Sels et Dérivés d’API
Les sels des Ingrédients Pharmaceutiques Actifs (API) sont des composés formés par la réaction d’un acide avec une base, aboutissant à un équilibre ionique. Ces sels améliorent souvent la solubilité et la stabilité des API, facilitant ainsi leur absorption par l’organisme. Les dérivés des API sont des variantes chimiques d’un principe actif qui peuvent présenter des propriétés améliorées ou modifiées afin d’optimiser leur efficacité thérapeutique. Les sels d’API sont utilisés dans la formulation de médicaments oraux, injectables et topiques. De plus, les dérivés d’API peuvent améliorer la pharmacocinétique des médicaments, notamment en permettant une libération contrôlée des substances actives.
Chez CymitQuimica, nous proposons des sels et dérivés d’API avec la pureté et la qualité requises pour la recherche et le développement de formulations pharmaceutiques.
79468 produits trouvés pour "Sels et Dérivés d’API"
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3-Hydroxypyridine
CAS :Produit contrôléFormule :C5H5NOCouleur et forme :White To Light BeigeMasse moléculaire :95.102-(2-Aminoethylamino)ethanol
CAS :Produit contrôlé<p>Applications 2-(2-Aminoethylamino)ethanol is a reagent used in the synthesis of various pharmacologically active compounds and functional groups. Its used in the synthesis of antitumor anthracene-diones and antitumor DNA intercalators. More recently used in the synthesis of ionic liquids with various thermal, dielectric and catalytic properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bair, K. et al.: J. Med. Chem., 33, 2385 (1990); Krapcho, A. et al.: J. Med. Chem., 37, 828 (1994); Karadag, A. et al.: J. Mol. Liq., 177, 369 (2013);<br></p>Formule :C4H12N2OCouleur et forme :NeatMasse moléculaire :104.15095-[[4-[3-(Aminocarbonyl)-1,4,5,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl]amino]pentanoic Acid
CAS :<p>Applications Apixaban Open chain Acid Is an open ring impurity of Apixaban (A726700). Apixaben is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.<br>References Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);<br></p>Formule :C25H27N5O5Couleur et forme :Light YellowMasse moléculaire :477.51Ticagrelor Sulfoxide (Mixture of Diastereomers)
CAS :Produit contrôlé<p>Applications Ticagrelor Sulfoxide is an impurity of ticagrelor (T437700). Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>Formule :C23H28F2N6O5SCouleur et forme :NeatMasse moléculaire :538.57Desacetyl Rifampicin Quinone
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Desacetyl Rifampicin Quinone is an impurity of Rifampicin (R508000).<br>References Wilson, W.L. et al.: J. Chrom., 144, 270 (1977);<br></p>Formule :C41H54N4O11Couleur et forme :NeatMasse moléculaire :778.892-Oxo Clopidogrel Hydrochloride(Mixture of Diastereomers)
CAS :Produit contrôlé<p>Applications The essential intermediate metabolite from which the active metabolite of Clopidogel is formed.<br>References Feliste, R., et al.: Thromb. Res., 48, 403 (1987), Savi, P., et al.: Biochem. Pharmacol., 44, 527 (1992), Herbert, J., et al.: Cardiovasc Drug. Rev., 11, 180 (1993), Sugidachi, A., et al.: B. J. Pharmacol., 132, 47 (2001)<br></p>Formule :C16H17Cl2NO3SCouleur et forme :NeatMasse moléculaire :374.28N1-Acetyl Triethylenetetramine Trihydrochloride
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications N1-Acetyl Triethylenetetramine is a monoacetylated metabolite of the selective CuII-chelator Triethylenetetramine (T776630).<br>References Murata, Y. et al.: Biomed. Res. Trace Elem., 4, 185 (1993): Lu, J. et al.: J. Clin. Pharmacol., 50, 647 (2010); Lu, J. et al.: J. Chrom. B Anal. Technol. Biomed. Life Sci., 859, 62 (2007);<br></p>Formule :C8H23Cl3N4OCouleur et forme :NeatMasse moléculaire :297.651-(3-Hydroxypropyl)theobromine
CAS :Produit contrôléFormule :C10H14N4O3Couleur et forme :White To Off-WhiteMasse moléculaire :238.243A77 1726 (E/Z) Mixture
CAS :Produit contrôlé<p>Impurity Leflunomide USP Related Compound B<br>Applications rac A77 1726 is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme’s teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective than injectable interferon beta 1a (Rebif®). Leflunomide USP Related Compound B.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kirsch, B.M., et al.: Arthritis Research and Therapy, 7, 3, R694, (2005)<br></p>Formule :C12H9F3N2O2Couleur et forme :NeatMasse moléculaire :270.211,1'-[(5E)-5-Methyl-7-oxo-5-undecene-1,11-diyl] Bis[Theobromine]
CAS :Formule :C26H34N8O5Couleur et forme :NeatMasse moléculaire :538.60(15R)-Bimatoprost Acid
CAS :Produit contrôlé<p>Applications (15R)-Bimatoprost Acid is an impurity of the antiglaucoma agent Bimatoprost (B386820). (15R)-Bimatoprost Acid is a metabolically stable analog of PGF2α (P838625) and is a potent agonist for the FP receptor.<br>References Balapure, A.K. et al.: Biochem. Pharmacol., 38, 2375 (1989); Hellberg, M.R. et al.: J. Ocular Pharmacol. Ther., 19, 97 (2003); Krishna, P.M. et al.: J. Pharm. res., 4, 2381 (2011); Resul, B., et al.: J. Med. Chem., 36, 243 (1993)<br></p>Formule :C23H32O5Couleur et forme :NeatMasse moléculaire :388.497Ethyl 2-Chloracetoacetate
CAS :<p>Applications Ethyl 2-Chloracetoacetate is used in the preparation of oxazoles and thiazoles as agonists for peroxisome proliferator-activated receptor δ. It is also used to synthesize dimethylimidazothiadiazolecarbohydrazides with anticancer activities.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sznaidman, M., et al.: Bioorg. Med. chem. Lett., 13, 1517 (2003); Terzioglu, N., et al.: Eur. J. Med. Chem., 38, 781 (2003)<br></p>Formule :C6H9ClO3Couleur et forme :NeatMasse moléculaire :164.59Ticagrelor
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>Formule :C23H28F2N6O4SCouleur et forme :WhiteMasse moléculaire :522.57Trandolapril
CAS :Produit contrôlé<p>Applications An antihypertensive. Angiotensin converting enzyme (ACE) inhibitor.<br>References Brown, N.L., et al.: Eur. J. Pharmacol., 148, 79 (1988), Kober, L., et al.: N. Engl. J. Med., 333, 1670 (1995), Malik, R.A., et al.: Lancet, 352, 1978 (1998)<br></p>Formule :C24H34N2O5Couleur et forme :NeatMasse moléculaire :430.54Ramiprilat-d5 (Mixture of Diastereomers)
CAS :Produit contrôlé<p>Applications A labelled metabolite of Ramipril (R111000).<br>References Teetz, V., et al.: Arzneim.-Forsch., 34, 1399 (1984), Ruggenenti, P., et al.: Lancet, 352, (1998), Bosch, J., et al.: Br. Med. J., 324, 1 (2002),<br></p>Formule :C212H5H23N2O5Couleur et forme :NeatMasse moléculaire :393.494-(3-Aminophenyl)-3-morpholinone
CAS :Produit contrôlé<p>Applications 4-(3-Aminophenyl)-3-morpholinone is an intermediate during the preparation of imidazothiazoles as protein kinase inhibitors for treating cancers.<br>References Bamaung, N., et al.: PCT Int. Appl. (2009), WO 2009070516 A1 20090604.<br></p>Formule :C10H12N2O2Couleur et forme :NeatMasse moléculaire :192.214Boc-L-Nitroarginine
CAS :Produit contrôlé<p>Applications Boc-L-Nitroarginine, can be used in peptide chemistry. It has been also shown to act as NO synthase inhibitor, and thus used in the study of The effects of methylene blue (MB) for treatment of sepsis induced by bowel perforation.<br>References Galili, Y. Euro. surg. Rese. vol. 29, P:390-395 (19997);<br></p>Formule :C11H21N5O6Couleur et forme :NeatMasse moléculaire :319.31Bimatoprost
CAS :<p>Stability Light Sensitive<br>Applications Bimatoprost is an antiglaucoma agent. Bimatoprost is an synthetic prostamide; structurally related to prostaglandin F2α.<br>References Brandt, J.D., et al.: Ophthalmology, 108, 1023 (2001), Woodward, D.F., et al.: J. Pharmacol. Exp. Ther., 305, 772 (2003), Quinones, R., et al.: J. Ocul. Pharmacol. Ther., 20, 115 (2004),<br></p>Formule :C25H37NO4Couleur et forme :WhiteMasse moléculaire :415.57A77 1726-d4
CAS :Produit contrôlé<p>Applications The active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function.<br>References Kirsch, B.M., et al.: Arthritis Research and Therapy, 7, 3, R694, (2005)<br></p>Formule :C122H4H5F3N2O2Couleur et forme :Off-WhiteMasse moléculaire :274.23Repaglinide-ethyl-d5
CAS :Produit contrôlé<p>Applications Deuterated Repaglinide, a non-sulfonylurea oral hypoglycemic agent which is used as an antidiabetic.<br>References Wolffenbuttel, B.H.R., et al.: Eur. J. Clin. Pharmacol., 45, 113 (1993), Ampudia-Blasco, F.J., et al.: Diabetologia, 37, 703 (1994),<br></p>Formule :C272H5H31N2O4Couleur et forme :White SolidMasse moléculaire :457.62Iomeprol
CAS :Produit contrôlé<p>Applications Diagnostic aid (radiopaque medium).<br>References Gallotti, A., et al.: Eur. J. Radiol., 18, Suppl 1 S1(1994), Morisetti, A., et al.: Eur. J. Radiol., 18, Suppl 1 S21(1994).<br></p>Formule :C17H22I3N3O8Couleur et forme :Off-WhiteMasse moléculaire :777.09Latanoprost Acid-d4(>85%)
CAS :Produit contrôlé<p>Applications Latanoprost Acid-d4 is the labeled analogue of Latanoprost Acid (L177310), a metabolite of Latanoprost. Latanoprost Acid (L177310) is a potent, selective FP prostanoid receptor agonist, a F-series Prostaglandin analog and is 200 times as potent as isopropyl ester form.<br>References Sjoquist, B., et al.: Drug Metab. Dispos., 26, 745 (1998), Watson, P., et al.: Drugs Today, 35, 449 (1999), Kashiwagi, K., et al.: Exp. Eye Res., 74, 41 (2002),<br></p>Formule :C23H30D4O5Degré de pureté :>85%Couleur et forme :ColourlessMasse moléculaire :394.545-Imino-N,4-bis(4-phenyl)-4,5-dihydro Riluzole
Produit contrôléFormule :C16H10F6N4O2SCouleur et forme :NeatMasse moléculaire :436.33Trandolapril Diketopiperazine
CAS :Produit contrôlé<p>Impurity Trandolapril EP Impurity D<br>Applications Trandolapril Diketopiperazine (Trandolapril EP Impurity D) is a metabolite of the antihypertensive Trandolapril (Ru44570) (T713500), an angiotensin-converting enzyme inhibitor.<br>References Bakshi, M., et al.: J. Pharm. Biomed. Anal., 28, 1011 (2002), Cedrowska, I., et al.: Acta Pol. Pharm., 60, 141 (2003), Singh, S., et al.: J. Pharm. Biomed. Anal., 41, 1037 (2006),<br></p>Formule :C24H32N2O4Couleur et forme :NeatMasse moléculaire :412.52Latanoprost
CAS :<p>Applications Prostaglandin analog, used to treat glaucoma and other degenerative diseases of the eye.<br>References Rhee, D.J., et al.: Clinic. Ophthalmol., 2, 313 (2008), Hernandez, M., et al.: Exp. Eye Res., 86, 798 (2008), Nagata, T., et al.: J. Pharmacol. Sci., 106, 423 (2008), Ikeda, Y., et al.: J. Ocular Pharmacol. Ther., 24, 230 (2008),<br></p>Formule :C26H40O5Couleur et forme :Light YellowMasse moléculaire :432.595-Methylisoxazole-4-carboxylic Acid
CAS :Produit contrôléFormule :C5H5NO3Couleur et forme :NeatMasse moléculaire :127.10Apixaban PG Ester-I
CAS :Produit contrôlé<p>Applications Apixaban PG Ester-I is one of the multiple constituents extracted from Biebersteinia multifida, that exhibits inhibitory activity on acetylcholinesterase.<br>References Xiang, F., et al.: Faming Zhuanli Shenqing (2019), CN 109432093 A 20190308.<br></p>Formule :C28H30N4O6Couleur et forme :NeatMasse moléculaire :518.563-((2-Chloroethyl)amino)propyl Dihydrogen Phosphate
CAS :Produit contrôlé<p>Impurity Ifosfamide EP Impurity A<br>Applications 3-((2-Chloroethyl)amino)propyl Dihydrogen Phosphate is a metabolite of Ifosfamide (I265000), which is a cytostatic drug.<br>References Gilard, V., et al.: J. Med. Chem., 42, 2542 (1999);<br></p>Formule :C5H13ClNO4PCouleur et forme :WhiteMasse moléculaire :217.59Ramipril (1 mg/mL in Methanol)
CAS :Formule :C23H32N2O5Couleur et forme :Single SolutionMasse moléculaire :416.51Diclofenac Levomenthol Ester
CAS :Produit contrôléFormule :C24H29Cl2NO2Couleur et forme :NeatMasse moléculaire :434.399RO 2433
CAS :Produit contrôlé<p>Impurity Sofosbuvir Metabolite GS331007<br>Applications RO 2433 is the deaminated metabolite of β-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine, an effective inhibitor of hepatitis C virus (HCV) replication in vitro.<br>References Asif, G., et. al.: Antimicrob. Agents Ch., 51, 2877 (2007)<br></p>Formule :C10H13FN2O5Couleur et forme :NeatMasse moléculaire :260.22Macitentan-d4
CAS :Produit contrôlé<p>Applications Macitentan-d4 is an isotopic form of Macitentan (M105005). Macitentan, is an orally active endothelin receptor antagonist used for pulmonary arterial hypertension.<br>References Emoto, N. Ensho to Men'eki, 20, 487 (2012);<br></p>Formule :C19H16D4Br2N6O4SCouleur et forme :NeatMasse moléculaire :592.31,2,3,4-Tetradehydro Argatroban
CAS :Produit contrôlé<p>Applications 1,2,3,4-Tetrahydro Argatroban is a metabolite of Argatroban (A769000); a synthetic thrombin inhibitor and antithrombotic.<br>References Abiko, Y., et al.: Thromb. Res., 24, 285 (1981); Kikumoto, R., et al.: Biochemistry, 23, 85 (1984)<br></p>Formule :C23H32N6O5SCouleur et forme :NeatMasse moléculaire :504.604-[4-[[(2R)-3-Chloro-2-hydroxypropyl]amino]phenyl]-3-morpholinone
CAS :Produit contrôlé<p>Impurity Rivaroxaban Impurity E<br>Applications 4-[4-[[(2R)-3-Chloro-2-hydroxypropyl]amino]phenyl]-3-morpholinone (Rivaroxaban Impurity E) is an impurity of Rivaroxaban (R538000), which is a antithrombotic agent and a FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Formule :C13H17ClN2O3Couleur et forme :NeatMasse moléculaire :284.74Hydroxy Brimonidine Trifluoroacetic Acid Salt
CAS :<p>Impurity Brimonidine EP Impurity G<br>Applications A possible metabolite of Brimonidine (B677520).<br></p>Formule :C11H12BrN5O·C2HF3O2Couleur et forme :NeatMasse moléculaire :424.1732Travoprost
CAS :<p>Stability Light Sensitive<br>Applications Travoprost is a selective FP prostaglandin receptor agonist used to treat glaucoma (1,2).<br>References (1) Hellberg, M.R., et al.: J. Ocul. Pharmacol. Ther., 17, 421 (2001) (2) Schuman, J.S., et al.: Am. J. Ophthalmol., 140, 242 (2005)<br></p>Formule :C26H35F3O6Couleur et forme :Colourless To BeigeMasse moléculaire :500.55
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