APIs pour la recherche et les impuretés

Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) that is used for the relief of inflammation and pain in osteoarthritis and rheumatoid arthritis. It is a stable, water-soluble prodrug of methylated meloxicam. The drug is metabolized to its active form, which is an inhibitor of cyclooxygenase-2 (COX-2). Meloxicam has been shown to be effective against COX-1, but not COX-2. This agent can be administered as an oral tablet or as a slurry in ethyl acetate and dimethyl sulfoxide.

a-(Aminocarbonyl)-4-[2-(5-ethyl-2-pyridinyl)ethoxy]benzeneethanesulfonic acid is an analytical standard that is used in the drug development process. It has a purity of 99.9% and is used as an HPLC standard, niche product, and pharmacopoeia impurity. This chemical can also be custom synthesized or found in nature.

<p>Cinacalcet is a drug product that is used for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease. It is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. Cinacalcet impurity E hydrochloride (CIN-E) is an analytical standard for use in HPLC as an impurity of cinacalcet. This compound has not been found to be pharmacologically active and its effects are unknown.</p>

<p>Olopatadine methyl ester is a non-sedating antihistamine that is used to treat allergic symptoms. It has a rapid onset of action and is effective for 24 hours. Olopatadine methyl ester blocks the effects of histamine by inhibiting its binding to H1 receptors in the body. This drug also inhibits the release of prostaglandins and leukotrienes, which are mediators of inflammation, thereby providing relief from allergy symptoms.</p>

<p>Indoxacarb is a racemic compound that is used as an insecticide. It belongs to the class of carbamate insecticides and is marketed under the trade name of "Provaunt". Indoxacarb inhibits acetylcholinesterase, which leads to increased acetylcholine in the synapse, resulting in death. The production of indoxacarb has been optimized to yield a high-level of stereoselectivity. This optimization was achieved through a biocatalytic process that uses a strain of Escherichia coli with high stereoselectivity. This strain produces indoxacarb with a high level of stereoselectivity, which can be confirmed by NMR analysis.</p>

<p>Isoginsenoside Rh3 is a metabolite of the natural product ginseng. It has been reported to have anti-inflammatory properties in vitro and in vivo, but it has not been studied extensively. Isoginsenoside Rh3 is not found in the human body, but it is an impurity of Ginseng extract that is routinely measured by HPLC. The concentration of this metabolite can be used as a quality control measure for Ginseng extracts.</p>

<p>[1-Hydroxy-3-(methylisopentylamino)propylidene] bisphosphonic acid monosodium (ibandronic acid impurity) is a metabolite of ibandronate, which is used in the treatment of osteoporosis. It is an impurity found in ibandronate drug products and can be detected using HPLC.</p>

<p>(Z)-Fluvoxamine-EP is a drug product that is used as an analytical standard. It is a synthetic metabolite of fluvoxamine, which is a drug used for the treatment of depression. The synthesis of (Z)-fluvoxamine-EP is based on the asymmetric synthesis of fluvoxamine and the use of chiral chromatography to purify the product. This synthetic process allows for the production of high-purity (Z)-fluvoxamine-EP with a purity greater than 99%.</p>

Dapoxetine N-oxide is a pharmaceutical agent that inhibits serotonin reuptake and has been shown to be effective in the treatment of premature ejaculation. It is a metabolite of dapoxetine, which is an antidepressant drug. Dapoxetine N-oxide has a terminal half-life of about 10 hours, which is shorter than that of its parent compound. Dapoxetine N-oxide also has a lower carcinogenic potential than its parent compound. This agent can inhibit the activity of rat liver microsomes, as well as human liver microsomes at high concentrations. It also has no effect on plasma concentrations at low doses, but does show dose proportionality at higher doses. Dapoxetine N-oxide also does not have any impurities or other drugs added to it.

<p>Quetiapine is a drug that belongs to the class of sulfoxides. It is usually administered orally, but can also be given intravenously or intramuscularly. Quetiapine has been studied for its clinical use in the treatment of schizophrenia and bipolar disorder. The plasma concentrations of quetiapine are determined by high-performance liquid chromatography (HPLC) with tandem mass spectrometry (LC-MS/MS) detection. Validation studies have shown that the HPLC-MS/MS method is accurate and precise, with good linearity over a range of concentrations. Analysis was performed on plasma samples from healthy volunteers who were administered either 2 mg or 10 mg doses of quetiapine by intravenous injection. Concentrations were calculated and compared to those found in patients with schizophrenia and bipolar disorder who had been given oral doses of 300 mg per day for four weeks, yielding a therapeutic plasma concentration range from 100 to 300 ng/mL.</p>

N-Demethyl pazopanib is a synthetic drug that has been researched and developed for the treatment of cancer. It is an impurity standard, custom synthesis, and drug product. Synthetic N-demethyl pazopanib is used in clinical trials as a research and development tool to explore the metabolism of this drug and its metabolites. High purity N-demethyl pazopanib is used as a pharmacopoeia reference material for HPLC analysis in pharmacological studies. The metabolite of N-demethyl pazopanib has been found to be carcinogenic in animal studies. Metabolism studies have shown that N-demethyl pazopanib undergoes extensive hydroxylation and glucuronidation, which are detoxification pathways for xenobiotics in mammals.

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<p>N-(3-Trifluoromethylphenyl)-phenylamine is a research and development drug product that is used as an analytical impurity standard. It has a CAS number of 101-23-5 and is classified under the trade name 3TFPPA. The chemical formula for N-(3-Trifluoromethylphenyl)-phenylamine is C12H8F3NO. This compound can be synthesized from phenylamine, 3-trifluoromethylaniline, and hydrochloric acid. The molecular weight of this compound is 197.19 g/mol, which falls within the range of 195 to 200 g/mol. N-(3-Trifluoromethylphenyl)-phenylamine can be found in the following pharmacopoeia: USP (United States Pharmacopeia), EP (European Pharmacopoeia), JP (Japanese Pharmacopeia), BP</p>

4-Methyl-N-(5-methyl-2-pyridinyl)benzamide is a birefringent, crystalline compound that is soluble in organic solvents. This compound exhibits liquid crystal composition and can be synthesized by the reaction of 2,4-dimethylbenzoyl chloride with 5-methylpyrimidine. It has been used in the production of photolytic materials such as fluorine. 4-Methylbenzamide has been shown to have a skeleton that is composed of two fused pyridine rings and an amide group. The impurities found in this product are mainly methyl benzoate and methyl pyridine.

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2,3,4-Trimethoxybenzaldehyde is an organic compound that is used as a chemical intermediate in the synthesis of pharmaceuticals. It is also used as a reagent in the chemical industry and as a flavoring agent. 2,3,4-Trimethoxybenzaldehyde has been shown to be metabolized by human liver microsomes to yield metabolites that are not well characterized. The impurities found in this drug product are 2-methoxy-5-methylphenol and 2,6-dimethoxyphenol.

<p>Warfarin is a clinically used drug that is an anticoagulant and has been shown to have anticancer activity. Warfarin has been shown to inhibit the synthesis of unsaturated ketones by carbonyl reduction and asymmetric synthesis. It also inhibits the growth of cancer cells in animals and human liver cells. Warfarin reduces the production of coagulation factors II, VII, IX, and X by inhibiting protein synthesis in the liver. The anticoagulant effect of warfarin is due to inhibition of the synthesis of vitamin K-dependent clotting factors II, VII, IX, and X. Warfarin also binds to a cytosolic protein called matrix metalloproteinase-9 (MMP-9) which inhibits its proteolytic activity.</p>

4-Hydroxy-α1-[[[6-(3-phenylpropoxy)hexyl]amino]methyl]-1,3-benzenedimethanol (4OHBZ) is a metabolite of the drug product 4OHBZ. It is an impurity standard for HPLC analysis of the drug product 4OHBZ. The impurity has been characterized by LCMS and MS studies. The purity of this compound is >99%.

<p>(4R)-1-(4-O-b-D-Galactopyranosyl-b-D-glucopyranosyl)-4-(2-methylpropyl)-2-pyrrolidinone is a synthetic, impurity standard and research and development compound. (4R)-1-(4-O-b-D-Galactopyranosyl-b-D-glucopyranosyl)-4-(2-methylpropyl)-2pyrrolidinone is used as an analytical reference in the synthesis of other compounds. It is also used in drug development for the treatment of tuberculosis. This product has a high purity level and is pharmacopoeia grade.</p>

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9-Glycine Desmopressin is a drug product that has been custom synthesized for use in research and development. This compound is an impurity standard that is used to identify the 9-glycine desmopressin impurities in the HPLC method. It is also used as a synthesis intermediate for the manufacture of the API. The CAS number for this compound is [CAS NO.]. This compound was manufactured using synthetic methods and has demonstrated high purity.

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Tortoside A is a potent inhibitor of protein kinases and has been found to have anticancer properties. It is an analog of a compound originally isolated from a Chinese medicinal plant. Tortoside A has been shown to induce apoptosis in cancer cells by inhibiting the activity of specific kinases that are involved in tumor growth and progression. This compound has also demonstrated promising results as an anticancer agent, with studies showing its ability to inhibit the growth of various human cancer cell lines. Tortoside A can be detected in urine, making it a potential biomarker for monitoring cancer treatment efficacy. Its unique properties make it an exciting candidate for further research and development as a potential cancer therapy.

<p>(S)-Aspartimide is a drug product that is used in the synthesis of pharmaceuticals. Its purity should be greater than 99% and it should be free from detectable impurities. (S)-Aspartimide is metabolized by esterases, glutathione reductase, cytochrome P450 enzymes, and conjugation with glucuronic acid. It has been shown to inhibit the growth of bacteria that are resistant to penicillin, ampicillin, erythromycin, and gatifloxacin. (S)-Aspartimide has been found to have an anti-inflammatory effect due to its inhibition of prostaglandin synthesis.</p>

Cortisol 21-M-maleimidobenzoate is a synthetic analog of the human hormone cortisol. It is commonly used as a kinase inhibitor in cancer research and medicinal chemistry. This compound has been shown to induce apoptosis in tumor cells by targeting specific proteins involved in cell cycle regulation, making it a promising candidate for anticancer therapy. Cortisol 21-M-maleimidobenzoate has demonstrated potent activity against various kinases and inhibitors, making it a valuable tool for studying their roles in cancer progression. Its unique chemical structure allows for precise targeting of specific proteins, making it an ideal choice for researchers seeking to develop new treatments for cancer. Additionally, this compound can be detected in urine samples, which makes it useful for monitoring disease progression and response to treatment.

<p>Teopranitol is a potent inhibitor of kinases, which are enzymes that play a critical role in cellular signaling pathways. It belongs to the class of protein kinase inhibitors and has been shown to have inhibitory activity against a wide range of kinases. Teopranitol has been tested on various cell lines, including human cancer cells and Chinese medicine-derived cell lines. It has been found to be effective in inhibiting the growth of mutant cancer cells by blocking the activity of specific kinases. This inhibitor shows promise as a potential treatment for cancer and tumors due to its ability to target specific pathways involved in cancer progression.</p>

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(±)-3',4'-Dihydro-1'-hydroxy-7'-methoxy-spiro[cyclopentane-1,2'(1'H)-naphthalene]-1'-acetonitrile is an impurity standard that is used as a research and development (R&D) chemical. It can be custom synthesized and is available as a drug product. This compound is synthetically derived and has high purity. It is also listed in the pharmacopoeia and can be used for drug development. Metabolite studies have been done on this compound, including metabolism studies that were conducted with HPLC standards.

The N-(4-hydroxyphenyl)propionamide (HPPA) is a synthetic drug that binds to the human liver. It has been shown to be effective in preventing implantation of fertilized eggs, and can be used as a diagnostic agent for determining the presence of HPPA in human liver tissue. HPPA is also used as a diluent for other drugs. The HPPA binds to chromatographic components and can be detected using electrochemical detection, which allows it to be used as a targetable probe for cancer research. HPPA is also used to study iontophoretic transport of ions across reconstituted membranes in vitro.

WAY 181187 oxalate is a metabolite of WAY-361507, a drug that has been studied for the treatment of cancer. The chemical structure of WAY 181187 oxalate is shown below.

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2-Ethoxy-1-[2'-[1-(trityl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-4-carboxylic acid methyl ester is an impurity in the drug product, which is a synthetic drug for research and development. The impurity standard for 2-ethoxy-1-[2'-[1-(trityl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H benzimidazole 4 carboxylic acid methyl ester is available in quantities of 10g. The CAS number for the impurity is 150058-29-0. This compound has an API purity of 99.9%. Impurities are not expected to be present at greater than 1% by weight.

<p>Tolterodine S-enantiomer is a drug product that belongs to the class of prodrugs. It is metabolized in vivo to the active form, tolterodine. Tolterodine S-enantiomer has been shown to have a natural origin and can be found in plants and animals. Metabolism studies of this compound have been conducted in human liver microsomes, with the major metabolite being tolterodine. Tolterodine S-enantiomer also has pharmacopoeia standards, including an analytical standard and an impurity standard, as well as an HPLC standard for research and development purposes.</p>

[(1S)-(1Alpha,2Beta,3Beta)]-3-(2-Amino-6-iodo-7H-purin-7-yl)-1,2-cyclobutanedimethanol dibenzoate ester is a synthetic drug product that is used in the development and manufacture of pharmaceutical products. It is an impurity standard for HPLC. This drug is also a metabolite of the parent drug, 7H-[1,2]oxazolo[4,5-b]pyridine. The chemical formula is C19H22N6O3 and molecular weight is 356.37 g/mol. CAS No. 1246812-29-2

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<p>Elbanizine is an anticancer agent that works by inhibiting kinase activity in cancer cells. This inhibitor has been shown to induce apoptosis, which is the programmed cell death of cancer cells. Elbanizine is a potent inhibitor of protein kinases and has been found to be effective against various types of tumors. It is an analog of a Chinese medicinal plant and has been isolated from human urine. Elbanizine has also been found to affect the cell cycle, leading to cell death in cancer cells. This promising anticancer agent shows great potential for the development of new cancer therapies and inhibitors.</p>

<p>rac-Des(isopropylamino) acebutolol diol is a synthetic drug substance that is used for research and development purposes. It has a purity of 99% or greater, does not contain any impurities, and is manufactured using the latest technology. The rac-Des(isopropylamino) acebutolol diol is a pharmaceutical grade product with high purity and quality standards that have been verified by HPLC analysis. This compound is an analytical standard that can be used to calibrate mass spectrometry instruments. Rac-Des(isopropylamino) acebutolol diol is also metabolized into the natural metabolite noracebutanol by cytochrome P450 enzymes in humans.</p>

<p>Nizatidine sulfoxide is a drug product with CAS No. 102273-13-2. It is a metabolite of nizatidine, a compound that inhibits gastric acid secretion and reduces the risk of ulcers and gastrointestinal bleeding. Nizatidine sulfoxide is an impurity in the synthesis of nizatidine. This impurity has been found in our synthesized material and has been found to be an analytical standard for HPLC analysis. Our research team has developed this impurity as a niche product for pharmacopoeia development and drug development.</p>

<p>2,4-Dicyano-3-isobutyl-glutaric acid is an impurity found in the synthesis of the drug product 2,4-D. It is a white solid that has been shown to have analytical properties. This compound has been used as a research and development standard and is used as an analytical reagent in HPLC. 2,4-Dicyano-3-isobutyl-glutaric acid can be custom synthesized or obtained from natural sources. Metabolites of 2,4-dicyano-3-isobutyl glutaric acid are not known at this time.</p>

1-β-D-Arabinofuranosyl-5-methylcytosine is an analog of the anticancer drug indirubin that has been shown to induce apoptosis in cancer cells. It is a potent inhibitor of human protein kinases, particularly those involved in cell cycle regulation and proliferation. This compound has been found in Chinese urine samples and has been studied extensively as a potential cancer treatment. 1-β-D-Arabinofuranosyl-5-methylcytosine inhibits tumor growth by blocking the activity of various kinases involved in cancer cell signaling pathways. As such, it is considered a promising candidate for future cancer therapies.

3α-Hydroxydesoxyartemether is a synthetic, natural product. It is an impurity of the API 3α-hydroxydesoxyartemisinin. It has been shown to have pharmacological properties similar to those of artemisinin. The metabolite has been shown to have activity against bacteria and fungi that are resistant to other drugs. Synthesis of this compound requires the use of a custom synthesis and can be obtained in high purity from a HPLC standard with analytical data. 3α-Hydroxydesoxyartemether is used as a research and development tool for drug development and as an impurity standard for pharmacopoeia.

2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol N-oxide is a peroxide that is used in pharmaceutical preparations as an antioxidant. It is a white solid that is insoluble in water and has a molecular weight of 168.13. 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol N-oxide has been shown to be effective against the development of cholesterol gallstones and can be used as a prophylactic agent against cardiovascular disease. This compound also inhibits the oxidation of drugs by hydrogen peroxide and other oxidizing agents. 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)eth

<p>Taxine A is a potent inhibitor of kinases that has been isolated from the Chinese yew tree. It has shown promising results in inhibiting the growth of cancer cells and inducing apoptosis. Taxine A exhibits a unique mechanism of action by binding to a specific site on the kinase, which prevents its activation and subsequent downstream signaling. This analog of linezolid has been shown to have potent anticancer activity against various tumor cell lines, including human breast cancer and lung cancer. Taxine A is also excreted in urine, making it an attractive candidate for non-invasive diagnostic tests for cancer. Its ability to inhibit kinases makes it a potential therapeutic agent for a wide range of cancers.</p>

Des[2-[(2-hydroxyethyl)amino]ethyl] mitoxantrone is a research and development impurity standard for synthesis. It is a synthetic, high purity compound with a CAS number of 89991-52-6. The chemical is not found in nature and does not have any natural metabolites. Des[2-[(2-hydroxyethyl)amino]ethyl] mitoxantrone has been shown to be metabolized by the liver into various metabolites that have been identified through analysis of urine samples. The metabolite of des[2-[(2-hydroxyethyl)amino]ethyl] mitoxantrone may be used as an analytical standard for HPLC methods.

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<p>GSK-2793660 is a potent and selective analog of a human protein kinase inhibitor that has been shown to induce apoptosis in cancer cells. It is a medicinal compound that inhibits the activity of kinases, which are enzymes involved in cell signaling pathways. GSK-2793660 has demonstrated anticancer activity in preclinical studies, particularly against Chinese hamster ovary (CHO) tumor models. This inhibitor has also been found in urine samples from cancer patients, indicating its potential as a diagnostic tool for cancer. Its ability to selectively target specific kinases makes it a promising candidate for the development of new cancer therapies.</p>

<p>(Αr,βs)-β-(acetylamino)-α-hydroxy-4-(phenylmethoxy)-benzenepropanoic acid ethyl ester is a drug product that is custom synthesized for research and development purposes. The CAS number for this product is 382596-25-0. This product has an analytical purity of ≥ 98% and can be used in metabolism studies. It can also be used as a natural metabolite or as a drug development pharmacopoeia standard. This product contains impurities at ≤ 1%.</p>

Endothion is a medicinal compound that has shown promising anticancer properties. It is an analog of a kinase inhibitor found in Chinese herbal medicine and has been shown to inhibit the activity of kinases involved in cancer cell growth and survival. Endothion induces apoptosis, or programmed cell death, in cancer cells by inhibiting protein synthesis and disrupting cellular processes necessary for tumor growth. Studies have also shown that Endothion can be excreted through urine, making it a potential non-invasive diagnostic tool for cancer detection. This compound is currently being researched as a potential treatment option for various types of cancer.

a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-propyl-benzeneacetonitrile is a drug product that is custom synthesized and has been shown to have high purity. It is also used in analytical studies, metabolism studies, and natural drug development. This compound can also be found as an impurity standard for HPLC or as an API impurity.

Moexipril methyl ester analog hydrochloride is a drug product that has been custom synthesized for research and development. It is a high purity, analytical grade compound with CAS No. 1356841-17-2. Moexipril methyl ester analog hydrochloride is metabolized through metabolic studies and is a natural metabolite of the drug moexipril. This substance can be found in the pharmacopoeia and is used as an impurity standard. Moexipril methyl ester analog hydrochloride also has niche applications in synthetic chemistry research and development.

Methapyrilene dihydrochloride is an anticancer drug that acts as a kinase inhibitor, preventing the activation of protein kinases that are involved in cancer cell growth and survival. It has been shown to induce apoptosis (cell death) in cancer cells by inhibiting the activity of certain kinases. Methapyrilene dihydrochloride is a potent inhibitor of tumor growth in Chinese hamsters, human tumors, and other animal models. It is also an analog of amphetamine and can be detected in urine tests. This drug has shown promising results as a potential treatment for various types of cancer.

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Secophenol is a potent inhibitor of Chinese hamster ovary (CHO) and human kinases. It has shown promising results in the treatment of cancer, inhibiting tumor growth and inducing apoptosis in cancer cells. Secophenol is an analog of surfactin, a protein that is produced by Bacillus subtilis. It has been found to be effective in inhibiting the growth of various types of cancer cells, including breast, colon, and lung cancer cells. In addition to its anticancer properties, Secophenol has also been detected in urine samples from patients with tumors, indicating its potential use as a diagnostic tool for cancer detection.

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(-)-Wine lactone is a medicinal compound with potent anticancer properties. It has been shown to be an effective inhibitor of kinase, a protein that plays a key role in tumor growth and cancer cell proliferation. Studies have demonstrated that (-)-Wine lactone analogs can induce apoptosis, or programmed cell death, in human cancer cells by inhibiting kinase activity. This compound has also been found in Chinese medicinal herbs and urine samples from healthy individuals. Its potential as an anticancer agent makes it an exciting area of research for the development of novel cancer therapies.

<p>2,3-Dimethylphenyl mefenamic acid is a synthetic drug product. It is used as an impurity standard for the HPLC analysis of N-(2,3-dimethylphenyl)mefenamic acid carboxamide, and is also a custom synthesis intermediate. 2,3-Dimethylphenyl mefenamic acid has been shown to be metabolized by liver microsomes in vitro and to inhibit prostaglandin synthesis. In vivo studies have shown that the primary route of elimination of 2,3-dimethylphenyl mefenamic acid is through the urine.<br>2,3-Dimethylphenyl mefenamic acid has been shown to be effective in inhibiting prostaglandin synthesis in vitro and in vivo studies. It has also been shown to be active against gram positive bacteria such as Bacillus subtilis and Staphylococcus aureus (ATCC 25923).</p>

<p>Roxithromycin impurity H is an analytical standard for Roxithromycin. It is a metabolite that has been identified in human urine and bile samples as well as in rat plasma following oral administration of Roxithromycin. It is also a byproduct of the synthesis of Roxithromycin, which can be eliminated through purification steps. This compound has not yet been evaluated in humans or animals, but it may cause adverse effects such as gastrointestinal disturbances, headache, or hepatotoxicity.</p>

<p>Des-[(S)-3-methyl-2-pentanamidobutanoic acid] valsartan 4’-bromomethyl is an impurity that was found in a pharmaceutical drug product. It is one of the metabolites of the active valsartan, which is used to treat high blood pressure and heart failure. Des-[(S)-3-methyl-2-pentanamidobutanoic acid] valsartan 4’-bromomethyl has been shown to have a molecular weight of 178.2 and a CAS number of 138402-33-2. This compound has been observed in pharmacopoeia as well as being listed in the United States Drug Enforcement Agency's (DEA) list of controlled substances.</p>

Candesartan acyl-glucuronide is a metabolite of candesartan. It is a white to off-white powder that is soluble in methanol and slightly soluble in ethanol, acetone, and chloroform. Candesartan acyl-glucuronide has been used as an impurity standard for the manufacture of candesartan. It is also used in drug development as a synthetic compound with high purity for research purposes only. It is not intended for use as an active pharmaceutical ingredient.

<p>L-745,870 is a subchronic atypical antipsychotic agent that is a potent D4 receptor agonist. Its efficacy in treating various mental disorders has been demonstrated in clinical studies with animals. L-745,870 has shown antidyskinetic activity in animal models of Parkinson's disease and dyskinesia. The molecular target for this drug is the dopamine D4 receptor. Clinical development of L-745,870 has begun in human studies.</p>

N-Demethyl lincomycin hydrochloride is a drug product that is used in the synthesis of pharmaceuticals. It is an analytical standard for natural lincomycin and an impurity in the synthetic production of lincomycin. N-Demethyl lincomycin hydrochloride is synthesized from the drug product, 4-demethyllincomycin, which is obtained from fermentation of Streptomyces lincolnensis. This drug product has been shown to inhibit bacterial protein synthesis by inhibiting ribosomal protein S12. N-Demethyl lincomycin hydrochloride has a purity greater than 98% and can be used as a high purity HPLC standard or as a pharmacopoeia standard.

<p>N’-(4-Aminophenyl)-N,N-dimethylacetamidine (ADAA) is a cholinergic anthelmintic drug that is effective against endoparasites. It has been shown to be effective against caenorhabditis, resistant mutants and acetylcholine receptor. ADAA is administered to animals and humans orally or intravenously. The pharmacokinetics of ADAA have been studied in rats, mice, pigs and humans. ADAA has a long half-life in rats and mice but not in humans.</p>

Oxaliplatin Impurity E is a drug product, which is an impurity that was discovered in the synthesis of oxaliplatin. It is a metabolite and an impurity standard for HPLC. Oxaliplatin Impurity E has been shown to inhibit the growth of cancer cells and may be used as a chemopreventive agent. Research is currently being conducted to determine how this compound interacts with the body's natural processes.

<p>Tri-o-(tert-butyldimethylsilyl) ractopamine is a compound that has been studied for its potential biological effects. It has been shown to have antioxidant properties, as it reduces the levels of malondialdehyde and IL-17A, which are markers of oxidative stress and inflammation. The compound's coordination geometry allows it to interact with fatty acid hydroperoxides and other complex molecules, potentially influencing their biological activity. Additionally, tri-o-(tert-butyldimethylsilyl) ractopamine can act as a cation, neutralizing reactive species that contribute to lipid peroxidation. Studies have also found impurities in this compound, which may affect its overall effectiveness. Further research is needed to fully understand the chemokine and human serum interactions of tri-o-(tert-butyldimethylsilyl) ractopamine.</p>

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Captopril-cysteine disulfide is an inhibitor that has been shown to induce apoptosis in cancer cells. It is a potent anticancer agent and has been found in human urine. This compound is an analog of capsaicin, which is known for its anticancer properties. Captopril-cysteine disulfide inhibits the activity of protein kinases, which are enzymes involved in cell growth and division. It has been shown to be effective against a variety of cancer types, including those of the lung, breast, and prostate. In Chinese hamster ovary cells, this compound inhibited the growth of tumor cells by up to 50%. Captopril-cysteine disulfide may have potential as a therapeutic agent for cancer treatment.

<p>Cefpodoxime proxetil impurity E is an active compound that belongs to the group of mixtures. It has been shown to have a film-forming property and it may contain sugar.</p>

<p>This product is a synthetic impurity of Allopurinol. It is a cyclization reaction product of dimethylhydrazine and allopurinol in the presence of an organic solvent such as DMF.</p>

5-Hydroxyindole-3-acetic acid-d2 is a drug product that can be used as an analytical reference standard for HPLC. It is also used as a metabolite in the metabolism studies of 5-hydroxyindole-3-acetic acid, a natural and synthetic compound. This product is manufactured synthetically and has been shown to have a purity of >98%. It is also manufactured for use in pharmacopoeias and can be used as an API impurity standard.

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α-Amylcinnamaldehyde dimethyl acetal is a medicinal compound that has shown promise in inhibiting the growth of cancer cells. This compound is an analog of α-amylcinnamaldehyde, a natural product found in Chinese cinnamon bark. Recent studies have shown that α-Amylcinnamaldehyde dimethyl acetal can inhibit the activity of protein kinases, which play a critical role in cell cycle regulation and tumor growth. This inhibition leads to apoptosis, or programmed cell death, in cancer cells. Researchers have also found that this compound has potential as an anticancer agent and may be useful in the development of new cancer treatments. Additionally, it has been detected in urine samples and may serve as a biomarker for certain types of cancer.

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<p>Hydroxymethyl tolperisone is a medicinal compound that has been identified as a kinase inhibitor with potential anticancer properties. It has shown promising results in inhibiting the growth of leukemia cells and tumor cell lines in human studies. Hydroxymethyl tolperisone works by interfering with protein synthesis, disrupting the cell cycle, and inducing apoptosis in cancer cells. This compound has also been found to be effective against various types of cancer, including breast, lung, and colon cancer. Hydroxymethyl tolperisone is an analog of tolperisone, a muscle relaxant that is excreted primarily through urine. The use of this compound as an anticancer agent is still under investigation, but it holds great promise for the future of cancer treatment.</p>

Mandelic acid is a naturally occurring organic compound that is the simplest aromatic carboxylic acid. It is used as an intermediate in chemical synthesis, and as a reagent in analytical chemistry. Mandelic acid can be produced synthetically by the oxidation of benzaldehyde or benzoic acid. Mandelic acid has been shown to inhibit the metabolism of many drugs, including diazepam, phenobarbital and propranolol. It also shows anti-inflammatory effects due to its ability to inhibit prostaglandin synthesis.

Digitoxigenin mono-β-D-digitoxoside is a potent inhibitor of tumor growth and cancer cell proliferation. It is an analog of the cardiac glycoside digitoxin, which is known for its anticancer properties. Digitoxigenin mono-β-D-digitoxoside has been shown to induce apoptosis in human cancer cells by inhibiting protein kinases such as AKT and ERK1/2. This drug also has potential therapeutic applications in the treatment of ghrelin-related diseases, as it has been shown to inhibit the activity of ghrelin, a hormone that stimulates appetite and promotes weight gain. Additionally, digitoxigenin mono-β-D-digitoxoside exhibits high water solubility due to its cellulose-based structure, making it ideal for use in urine-based diagnostic tests for cancer detection.

1-[(1-Methylethyl)amino]-3-phenoxy-2-propanol is an organic compound that belongs to the class of phenoxyethanol derivatives. It has been used in milligram amounts to assist in the separation of racemic mixtures by countercurrent chromatography. The compound is a racemate and the enantiomers are separated by chiral high performance liquid chromatography. The β-adrenergic agonist activity of 1-[(1-methylethyl)amino]-3-phenoxy-2-propanol has been shown in rats.

5-(Hydroxymethyl)-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide is a chemical compound that is used as an analytical reference standard, research and development, drug development and API impurity. 5-(Hydroxymethyl)-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide has a purity of 98% or higher and is available for purchase in bulk quantities. This compound can also be purchased as a HPLC standard, niche product, drug product or impurity standard. 5-(Hydroxymethyl)-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide can be synthesized naturally or synthetically. The CAS number for this chemical is 1058722-46-5.

<p>Deiodo amiodarone is a noncompetitive inhibitor that binds to the active site of the enzyme and blocks the binding of substrate, thereby inhibiting the synthesis of catecholamines. Deiodo amiodarone has been shown to inhibit the oxidation of benzofuran derivatives in rat liver microsomes, human liver tissue samples, and chromatographic conditions. The inhibition constant for deiodo amiodarone was determined by liquid chromatography with a homogenizing technique.</p>

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4-Methyl trans-Doxercalciferol is a synthetic drug product that is used as an analytical reference material for the study of metabolism. It is a natural, API impurity, and synthetic metabolite that has been prepared as an impurity standard for HPLC analysis. 4-Methyl trans-Doxercalciferol has not been evaluated in living systems, but it may be useful in research and development of drugs, such as those used to treat cardiovascular disease. 4-Methyl trans-Doxercalciferol has shown no adverse effects in pharmacological studies.

2,3-Dimethyl-N-phenylbenzenamine is a medicinal compound that has been found in urine and has shown potential as an anticancer agent. It acts as a kinase inhibitor, specifically targeting proteins involved in cancer cell growth and survival. In Chinese hamster ovary cells, this compound has been shown to inhibit the activity of protein kinases and induce apoptosis, or programmed cell death. This analog also displays potent antitumor activity against leukemia cells in vitro. As a promising candidate for cancer treatment, 2,3-Dimethyl-N-phenylbenzenamine may serve as a valuable tool in developing novel inhibitors for various types of cancers.

The Cl2 linker is an analog of saxagliptin, a kinase inhibitor that has shown promise in the treatment of tumors and cancer. It has been studied extensively in Chinese hamster ovary cells and human urine, where it has demonstrated potent inhibitory activity against a variety of kinases. The Cl2 linker has also been shown to induce apoptosis in cancer cells, making it a potential therapeutic agent for the treatment of cancer. Additionally, it has been investigated as an inhibitor of xylanase, an enzyme involved in the breakdown of plant cell walls. The Cl2 linker may also have potential as an inhibitor of other kinases, such as those targeted by aprepitant, which is used to treat chemotherapy-induced nausea and vomiting.

(17α)-13-Ethyl-3-methoxy-18,19-dinorpregna-2,5(10)-dien-20-yn-17-ol (levonorgestrel impurity T) is an analog of levonorgestrel with potent anticancer properties. It has been shown to induce apoptosis in human cancer cell lines by inhibiting kinase and elastase activities. This compound has also been tested against a variety of tumor cell lines and has demonstrated significant anticancer activity. In Chinese hamster ovary cells, levonorgestrel impurity T was found to arrest the cell cycle at the G1 phase, leading to decreased protein synthesis and ultimately cell death. As an inhibitor of kinases and other enzymes involved in cellular signaling pathways, this compound may have potential as a therapeutic agent for the treatment of cancer.

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Kaempferol di-O-methoxymethyl ether is a natural product that has been identified as a metabolite of kaempferol. It is an API impurity in the drug product and can also be found in the synthesis of kaempferol. Kaempferol di-O-methoxymethyl ether is a synthetic compound that can be used for drug development, research and development, and analytical purposes. It is an HPLC standard for pharmacopoeia.

Guaimesal is a protein analog that acts as an inhibitor of tumor growth and induces apoptosis in human cancer cells. It has been shown to inhibit the activity of kinases, including cyclin-dependent kinases, which play a key role in regulating cell division. Guaimesal has been isolated from Chinese urine and has demonstrated potent anticancer activity both in vitro and in vivo. This compound shows promise as a novel therapeutic agent for the treatment of cancer.

<p>Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile (TMBDAC) is an impurity standard and a metabolite of the drug product. It is an analytical standard for HPLC. Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile is a high purity research and development chemical that can be custom synthesized to meet specific needs. This synthetic compound has shown potential as a niche metabolite in metabolism studies. CAS No. 120511-84-4.</p>

<p>4-Desfluoro-4-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-3,6-dihydropyridin-1(2H)-yl] droperidol is a research chemical that belongs to the class of drugs. The 4DDRP is an analytical standard for impurities in droperidol and also has been used as an API impurity in HPLC standards. The chemical is also used for drug development and drug product synthesis. 4DDRP has been shown to be metabolized into oxalic acid, benzeneacetic acid, and benzoic acid.</p>

Bazedoxifene bis-β-D-glucuronide disodium salt is a medicinal compound that has been developed as a kinase inhibitor. It is an analog of bazedoxifene, which is used in the treatment of osteoporosis and breast cancer. Bazedoxifene bis-β-D-glucuronide disodium salt has been shown to induce apoptosis in human tumor cells, making it a potential anticancer agent. It inhibits various kinases, including protein kinase C and cyclin-dependent kinases, which are involved in cell division and growth. Bazedoxifene bis-β-D-glucuronide disodium salt has also demonstrated activity against Chinese hamster ovary cells and can be detected in human urine after administration.