Acides Gras et Dérivés Lipidiques

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Simvastatin hydroxy acid methyl ester is a drug product that belongs to the group of statins. It is an impurity standard for synthetic simvastatin as well as a natural metabolite formed from simvastatin through oxidation and hydroxylation. This impurity is used in analytical and pharmacopoeia testing for simvastatin, and has been shown to inhibit the production of cholesterol by blocking the synthesis of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR).

Atorvastatin is a drug product that is metabolized to atorvastatin epoxy pyrrolooxazin tricyclic impurity. Due to the presence of this impurity, the purity of the drug product is not 100%. Atorvastatin epoxy pyrrolooxazin tricyclic impurity is a natural metabolite with CAS number 516-80-1. It has been shown to have effects on metabolism and may be involved in the development of atherosclerosis. Metabolism studies have been conducted on animals, but not humans.

3-Methylene simvastatin impurity is an impurity that is formed during the synthesis of simvastatin. It has a molecular formula of C14H24O2 and its molecular weight is 256. 3-Methylene simvastatin impurity can be synthesized by reacting acetone with hydrochloric acid in the presence of hydroxyl groups. The target product, simvastatin, can then be obtained by reacting the hydroxyl groups with chloroacetic acid and sodium methoxide.

Rosuvastatin impurity B is a hydrophilic impurity with a molecular weight of 716.8 that is found in the formulation of rosuvastatin. It is an analyte that can be detected by liquid chromatography and interacts with metformin, one of the analytes in the analysis. The calibration curve for this impurity was generated by adding ammonium formate to the mobile phase at different concentrations and measuring its interaction with rosuvastatin. The validation of this method was done by injecting samples containing known amounts of rosuvastatin impurity B and comparing the results to those obtained from the calibration curve. This method has a flow rate of 1 mL/min, which is sufficient for analyzing compounds that are eluted at low concentrations.

The Z-isomer impurity of pitavastatin is a synthetic compound that has been used as an analytical standard and pharmacopoeia reference. The Z-isomer impurity is not found in nature, but is generated by the hydrogenation of the natural product. It has been shown to be metabolized by CYP3A4 and CYP2C9 enzymes, which are the primary enzymes responsible for drug metabolism. This impurity does not have any therapeutic effect on the body, but can be used as a research and development standard for HPLC.

Demethylpiperazinyl Sildenafil Sulfonic Acid is a prodrug of sildenafil, which is an organic compound. It is used in the treatment of erectile dysfunction and pulmonary arterial hypertension. This drug is metabolized by hydrolysis to form sildenafil citrate, which then acts as an inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5). This enzyme regulates the intracellular levels of cyclic guanosine monophosphate (cGMP), which are needed for the relaxation of smooth muscles in the corpus cavernosum and pulmonary arteries. Demethylpiperazinyl Sildenafil Sulfonic Acid has been shown to have a good safety profile with no major adverse effects or interactions with other drugs.

(2E,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-Dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-2,6-dimethyl-1-naphthalenyl]-5-hydroxy-2-heptenoic acid sodium salt is a synthetic drug product. It is an impurity in a pharmaceutical API (Active Pharmaceutical Ingredient). The chemical name of the product is 7-[(1S*,2S*,6R*,8S*,8aR*)-8-(2,2-Dimethyl-1 oxobutoxy)-1, 2 6 7 8 8a 1 -hexahydro 2 6 -dimethyl 1 -naphthalenyl]-5 hydroxy 2 heptenoic acid sodium salt. It has the following CAS Number: 39

Simvastatin 4'-methyl ether is a metabolite of simvastatin. It is an impurity in the drug product and can be used as an analytical standard for HPLC. It is not a drug product or a pharmaceutical ingredient, but it can serve as an impurity standard for pharmacopoeia.

Atorvastatin is a potent inhibitor of the enzyme HMG-CoA reductase, which is responsible for the conversion of HMG-CoA to mevalonate. This inhibition reduces the production of cholesterol and other lipids in the liver. Metabolism studies have shown that atorvastatin undergoes extensive presystemic metabolism by cytochrome P450 enzymes, primarily CYP3A4 and CYP2C9. The drug is converted to inactive metabolites that are eliminated primarily through renal excretion. Atorvastatin has not been found to inhibit any of the following: cytochrome P450 1A1/2, 2C8/9, 2D6, 2E1, 3A4/5 or glucuronidases.

(S)-3''-Hydroxy pravastatin sodium salt is a drug product that is custom synthesized. It is the sodium salt of (S)-3''-hydroxypravastatin, which has been shown to be a natural product with high purity. The metabolite of (S)-3''-hydroxypravastatin sodium salt is 3'-hydroxypravastatin. This product can be used for analytical purposes as well as in pharmacopoeia, drug development, and research and development. It can also be used as an impurity standard for HPLC and GC analysis.

Atorvastatin is a synthetic drug product. It is a prodrug that is converted to its active form, atorvastatin acid, in the body. Atorvastatin is used for lowering blood cholesterol levels in people with hypercholesterolemia and reducing the risk of coronary heart disease. This drug has been shown to reduce the number of deaths from coronary heart disease by 30% after five years of use. Atorvastatin also reduces the risk of stroke and fatal or non-fatal heart attack by 20%.

(3S,5R)-Atorvastatin calcium is an analytical standard for the drug atorvastatin. It has a purity of 99.9% and is manufactured in accordance with the requirements of the pharmacopoeia. The product is available as a white crystalline powder and is soluble in water, acetone, and ethanol. (3S,5R)-Atorvastatin calcium has been used in drug development and as an impurity standard for HPLC analysis. It also serves as a metabolite to characterize the production process of atorvastatin.

3alpha-Hydroxy pravastatin sodium salt is a white to off-white crystalline powder. It is used as an analytical standard for 3alpha-hydroxypravastatin and its metabolites. The CAS number is 81093-43-8, and the molecular weight of this compound is 467.6 g/mol. This product can be custom synthesized to meet your needs.

(S)-3-Hexyl-5,6-dihydro-6-undecyl-2H-pyran-2-one is a natural metabolite that is used for the analytical standardization of HPLC. It is also used in research and development for drug development and as an impurity in pharmaceuticals. This compound has a purity of 99% and a CAS number of 130676-64-1. (S)-3-Hexyl-5,6-dihydro-6-undecyl-2H-pyran-2one is synthesized from 2,4,5,7 tetrahydrobenzofuran.

Oxo Simvastatin is a synthetic drug product that belongs to the class of statins. It is used as a research and development impurity standard in pharmacopoeia, and as a high-purity analytical standard in niche applications. Oxo Simvastatin is metabolized by cytochrome P450 enzymes to form a variety of metabolites, including simvastatin acid, which can be measured using HPLC.

(3S,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM).

Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a synthetic prostaglandin analogue of PGF2α which has the effect of oxytocic.