APIs pour la recherche et les impuretés

Applications Estradiol derivative used in the preparation of alkylated estratrienes.

Applications Protected Enalapril (E555250), an antihypertensive and an angiotensin-converting enzyme (ACE) inhibitor.
References Iwasaki, G. et a.: Chem. Pharm. Bull., 37, 280, 1989; Miyake, A. et al.: Chem. Pharm. Bull., 34, 2852 (1986)

Applications Intermediate in the preparation of prostaglandin derivatives

Applications (2S,3S)-3-Hydroxy-2-methyl-butanoic Acid Methyl Ester is an intermediate in the synthesis of (+)-Echimidine N-Oxide, which is a a hepatotoxic pyrrolizidine alkaloid. Different extracts and echimidine-N-oxide from Symphytum sylvaticum Boiss. Subsp. sepulcrale, has been shown to have Antifungal activity.
References Kartal, M., et al.: Turkish, J. Med. Sci., 31, 487 (2001); Cao, Y., J. Food Comp. Anal., 29, 106 (2013);

Applications A reactant used in the preparation of specific transporter for iron(III)-phytosiderophore complex involved in iron uptake by barley roots.
References Murata, Y. et al.: Pure App. Chem., 80, 2689 (2008)

Applications N-(3-Nitro[1,1'-biphenyl]-4-yl)carbamic Acid tert-Butyl Ester is a reactant used in the optimization of selective HDAC1/HDAC2 inhibitor and preparation of selective HDAC inhibitors.
References Stolfa, D. et al.: ChemMedChem., 7, 1256 (2012); Witter, D. et al.: Bioorg. Med. Chem. Lett., 18, 726 (2008)

Applications Oxazolidinone derivative, as factor Xa inhibitor.

Applications Quinoline derivative used in the preparation of compounds with anticonvulsant activity as well as compounds with potent antibacterial activity against gram-positive pathogens.
References Guo, L. et al.: Eur. J. Med. Chem., 44, 954 (2009); Jarvest, R.L. et al.: J. Med. Chem., 45, 1959 (2002);

Applications Iso Sildenafil (I900800) derivative. Intermediate in the preparation of Iso Sildenafil and Iso Viagra.
References El-Abadelah, M. et al.; J. Heterocyclic Chem. 39, 1055 (2002)

Applications Intermediate in the synthesis of a labelled metabolite of Propranolol (P831800).

Applications An intermediate in the production of Irbesartan metabolites
References Perrier, L., et al.: J. Pharmacol. Exp. Ther., 271, 91 (1994), Wexler, R., et al.: J. Med. Chem., 39, 625 (1996),

Applications A labelled metabolite of Milnacipran.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bonnaud, B., et al.: J. Med. Chem., 30, 318 (1987), Kazuta, Y., et al.: Bioorg. Med. Chem., 10, 3829 (2002), Iversen, L., et al.: Br. J. Pharmacol., 147, S82 (2006),

Applications Precursor to chelating agents.

Stability Hygroscopic
Applications Desfluoroprasugrel is a defluorinated impurity of the antiplatelet agent, Prasugrel (P701150).

Applications Synthetic intermediate of Ranitidine.

Stability Hygroscopic
Applications A labeled metabolite of Omeprazole, an antiulcerative.
References Andersson, T., et al.: Ther. Drug Monit., 12, 415 (1990), de Morais, S., et al.: J. Biol. Chem., 269, 15419 (1994), Tanigawara, Y., et al.: Clin. Pharmacol. Ther., 66, 528 (1999), Abelo, A., et al.: Drug Metab. Disos., 28, 966 (2000),

Applications 1-[5-Chloro-2-(2,4-dichlorophenoxy)phenylethanone]-d3 (cas# 1189886-69-8) is a compound useful in organic synthesis.

Applications 4-Chloro-3-methyl-2,2-diphenylbutyronitrile, is an intermediate in the synthesis of rac-Moramide (M630200).

Applications A labelled protected form of a diastereomer of Benazepril.

Applications Loratadine-d4 Epoxide N-Oxide (cas# 1794754-14-5) is a compound useful in organic synthesis.

Applications 5’-(tert-Butyldimethylsilyloxy)methyl 5’-Desmethyl Meloxicam (cas# 1076199-65-9) is a compound useful in organic synthesis.

Applications 1,2-Dimethoxy-4-fluorobenzene

Applications Intermediate for the preparation of Isotope Labelled Tolmetin.

Applications N-Cyano-N',S-dimethylisothiourea, is a building block used in various chemical synthesis.

Applications Cotinine derivative. Carcinogen.

Applications Curcumin (C838500) derivative. Selective inhibitor of DNA polymerase λ.
References Takeuchi, T. et al.; Genes Cells 11, 223 (2006)

Applications 2-Fluoro-4-(3-trifluoromethyl)-3H-diazirin-3-ylbenzyl Benzoate (cas# 1391052-78-0) is a compound useful in organic synthesis.

Applications Can be used in the preparation of CCR5 antagonists, for treatment of HIV-1.
References Tallant, M. et al., Bioorg. Med. Chem. 21, 1394 (2011)

Applications 10,11-Dihydrobenz[a]anthracene is an intermediate in the synthesis of phenols of Benz[a]anthracene (B183560).
References Fu, P.P.,e t al.: J. Org. Chem, 44, 4265 (1979)

Applications A reactant used in the synthesis of natural polyhydroxystilbenes.
References Cardona, M. et al.: Tetrahedron, 42, 2725 (1986)

Applications 6,7-Dibromo-2-naphthalenecarbonitrile is an intermediate in the synthesis of potent and orally active small molecule PTP1B inhibitors.
References Han, Y.X., et al.: Bioorg. Med. Chem. Lett., 18, 3200 (2008);

Applications A useful synthetic intermediate. used in the synthesis of (+)-[(8,8-Dichlorocamphoryl)sulfonyl]oxaziridine (D433990).

Applications Protected, labelled Lisinopril (L468985).

Stability Hygroscopic
Applications A useful compound for making immunogens for the production of antibodies to nicotine.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Langone, J.J., et al.: Methods in Enz., 84, 629 (1982), Obach, R.S., et al.: Drug Metab. Disposition, 19, 289 (1991),

Applications Useful as inhibitor of both farnesyl protein transferase and geranylgeranyl protein transferase in the treatment of cell-proliferative diseases.
References Villani, et al.: J. Med. Chem., 15, 750 (1972),

Applications 2-[4-(1,3,4-Oxadiazol-2-yl)phenoxy]acetonitrile is an intermediate in the synthesis of potential class II human histone deacetylase inhibitors.

Applications N’-[2-[[[2-[(Dimethylamino)methyl]-4-thiazolyl]methyl]thio]ethyl] Nizatidine is an impurity of the histamine H2-receptor antagonist Nizatidine (N598500).

Applications An isotope Labelled intermediate for the synthesis of Bisoprolol.
References Brodde, O., et al.: J. Cardiovasc Pharmacol., 8, S29 (1986) , Booze, R., et al.: J. Pharm. Exp. Ther., 249, 911 (1989) , Dutta, A., et al.: J. Clin. Pharmacol., 34, 829 (1994) , Doze, P., et al.: Eur. J. Pharmacol., 24, 215(1998)

Applications N-(4-Chloro-2-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine is an intermediate in the synthesis of 5-((2-((2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino)pyrimidin-4-yl)amino)-2-methylbenzenesulfonamide Hydrochloride (D474433) which is an impurity of Pazopanib (P210925), which is an oral angiogenesis inhibitor targeting VEGFR and PDGFR.
References Olaussen, K., et al.: Oncogen., 28, 4249 (2009), Sleijfer, S., et al.: J. Clin. Oncol., 27, 3126 (2009), Chan, A., et al.: Drugs, 69, 167 (2009),

Applications Intermediate in the synthesis of Lumiflavin (L473900).

Applications Intermediate in the production of Ramelteon.

Applications Phinothricin metabolite.
References Komossa, D. et al.: Pestic. Biochem. Phys. 43, 95 (1992)

Applications An intermediate for the synthesis of labelled thiazolidinedione anti-diabetic drugs
References Cantello, B., et al.: Bioorg. Med. Chem. Lett., 4, 1181 (1994),

Applications Intermediate in the preparation of (arylamino)phenylacetic acids as COX-2 cyclooxygenase inhibitors.

Applications (4Z,6E)-4,6-Octadienoic Acid Ethyl Ester is an intermediate in the synthesis of Spilanthol (S681850), a fatty acid amide isolated from Acmella oleracea.
References Khadir, H., et al.: Pestic. Sci., 25, 329 (1989); Cech, N., et al.: Planta Med., 72, 1372 (2006); Saritha, K., et al.: Biol. Plant, 52, 334 (2008),

Applications N-Benzy N,N-Didesmethyl Trimebutine is an intermediate in the preparation of Trimebutine (T795605) metabolites as potential opioid receptor agonist.

Stability Very Hygroscopic
Applications The labelled N-oxide of the local anesthetic Bupivacaine (B689546).

Applications N-(3-Acetylthio-2-methylpropanoyl)glycine tert-Butyl Ester-d5 (cas# 1190018-72-4) is a compound useful in organic synthesis.

Applications Used in the preparation of amino steroids useful in the treatment of neurological disorders.

Applications 3-(Acetyloxy)octanedioic Acid is an intermediate in the synthesis of 3-Hydroxysuberic Acid (H953795). 3-Hydroxysuberic Acid is a derivative of sebacic acid (S211410) a urinary metabolite that has been identified as an anti-fatigue biomarker.
References Ma, C. et. al.: J. Pharmaceut. Biomed. Anal. 105, 84 (2015)

Applications Intermediate in the preparation of antiinflammatory agents.

Applications (2S)-3-Azido-2-hydroxy-2-methyl-propanoic Acid Methyl Ester (cas# 549504-45-2) is a compound useful in organic synthesis.

Applications 4-Fluorobenzamide-D4 is an intermediate in the synthesis of Flurofamide-d4 (F596687), which is an isotope labelled Fluorofamide acts as a urease inhibitor, useful in the treatemtnt of gastritis and irregular urease activity in the urinary tract.
References Loes, A. et al.: Lett. App. Microbiol., 58, 31 (2014); Ohta, T.et al.: Biochem. Biophys, Res. Comm., 285, 728 (2001);

Applications Intermediate for the synthesis of labelled Lercanidipine HCl

Applications Levofloxacin (L360000) derivative.

Applications An intermediate in the preparation of 5-(2,3-Dichloro-4,6-dibromophenyl)-1,2,3,4,7,7-hexachloro-2-norbornene (D434130).

Applications Deshydroxyethoxy-2,3-O-(dimethylmethylene) Ticagrelor is a precursor for the synthesis of Ticagrelor (T437700), an antiplatelet agent.
References Zhang, H. et. al.: Bioorg. Med. Chem. Lett., 22, 3598(2012)

Applications Intermediate in the preparation of Reversan (R279800), a new class of nontoxic MRP1 inhibitor.

Applications 2-Methyl-5-nitrobenzophenone (cas# 39272-00-9) is a compound useful in organic synthesis.

Applications D-Digitoxose (D445990) derivative. A derivative of D-ribo-Hexonic acid that is metabolized in the liver. It inhibits glucose-stimulated insulin release.
References Domschke, W. et al.: Naun.-Schmied. Arch. Pharmacol., 265, 149 (1969); Brown, D.F. et al.: Experientia, 39, 979 (1983); Hussain, M. et al.: Biochem. Biophys. Res. Comm., 129, 358 (1985); Binkley, R.W. & Schneider, J.S., J. Carbohyd. Chem., 7, 157 (1988)

Applications A derivative of Atorvastatin.

Applications Valacyclovir (V085000) impurity

Applications 3-Carboxy Detomidine Methyl Ester is an intermediate used in the preparation of 3-Carboxy Detomidine (C177915), a major metabolite of the drug Detomidine.
References Cardin, C. et al.: J. Chem. Res., 12, 389 (1992)

Applications Intermediate in the preparation of Ertapenem (E635000).

Applications Amikacin is an antibacterial compound used in the treatment of diseases and illnesses arising from gram-negative bacterium. Antituberculosis agent.
References Villegas, M. et al.: Antimicrob. Agents Chemother., 51, 1553 (2007); Boshoff, H. et al.: J. Biol. CHem., 279, 40174 (2004);

Applications 9,14-Deepoxy-15-deoxo-14-deoxy-9,15-epoxy-15-hydroxy-14-oxorapamycin can be prepared as an immunosuppressant.
References Hughes, P.F.: U.S. 4 pp. Patent 1993 CODEN:USXXAM

Applications Intermediate in the preparation of Carvedilol derivatives.
References Mewshaw, R., et al.: J. Med. Chem., 47, 3823 (2004),

Applications: D-(-)-Pseudoephedrine, is an enantiomer of (+)-Pseudoephedrine Hydrochloride (P839350), a non-selective adrenergic agonist, used as nasal decongestant.Controlled precursor.
References Fairchild, M.D., et al.: J. Pharmacol. Exp. Ther., 158, 135 (1967); Hughes, D.T.D., et al.: J. Clin. Hosp. Pharm., 8, 315 (1983); Gurley, B.J., et al.: J. Pharm. Sci., 87, 1547 (1998);

Applications Protected 5-Fluorouracil N-β-D-Glucuronide (F596010), a derivative of 5-Fluorouracil (F596010). 5-Fluorouracil N-β-D-Glucuronide unlike its O-glucuronide analog does not possess significant antitumor activity.
References Baba, T. et al.: Gann, 69, 283 (1978); Kaneko, M. et al.: Nucleic Acid Res., 3, 35 (1977);

Applications 4-(Dimethylamino)benzoic Acid 6-Acetyl-2,3-dimethoxyphenyl Ester is a reactant used in the preparation of 7,8-Dihydroxyflavone (D452830) derivatives which promote neurogenesis and exhibits potent antidepressant effect.
References Liu, X. et al.: J. Med. Chem., 53, 8274 (2010)

Applications An intermediate for the synthesis of Atazanavir-d5 and the preparation of some peptide analogs.
References Martin, J., et al.: Prog. Med. Chem., 32, 239 (1995), Jadhav, P., et al.: J. Med. Chem., 40, 181 (1997), Bold, G., et al.: J. Med. Chem., 41, 3387 (1998).

Applications Guanosine (G837900) derivative. Used as chemical probes in protein S-guanylation by endogenous nitrated nucleosides.
References Saito, Y. et al.: Chem. Commun., 45, 5984 (2008)

Applications Quinoline derivative used in the preparation of compounds with anticonvulsant activity as well as compounds with potent antibacterial activity against gram-positive pathogens.
References Guo, L. et al.: Eur. J. Med. Chem., 44, 954 (2009); Jarvest, R.L. et al.: J. Med. Chem., 45, 1959 (2002);

Applications 2-Acetamido-6-chloro-9-(2’,3’,5’-tri-O-acetyl-β-D-ribofuranosyl)purine (cas# 137896-02-7) is a compound useful in organic synthesis.
References Matsuda, A., et al.: J. Med. Chem., 35, 241 (1992),

Applications N,4-Diacetyl-L-phenylalanine Ethyl Ester is an analogue of the essential amino acid L-phenylaniline (P319415). N,4-Diacetyl-L-phenylalanine Ethyl Ester was incorporated into an artificial extracellular matrix protein within a bacterial expression host to understand the conjugation process in order to suppress nonspecific adhesion of human umbilical vein endothelial cells.
References Takasu, A., et al.: Biomacromolecules., 12, 3444 (2011);

Applications A synthetic, nonsteroidal estrogen derivative.
References White, W. A. et. al.: J. Agric. Food Chem. 19(2), 388-390 (1971).