APIs pour la recherche et les impuretés

Applications A quinazoline derivative use for modulating serine/threonine protein kinase function; antitumor and anti-fibrotic agents.
References Harris, N., et al.: J. Med. Chem., 33, 434 (1990), Chan, J., et al.: J. Med. Chem., 38, 3608 (1995), Rafi, I., et al.: Clin. Cancer Res., 1, 1275 (1995),

Applications A weak water soluble A2 -adenosine receptor antagonist. UV lmax (log e, MeOH): 203 nm (4.45), 239 nm (4.34), 301 nm (4.26).
References J. Med. Chem., 38, 2639 (1993); Biochem. Biophys. Res. Commun., 198, 626 (1994)

Applications Intermediate for the synthesis of 2-Hydroxymethyl Loratadine.
References Cerrada, V., et al.: ARKIVOC, 9, 200 (2005).

Applications 4-[(2-Chloroethyl)amino]-N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanine Methyl Ester is an intermediate in the synthesis of metabolites of Melphalan (M216900), a chemotherapy drug that chemically alters DNA through alkylation of the DNA nucleotide guanine which results in linkages to occur between strands.
References Ross, W.C.J., et al.: Biochem. Pharmacol., 13, 969 (1964); Donelli, M.G., et al.: J. Pharm. Pharmacol., 18, 760 (1966); Furner, R.L., et al.: Cancer Treat. Rep., 64, 559 (1980)

Applications Saroglitazar, is a drug for the treatment of diabetic dyslipidemia and hypertriglyceridemia with Type 2 diabetes mellitus not controlled by statin therapy. Its trade name is Lipaglyn. It is also a 1,2-Diarylpyrroles derivative, which can be used in the preparation of Nonsteroidal anti-inflammatory drugs (NSAIDs).
References Khanna, I. K., et al.: J. Med. Chem., 40, 1619 (1997);

Applications 1-BOC-2,3-Dihydropyrrole-4-boronic acid, pinacol ester is a useful research chemical for organic synthesis and other chemical processes.
References Lewis, R. T., et al.: From PCT Int. Appl. (2017), WO 2017004359 A1 20170105

Applications 3-Methyl-3-azetidinecarboxylic Acid is a useful reagent for the synthesis of PD-1/PD-L1 inhibitors for treatment of cancer.
References Aktoudianakis, E., et al.: PCT Int. Appl. (2020), WO 2020014643 A1

Applications 1-(4-Methoxybenzyl)-3-acetoxynorcotinine (cas# 887406-83-9) is a compound useful in organic synthesis.

Applications N-[(1R)-1-(Phenylmethyl)-2-propen-1-yl]carbamic Acid 1,1-Dimethylethyl Ester is an intermediate used in the synthesis of N-protected α-amino epoxids, key intermediates for HIV protease inhibitors.
References Blacker, A.J., et al.: Org, Proc. Res, Develop., 15, 331 (2011)

Applications N,N-Diethyl-2-bromobenzamide (cas# 76041-86-6) is a compound useful in organic synthesis.

Applications Intermediate for the preparation of Metoprolol Acid.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2-Bromo-1,4-dichlorobenzene is a reactant used in the synthesis of C-13 and C-14-labeled versions of the investigational proteasome inhibitor MLN9708.
References Plesescu, M., et. al.: J. Labelled Compd. Rad., 56, 464 (2013)

Applications A nucleoside analog as inhibitor or substrate of adenosine kinase from M. tuberculosis.
References Barrow, E., et al.: J. Antimicrob. Chemother., 252, 801 (2003), Long, M., et al.: J. Bacteriol., 185, 6548 (2003), Yadav, V., et al.: J. Med. Chem., 47, 1987 (2004),

Applications 2-(1-Hydroxypropyl)promazine is a metabolite of propionylpromazine (P827500).
References Park, J. et al.: J. Chrom. Biomed. Appl., 489, 313 (1989);

Applications 2-Benzyloxy-5-nitrobenzenethiol (90%) (cas# 887353-11-9) is a compound useful in organic synthesis.

Applications (2S,3R)-3-Hydroxynorleucine is an analogue of DL-6-Hydroxy Norleucine (H948855) which is an intermediate for antiviral and antihypertensive drugs.
References Kaufman, S., et al.: J. Biol. Chem., 257, 14667 (1982), Hanson, R., et al.: Bioorg. Chem., 18, 116 (1990), Oshima, T., et al.: J. Bacteriol., 173, 3943 (1991), Oshima, T., et al.: Eur. J. Biochem., 222, 305 (1994), Robl, J., et al.: J. Med. Chem., 40, 1570 (1997)

Applications Intermediate in the preparation of Tyrosine Kinase Inhibitors.
References Schroeder, M., et al.: J. Med. Chem., 44, 1915 (2001), Nandi, S., et al.: J. Enz. Inhibit. Med. Chem., 24, 937 (2009),

Applications N2-t-Boc-N6-(biotinamido-6-N-caproylamido)lysine (cas# 102910-26-9) is a compound useful in organic synthesis.

Applications Dimethyl 1,4-Dihydro-2,6-dimethyl-4-(2’-aminophenyl)-pyridine-3,5-dicarboxylate (cas# 21889-33-8) is a compound useful in organic synthesis.

Applications 4-Hydroxy-7-methoxycoumarin (cas# 17575-15-4) is a compound useful in organic synthesis.

Applications 1,5-Diiodo-3-oxopentane (cas# 34270-90-1) is a compound useful in organic synthesis.

Applications 2-Hydroxyethylbenzimidazolidinone-2 (cas# 63388-01-2) is a compound useful in organic synthesis.

Stability Hygroscopic
Applications 2,4-Dithiouridine (cas# 13239-96-8) is a compound useful in organic synthesis.

Applications 1-Acetyl-5-(2-aminopropyl)indoline-7-carbonitrile is an intermediate in the synthesis of Silodosin (S465000), an α1a-adrenoceptor antagonist. It is used in treatment of benign prostatic hypertophy.
References Barve, I.J., et. al.: Tetrahedron, 69, 2834 (2013); Shibata, K., et al.: Mol. Pharmacol., 48, 250 (1995); Murata, S., et al.: J. Urol., 164, 578 (2000)

Applications Methyl 2-cyanobenzoate

Impurity Solifenacin EP Impurity D
Applications ((R)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)((S)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)methanone is a possible impurity of solifenacin (S676700) which is a muscarinic M3 receptor antagoinst. Solifenacin is used in treatment of urinary incontinence.
References Ikeda K., et al.: Arch. Pharmacol., 366, 97, (2002); Chapple, C.R., et al.: Br. J. Urol., 93, 303 (2004); Ohtake, A., et al.: Eur. J. Pharmacol., 492, 243 (2004); Brunton, S., et al.: Curr. Med. Res. Opin., 21, 71 (2005); Habb, F., et al.: Eur. Urol. 47, 376 (2005); Payne, C.K., et al.: Drugs, 66, 175 (2006)

Stability Hygroscopic
Applications Ranitidine N,S-Dioxide is a possible metabolite of Ranitidine (R120000).

Stability Unstable in Solution
Applications An important ß-lactone inhibitor.
References Willins, D.L., et al.: J. Pharmacol. Exp. Ther., 260. 1145 (1992), Kaddis, F., et al.: Pharmacol. Biochem. Behav., 46, 703 (1993),

Applications Isotopically labelled intermediate of Dapsone.

Stability Air Sensitive, Temperature Sensitive
Applications 6-Hydroxy-N-demethyldimethidene is a metabolite of the antihistaminic drug dimethindene.
References Rudolf, J., Blaschke, G.: Enantiomer, 4, 317 (1999)

Applications N-(4-Methoxybenzyl)-N-2-pyridinyl-1,2-ethanediamine (cas# 109912-28-9) is a compound useful in organic synthesis.

Applications Used in the preparation of Clotiazepam (C587410) and thienylamide derivatives as cholecystokinin inhibitors.

Applications 2,6-Dimethylanthracene (cas# 613-26-3) is a compound useful in organic synthesis.

Applications 2-Iodo-5’-ethylcarboxamido Adenosine is a potent and selective adenosine receptor agonist (1,2). 2-Iodo-5’-ethylcarboxamido Adenosine can be used to determine binding and structural properties between receptor subtypes.
References (1) Cristalli, G., et al.: J. Med. Chem. 38, 1462 (1995) (2) Reiger, J. M., et al.: J. Med. Chem., 44, 531 (2001)

Applications Diiododifluoromethane is useful for the synthetic preparation of alpha,omega-diiodoperfluoroalkanes.
References Martin, S. J., et al.: PCT Int. Appl. (2014), WO 2014062450 A2

Applications 2-Anthracenecarboxylic Acid (cas# 613-08-1) is a useful research chemical.

Applications PHNO precursor. Used for the preparation of radiolabeled amines, which are useful in Positron Emission Tomog. (PET) and Single Photon Emission Computed Tomog. (SPECT), and hence, can be utilized for imaging neuro-receptors with radiolabeled agonists.
References Seiler, M., et al.: J. Med. Chem., 29, 912 (1986), Halldin, et al.: J. Nuclear Med., 36, 1275 (1995), Hwang, D., et al.: Nuclear Med. Biol., 27(6), 533 (2000),

Applications A metabolite of Perhexiline.
References Shah, R., et al.: Br. Med. J., 284, 295 (1982), Gould, B., et al.: Xenobiotica, 16, 491 (1986), Marquet, P., et al.: Ther. Drug Monit., 24, 255 (2002), Sallustio, B., et al.: Br. J. Clin. Pharmacol., 54, 107 (2002),

Applications A metabolite of Alpidem.
References Padovani, P., et al.: Eur. J. Drug Metab. Pharmacokinetics, 12, 295 (1987).

Applications 1,5-Dichloro-2-methoxy-4-(4-nitrophenoxy)benzene, is used for the synthesis of three major ring-hydroxylated metabolites of Diclofop-methyl, acting as herbicide.
References Tanaka, F. S., et al.: J. Agri. Food Chem., 38, 553 (1990);

Applications A protected inhibitor of RNA synthesis (causes premature termination of transcription).
References Braedlye, J. and Sporns, O.: Brain Res., 815, 140 (1999), Ljungman, M., et al.: Oncogene, 18, 583 (1999), Roele, R.H., et al.: Oncogene, 18, 5765 (1999)

Applications Used for preparation of glycopyranoside phosphates for treatment of T lymphocyte mediated inflammatory diseases.
References Detheux, M., et al.: Eur. J. Biochem., 200(2), 553 (1991),

Applications 7-Benzyloxy-N-des[[2-(2-hydroxy)ethoxy]ethyl] Quetiapine-d8 (cas# 1185177-12-1) is a compound useful in organic synthesis.

Applications An intermediate for the synthesis of Paraxanthine.

Applications A metabolite of all-trans Retinoic acid.
References Omiecinski, C., et al.: Cancer Res., 50, 4315 (1990), Chapman, D., et al.: Biochem. Pharmacol., 48, 1807 (1994), White, J., et al.: J. Biol. Chem., 271, 29922 (1996), Chen, H., et al.: Drug Metab. Dispos., 28, 1051 (2000),

Applications 2,4-Dibromobenzoic acid

Applications 3-Fluoro-4-(trifluoromethyl)benzonitrile is a reactant in the synthesis of amino-acetonitrile derivatives. as a new class of synthetic anthelmintic compounds.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ducray, P., et. al.: Bioorg. Med. Chem. Lett., 18, 2935 (2008)

Applications Veratric Acid 4-Chlorobutyl Ester is a metabolite of Mebeverine (M202490, HCl); a smooth muscle relaxant and antispasmodic.
References Bertaccini, G., et al.: Farmaco. Ed. Sci., 30, 823 (1975); Robertson, D., et al.: Cardiovasc. Toxicol.,1, 7 (2001); McGovern, S., et al.: J. Med. Chem., 45, 1712 (2002)

Applications Isoquinine (cas# 697260-51-8) is a compound useful in organic synthesis.

Applications Protected 4-Hydroxy Toremifene (H954500), a metabolite of Toremifene (T547500). 4-Pivaloyloxy Toremifene is used in the preparation of Tamoxifen (T006000) analogs with improved binding selectivity towards the orphan estrogen-related receptor γ and the classical estrogen receptor α.
References Chao, E. et al.: Bioorg. Med. Chem. Lett., 16, 821 (2006)

Applications A sulfhydryl reactive heterobifunctional crosslinking reagent.Spacer Arm: 15.7 Angstroms
References Rich, D., et al.: J. Med. Chem., 18, 1004 (1975), Moroder, L., et al.: BioPolymers, 22, 481 (1983)

Applications Anti-inflammatory agent.
References Jeong, G. et al.; Eur. J. Pharmacol. 644, 230 (2010); Washiyama, M. et al.; Biol. Pharm. Bull. 32, 941 (2009)

Applications A Tamoxifen analogue. A derivative of Tamoxifen (T006000).
References Jordan, V.C., et al.: Eur. J. Cancer, 17, 193 (1981),

Stability Hygroscopic
Applications Conformations and chiroptical properties of L-cystine derivatives.
References Ingram, V.M., et al.: J. Biol. Chem., (1953), 202, 193 (1953),

Applications 3-Methyl-2-chloro-3H-imidazo[4,5-f]quinoline (cas# 161087-48-5) is a compound useful in organic synthesis.

Applications An intermediate in the preparation of Zolpidem metabolites
References Klupsch, F., et al.: Chem. Pharm. Bull., 54, 1318 (2006),

Applications Labeled Sucrose (S697000). Yuanzhen sugar is a polysaccharide polymer, containing a certain amount of fructooligosaccharides.
References Watanabe, T., et al.: Biosci. Biotech. Biochem., 72, 3167 (2008), You, Y., et al.: J. Agric. Food Chem., 57, 709 (2009),

Applications 3-Bromo-5-methylanisole (cas# 29578-83-4) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Labelled Lamivudine Acid (L172490). Lamivudine Acid is an impurity of Lamivudine (L172500). Labelled Impurity A per European Pharmacopoeia.
References Dwyer, O., et al.: Synlett, 11, 1163 (1995),

Applications Used for clinical pharmacokinetic studies.
References Kyte, J., et al.: J. Mol. Biol., 157, 105 (1982), Kamo, M., et al.: Eur. J. Biochem., 255, 162 (1998), Wu, C., et al.: Nat. Biotechnol., 21, 532 (2003),

Applications An intermediate in the preparation of labelled Imidaprilat
References Hayashi, K., et al.: J. Med. Chem., 32, 289 (1989), Fujita, M., et al.: Chem. Pharm. Bull., 46, 787 (1998),

Stability Light Sensitive
Applications Methyl Stearidonate can be isolated from diatom Navicula delognei and has antibacterial activity against Staphylococcus aureus, S. epidermidis, Salmonella typhimurium, and Proteus vulgaris.
References Findlay, J.A., Patil, A.D.: J. Nat. Prod., 47, 815 (1984)

Applications Butachlor ESA Sodium Salt (cas# 1173022-75-7) is a compound useful in organic synthesis.

Stability Unstable in Solution
Applications Desphenyl Tenofovir Alafenamide-d7 Ammonium Salt is labeled form of Desphenyl Tenofovir Alafenamide (D297043), which belongs to a group of tenofovir diesters compounds, which can inhibit HIV-1 virus replication. Desphenyl Tenofovir Alafenamide can also be used to investigate the effect of oral absorption and lymphoid cell loading of GS-7340 (a prodrug of tenofovir)
References You, G., et al.: PCT Int. Appl. WO 2014026582 A1 2014022 (2014); Babusis, D., et al.: Mol. Pharm. 10, 459 (2013)

Applications cyclohexyl 4-methylbenzenesulfonate (cas# 953-91-3) is a useful research chemical.

Applications 2-tert-Butyl-5-methyl-1,3-dioxane-5-carboxylic Acid Vinyl Ester-d3 (cas# 1189464-68-3) is a compound useful in organic synthesis.

Applications A useful deuterated synthetic intermediate.

Applications N2-[1-Deoxy-2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranos-1-yl]-L-asparagine (cas# 794477-75-1) is a compound useful in organic synthesis.

Applications 2-Des(5-methyl-1,3,4-oxadiazole-2-carboxamide) (E)-2-(N,N-Dimethylformimidamide) Raltegravir is an impurity of Raltegravir (R100300), a potent human immunodeficiency virus (HIV) integrase inhibitor. A novel anti-AIDS drug.
References Wade, K., et al.: J. Pharmacol. Biomed. Anal., 8, 401 (1990), Hazuda, D., et al.: Science, 287, 646 (2000), Williams, J., et al.: Drug Metab. Dispos., 32, 1201 (2004), Duckett, C., et al.: Xenobiotica, 36, 59 (2006), Miners, J., et al.: Biochem. Pharmacol., 71, 1531 (2006), Summa, V., et al.: J. Med. Chem., 49, 6646 (2006),

Applications Used for the rapid and selective modification of sulfhydryl groups of enzymes.
References Stauffer, D.A., and Karlin, A.: Biochemistry, 33, 6840 (1994), Yang, N. et al.: Neuron, 16, 113 (1996), Kuner, T. et al.: Neuron, 17, 343 (1996)

Applications 2-Chloro-4-fluoro-5-sulfamoylbenzoic Acid is used as a reagent in the synthesis of N-benzyl-N'-(4-piperidinyl)urea CCR5 antagonists as anti-HIV-1 agents.
References Duan, M., et al.: Bioorg. Med. Chem. Lett., 20, 7401 (2010)

Applications Possesses antiviral activity. It is an inhibitor of leukocyte adhesion to TNF-treated endothelial cells.
References Jurgensen, C.H., et al.: J. Immunol., 144, 653 (1990), Flexner, C.W., et al.: Lancet, 339, 438 (1992), Reddy, M., et al.: Prot. Sci., 17 2134 (2008),

Applications (-)-OSU is a weak dopamine D2 receptor antagonist.
References Carlsson, M., et al.: Curr. Med. Chem., 11, 267 (2004); Natesan, S., et al.: J. Pharmacol. Exp. Ther., 318, 810 (2006); Seeman, P., et al.: Eur. J. Pharmacol., 557, 151 (2007);