid
CAS :Formule :C9H15NO2Couleur et forme :White To Off-WhiteMasse moléculaire :169.22AR-C133913XX
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications AR-C133913XX is an metabolte of Ticagrelor (T437700) which is the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Ticagrelor is used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004); Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007); Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>Formule :C14H22N6O4SCouleur et forme :NeatMasse moléculaire :370.43(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol
CAS :<p>Stability Hygroscopic<br>Applications (3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol was used to preapare AZD6140 as an orally active reversible P2Y12 receptor antagonist for prevention of thrombosis.<br>References Zhang, H., et al.: Bioorg. Med. Chem. Lett., 22, 3598 (2012);<br></p>Formule :C8H15NO3Couleur et forme :NeatMasse moléculaire :173.21Cyclosporin C
CAS :Produit contrôlé<p>Applications A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>Formule :C62H111N11O13Degré de pureté :>80%Couleur et forme :NeatMasse moléculaire :1218.614-(Trifluoromethyl)aniline
CAS :Produit contrôlé<p>Impurity Leflunomide EP Impurity A; Leflunomide USP Related Compound A<br>Applications 4-(Trifluoromethyl)aniline (Leflunomide EP Impurity A; Leflunomide USP Related Compound A) is a 4-Substituted aniline derivatives exert special hematotoxicity on the red blood cells and induce leukocytosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Weber, W., et al.: Pharmacol. Rev., 37, 25 (1985), Hein, D., et al.: Carcinogenesis, 14, 1633 (1993), Payton, M., et al.: Microbiology, 147, 1137 (2001), Mushtaq, A., et al.: J. Biol. Chem., 277, 12175 (2002),<br></p>Formule :C7H6F3NCouleur et forme :NeatMasse moléculaire :161.12Methyl 2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylate
CAS :Produit contrôléFormule :C17H18N2O3SCouleur et forme :NeatMasse moléculaire :330.42-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one
CAS :Produit contrôlé<p>Applications Intermediate in the production of Deferasirox.<br></p>Formule :C14H9NO3Couleur et forme :NeatMasse moléculaire :239.23Methylamine Hydrochloride
CAS :Produit contrôlé<p>Applications Methanamine Hydrochloride is used in the synthesis of betaine-homocysteine S-methyltransferase. Also used in the synthesis of novel oxazinones as polymerase inhibitors.<br>References Picha, J. et al.: Eur. J. Med. Chem., 65, 256 (2013); Gangloff, A. et al.: Bioorg. Med. Chem. Lett., 23, 4501 (2013);<br></p>Formule :CH5N·HClCouleur et forme :White To Off-WhiteMasse moléculaire :67.5185-Chloro-2-Thiophenecarboxylic Acid 4-Nitrophenyl Ester
CAS :Produit contrôléFormule :C11H6ClNO4SCouleur et forme :NeatMasse moléculaire :283.69Febuxostat n-Butyl Isomer
CAS :Produit contrôlé<p>Applications Febuxostat n-butyl Isomer is an impurity of Febuxostat (F229000) which is a xanthine oxidase/xanthine dehydrogenase inhibitor.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)<br></p>Formule :C16H16N2O3SCouleur et forme :NeatMasse moléculaire :316.375-[(1S)-1-(2-Chlorophenyl)-2-methoxy-2-oxoethyl]-6,7-dihydro-Thieno[3,2-c]pyridinium Bromide
CAS :Produit contrôléFormule :C16H15BrClNO2SCouleur et forme :NeatMasse moléculaire :400.722,5-Bis(2,2,2-trifluoroethoxy)benzoic Acid
CAS :Produit contrôlé<p>Impurity Flecainide EP Impurity D<br>Applications Flecainide Acetate Impurity D.<br>References Banitt, E., et al.: J. Med. Chem., 18, 1130 (1975),<br></p>Formule :C11H8F6O4Couleur et forme :White To Off-WhiteMasse moléculaire :318.17(1S,2S,3R,5S)-3-[[3-[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-yl]amino]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol
CAS :Produit contrôléFormule :C23H28F2N6O4SCouleur et forme :NeatMasse moléculaire :522.574-Hydrazinobenzoic Acid
CAS :Produit contrôlé<p>Applications 4-Hydrazinobenzoic Acid, is an organic building block used for the synthesis of various chemical and pharmaceutical compounds. It can be used for the synthesis of Deferasirox (D228650), an orally active tridentate iron chelator.<br>References Ying, Ch., et al.: Xiandai Yaowu Yu Linchuang, 27, 446 (2012); Galanello, R., et al.: J. Clin. Pharmacol., 43, 565 (2003), Nick, H., et al.: Curr. Med. Chem., 10, 1065 (2003);<br></p>Formule :C7H8N2O2Couleur et forme :NeatMasse moléculaire :152.15
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