APIs pour la recherche et les impuretés

Applications α,α'-Bis[(2-methoxyphenoxy)methyl]-1,4-piperazinediethanol is a metabolite of Ranolazine (R122500), an anti-ischemic agent which modulates myocardial metabolism. α,α'-Bis[(2-methoxyphenoxy)methyl]-1,4-piperazinediethanol is also known to exhibit anti-anginal activities.
References Aalla, S., et al.: Org. Process. Rsch. Develop., 16, 748 (2012); Chaitman, B.R., et al.: J. Am. Coll. Cardial., 43, 1375 (2004); McCormack, J.G., et al.: Gen. Pharmacol., 30, 639 (1998); Schofield, J.A.H., et al.: Expert Opin. Invest. Drugs, 11, 117 (2002);

Applications Amino Hydroxynimesulide is an analog of Nimesulide (N477500), an antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-alpha production.
References Pairet, M., et al.: Inflamm. Res., 47, S93 (1998), Fukutake, M., et al.: Carcinogenesis, 19, 1939 (1998), Okajima., E., et al.: Cancer Res., 58, 3028 (1998), Azab, A., et al.: Life Sci., 63, 323 (1998); Li, F. et al.: Chem. Res. Toxicol., 22, 72 (2009);

Applications nucleoside analogue
References Hirth, B., et al.: Bioorg. Med. Chem. Lett., 19, 2916 (2009),

Applications 1-O-Methyl-β-D-glucuronide Methyl Ester is a carbohydrate derivative used in various synthesis of pharmaceutical significant compounds.
References Lau, J.M., et al.:Carbo. Res., 168, 219 (1987);

Applications 8-Bromo-2’,3’,5’-tri-O-acetylguanosine (cas# 15717-45-0) is a compound useful in organic synthesis.
References Kazmers, I.S., et al.: Science, 214, 1137 (1981), Chern, J-W., et al.: J. Med. Chem., 36, 1024 (1993)

Applications A novel labelled HIV reverse transcriptase inhibitor useful in treatment of HIV infection.
References Scholler-Gyure, M., et al.: J. Clin. Pharmacol., 48, 322 (2008), Thakur, A., et al.: Eur. J. Med. Chem., 43, 471 (2008),

Stability Light and Moisture Sensitive
Applications A photoaffinity reagent.
References Hatanaka, Y. et al: Bioorg. Med. Chem., 2, 1367 (1994); Hatanaka, Y. et al: J. Org. Chem., 59, 383 (1994); Hatanaka, Y. et al: Bioorg. Med. Chem. 2, 1367 (1994)

Stability Hygroscopic, Light Sensitive
Applications A Rifamicyn derivative with therapeutic effect on pulmonary tuberculosis.
References Gozalbes, R., et al.: J. Pharm. Pharmacol., 51, 111 (1999), Estrada, E., et al.: J. Med. Chem., 43, 1975 (2000), Gonzalez-Diaz, H., et al.: Chem. Res. Toxicol., 16, 1318 (2003), Garcia-Garcia, A., et al.: J. Antimicrob. Chemother., 53, 65 (2004),

Applications Tunicamycin is a competitive cell cycle inhibitor exhibiting antiungal properties.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 6β-Naltrexol Hydrochloride is a neutral opioid antagonist that has shown minimal withdrawal symptoms in patient with opioid-dependence.
References J. Addict. Res. Ther., 2, 108 (2011)

Applications rac Enterolactone (E558950) derivative.

Applications Intermediate in the production of Deoxyfuconojirimycin
References Jefferies, I., et al.: Bioorg. Med. Chem. Lett., 7, 1171 (1997),

Applications N-Carbamoyl-DL-aspartic Acid (cas# 923-37-5) is a useful research chemical.

Applications 1-(6-Amino-9-β-D-ribofuranosyl-9H-purin-2-yl)-1H-pyrazole-4-carboxylic acid is used in the preparation of adenosine receptor nanoagonists.
References Gao, X., et al.: ACS Nano, 8, 3678 (2014)

Applications Used in the preparation of triazole antifungal agents.

Applications A useful building block for oligoribonucleotide synthesis.

Applications 2,5-Dimethylterephthalic acid

Applications 3-(Bromomethyl)-α,α,5-trimethyl-benzeneacetonitrile (cas# 120512-36-9) is a compound useful in organic synthesis.

Applications 5-Carboxyhydroxymethyluridine is a naturally occuring modified nucleoside in RNA that assists in RNA stability, folding and other functions.
References Aduri, R., et al.: J. Chem. Theory Comput., 3, 1464 (2007); Xu, Y., et al.: J. Comput. Chem., 37, 896 (2016)

Applications A fluorescent reagent used for labelling carboxylic acids.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2-Cyclopropyl-4-phenylquinoline-3-carbaldehyde is an impurity of Pitavastatin (P531000), a HMG CoA reductase inhibitor and an antilipemic agent.

Impurity Cefuroxime Sodium EP Impurity A
Stability Hygroscopic
Applications Descarbamoyl Cefuroxime (Cefuroxime Sodium EP Impurity A) is a degradation product of Cefuroxime, and an intermediate for the synthesis of Cephalosporin antibiotics
References Nomura, H., et al.: J. Med. Chem., 17, 12 (1974), Takaya, T., et al.: J. Antibiotics, 34, 1300 (1981), Wang, D., et al.: J. Pharm. Sci., 83, 577 (1994), Okamoto, Y., et al.: J. Pharm. Sci., 85, 985 (1996),

Applications Labelled 2,4-Di-tert-butylphenol (D429475). A chemical constituent of volatile oils from Catunaregam spinosa fruits.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References amaguchi, S., et al.: J. Food Sci., 36, 846 (1971); Ajlouni, S., et al.: Food Flavors, 1865 (1995); Mau, J., et al.: J. Agric. Food Chem., 45, 4726 (1997);

Applications Fesoterodine-d7, is the labeled analogue of Fesoterodine (F321300), a muscarinic receptor antagonist for the treatment of Lower Urininary Tract Symptoms (LUTS). It is very similar to Tolterodine (T535800).
References Rogers, D., et al.: Pharmacotherapy, 20, 1092 (2000), Praharaj, S., et al.: J. Psychopharmacology, 19, 426 (2005),

Applications 2-[p-(2-Methyl-1,2-epoxypropyl)phenyl]propionic Acid (cas# 75626-00-5) is a compound useful in organic synthesis.

Applications A labelled isotpe of Isopropyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate (I485580). A short-acting intravenous anaesthetic agent used for dislocated joints, tracheal intubation, cardioversion and electroconvulsive therapy.
References Goetz, E., et al.: Anaesthesist, 23, 331 (1974), Chang, Z. L., et al.: Anal. Profiles Drug Subs., 12, 191 (1983),

Applications (R)-1-Methylmephenytoin (cas# 201606-44-2) is a compound useful in organic synthesis.
References Shimada: Anal. Biochem., 147, 174 (1975)

Applications rac 1,2-Bislauroyl-3-chloropropanediol is a glycerol fatty acid ester found in a variety of vegetable oils.
References Velisek, J., et al.: J. Agric. Food Chem., 28, 1142 (1980), Zelinkova, Z., et al.: Food Addit. Contam., 23, 1290 (2006), Weisshaar, R., et al.: Eur. J. Lipid Sci. Technol., 110, 183 (2008),

Applications Labelled 2-[(Ethylamino)methyl]-4-nitrophenol (E898825). 2-[(Ethylamino)methyl]-4-nitrophenol is used in synthesis of some novel amodiaquine analogs as potential antimalarial and antifilarial compounds.

Applications A spin trap useful as a probe for free radical formation during myocardial ischemia/reperfusion injury. An analogue of DMPO.
References Xu, Y-K., et al.: J. Org. Chem., 67, 7624 (2992)

Applications A chiral derivative of Camphor.
References Peng, R., et al.: Biochem. Pharmacol., 35, 1391 (1986), Tanaka, E., et al.: Biochem. Pharmacol., 41, 472 (1991),

Applications 3-Chloro-6-(chloromethyl)benzene-1,2,4,5-d4 is an isotope-labeled analog of 4-Chlorobenzyl Chloride (C364730), which is a benzylchloride derivative used in the preparation of various biologically active compounds such as bronchodilators and antibacterial agents.
References Adams, M. et al.: Synth. Comm., 29, 2419 (1999); Foroumadi, A. et al.: Arch. Pharm. Res., 30, 138 (2007);

Applications (-)-(2R,5S)-1-Allyl-2,5-dimethylpiperazine (cas# 155836-78-5) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bishop, M., et al.: Bioorg. Med. Chem. Lett., 5, 1311 (1995), Bishop, M., et al.: J. Med. Chem., 46, 623 (2003),

Applications A Trimethoprim (T795615) derivative.
References Manius, G.J., et al.: Anal. Profiles Drug Subs., 7, 445 (1978); Roth, B., et al.: J. Med. Chem., 23, 379 (1980); Brogden, R.N., et al.: Drugs, 23, 405 (1982);

Applications Intermediate in the synthesis of a major Ropivacaine (R675000) metabolite.

Stability Acid Sensitive
Applications 2,3,4-Tri-O-acetyl-D-glucuronic Acid Methyl Ester (cas# 3082-95-9) is a compound useful in organic synthesis.

Applications N-[(2R)-2-Hydroxy-2-(3-hydroxyphenyl)ethyl]-N-methyl-glycine is an impurity of Phenylephrine (P320640), an α-Adrenergic agonist. Mydriatic; decongestant.
References Warren, M.R., et al.: J. Pharmacol. Exp. Ther., 86, 284 (1946), Gaglia, C.A., et al.: Anal. Profiles Drug Subs., 3, 483 (1974)

Applications N,N’-Di-Boc-(L)-cystine-dimethyl Ester (cas# 77826-55-2) is a compound useful in organic synthesis.

Applications 5-​(4-Fluorophenyl)​-​4,​5-​dihydro-​4-​methyl-2-​oxazolamine is a derivative of Aminorex (A629200), an anorectic stimulant drug of the 2-amino-5-aryl oxazoline class. Aminorex has been shown to have locomotor stimulant effects similar to Methamphetamine (M258795).
References Poos, G., et al.: J. Med. Chem., 6, 266 (1963), Watson, A., et al.: Res. Vet. Sci., 45, 411 (1988), Russell, B., et al.: Pharmacol. Biochem. Behav., 51, 375 (1995),

Stability Temperature sensitive
Applications Labelled Glycidyl Linolenate. An inhibitor of monoacylglycerol lipase and fatty acid amide hydrolase.
References Karlsson, M., et al.: J. Biol. Chem., 272, 27218 (1997), de Lago, E., et al.: Biochem. Pharmacol., 70, 446 (2005), Romero, F., et al.: J. Med. Chem., 50, 1058 (2007),

Applications (2,3-Dimethylpyridin-4-yl)boronic Acid is used to prepare substituted azaanthracene derivatives as GLP-1 receptor modulators useful in the treatment of GLP-1 receptor-mediated diseases
References Mjalli, A., et al.: PCT Int. Appl. (2010), WO 2010114824 A1 20101007

Applications Maintains anti-proliferative activity against human malignant cell strains.
References Pratsinis, H. et al.: J. Med. Food, 13, 286 (2010);

Applications 5beta-Androstan-3alpha,17beta-diol-2,2,3,4,4-d5 (CAS# 1224710-37-5) is a useful isotopically labeled research compound. This compound can be used to detect androgen, estrogen, progestagen abuse in bovine samples using multi-residue urinary assay.
References Scarth, J.et.al., Chromatographia, 71,241-252,(2010);

Applications A labelled derivative of D-Mannosamine (M167000).
References Pukanud, P. et al.: Drug Delivery, 16, 289 (2009);

Applications Labelled Azathioprine (A803350). An immunosuppressive antimetabolite. Also active as disease modifying antirheumatic drug (DMARD).
References Mitrou, P.S., et al.: Arzneim.-Forsch., 29, 483, 662 (1979), Ding, T.L., et al.: Drug. Metab. Dispos., 7, 373 (1979), Chan, G.L.C., et al.: Pharmacotherapy, 7, 165 (1987), Sandborn, W.J., et al.: : Scand. J. Gastroenterol., 33, Suppl. 225, 92 (1998,)

Applications 3-Methoxy-N-methyldesloratadine (cas# 165739-72-0) is a compound useful in organic synthesis.

Applications 6-[4-(3-Trifluoromethylpyridin-2-yloxy)-2-methylphenyl]-1,5-dimethyl-2,4(1H,3H)-pyrimidinedione is a useful synthetic intermediate.

Applications 2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one is a small molecule that has shown promising preclinical activity in various cancer types. 2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one shows antitumor activity in multiple myeloma by induction of p73 and Noxa.
References Saha, M.N., et. al.: Mol. Cancer Ther., 12, 2331 (2013); Aryee, D.N.T., et. al.: Brit. J. Cancer, 109, 2696 (2013)

Applications Steroidal fused pyrazoles useful as bile acid transporters.
References Bhat, L. et al.; Bioorgan. Med. Chem. 15, 85 (2005)

Applications Skepinone-L is a potent and highly selective inhibitor of p38 MAP kinase which impairs platelet activation and thrombus formation.
References Borst, O., et. al.: Cell Pysiol. Biochem., 31, 914 (2013)

Stability Hygroscopic
Applications (3R,5S)-5-(6-Cyclopropyl-10-fluorobenzo[k]phenanthridin-8-yl)-3,5-dihydroxypentanoic Acid is an impurity of pitavastatin (P531000), a competitive inhibitor of HMG-CoA reductase. Antilipemic.
References Grobelny, P., et. al.: J. Pharmaceut. Biomed. Anal., 50, 597 (2009); Aoki, T., et al.: Arzneim.-Forsch., 47, 904 (1997); Yamada, I., et al.: Xenobiotica, 33, 789 (2003); Park, S., et al.: Clin. Ther., 27, 1074 (2005)

Applications A derivative of Etodolac metabolite.,
References Chan, et al.: J. Pharmacol., Exp. Ther., 274, 1531 (1995), Dajani, et al.: J. Physiol. Pharmacol., 46, 3 (1995), Sano, et al.: Cancer Res., 55, 3785 (1995),

Applications 3,5-Difluoro-D-phenylalanine

Applications 4-Chloro-8-(trifluoromethyl)quinoline is used as a reagent for the potent CRTh2 (DP2) receptor antagonists discovery which is used for treatment of asthma, allergic rhinitis and other inflammatory diseases.
References Birkinshaw, T.N., et al.: Bioorg. Med. Chem. Lett., 16, 4287 (2006)

Applications An intermediate for the synthesis of Labelled Ketoprofen.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Derewenda, Z., et al.: J. Mol. Biol., 227, 818 (1992), Grochulski, P., et al.: J. Biol. Chem., 268, 12843 (1993).

Applications 3,3,3-Trideuterio-2,2-difluoro-propanoic acid is a useful labeled building block.

Applications 2,7-Dibromopyrene (cas# 102587-98-4) is a useful research chemical.

Applications 2'-Deoxyguanosine 3’,5’-Dibutanoate is an intermediate in the synthesis of DNA adducts of Aflatoxin B1 (A357460).
References Brown, K.L., et al.: J. Am. Chem. Soc., 128, 15188 (2006);

Applications An intermediate in the preparation of Cletoquine Oxalate It is a COVID19-related research product.

Applications Intermediate in the synthesis of prolyl hydroxylase inhibitors.

Applications N,N-Diethyl-p-toluamide, is a buildig block used in the synthesis of phthalocyanines. It can also be used in preparation of new insect repellents.
References Liang, J., et al.: Nongyaoxue Xuebao, Vol. 16,P: 644-650 (2014);

Applications A metabolite of Arteether. Artemisinin analogue; antimalarial agent.
References Klayman, D., et al.: Science, 228, 1049 (1985), Avery, M., et al.: Adv. Med. Chem., 4, 125 (1999),Avery, M., et al.: J. Med. Chem., 45, 292 (2002), Cheng, F., et al.: Bioorg. Med. Chem., 10, 2883 (2002),

Applications 3β-17-Imino-androst-5-en-3-ol Dimer is an impurity of Abiraterone (A108490), a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17). Abiraterone is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.
References Denis, L., et al.: Cancer, 72, 3888 (1993), Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995), Denmeade, S., et al.: Nat. Rev., 2, 389(2002), Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005)

Applications 5,6,8,9-Tetrahydro-7H-dibenzo[c,g]carbazole (cas# 117766-87-7) is a compound useful in organic synthesis.

Stability Hygroscopic
Applications 5-(4-aminophenyl)-1,3,4-oxadiazol-2-ol (cas# 113118-47-1) is a useful research chemical.

Applications Hesperetin Benzyl Ether is an intermediate in the synthesis of (S)-Hesperetin (H289480), a flavanone found in citrus fruits.
References Tsujimoto, M., et al.: Biol. Pharm. Bull., 32, 671 (2009), Wang, H., et al.: J. Pharm. Biomed. Anal., 49, 1157 (2009)