APIs pour la recherche et les impuretés

Applications N,N-Dimethyltryptamine intermediate.

Applications 3-Chloro-4-nitrophenol was used as a reactant in the synthetic preparation of highly potent BTK and JAK3 dual inhibitors and it may also have antifungal activity.
References Ge, Yang, et al.: Euro. J. of Med. Chem., 143, 1847-1857 (2018); Gershon, H., et al.: Monatshefte fuer Chemie, 126(10), 1161-6  (1995)

Applications L-Iditol Hexaacetate (cas# 13443-46-4) is a compound useful in organic synthesis.

Applications 1,2-Dinitro-4,5-methylenedioxybenzene (cas# 7748-59-6) is a compound useful in organic synthesis.
References Kajihara, Y., et al.: Carb. Res., 331, 455 (2001)

Applications N2'-​Deacetyl-​N2'-​[3-​[(1-​ethyl-​2,​5-​dioxo-​3-​pyrrolidinyl)​thio]​-​1-​oxopropyl]​-maytansine is a derivative of Mertansine (M257800) which is a cytotoxic agent. It is used as the cytotoxic component in antibody-drug conjugates.
References Erickson, H., et al.: Cancer Res., 66, 4426 (2006); Kellogg, B., et al.: Bioconjugate Chem., 22, 717 (2011)

Applications 3-Chloro-6-(chloromethyl)benzene-1,2,4,5-d4 is an isotope-labeled analog of 4-Chlorobenzyl Chloride (C364730), which is a benzylchloride derivative used in the preparation of various biologically active compounds such as bronchodilators and antibacterial agents.
References Adams, M. et al.: Synth. Comm., 29, 2419 (1999); Foroumadi, A. et al.: Arch. Pharm. Res., 30, 138 (2007);

Applications 4-(3,5-Dicarboxyphenyl)phenol

Applications 3,4-Dihydro-3,3-dimethylisoquinoline can be used as reagent/reactant in synthetic preparation and reactivity of hydroisoquinoline-derived oxaziridines.
References Kammoun, M., et al.: Synthetic Commun., 41, 1520-1528 (2011)

Applications A spin label.
References Berliner, L.J., et al.: Analytical Biochemistry, 119, 450 (1982)

Applications 2-Phenyl-d5-propane (CAS# 97095-85-7) is a useful isotopically labeled research compound.

Applications 4-Acetylthiobutyronitrile (cas# 4781-82-2) is a compound useful in organic synthesis.

Applications N-Methyl-N-(3R,4R)-1-cyanoacetyl-4-methylpiperidin-3-yl-2-chloro-7-deazapurine-6-amine is a Tasocitinib (Tofacitinib [T528000]) impurity.

Applications A bioreductive anticancer agent. Selectively toxic to cells under hypoxic conditions. An antineoplastic.
References Brown, J.M.: Brit. J. Cancer, 67, 1163 (1993), Johnson, C.A., et al.: J. Clin. Oncol., 15, 773 (1997)

Applications 1-Ethylpyrrole (cas# 617-92-5) is a useful research chemical.

Applications An intermediate for the synthesis of Labelled Ketoprofen.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Derewenda, Z., et al.: J. Mol. Biol., 227, 818 (1992), Grochulski, P., et al.: J. Biol. Chem., 268, 12843 (1993).

Stability Hygroscopic
Applications The hydrochloride salt of AZ 5104 (A795170), which is a derivative of AZD 9291 (A808075) and a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC).
References Finlay, M.R.V., et al.: J. Med. Chem., 57, 8249 (2014);

Applications (2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetic acid (cas# 4113-97-7) is a useful research chemical.

Stability Hygroscopic
Applications An impurity of Torsemide.

Applications 2-Bromoethyl benzoate (cas# 939-54-8) is a useful research chemical.

Applications (2S)-3-{[tert-Butyl(dimethyl)silyl]oxy}-2-methylpropan-1-yl Tosylate (cas# 222539-29-9) is a compound useful in organic synthesis.

Applications Methyl Benzoate-2,3,4,5,6-d5 (CAS# 68661-19-8) is a useful isotopically labeled research compound.

Applications 4-Pregnen-17alpha,21-diol-3,20-dione-21,21-d2 (CAS# 1271728-08-5) is a useful isotopically labeled research compound.

Applications 25-Cyclohexyl-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-oxo-avermectin A1a is an intermediate in synthesizing 4'-O-2,6-Dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl Selamectin (D440100), which s an impurity of Selamectin (S247990), a topical parasiticide. Selamectin (S247990) is also used as a veterinary antihelminithic agent on animals.
References Eshar, D., et al.: J. Am. Veterin. Med. Association., 241, 1056 (2012); Geis-Asteggiante, L., et al.: J. Chromatograph., 1258, 43 (2012);

Applications Simvastatin-d11 (2,2-dimethylbutyrate-d11) (CAS# 1002347-74-1) can be used to treat hypercholesterolemia and heart disease. This compound can also be used to treat various diseases by preparing it as HMG-CoA reductase inhibitor.
References Czarnik, A., U.S Pat.Appl.Publ., 8,(2008); Gant, T., et.al., PCT Int.Appl.,88,(2008);

Applications N-[(2R)-2-Hydroxy-2-(3-hydroxyphenyl)ethyl]-N-methyl-glycine is an impurity of Phenylephrine (P320640), an α-Adrenergic agonist. Mydriatic; decongestant.
References Warren, M.R., et al.: J. Pharmacol. Exp. Ther., 86, 284 (1946), Gaglia, C.A., et al.: Anal. Profiles Drug Subs., 3, 483 (1974)

Applications An intermediate in the preparation of Cletoquine Oxalate It is a COVID19-related research product.

Applications Used in the preparation of carcinogenic Benzo[a]pyrene Diol Epoxide (B287550).
References Huang, X. & Harris, T.: J. Chem. Soc. Chem Comm., 1699 (1995)

Applications A labelled derivative of D-Mannosamine (M167000).
References Pukanud, P. et al.: Drug Delivery, 16, 289 (2009);

Applications A major metabolite of Lopinavir (L469480) . It is a COVID19-related research product.
References Molla, A., et al.: J. Virology, 250, 255 (1998), Sham, H., et al.: Antimicrob. Agents Chemother., 42, 3218 (1998), Kumar, G., et al.: Drug Metab. Dispos., 27, 86 (1999),

Applications Labelled 2,4-Di-tert-butylphenol (D429475). A chemical constituent of volatile oils from Catunaregam spinosa fruits.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References amaguchi, S., et al.: J. Food Sci., 36, 846 (1971); Ajlouni, S., et al.: Food Flavors, 1865 (1995); Mau, J., et al.: J. Agric. Food Chem., 45, 4726 (1997);

Applications A fluorescent reagent used for labelling carboxylic acids.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2'-Amino-2'-deoxyuridine (cas# 26889-39-4) is a useful research chemical.

Applications 20β-Dihydro Pregnenolone is a metabolite of Pregnenolone (P712200).
References Purdy, R., et al.: J. Med. Chem., 33, 1572 (1990), Bixo, M., et al.: Brain Res., 764, 173 (1997), Huang, X., et al.: J. Biol. Chem., 275, 29452 (2000),

Applications [18O] Cholesterol can be used as a practical tracer for studies of cholesterol metabolism in humans.
References Hudgins, L.C., et al.: Biomed. Environ. Mass Spect., 17, 463 (1988),

Applications 5-Carboxyhydroxymethyluridine is a naturally occuring modified nucleoside in RNA that assists in RNA stability, folding and other functions.
References Aduri, R., et al.: J. Chem. Theory Comput., 3, 1464 (2007); Xu, Y., et al.: J. Comput. Chem., 37, 896 (2016)

Applications Bis(3-aminopropyl-d6)amine (CAS# 1219805-55-6) is a useful isotopically labeled research compound.

Applications 5,6-Dihydroimidazo[4,5,1-jk][1]benzazepine-2,7(1H,4H)-dione (cas# 92260-81-6) is a compound useful in organic synthesis.

Applications A metabolite of Rosiglitazone.The ratio of the diastereomers will be quite variable due to the acidic proton at one chiral centre.
References Balton, G.C., et al.: Xenobiotica, 26, 6, 627 (1996),

Applications A metabolite of Maraviroc.
References Beaumont, K., et al.: Eur. J. Pharm. Sci., 12, 41 (2000), Walker, D.K., et al.: Drug Metab. Dispos., 33, 587 (2005).

Applications 5-bromo-1-chloro-3-fluoro-2-methoxybenzene

Applications 5,7-Dichloroimidazo[1,2-a]pyrimidine (cas# 57473-32-2) is a compound useful in organic synthesis.

Applications Intermediate in the preparation of labelled Nilotinib.
References Capdeville, R., et al.: Nat. Rev. Drug Discov., 1, 493 (2002), Prenen, H., et al.: Pharmacol., 77, 11 (2006),

Applications Induction of Glutathione S-transerase (GST) activity by anticarcinogenic compounds is believed to be a major mechanism for carcinogen detoxification. This compound has shown to induce Glutathione S-transerase activity in target organs of mice with no apparent toxic effects.
References Benson, A.M., et al.: Cancer Res., 38, 4486 (1978); Spanins, V.L., et al.: J. Natl. Cancer Inst., 68, 493 (1982); Lam, L.K.T., et al.: Nutr. Cancer, 12, 43 (1989); Zheng, G., et al.: J. Med. Chem., 35, 185 (1992)

Applications An intermediate for the synthesis of Alpidem.

Applications 4,4’-Bis(trimethylacetoxy)benzophenone (cas# 112004-83-8) is a compound useful in organic synthesis.
References Miyano, M., et al.: J. Med. Chem., 31, 1052 (1988),

Applications Used in the preparation of Clotiazepam (C587410) and thienylamide derivatives as cholecystokinin inhibitors.

Stability Air Sensitive, Temperature Sensitive
Applications 6-Hydroxy-N-demethyldimethidene is a metabolite of the antihistaminic drug dimethindene.
References Rudolf, J., Blaschke, G.: Enantiomer, 4, 317 (1999)

Applications Isotopically labelled intermediate of Dapsone.

Applications 2-Hydroxyethylbenzimidazolidinone-2 (cas# 63388-01-2) is a compound useful in organic synthesis.

Applications 1,5-Diiodo-3-oxopentane (cas# 34270-90-1) is a compound useful in organic synthesis.

Applications 4-Hydroxy-7-methoxycoumarin (cas# 17575-15-4) is a compound useful in organic synthesis.

Stability Moisture and Temperature Sensitive
Applications (R,S)-Equol 4’-Sulfate is a sulfated metabolite of isoflavone Daidzein (D103500).
References Heinonen, S., et al.: Anal. Biochem., 274, 211 (1999), Setchell, K., et al.: J. Nutr., 132, 3577 (2002), Thigpen, J., et al.: Comp. Med., 53, 607 (2003), Yee, S., et al.: Food Chem. Toxicol., 46, 2713 (2008),

Applications Dimethyl 1,4-Dihydro-2,6-dimethyl-4-(2’-aminophenyl)-pyridine-3,5-dicarboxylate (cas# 21889-33-8) is a compound useful in organic synthesis.

Applications Intermediate in the preparation of Tyrosine Kinase Inhibitors.
References Schroeder, M., et al.: J. Med. Chem., 44, 1915 (2001), Nandi, S., et al.: J. Enz. Inhibit. Med. Chem., 24, 937 (2009),

Applications 2-(1-Hydroxypropyl)promazine is a metabolite of propionylpromazine (P827500).
References Park, J. et al.: J. Chrom. Biomed. Appl., 489, 313 (1989);

Applications p-(Dimethyl-d6-amino)nitrosobenzene is labelled p-(Dimethylamino)nitrosobenzene (D2907600 which is an intermediate in the synthesis of Meldola Blue (M215120), a biosensor for the measurement of lactate in serum.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Vinothkumar, S.P., et al.: J. Pharma. Res., 3, 1371 (2010); Huang, R., et al.: Chem. Res. Toxicol., 21, 659 (2008);

Applications 3,4-Dihydro-2H-1,4-benzoxazine-7-boronic acid pinacol ester is a useful intermediate for the synthesis of naphthamides which functions as VEGFR-2 kinase inhibitors for cancer treatment.
References Lv, Y., et al.: ACS Med. Chem. Lett., 5, 592 (2014)

Applications 4-(2-Hydroxy-1,1-dimethylethyl)-N-[6-chloro-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl]benzenesulfonamide (cas# 1076198-22-5) is a compound useful in organic synthesis.
References Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994), Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1996), Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1996), Krum, H., et al.: N. Engl. J. Med., 338, 784 (1998)

Applications Itraconazole Desethylene-seco-piperazine Mono-N-formyl Impurity of Itraconazole (I937500). Itraconazole is an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.
References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993),

Applications 2,2,5-Trimethyl-1,3-dioxane-5-carboxylic Acid (cas# 16837-14-2) is a compound useful in organic synthesis.

Applications A protected metabolite of Tolterodine (T535800).
References Lowry, O., et al.: J. Biol. Chem., 193, 265 (1951), Andersson, K., et al.: Drugs, 35, 477 (1988), Chiu, S., et al.: J. Pharmacol. Toxicol. Methods, 29, 77 (1993), Shimada, T., et al.: J. Pharmacol. Exp. Ther., 270, 414 (1994), Postlind, H., et al.: Drug Metab. Disp., 26, 289 (1998),

Applications 10,11-Dichloro-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide is an intermediate in the synthesis of derivative of Carbamazepine (C175840) which is used in treatment of pain associated with trigeminal neuralgia.
References Stenger, E.G., et al.: Med. Exp., 11, 191 (1964), Pynnonen, S., et al.: Ther. Drug Monit., 1, 409 (1979), Sidebottom, A., et al.: J. Clin. Pharm. Ther., 20, 31 (1995)

Stability Hygroscopic
Applications 2,4-Dithiouridine (cas# 13239-96-8) is a compound useful in organic synthesis.

Impurity Solifenacin EP Impurity D
Applications ((R)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)((S)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)methanone is a possible impurity of solifenacin (S676700) which is a muscarinic M3 receptor antagoinst. Solifenacin is used in treatment of urinary incontinence.
References Ikeda K., et al.: Arch. Pharmacol., 366, 97, (2002); Chapple, C.R., et al.: Br. J. Urol., 93, 303 (2004); Ohtake, A., et al.: Eur. J. Pharmacol., 492, 243 (2004); Brunton, S., et al.: Curr. Med. Res. Opin., 21, 71 (2005); Habb, F., et al.: Eur. Urol. 47, 376 (2005); Payne, C.K., et al.: Drugs, 66, 175 (2006)

Stability Hygroscopic
Applications Ranitidine N,S-Dioxide is a possible metabolite of Ranitidine (R120000).

Applications 2,6-Dimethylanthracene (cas# 613-26-3) is a compound useful in organic synthesis.

Applications Diiododifluoromethane is useful for the synthetic preparation of alpha,omega-diiodoperfluoroalkanes.
References Martin, S. J., et al.: PCT Int. Appl. (2014), WO 2014062450 A2

Applications 2-(4-Amino-1,3,5-triazin-2-yl)sulfanylethanesulfonic acid is an impurity of Mesna (M225750).

Applications 1-Palmitoyl-3-O-benzyl-rac-glycerol (cas# 1487-51-0) is a compound useful in organic synthesis.

Stability temperature Sensitive
Applications Δ2-Cefoxitin is a derivative of Cefoxitin (C243200), a semi-synthetic antibiotic derived from Cephamycin C, possessing high resistance to β-lactamase inactivation. An antibacterial.
References Wallick, H., et al.: Antimicrob. Agents Chemother., 5, 25 (1974), Brenner, G.S., et al.: Anal. Profiles Drug Subs., 11, 169 (1982),