APIs pour la recherche et les impuretés

<p>5-Benzoyl-1,3-dihydro-2H-benzimidazol-2-one is a synthetic compound that has been used as an impurity standard. This substance is also found in the drug product Loxapine (Loxitane) and is metabolized to the active ingredient loxapine. 5-Benzoyl-1,3-dihydro-2H-benzimidazol-2-one has not been shown to have any therapeutic effects.</p>

Please enquire for more information about Losartan azide including the price, delivery time and more detailed product information at the technical inquiry form on this page

6-Hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-7-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone is a synthetic impurity standard that is used as a reference material in the analytical, natural and drug development, and metabolite studies. 6-Hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-7-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone has a molecular weight of 390.27 and chemical formula C26H28N2O3S. It is also referred to by its CAS number 1391054-73-1.6

Emtricitabine impurity 9 is an analytical standard that is used to calibrate HPLC instruments. It is a natural product, which is synthesized and purified. Emtricitabine impurity 9 can be custom-synthesized and is used in drug development research. This chemical compound has a purity of >98% and a CAS number of 20752-33-4. The API impurity is the active pharmaceutical ingredient in the drug product, emtricitabine.

<p>Leuprolide acetate ep impurity F is a drug product that is an impurity standard for the leuprolide acetate API. It is used in analytical and clinical studies to identify the presence of leuprolide acetate impurities, as well as to determine the metabolism of leuprolide acetate. Leuprolide acetate ep impurity F has been shown to be a natural metabolite of leuprolide acetate and have a niche application in pharmacopoeia.</p>

<p>6-Bromo-8-cyclopentyl-5-methylquinazoline-2,7(3H,8H)-dione is a compound with antiviral properties. It belongs to the class of tenofovir and has been shown to inhibit the replication of certain viruses. This compound also exhibits calpain inhibitory activity, which may have potential therapeutic applications in conditions related to calpain dysregulation. Additionally, 6-Bromo-8-cyclopentyl-5-methylquinazoline-2,7(3H,8H)-dione has been studied for its impurities and interactions with other compounds such as etoricoxib, blonanserin, 27-hydroxycholesterol, peptidoglycan, cellulose, oxysterols, proton pump inhibitors like omeprazole or esomeprazole, dopamine antagonists like haloperidol or risperidone and nonsteroidal anti</p>

Dtpa-bma is an anticancer agent that acts as a kinase inhibitor. It has been shown to induce apoptosis in cancer cells by inhibiting the activity of kinases, which are enzymes that play a key role in cell signaling pathways. Dtpa-bma is an analog of Chinese hamster ovary (CHO) cell-derived ghrelin and is excreted in urine. This drug is effective against various types of cancer, including human tumors, and has been shown to inhibit tumor growth in vivo. Dtpa-bma is formulated as a cellulose-based resin for use in chromatography purification processes.

<p>aH 11110 Hydrochloride is an analytical standard for HPLC. It is a white powder that can be used to make up a solution of known concentration for use in HPLC analysis. It has been shown to have no pharmacological activity, and is not considered to be toxic. The impurity profile of aH 11110 Hydrochloride is similar to the corresponding impurity profile of the drug product, which is consistent with the chemical structure.</p>

Please enquire for more information about Levothyroxine EP impurity B including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>Gabapentin EP Impurity G is a synthetic impurity that is also known as 5-[[[(2R,3S)-2-amino-3-(4-hydroxyphenyl)propyl]amino]carbonyl]-1,3-benzenediol. It has CAS No. 1500558-49-5 and a molecular weight of 447. The chemical formula for Gabapentin EP Impurity G is C14H22N2O4 and its chemical structure is shown below:</p>

Pemetrexed is a drug product that belongs to the group of drugs called antifolate agents. It is used in the treatment of cancer and is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. The impurity C is a natural metabolite that can be found in urine as well as in plasma. This impurity has not been identified as a major metabolite of pemetrexed.

<p>7-O-methyl ivermectin is a drug product that is an analytical standard for the impurity 7-O-methyl ivermectin B1a. Impurity 7-O-methyl ivermectin B1a is a natural API that is found in the synthesis of Ivermectin. It has a CAS number of 90589-08-4 and is produced through custom synthesis. This impurity can be used as an analytical standard for HPLC methods, such as high purity and pharmacopoeia grade. 7-O-methyl ivermectin B1a has shown to have little or no activity against bacteria, fungi, or parasites.</p>

2-(2-Fluoro-[1,1'-biphenyl]-4-yl)-2-methylmalonic acid is an analog of ginsenoside, a Chinese herbal medicine known for its anticancer properties. This compound has been shown to inhibit protein kinases, which are enzymes that play a critical role in cancer cell proliferation and survival. 2-(2-Fluoro-[1,1'-biphenyl]-4-yl)-2-methylmalonic acid induces apoptosis in human tumor cells by inhibiting the activity of glutathione S-transferase P1-1 (GSTP1-1), an enzyme involved in detoxification and drug resistance. The inhibition of GSTP1-1 leads to the accumulation of reactive oxygen species and DNA damage, ultimately resulting in cell death. This compound represents a promising class of kinase inhibitors with potential therapeutic applications for cancer treatment.

13-Ethyl-17-hydroxy-18,19-dinor-17a-pregn-5(10)-en-20-yn-3-one EP is an analytical standard and an impurity. It is used as the reference substance for HPLC drug analysis. It is also a metabolite that can be found in drugs such as metoprolol, clonidine, and propranolol. 13EP was first synthesized by a custom synthesis company to meet the needs of niche drug products. The synthetic compound has been shown to be natural and it is not chemically related to any other compounds.

<p>1,3-Bis-O-(tert-butyldimethylsilyl)-calcipotriene is a synthetic silyl ether of calcipotriene. It is used for the synthesis of drugs and as an impurity standard for HPLC analysis. 1,3-Bis-O-(tert-butyldimethylsilyl)-calcipotriene has been studied in metabolism studies and found to be natural, but it is not an API because it does not have a biological activity. It is also used in the development process of drugs and has been shown to be pharmacopoeia grade with a purity of at least 98%.</p>

2-(4′-Chloro-2,3,4,5-tetrahydro-[1,1′-biphenyl]-4-yl)-3-hydroxynaphthalene-1,4-dione is a research and development impurity standard. It is a synthetic compound that is used as an impurity standard for the manufacture of drug product. 2-(4′-Chloro-2,3,4,5-tetrahydro-[1,1′-biphenyl]-4-yl)-3-hydroxynaphthalene-1,4-dione has high purity and can be used in pharmacopoeia and drug development studies to measure metabolism. 2-(4′-Chloro-2,3,4,5-tetrahydro-[1,1′-biphenyl]-4-yl)-3 -hydroxynaphthalene -1

Ruxolitinib Impurity 3 is an analytical chemical that is used as a reference standard in the field of drug development. It is a high purity, HPLC-grade chemical that meets the requirements set by the U.S. Pharmacopoeia (USP) and is manufactured using natural or synthetic methods. This compound has been shown to be an impurity in Ruxolitinib, which is an API for treating myelofibrosis and thrombocythemia. Ruxolitinib Impurity 3 has also been found to be a metabolite of ruxolitinib, with a molecular weight of 2102675 daltons and CAS number 2102675-40-9.

Iferanserin is a medicinal analog that has shown promising anticancer activity. It is an inhibitor of kinase, a protein that plays a crucial role in cancer cell growth and tumor formation. Iferanserin induces apoptosis, or programmed cell death, in cancer cells by disrupting the cell cycle. This drug has been studied extensively in Chinese patients with various types of cancer and has shown significant antitumor effects. Iferanserin acts as a potent inhibitor of protein kinases, which are enzymes that regulate cellular processes such as gene expression, cell division, and differentiation. It is excreted primarily in urine and may have potential as a novel therapy for cancer treatment.

4-Desmethyl-4-ethylimidazolyl nilotinib is a synthetic drug product that is custom-synthesized for research and development purposes. This compound is a metabolite of nilotinib, an inhibitor of the tyrosine kinase ABL1 and BCR-ABL1. 4-Desmethyl-4-ethylimidazolyl nilotinib has been shown to be a substrate for CYP2C8, CYP2C9, CYP3A4, and CYP3A5. It has also been found to be an impurity in API standards of nilotinib.

Please enquire for more information about Glimepiride EP Impurity J hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Amoxicillin trihydrate impurity G is an analytical standard, a high purity API impurity, and an HPLC standard. It is also used in the development of drugs and as a drug product impurity. Amoxicillin trihydrate impurity G is a metabolite that has been shown to be present at low levels in amoxicillin trihydrate products. This impurity is not listed on the pharmacopoeia for compounds of natural origin or for compounds of synthetic origin.

<p>Please enquire for more information about 3-(1,1-Difluoro-2-propen-1-yl)-2(1H)-quinoxalinone including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Amiodarone is a drug product that is used in the treatment of various heart conditions. It contains impurity G and HCL. Impurity G is a metabolite that is found in the urine of patients who have taken Amiodarone and can be detected by HPLC. Impurity G has not been shown to be toxic to humans, but it may interfere with the metabolism of other drugs. The impurity standard for Amiodarone includes Impurity G, which is an analytical impurity, and Impurity HCL, which is an API impurity.</p>

<p>Please enquire for more information about Linezolid N-oxide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

aR-C 66096 Tetrasodium is a drug product that has been developed for use in analytical, research and development, and other applications. The active ingredient of aR-C 66096 Tetrasodium is Metabolism studies (145782-74-7). It is a natural API impurity with CAS No. 145782-74-7. The impurity standard of this compound is Synthetic (145782-74-7). This product has been custom synthesized to meet the requirements of an Impurity Standard (145782-74-7). aR-C 66096 Tetrasodium is manufactured in the United States and meets all USP/EP specifications. aR-C 66096 Tetrasodium was developed to be used as an HPLC standard for pharmacopoeia testing.

<p>Spirolaxine is a coumarin derivative that has been shown to have anti-cancer properties. It was isolated from an extract of the fungus Spirolaxine, which was found in the gastroduodenum (gut) of a frog. The structure of spirolaxine is similar to that of retinoic acid, and it has been shown to inhibit cancer cell proliferation. Spirolaxine also inhibits the production of proinflammatory cytokines in mice with colitis. This drug has not yet been tested for its ability to treat other diseases, such as diabetes, but may be able to regulate blood sugar levels by inhibiting insulin secretion and increasing glucose uptake by cells.</p>

<p>Carfilzomib is a drug product that belongs to the class of drugs called proteasome inhibitors. It has been used in the treatment of multiple myeloma, and is also being studied for use in other diseases such as chronic obstructive pulmonary disease and cystic fibrosis. Carfilzomib is an impurity standard for HPLC analysis and an analytical reference material. It is also used as a pharmacopoeia reference material. Carfilzomib is a natural product, with the synthetic route being developed by researchers at Pfizer. The drug product contains 2R,4S-diol as its main metabolite and impurity.</p>

<p>Please enquire for more information about 3,5-Diiodo-4’-o-methyl thyroacetic acid ethyl ester including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

Cefixime is a broad-spectrum oral antibiotic used to treat bacterial infections, including respiratory tract and ear infections. Cefixime is the prodrug of cefixime acid, which is hydrolyzed in vivo to cefixime. This impurity is an analytical standard that can be used for research and development, high purity drug product, API impurity, HPLC standard and niche drugs. It can also be used as a metabolite and an impurity standard. The CAS number for this compound is 1335475-08-5. This chemical has natural or synthetic origins but is not specified.

<p>Roxithromycin impurity I is a natural metabolite of roxithromycin. The substance has been synthesized in order to serve as an analytical impurity standard for HPLC. Roxithromycin impurity 1 is also a metabolite of roxithromycin, which has been shown to produce pharmacological effects similar to those seen with the parent compound. Roxithromycin impurity I is not an API, but has been developed as a HPLC analytical impurity standard and will be used for metabolism studies.</p>

3-((1R)-3-Hydroxy-1-phenyl-propyl)-4-hydroxy-benzoic acid methyl ester is a drug product that is used to synthesize standards for HPLC. It is an impurity in the API, Metabolism studies, Natural, CAS No. 1292905-33-9. This compound has been synthesized and can be custom synthesized. The purity of this compound is high with a purity of 99% or greater for the 3-(2′,4′-dihydroxyphenyl)propionic acid methyl ester.

N,N-Dimethylsulfonyl dofetilide is a research and development impurity with no known drug product. It is synthesized in a high-purity form for use as an analytical standard. N,N-Dimethylsulfonyl dofetilide is not found in any pharmacopoeia. This compound has been used in metabolite studies and HPLC standards.

<p>Pteroic acid is a naturally occurring substance found in plants and animals. It has inhibitory activities against enzymes such as butyrate kinase, acetyl-CoA synthetase, and glutamate dehydrogenase. Pteroic acid is used to synthesize quinoxalines, which are used for the treatment of cancer. Pteroic acid also inhibits cell growth by inhibiting protein synthesis. This is done by conjugating with amino acids and inhibiting their uptake into the ribosome. The inhibition of glutamate dehydrogenase may be due to its ability to reduce levels of glutathione, which is an inhibitor of this enzyme.</p>

1,3-Dihydro-6-methylfuro[3,4-c]pyridin-7-ol is a compound that contains impurities such as fatty acids and uridine. It has been found to be an inhibitor of α-mangostin adduct formation with fatty acids. Additionally, it has been shown to inhibit the activity of GSK-3β, an enzyme involved in various cellular processes. This compound also exhibits inhibitory effects on monascus and safranal, two enzymes involved in the production of certain compounds. Furthermore, it has been found to inhibit calpain, an enzyme responsible for protein degradation. The compound can be used in various research applications involving electrode modification and polylysine immobilization. It may also have potential interactions with other drugs such as cefdinir.

<p>Regadenoson Impurity 28 is an analytical standard and research and development impurity. It is a high-purity, synthetic, drug product impurity that can be used as a reference material for HPLC. This drug impurity is also available in a custom synthesis service. Regadenoson Impurity 28 is an API impurity that can be used in the development of drugs. It has been shown to have pharmacopoeia purity standards and niche applications. Regadenoson Impurity 28 is metabolized by cytochrome P450 enzymes to form active metabolites that are not active against the beta-1 adrenergic receptor in rat heart cells, but are active against the alpha 1 adrenergic receptor in rat vascular smooth muscle cells.</p>

<p>Cefazedone Impurity 12 is a drug product that has been custom synthesized for research and development purposes. The impurity has been shown to have a high purity level, with a CAS number of 184696-69-3. Cefazedone Impurity 12 is an analytical standard and metabolite of Cefazedone. It is also used as a natural drug development standard, which can be used for pharmacopoeia studies or as a metabolite in niche research. This impurity can be synthesized in the laboratory and can be used as an impurity standard for HPLC.</p>

<p>3’-Hydroxytyrosol 3’-glucuronide is a metabolite of tyrosol that has been found in human urine. It is an impurity in the API (active pharmaceutical ingredient) and drug product. The analytical purity of this compound should be at least 98%. This substance can be synthesized from tyrosol and 3'-hydroxy-D-glucuronic acid, according to the following chemical equation: 3' - Hydroxytyrosol + 3'-Hydroxy-D-Glucuronic Acid → 3' - Hydroxytyrosol 3' - Glucuronide</p>

<p>6-O-Desmethyl moxonidine is a drug product that is a metabolite of the parent compound, moxonidine. It has been shown to be an impurity in the API (active pharmaceutical ingredient) and is used as an analytical standard for HPLC. 6-O-Desmethyl moxonidine is synthetically prepared and can be found in natural sources, such as plants or animals. The metabolism studies indicate that the substance is excreted unchanged in urine following oral administration and undergoes extensive hydrolysis in liver microsomes to yield 4-hydroxy-3-(3-hydroxymethylpiperidinopropyl) piperidine, which is then oxidized to 3-(4-hydroxypiperidinopropyl)-1H-1,2,4-triazole. This product may cause skin irritation.</p>

<p>Desmethyl dehydro lercanidipine is a metabolite of lercanidipine, an antihypertensive agent. Lercanidipine is a dihydropyridine calcium channel blocker that inhibits the influx of calcium ions into cardiac muscle cells and vascular smooth muscle cells. The desmethyl form of lercanidipine has been shown to have anti-inflammatory effects in rats with experimental arthritis. It has also been shown to inhibit the production of inflammatory cytokines in lipopolysaccharide-stimulated human peripheral blood mononuclear cells.</p>

<p>1-(2-Furoyl)piperazine is a potent inhibitor of tyrosinase, an enzyme involved in the production of melanin. It can be used to treat cancer, as well as hyper-pigmentation disorders such as melasma and chloasma. 1-(2-Furoyl)piperazine inhibits tyrosinase by binding to the active site of the enzyme and blocking its access to substrates. This inhibition prevents the conversion of tyrosine to DOPA and further conversion to melanin. 1-(2-Furoyl)piperazine also inhibits other enzymes in the melanin synthesis pathway, including amine oxidase and dopa oxidase.</p>

<p>3'-[3-(3-Azido-2,3-dideoxy-b-D-erythro-pentofuranosyl)-3,6-dihydro-5-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-3'-deoxythymidine is an analytical standard used in the R&amp;D and drug development of 3'-azido derivatives of thymidine. It is a synthetic intermediate that has been shown to be a potent inhibitor of human immunodeficiency virus type 1 (HIV) replication and to inhibit intracellular HIV type 2 (HIV2) production in cultured cells. 3'-[3-(3-Azido-2,3,-dideoxy--b erythro--pentofuranosyl)-3,6--dihydro--5--methyl--2,6--dioxo--1(2H)--pyrimidinyl]-</p>

<p>Please enquire for more information about (R)-3-Azido-1-phenyl-1-(2-methylphenoxy)propane including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

2,2'-Methylenebis[4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol] is a synthetic drug product that is used as a reference standard for HPLC and GC analyses. It is also a metabolite of the drug product 2,2'-methylenebis[4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol], which is used in pharmaceuticals. This impurity standard exhibits analytical properties similar to those of the API impurity. The chemical structure of this compound consists of an aromatic ring with two methyl groups and two methoxy groups attached to it.

<p>6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid is an imidazopyridine that is soluble in organic solvents. It is a white crystalline solid at room temperature. This compound has been shown to form polymorphs with different crystal structures and melting points. 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid can be used as a precursor for the synthesis of other imidazopyridine derivatives.</p>

2'-Epi-lamivudine is a chiral, racemic mixture of the two enantiomers of lamivudine. The synthesis and purification of 2'-epi-lamivudine is achieved by using a chiralpak column to separate the optical isomers from each other and then an immunoaffinity column to remove the undesired enantiomer (the S-enantiomer). The final product is a mixture of both enantiomers in a 1:1 ratio, which has been shown to have antiviral activity against HIV. 2'-Epi-lamivudine has been shown to be more potent than its parent compound lamivudine and is less toxic. This antiviral agent inhibits HIV replication by inhibiting reverse transcriptase, which is an enzyme that synthesizes viral DNA from viral RNA. It also has anti-inflammatory properties that may be due to inhibition of prostaglandin synthesis.

<p>Fluticasone furoate EP impurity E is an analytical reference standard for pharmacopoeia and research. It is a synthetic fluticasone furoate EP impurity that has been custom synthesized for use as a high-purity, HPLC-grade standard. Fluticasone furoate EP impurity E is characterized by its natural origin and purity, making it appropriate for use in drug development and research. The CAS number for this product is 398454-97-2.</p>

<p>Please enquire for more information about (1R,1’R, 2’S)-2-Desmethyl cisatracurium besylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Epi-canagliflozin is a drug product that is manufactured by HPLC. It is a natural, synthetic drug development and research and development of the API impurity standard for analytical. The metabolite of this synthetic API impurity standard is used as an analytical impurity in the pharmacopoeia. This synthetic API impurity standard can be custom synthesized to meet your needs.</p>

Bosentan impurity C is a stable crystalline compound that is soluble in organic solvents. It has been identified as an impurity of the drug bosentan, and has been found to be present in the drug at concentrations of up to 0.2%. Bosentan impurity C can be prepared by crystallization from an alkaline solution and can also be obtained as a salt form. The salt form is a dimer that consists of two bosentan molecules linked together by one oxygen atom. Bosentan impurity C is stable under normal conditions and does not undergo any changes when exposed to light or heat. This compound has shown no significant adverse effects on humans who have taken it, with no adverse effects on the kidney, liver, or lungs reported.

<p>Salbutamol EP Impurity C is an impurity of Salbutamol EP, which is an active pharmaceutical ingredient. It is a hydrophilic interaction chromatography and reverse-phase high-performance liquid chromatography method that can be used to screen for the presence of impurities in this product. The detection method is based on the use of a diode array detector with a synchronous detection mode. The column used in this screening process is a liquid chromatography column with a particle size of 5 microns and a length of 250 mm, which has been packed with 5% phenyl-95% dimethyl polysiloxane stationary phase. This process requires acetonitrile as the mobile phase, and the detection wavelength ranges from 220 nm to 240 nm.</p>

Please enquire for more information about 2-(Tritylamino)-4-thiazolylacetic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarboxaldehyde oxime is an impurity in the drug product of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran. It is a metabolite that is formed during the metabolism of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran by cytochrome P450 enzymes. The CAS number for this compound is 227954–88–3. This chemical is not found in nature and can be synthesized in the laboratory.</p>

N-[4-[2-[[(2R)-2-Hydroxy-2-phenylethyl]amino]ethyl]phenyl]-acetamide is a synthetic drug product that belongs to the class of drugs called acetamides. It is an impurity in the API, Acetaminophen, which is used to treat pain and reduce fever. N-[4-[2-[[(2R)-2-Hydroxy-2-phenylethyl]amino]ethyl]phenyl]-acetamide is also used as a research and development chemical for drug discovery. The compound is made by reacting 4-(aminophenyl)benzeneacetic acid with 2-(hydroxyphenyl)ethanol in the presence of sodium methoxide or lithium chloride. The resulting product has been shown to have antiinflammatory properties and may be useful for treating heart diseases or diabetes.

<p>Naproxen Impurity C is an analytical impurity that is found in Naproxen. It is a white crystalline powder with a melting point of 210°C and an assay of 99%. It has been shown to be a metabolite of Naproxen, and may have therapeutic value for the treatment of pain, inflammation, or fever. The purity of this product has been verified by HPLC analysis.</p>

<p>Roxithromycin is a macrolide antibiotic that inhibits protein synthesis in bacteria. It binds to the 50S ribosomal subunit, thereby inhibiting bacterial growth. Roxithromycin has been used to diagnose intestinal and esophageal diseases, inflammatory diseases, and cancer. There are some cardiac effects associated with Roxithromycin that may be related to its ability to inhibit serotonin reuptake. This drug also has anti-inflammatory properties and has been shown to be effective against influenza virus infections as well as other infectious diseases such as tuberculosis and HIV/AIDS.</p>

N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine is a cytotoxic drug that belongs to the class of maytansinoids. It is metabolized in vivo to produce cytotoxic metabolites which inhibit protein synthesis by binding to ribosomes, preventing peptide bond formation. The preclinical studies have shown that N2'-deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine has a better therapeutic index than other maytansinoids, with fewer side effects. In animal models, N2'-deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine showed efficacy against human tumor cells and was not toxic to normal cells. This agent also showed no impurities when incubated with human liver microsomes and it was well tolerated in clinical trials in humans

<p>(R)-Apremilast-d5 is a metabolite of apremilast, which is a small molecule drug that inhibits phosphodiesterase (PDE) enzymes. It has been shown to suppress inflammation in vitro and in vivo. Metabolism studies have shown that the main metabolites of apremilast are the acid form and the glucuronide form. Apremilast-d5 is a synthetic impurity generated by oxidation of an intermediate during synthesis. It can also be found as a natural metabolite in plants such as licorice or black pepper. This product is used for HPLC standards for apremilast and its metabolites.</p>

<p>Please enquire for more information about Dibromodibenzo(b,def)chrysene-7,14-dione including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-Oxo ticlopidine oxalic acid is a synthetic compound that has been used as an impurity standard in the synthesis of other compounds. The CAS number for this compound is 89481-79-8. 2-Oxo ticlopidine oxalic acid can be custom synthesized to meet specific requirements. It is typically used as a drug product or pharmacopoeia and can be used for research and development purposes. Metabolism studies have been conducted on 2-oxo ticlopidine oxalic acid, which has shown it to be metabolized through oxidation and conjugation with glutathione, glucuronide, or sulphate. HPLC standards for this compound are available at Sigma Aldrich.</p>

Iso propyl ether abiraterone is a medicinal compound that has shown promising results in the treatment of cancer. It is an inhibitor of CYP17A1, which is a protein involved in the production of androgens such as testosterone. By inhibiting this protein, iso propyl ether abiraterone can reduce the levels of androgens in the body, which can slow or stop the growth of certain types of cancer cells. This compound has been shown to induce apoptosis (cell death) in cancer cells and has demonstrated anticancer activity in both human and Chinese hamster ovary cell lines. Iso propyl ether abiraterone is an analog of other kinase inhibitors and has potential for use in combination with other anticancer drugs.

<p>Deacetyl-N,o-didemethyldiltiazem is a drug product that is used for the treatment of hypertension. It is a synthetic compound and has not been found in nature. The impurity standard for this product is an analytical chemical that can be used to identify the presence of impurities in a sample. Deacetyl-N,o-didemethyldiltiazem can be synthesized from commercially available starting materials using custom synthesis methods. It is an API impurity and can be developed into a drug by researching and developing it as a niche therapy for hypertension. This compound has high purity and can be used as an HPLC standard.</p>

Please enquire for more information about 5-Amino-2-(phenylmethoxy)benzoic acid methyl ester including the price, delivery time and more detailed product information at the technical inquiry form on this page

Mesalamine impurity S is a mesalamine metabolite that has been identified as an impurity in the drug product. Mesalamine impurity S is an analytical standard that is used for HPLC analysis and can be used as a reference material for the pharmacopoeia. Mesalamine impurity S can also be synthesized from natural or synthetic sources.

<p>4-aminobenzenesulfonyl sulfamethoxazole N-acetate is a drug product that has been approved for use in humans. It is an impurity standard of the API sulfamethoxazole, which is used to treat bacterial infections. 4-Aminobenzenesulfonyl sulfamethoxazole N-acetate is a metabolite and impurity of the synthesis process. It has been shown to be active against methicillin resistant Staphylococcus aureus (MRSA) and other bacteria, as well as being effective for the treatment of urinary tract infections. This product has niche applications in the pharmaceutical field and can be used for research and development or analytical purposes. 4-Aminobenzenesulfonyl sulfamethoxazole N-acetate is a white solid with high purity, making it suitable for pharmacopoeia applications.</p>

<p>Tobramycin impurity 3 is a natural product that belongs to the class of antibiotics. It is an impurity in the drug tobramycin, which is used for the treatment of respiratory tract infections. Tobramycin impurity 3 has been shown as a major metabolite of tobramycin by HPLC and GC-MS. The chemical structure is not known, but it has been identified as a metabolite based on its similarity to other metabolites. Metabolism studies are required to elucidate the metabolic pathway and identify the enzyme responsible for its formation.</p>

Hexadecanedioic acid mono-L-carnitine ester chloride is an analog of a naturally occurring compound that has been found to have medicinal properties. This compound has shown potential as an anticancer agent due to its ability to inhibit cancer cell replication and induce apoptosis. It has been studied extensively in human tumor cells, where it has been shown to inhibit kinase activity and protein synthesis. This inhibitor may also have potential as a urinary biomarker for cancer diagnosis. Additionally, this compound has been tested in Chinese hamster ovary cells, where it showed potent inhibitory effects on the growth of these cells. Overall, Hexadecanedioic acid mono-L-carnitine ester chloride is a promising candidate for further research into its potential therapeutic uses in cancer treatment.

Cis-ethyl 2-hydroxyimino-3-oxobutyrate is an organic acid that can be used as a reagent for the detection of primary amines and chiral amines. It is used to detect the presence of formaldehyde, acetamide, and other amine compounds in organic extracts. Cis-ethyl 2-hydroxyimino-3-oxobutyrate reacts with primary amines to form a tertiary amine that can be detected by chromatography or by spectrophotometry. This product is used as a chromatographic reagent for the determination of histidine, hydrochloric acid, and chiral molecules. Cis-ethyl 2-hydroxyimino-3-oxobutyrate is extracted from nitrite and acetate group using solvents such as chloroform or ethyl acetate. The extract can then be separated using chromatography methods such as gas chromatography (GC) or

<p>Descarboxymethyl treprostinil is a synthetic compound that has been researched for use as a drug product. It is currently in the development stage and is not yet approved for sale to the public. Descarboxymethyl treprostinil is not found in nature and was synthesized from para-chloro-benzoic acid and 1,2,3,4-tetrahydroisoquinoline. This compound is an impurity standard with a purity greater than 98%. Descarboxymethyl treprostinil has been used in pharmacopoeia research as well as drug development studies. It has also been studied for metabolism and analytical properties.</p>

MDM2 inhibitors are a class of cancer drugs that inhibit the activity of MDM2, which is an oncoprotein that prevents the degradation of p53. This inhibition leads to increased levels of p53 and the activation of its tumor-suppressing functions. The anti-cancer activity of this drug has been shown in a number of cancer cells, including human colon cancer cells, human prostate cancer cells, and murine leukemia cells. Furthermore, this drug has been shown to have synergistic effects when combined with other chemotherapeutic agents such as cisplatin and vincristine.

Mono-(4-methyl-7-oxooctyl)phthalate (MMP) is a metabolite of the phthalate esters, which are synthetic chemicals used in plastics and other materials. MMP has been detected in the urine of neonates and preschool children, suggesting that it can be absorbed through skin contact. This compound is also found in wastewater, where it may cause estrogenic effects on human cells. The reaction solution of MMP with insulin-like growth factor (IGF) was studied by kinetic analysis and logistic regression to determine its binding affinity for IGF binding proteins. MMP has shown to be biodegradable under aerobic conditions.

<p>3-[4-(2-Pyridylsulfamoyl)phenyl] sulfasalazine is an analytical standard and a metabolite of sulfasalazine. It is used as a reference compound in the analysis of high purity sulfasalazine by HPLC. 3-[4-(2-Pyridylsulfamoyl)phenyl] sulfasalazine is also used as an impurity in the drug product, API, and drug development. The CAS number for 3-[4-(2-Pyridylsulfamoyl)phenyl] sulfasalazine is 1391062-34-2.</p>

Tetrahydro-α-(1-naphthalenylmethyl)-2-furanpropanoic acid is a reagent that is used in analytical procedures for the determination of phosphate and potassium. Tetrahydro-α-(1-naphthalenylmethyl)-2-furanpropanoic acid can be used to determine the concentrations of phosphate and potassium in human plasma, serum, or other biological fluids. It reacts with phosphates to form an insoluble salt which can be detected by fluorimetry. Tetrahydro-α-(1-naphthalenylmethyl)-2-furanpropanoic acid can also be used as an analytical standard in high performance liquid chromatography (HPLC) to measure the concentration of phosphate.

<p>4’-(7-Dechloroquinolinyl) piperaquine is an inhibitor of tumor kinases and has shown potent anticancer activity against various cancer cells. This compound is a derivative of piperaquine, which is commonly used as an antimalarial drug. 4’-(7-Dechloroquinolinyl) piperaquine has been found to induce apoptosis in human cancer cells by inhibiting the activity of protein kinases that are essential for cell growth and division. It has also been shown to have synergistic effects with capsaicin, a natural compound found in chili peppers, in inhibiting the growth of cancer cells. Additionally, this analog has been detected in human urine after administration, indicating its potential use as a therapeutic agent for cancer treatment.</p>

Tiagabine is an ester hydrochloride that is used to treat the symptoms of Parkinson's disease. Tiagabine inhibits GABA transaminase, which converts GABA into its active form, and thus prevents the breakdown of GABA in the brain. This drug also has inhibitory properties against HIV infection and has been shown to reduce neuronal death in vitro. Tiagabine has shown a positive response in clinical trials with human subjects with Parkinson's disease. Tiagabine can be taken orally or intravenously, but should not be taken with food or grapefruit juice due to increased bioavailability of the drug. This medication does not have any clinically significant pharmacokinetic interactions and does not affect hepatic function.

<p>Desloratadine is a drug that belongs to the group of antihistamines and is indicated for the treatment of allergic rhinitis. It has been shown to be as effective as loratadine, cetirizine, and fexofenadine in clinical trials. Desloratadine is metabolized by cytochrome P450 enzymes including CYP2D6 to its active form, desloratadine N-oxide. The metabolites are excreted in the urine.</p>

The N-(4-hydroxyphenyl)propionamide (HPPA) is a synthetic drug that binds to the human liver. It has been shown to be effective in preventing implantation of fertilized eggs, and can be used as a diagnostic agent for determining the presence of HPPA in human liver tissue. HPPA is also used as a diluent for other drugs. The HPPA binds to chromatographic components and can be detected using electrochemical detection, which allows it to be used as a targetable probe for cancer research. HPPA is also used to study iontophoretic transport of ions across reconstituted membranes in vitro.

<p>(S)-Aspartimide is a drug product that is used in the synthesis of pharmaceuticals. Its purity should be greater than 99% and it should be free from detectable impurities. (S)-Aspartimide is metabolized by esterases, glutathione reductase, cytochrome P450 enzymes, and conjugation with glucuronic acid. It has been shown to inhibit the growth of bacteria that are resistant to penicillin, ampicillin, erythromycin, and gatifloxacin. (S)-Aspartimide has been found to have an anti-inflammatory effect due to its inhibition of prostaglandin synthesis.</p>

<p>N-Desmethyl phenyltoloxamine hydrochloride is a white crystalline powder that is soluble in water and slightly soluble in ethanol. It has an analytical purity of greater than 99% with a melting point of 188-190°C. This compound is a metabolite of phenyltoloxamine, which is used as an analgesic and anti-inflammatory drug. N-Desmethyl phenyltoloxamine hydrochloride can be used as a pharmacopoeia reference standard for the analysis of this metabolite and also as a research and development starting material for the synthesis of other compounds.</p>

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<p>Indoxacarb is a racemic compound that is used as an insecticide. It belongs to the class of carbamate insecticides and is marketed under the trade name of "Provaunt". Indoxacarb inhibits acetylcholinesterase, which leads to increased acetylcholine in the synapse, resulting in death. The production of indoxacarb has been optimized to yield a high-level of stereoselectivity. This optimization was achieved through a biocatalytic process that uses a strain of Escherichia coli with high stereoselectivity. This strain produces indoxacarb with a high level of stereoselectivity, which can be confirmed by NMR analysis.</p>

<p>(-)-Cloprostenol is an analog of prostaglandin F2α and a potent inhibitor of protein kinase C. It has been shown to induce apoptosis in human cancer cells, making it a potential anticancer agent. (-)-Cloprostenol has also demonstrated inhibitory effects on tumor growth in Chinese hamster ovary cells and has been investigated for its medicinal uses in cancer treatment. This compound works by binding to the prostaglandin receptor and activating downstream signaling pathways that lead to cell death. Its ability to inhibit kinases makes it a promising candidate for the development of kinase inhibitors as a new class of anticancer drugs.</p>

<p>Cinacalcet is a drug product that is used for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease. It is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. Cinacalcet impurity E hydrochloride (CIN-E) is an analytical standard for use in HPLC as an impurity of cinacalcet. This compound has not been found to be pharmacologically active and its effects are unknown.</p>

Ml 10302 hydrochloride is a drug that has anxiolytic-like effects in animals. Ml 10302 hydrochloride binds to the GABAA receptor and enhances its sensitivity to the neurotransmitter GABA. It also binds to the benzodiazepine site on the GABAA receptor and inhibits a variety of ligands, including benzodiazepines, barbiturates, and alcohols. Ml 10302 hydrochloride was shown to have anxiolytic-like effects in humans and it is thought that this effect may be due to its ability to increase the sensitivity of GABAA receptors. Studies suggest that Ml 10302 hydrochloride increases the affinity of GABA for its binding site on the GABAA receptor, which is thought to be mediated through an allosteric mechanism.

Ethylene terephthalate cyclic hexamer-d24 is a synthetic drug product. It is a metabolite of ethylenediaminetetraacetic acid, which is an analytical standard for HPLC and GC analysis. The substance has been used in pharmacopoeia and as a research and development impurity standard.