APIs pour la recherche et les impuretés

Applications The main phase I metabolites of Azelastine.
References Adusumalli, V., et al.: Drug Metab. Dispos, 20, 530 (1992), Mano, N., et al.: J. Pharm. Biomed. Anal., 12, 557 (1994), Baldwin, S., et al.: Xenobiotica, 25, 261 (1995), Kobayashi, K., et al.: J. Pharmacol. Exp. Ther., 280, 927 (1997),

Applications A derivative of imidazole used in the synthesis of heteroxanthine.
References Sarasin, J., et al.: Helv. Chim. Acta, 7, 713 (1924),

Applications N-Aminocarbonyl Felbamate is an impurity of Felbamate (F231000), an antiepileptic, structurally similar to meprobamate.

Applications Labelled analog of a triazinetrione anticoccidial. Coccidiostat.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Eberts, T., et al.: Clin. Chem., 25, 1440 (1979), Goodwin, M., et al.: Avian Dis., 29, 630 (1985), Sorensen, S., et al.: Clin. Chim. Acta, 264, 103 (1997), Conway, D., et al.: Poult. Sci., 280, 426 (2001),

Applications Daidzein-3',5',8-d3 is labelled Daidzein (D103500) which is an inactive analog of Genistein (Cat. #G350000). It blocks the G1 phase of the cell cycle in Swiss 3T3 cells by inhibiting casein kinase II activity.
References Jones, P., et al.: J. Biol. Chem., 274, 32008 (1999), Hassan, M., et al.: Anticancer Res., 19, 5657 (1999), Salti, G., et al.: Eur. J . Cancer, 36, 796 (2000).

Applications A metabolite of Varenicline. Metabolite M7.
References Dow, J., et al.: Drug Metab. Dispos., 22, 738 (1994), Toide, K., et al.: Biochem. Pharmacol., 67, 1269 (2004), Coe, J., et al.: J. Med. Chem., 48, 3474 (2005), Doll, R., et al.: Br. J. Cancer, 92, 426 (2005),

Applications 10,16-Dihydroxyhexadecanoic Acid is a component of cutin found in trees.
References Hernandez Velasco, Brenda L., et al.: Phytochemistry, 144, 78-86 (2017);Yang, Weili, et al.: Phytochemistry, 130, 159-169 (2016)

Applications (3R,4S,5R)-4-Hydroxy-5-[(1S)-1-hydroxy-2-methylpropyl]-3-methyl-2-pyrrolidinone-5-carboxylic Acid (cas# 145451-97-4) is a compound useful in organic synthesis.

Applications 1,2,3,7,8-Pentachloronaphthalene is a persistent organohalogenated pollutant found in the air and wastewater.
References Bordajandi, L.R., et. al.: J. Chrom. A., 1186, 312 (2008); Li, F., et. al.: J. Hazard. Mater., 280, 111 (2014); Ryu, J., et. al.: Environ. Sci. Technol., 47, 2394 (2013)

Applications 6-Hydroxymelatonin Glucuronide is a glucuronide-conjugated metabolite of Melatonin (M215000).
References Li, Chaoyue, et al.: J. of Pineal Res., 54(1), 100-106 (2013)

Applications cis-3,5-Dimethylpiperidine (cas# 14446-75-4) is a useful research chemical.

Applications Levophacetoperane Hyrochloride, is a sympathomimetic central nervous system stimulant and is commonly used to treat depression. Levophacetoperane is also a known analeptic and is strongly linked to apnea reversal in dogs after a single intravenous injection.
References Dobkin, A. B.: Anaesthesia, 15, 146 (1960); Dugal, R., et al.: J. Anal. Toxicol., 2, 101 (1978)

Applications 7-Hydroxy-2-acetylaminofluorene (cas# 363-49-5) is a compound useful in organic synthesis.
References Monteith, D.K.: Cancer Lett. (Shannon, Irel.), 64(2), 109 (1992), Mackenzie, P.I., et al.: Cancer Res., 53(7), 1529 (1993), Jin, C.J., et al.: Carcinogenesis, 14(12), 2637 (1993), Juchau, M.R., et al.: Toxicol. Appl. Pharmacol., 80(1), 137 (1993)

Applications Labelled Dabigatran (D100090). Nonpeptide, direct thrombin inhibitor. Antithrombotic.
References Hauel, N., et al.: J. Med. Chem., 45, 1757 (2002), Mungall, D., et al.: Curr. Opin. Invest. Drugs, 3, 095 (2002), Stangier, J., et al.: J. Clin. Pharmacol., 45, 555 (2005),

Applications A fluorescent trifunctional highly symmetric probe. Shows remarkably high nonlinear optical properties.
References Bollaert, V., et al.: Adv. Mater., 5, 4, 268 (1993)

Impurity Salicylic Acid Related Compound A
Applications Acetylsalicylic Acid Impurity A.
References Walter, M., et al.: Eur. J. Biochem., 1996, 239, 281 (1996), Bantignies, B., et al.: Plant Mol. Biol., 42, 871 (2000), Bais, H., et al.: J. Biol. Chem., 278, 32413 ( 2003), Finkler, C., et al.: Genetica, 124, 117 (2005),

Applications A deuterated topical corticosteroid used as an anti-inflammatory.
References Shapiro, E.L., et al.: J. Med. Chem., 30, 1581 (1987), Graft, D., et al.: J. Allergy Clin. Immunol., 98, 724 (1996)

Applications Vardenafil-d5 is a labelled selective phosphodiesterase type 5 (PDE5) inhibitor.
References Bischoff, E., et al.: J. Urol., 165, 1316 (2001), Kim, N.N., et al.: Life Sci., 69, 2249 (2001), Kendirci, M., et al.: Expert Opin. Pharmacother., 5, 923 (2004),

Stability Hygroscopic
Applications A metabolite of Daidzin, Daidzein and Puerarin.
References Griffiths, L., et al.: Biochem. J., 130, 141 (1972), Zhu, X., et al.: Acta Pharm. Sin., 14, 349 (1979), Powell, G., et al.: Drug Metab. Drug Interact., 6, 203 (1988), Bamforth, K., et al.: Eur. J. Pharmacol., 228, 15 (1992), Walle, T., et al.: Biochem. Pharmacol., 50, 731 (1995),

Applications A thiol specific spin label.
References Seelig, B., et al.: Chem. Biol., 6, 167 (1999),

Applications An labelled epilepsy drug. It has been used as co-therapy for treatment of epilepsy. It inhibits the enzymes responsible for metabolism of other anti-convulsant agents.
References Laurie, D., et al.: J. Neurosci., 12, 4151 (1992), Smith, A., et al.: J. Pharmacol. Exp. Therap., 311, 601 (2004), Trojnar, M., et al.: Pharm. Rep., 57, 154 (2005), Drafts, B., et al.: J. Pharm. Exp. Ther., 318, 1094 (2006), Picton, A., et al.: Brain Res., 1165, 40 (2007),

Applications 6β-Keto-gestodene is an impurity of Gestodene (G368250), an orally active gestogen with progesterone-like profile of activity. Used in combination with estrogen as oral contraceptive.
References Duesterberg, B., et al.: Contraception, 24, 673 (1981); Duesterberg, B., et al.: Seroids, 43, 43 (1984); Losert, W., et al.: Arzneim.-Forsch., 35, 459 (1985)

Applications Aminorex (A629200) derivative.

Applications An antiinflammatory expectorant used in the treatment of MUC5 mucin obstructive pulmonary disease.
References Takeyama, K., et al.: J. Immunol.,164, 1546 (2000), Komatsu, H., et al.: Pulm. Pharmacol. Ther., 18, 121 (2005), Rhee, C., et al.: Eur. Respir. J., 32, 1195 (2008),

Applications L-Phenylephrine (cas# 59-42-7) is a useful research chemical.

Stability Hygroscopic
Applications A labelled selective β2-adrenergic receptor agonist. Used as an antiasthmatic.A representative lot is 80% d6, 18% d5, 2% d4.
References Yoshida, T., et al.: Pharmacometrics, 26, 811 (1983), Anderson, G.P., et al.: 52, 2145 (1993), Bartow, R.A., et al.: Drugs, 55, 303 (1998)

Applications A labelled metabolite of Torsemide (T548750).
References Besenfelder, E., et al.: J. Pharm. Biomed. Anal., 5, 259 (1987), Vormfelde, S., et al.: Clin. Pharmacol. Ther., 76, 557 (2004),

Applications rac 1-Palmitoyl-2-oleoyl-3-chloropropanediol-d5 is labelled rac 1-Palmitoyl-2-oleoyl-3-chloropropanediol (P160500) which is a fatty acid ester with glycerol chlorohydrins found in a variety of vegetable oils.
References Hamlet, C., et al.: Food Addit. Contam., 19, 619 (2002); Zelinkova, Z., et al.: Eur. Food Res. Technol., 228, 571 (2009)

Impurity Cefuroxime Sodium EP Impurity E
Applications Desethyl Acetate (E)-Cefuroxime Axetil (Cefuroxime Sodium EP Impurity E) is a product from the photoisomerization of Cefuroxime Axetil (C248065), which is s widely used to treat respiratory tract infections. Antibacterial.
References Fabre, H., et. al.: J. Pharm. Sci., 83, 553 (1994); Nguyen, N., et al.: Pharm. Res., 8, 893 (1991); Stoeckel, K., et al.: Antimicrob. Agents Chemother., 42, 2602 (1998); Scott, L., et al.: Drugs, 61, 1455 (2001); Bulitta, J. B., et al.: Antimicrob. Agents Chemother., 53, 3462 (2009)

Applications 1,3-Diacetyl Aloe-emodin is an intermediate in the synthesis of Aloe Emodin 8-Glucoside which is a anthraquinone glycoside that was investigated for antioxidant activities and neuroprotective properties.
References El-Toumy, S.A., et al.: Carb. Res. 360, 47 (2012); Xiang, L., et al: TsingHua. Sci. Tech., 10, 426 (2005); Shi, Y.Q., et al: Anticancer. Res., 21, 2847 (2001);

Applications (3S,8R,9S,10R,13S,14S)-10,13-Dimethyl-17-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl heptanoate (cas# 23983-43-9) is a useful research chemical.

Applications p-Azidoacetophenone (cas# 20062-24-2) is a compound useful in organic synthesis.
References Zarghi, A., et al.: Bioorg. Med. Chem., 14, 7044 (2006), Cline, M., et al.: Biochem., 46, 1981 (2007),

Applications iMeloxicam- 13CD3 is an isotopic labeled form of Meloxicam(M216100). Meloxicam is a preferential cyclooxygenase (COX-2) inhibitor. Sudoxicam and Meloxicam are nonsteroidal anti-inflammatory drugs (NSAIDs) from the enol-carboxamide class.
References Hawkey, C., et al.: Br. J. Rheumatol., 35, Suppl. 1, 1 (1996), Fleischmann, R., et al.: Expert Opin. Pharmacother., 3, 1501 (2002),

Applications α-Oxo-2-furanacetic Acid is an α-ketocarboxylic acid with inhibitory activity against protein tyrosine phosphatases.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chen, Y.T. et al.: Bioorg. Med. Chem., 11, 1935 (2001);

Applications 4-{[4-(4-Methyloxy-phenyl)-piperazin-1-yl]-phenyl}-carbamic Acid Phenyl Ester (cas# 74853-06-8) is a compound useful in organic synthesis.

Impurity Beclomethasone Dipropionate EP Impurity F
Applications 6α-Bromo Beclomethasone Dipropionate (Beclomethasone Dipropionate EP Impurity F) is an impurity of Beclomethasone Dipropionate (B131030).

Applications Indacaterol is a β-adrenoreceptor agonists for treatment of asthma and bronchodilator treatment for patients with chronic obstructive pulmonary diseases.
References Crisafulli, E., et al.; Expert Opinion Pharmacother., 18, 1499 (2017); Aparici, M., et al.: Pul. Pharmacol. Ther., 46, 1 (2017); Demin, I., et al.: Int. J. Clin. Pharmacol. Ther., 54, 405 (2016)

Applications Labelled 2-Oleoylglycerol (O528020). A metabolite of 2-acylglycerol used as biomarker.
References Owen, M., et al.: Biochem. J., 323, 17 (1997), Waterman, I., et al.: J. Lipid Res., 43, 1555 (2002), Chon, S., et al.: J. Biol. Chem., 282, 33346 (2007),

Applications A B-Adrenergic receptor agonist. A Bronchodilator.
References Akhtar, S., et al.: J. Vet. Pharmacol. Ther., 21, 388 (1998), Kasprowicz, D.J., et al.: J. Immunol., 165, 680 (2000)

Applications 4-Methoxy-3-nitrobenzonitrile

Stability Hygroscopic
Applications Used in the synthesis of cyanogen glycoside. A component of antiperspirants, deodorants, body soaps, shampoos, hair rinses, and hair; it inhibits volatile steroid formation by resident bacteria.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Marouf, A., et al.: Pharm. Biol., 39, 263 (2001), Fukuda, T., et al.: Biol. Pharm. Bull., 26, 271 (2003), Butler, M., et al.: J. Nat. Prod., 67, 2141 (2004), He, J., et al.: J. Nat. Prod., 69, 121 (2006),

Stability Hygroscopic
Applications A metabolite of Azelastine (A808250).
References Heinemann, U. et al.: J. Chrom. B Anal. Tech. Biomed. Life Sci., 793, 389 (2003); Tasaka, K., et al.: Arzneim.-Forsch., 29, 488 (1979);

Applications A derivative of Danazol (D145000).
References Manson, A.J., et al.: J. Med. Chem., 6, 1 (1963), Jordan, V.C., et al.: Endocrinology, 124, 1717 (1989),

Stability Hygroscopic
Applications A semi-synthetic analogue of Carminomycin with cytostatic activity.
References Mossman, T., et al.: J. Immunol. Methods, 65, 55 (1983), Janicke, R.U., et al.: J. Biol. Pharm., 273, 9357 (1998), Sidorova, T.A., et al.: J. Med. Chem., 21, 5330 (2002),

Applications A metabolite of Tamoxifen (T006000).
References Clarke, R., et al.: Pharmacol. Rev., 53, 25, (2001), Rae, J.M., et al.: Drug Metab. Dispos., 30, 525 (2002), Coller, J.K., et al.: Br. J. Clin. Pharmacol., 57, 105 (2004)

Applications A fat-metabolism stimulator.
References Plotzker, R., et al.: Am. J. Med. Sci., 283, 79 (1982),

Applications Azilsartan Amidoxime is an intermediate used in the preparation of azilsartan kamedoxomil for use as an angiotensin II receptor blocker. Azilsartan Impurity.
References Garaga, S., et al.: Org. Process Res. Dev., 19, 514 (2015); Sethi, M. K., et al.: Pharma Chemica, 7, 20 (2015)

Stability Hygroscopic
Applications Disodium salt of Taurolithocholic Acid Sulfate, a metabolite of bile acids. Sulfation is a major metabolic pathway involved in the elimination and detoxification of bile acids (BAs).
References Kawamata, Y., et al.: J. Biol. Chem., 278, 9435 (2003); Alnouti, Y., et al.: Toxicol. Sci., 108, 225 (2009); Griffiths, W., et al.: J. Lipid Res., 51, 23 (2010); Huang, J., et al.: Xenobiotica, 2010, 40, 184 (2010);

Applications Labelled Nitisinone. Nitisinone is a herbicidal triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. It is used in treatment of inherited tyrosinemia type I.
References Lindstedt, S., et al.: Lancet, 340, 813 (1992), Ellis, M.K., et al.: Toxicol. Appl. Pharmacol., 133, 12 (1995), Lock, E.A., et al.: J. Inherited Metab. Dis., 21, 498 (1998),

Applications The isotopically labelled drug Sulfadiazine. Antibacterial.
References Bohni, et al.: Chemotherapy, 14, 195 (1969), Carr, et al.: Antimicrob. Agents Chemother., 4, 585 (1973), Stober, H., et al.: Anal. Profiles Drug Subs., 11, 523 (1982),

Applications (1S,2S,5S)-4-[2-[2-(6,6-Dimethylbicyclo[3.1.1]hept-2-yl)ethoxy]ethyl]morpholine, is used for the synthesis of Pinaverium Bromide (P465000), a drug used for functional gastrointestinal disorders.
References Gan, Y., et al.: Shenyang Yaoke Daxue Xuebao, 25, 370 (2008); He, L., et al.: Huaxue Yanjiu Yu Yingyong, 20, 600 (2008);

Applications Antipsychotic used in the treatment of schizophrenia.
References Nourian, Z., et al.: Eur. J. Pharmacol., 596, 32 (2008), Karczewski, J., et al.: Biochem. Pharmacol., 77, 1602 (2009), Isoherranen, N., et al.: Chem. Res. Toxicol., 22, 294 (2009), Goetghebeur, P., et al.: Psychopharmacol., 202, 287 (2009),

Applications Xipamide intermediate.
References Smirnov, V., et al.: Pharm. Chem. J., 34, 198 (2000),

Applications Albendazole-d3 (methoxy-d3) is deuterium labelled Albendazole (A511610), which is an anthelmintic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Zhao, Y., et al.: Org. Biomol. Chem., 6, 4509 (2008), Sanderson, H., et al.: Toxicol. Lett., 187, 84 (2009),

Stability Air Sensitive, Light Sensitive, Temperature Sensitive
Applications A protein kinase C inhibitor.
References Marki, H.P., et al.: Helv. Chimica Acta, 71, 320 (1988), Iwagami, H., et al.: Bull. chem. Soc. Jpn., 63, 3073 (1990), Funahashi, T., et al.: J. Bacteriol., 184, 936 (2002),

Applications Suvorexant-d6 is the labeled analog of Suvorexant (S870000), a dual (non-selective) orexin receptor antagonist in development by Merck & Co. for the treatment of insomnia. It works by turning off wakefulness rather than by inducing sleep. Users of higher doses had an increased rate of suicidal ideation.
References Cox, C., et al.: J. Med. Chem., 53, 5320 (2010); Baxter, C., et al.: Org. Process Res. Dev., 15, 367 (2011); Winrow, C., et al.: J. Neurogenet., 25, 52 (2011); Mieda, M., et al.: CNS Drugs, 27, 83 (2013); Osborne, R.: Nat. Rev. Drug Discov., 12, 492 (2013)

Applications rac-1, 2-Didecanoyl-3-chloropropanediol belongs to a group of 3-Chloropropanediol fatty acid esters, which are contaminants found in edible oils and other food sources.
References Z. Zelinková, et al.: Food Addi. & Conta., 23:12, 1290-1298 (2006)

Applications Antibacterial.
References Bourguignon, G.J., et al.: Antimicrob. Agents Chemother., 4, 479 (1973), Grubb, P.E., et al.: Anal. Profiles Drug Subs., 8, 371 (1979), Wright, H.T., et al.: Science, 213, 455 (1981),

Applications Calycosin is a known antioxidant that prevent redox imbalance in organisms. Also, it possesses anti-tumor, anti-inflammation and osteogenic properties; Useful as a therapeutic reagent for bone loss-associated diseases.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lu, L., et al.: J. Biosci. Bioeng., 124, 1-7 (2017); Quan, G., et al.: Int. J. Mol. Sci., 16, 29496-29507 (2015)