APIs pour la recherche et les impuretés

Tirzepatide impurities.

Erythromycin impurity M is a natural, API impurity (impurity standard) that is a metabolite of erythromycin. It has been synthesized as a high purity HPLC standard to meet the requirements of pharmacopoeia and drug development. Erythromycin impurity M is an analytical reference material with CAS number 528-73-2.

2H,5H-Pyrano[4,3-b]pyranyl mupirocin sodium impurity is an impurity standard that has been custom synthesized for research and development purposes. It has a CAS number of 116182-44-6, which is the same as the parent compound. 2H,5H-Pyrano[4,3-b]pyranyl mupirocin sodium impurity is a metabolite of Mupirocin Sodium (CAS No. 99765-92-8). This impurity has been used in pharmacopoeia drug development and for analytical studies such as HPLC.

9-Oxo azithromycin B is a metabolite of azithromycin. It is an analytical standard for the HPLC analysis of azithromycin and its metabolites. 9-Oxo azithromycin B has been shown to bind to the ribosomes of bacteria, and inhibit protein synthesis. This drug also has antibiotic activity against Mycobacterium avium and Mycobacterium tuberculosis. 9-Oxo azithromycin B can be used in niche research or as an API impurity.br>
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Soluble in Chloroform & in Methanol Confirmed
Insoluble in Water

N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) is a solid with a low melting point which has been identified as a potentially carcinogenic component of both tobacco and tobacco smoke. NMBA is also one of a number of nitrosamine impurities which have been found to be present in angiotensin II receptor blocker (ARB) drugs used to treat high blood pressure.

Remdesivir is an antiviral drug. It is an RNA-dependent RNA polymerase inhibitor that has been shown to be effective against a broad range of RNA viruses, including influenza A and B, rhinovirus, respiratory syncytial virus, and parainfluenza virus. Remdesivir impurity 7 (impurity) is a byproduct of the synthesis process of remdesivir. It is a white crystalline solid with a strong chemical odor. This impurity can be synthesized in high purity as well as in custom specifications to meet the needs of pharmaceutical companies developing new drugs.

Trazodone is a psychotropic agent that belongs to the group of antidepressants. Trazodone hydrochloride impurity C is a metabolite of trazodone and can be used as an impurity standard for the drug product in pharmacopoeia. Trazodone hydrochloride impurity C has been found in urine, blood, and saliva after administration of trazodone. It is also found in the plasma of pregnant women who are taking trazodone to treat depression or anxiety during pregnancy.
Trazodone hydrochloride impurity C is synthesized using a custom synthesis with high purity. It has been shown to have a niche market as an analytical reference material for HPLC standards.

N-Acetylmemantine is a drug that inhibits the activity of acetylcholinesterase in the brain. It has been shown to inhibit cancer cell growth and induce apoptosis, as well as inhibit the reaction of hydrolysis of acetonitrile with hydrochloric acid in an organic solvent. N-Acetylmemantine is synthesized by heating ethylene in the presence of hydrochloric acid. The synthesis yields a white solid that consists mainly of N-acetylmethamphetamine. This drug interacts with cellular membranes, which may be due to its ability to react with cholesterol or phospholipids. The interaction leads to changes in membrane permeability, which can result in apoptosis.

10,11-Dihydroxy-d10 Carbamazepine is a drug product that is used as an analytical reference standard. It is natural and synthetic impurity in the API (active pharmaceutical ingredient) Carbamazepine. The CAS number for 10,11-Dihydroxy-d10 Carbamazepine is 513-81-5. This compound has been synthesized by custom synthesis and is an impurity standard for HPLC analysis of carbamazepine. 10,11-Dihydroxy-d10 Carbamazepine is also a research and development chemical for the drug development industry. It has been classified as a niche chemical due to its high purity and pharmacopoeia grade.

Lenvatinib impurity 10 is a synthetic impurity that is used as an analytical standard in HPLC. It is also a metabolite of lenvatinib and has been found to have anti-inflammatory properties. Lenvatinib impurity 10 is available in high purity and can be custom synthesized to meet the needs of your research or development.

Cefazolin impurity A is a by-product in the synthesis of Cefazolin, which is a drug product. It has CAS No. 30246-33-4 and is used as an impurity standard for analytical purposes. The Impurity Standard is also known as Metabolite A. Research and Development (R&D) studies are needed to identify the appropriate analytical impurities for this API, which will be reported on Pharmacopoeia's List of Impurities for reference. The high purity and custom synthesis of this API makes it ideal for use in R&D studies, HPLC standards, or niche markets.
CAS No.: 30246-33-4
Synonyms: Metabolite A
Formula: C11H14N2O5S
Molecular weight: 289.24 g/mol
Appearance: white solid powder

The following is a description of an impurity standard for the metabolite 2-(3-Hydroxy-2,2-Dimethylpropoxy)-1-(6-Hydroxy-2-Naphthyl)Propan-1-One:

Bis-[[2-[(diaminomethylene)amino]thiazol-4-yl]methyl]disulfide is a disulfide derivative of famotidine. It has been used as an analytical reagent for the determination of impurities in famotidine and other related compounds. Bis-[[2-[(diaminomethylene)amino]thiazol-4-yl]methyl]disulfide is soluble in methanol, ethanol and water, but not in acetone. The compound can be prepared by reacting 4-(dimethylamino)-1H-1,2,3-benzothiadiazole with 2-[(diaminomethylene)amino]-4-(N'-methoxycarbonylthio)benzaldehyde and then reductive amination with sodium bisulfite.

Cimetidine impurity F is a research and development, drug product, analytical, synthetic, natural, niche, HPLC standard and pharmacopoeia impurity.
CAS No. 55272-86-1

5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulphonyl]-1H-benzimidazole N-oxide is a cyclic sulfoxide that has shown to be a potent inhibitor of gastric acid secretion. It is an important intermediate in the synthesis of esomeprazole magnesium, a proton pump inhibitor used to treat gastroesophageal reflux disease and other gastrointestinal disorders. 5-Methoxy-2-[(4-methoxy 3,5 dimethyl 2 pyridinyl) methyl] sulphonyl]-1H benzimidazole N oxide is also known as (RS)-N-[4-(4′ methoxyphenyl)-3,5 dimethylpyrazol -2 - ylmethyl] methanesulfonamide. This compound has been shown to have a polymorphic form with two different

Memantine impurity IV is a hydrolysis product of memantine. It appears as a white to off-white powder and has a molecular weight of 198.1 g/mol. Memantine impurity IV is an intermediate in the production of memantine and is therefore not used for any other purpose. The compound contains hydroxy groups, hydroxy, alcohols, and bridgehead groups which are efficient at hydrolyzing to form amino acids.

Acyclovir is an antiviral drug that inhibits the replication of herpes viruses by selectively inhibiting viral DNA polymerase. The drug is active against a broad range of herpes viruses, including both types of herpes simplex virus (HSV-1 and HSV-2) and varicella zoster virus. Acyclovir has also been shown to be effective against aciclovir-resistant mutants. This drug can be used as a prophylaxis or in combination with other antiviral agents for the treatment of active infections. Acyclovir can cause headaches, nausea, vomiting, and diarrhea when taken orally. It should not be taken with certain medicines such as aminoglycosides or high doses of aspirin because this may increase the risk for kidney problems.

2-Mercaptobenzimidazole is a chemical compound that can be used for the treatment of infectious diseases. It has been shown to have antioxidative properties and inhibit the growth of bacteria. 2-Mercaptobenzimidazole also has an effect on human serum, which may be due to its ability to bind with proteins in serum and form hydrogen bonds. 2-Mercaptobenzimidazole is stable at high temperatures and has been shown as an effective antimicrobial agent against gram positive and gram negative bacteria.

Tirzepatide Impurity

Albendazole sulfoxide is a sulfoxide of albendazole. The molecular docking analysis of the two molecules showed that the sulfoxide group is located in the same position as the hydroxyl group on albendazole. It has been shown that this replacement of hydroxyl with a sulfoxide group increases the solubility and stability of albendazole, which may be due to hydrogen bonding interactions between these groups. Albendazole sulfoxide has been shown to be an effective treatment for infections caused by parasites such as helminths. However, it should not be used in combination with drugs that are metabolized by cytochrome P450 enzymes because it can inhibit their activity.

When bound with 68Ga is used in PET/CT as a diagnostic in multiple myeloma detection

2-[[[(4-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfonyl]-1H-benzimidazole is a protonated sulfonamide that is used as an analytical method to detect the presence of other drugs in human liver tissue. It has been shown to inhibit the activity of cytochrome P450 3A4 (CYP3A4), one of the enzymes responsible for metabolizing many drugs. Bromoenol lactone and powder diffraction spectrum are two additional analytical methods that can be used to detect 2-[([(4-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfonyl]-1H-benzimidazole.

Atorvastatin diepoxide is an analytical standard for the drug atorvastatin that is used in the development of pharmaceuticals. It is synthesized by reacting atorvastatin with epichlorohydrin, which produces a diepoxide derivative. This synthetic molecule can be used as an impurity standard for HPLC analysis. The CAS number for atorvastatin diepoxide is 887470-43-1.

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