APIs pour la recherche et les impuretés

(+)-SHIN1 is an analog of a compound found in human urine that has shown promising results in the fight against cancer. It functions as a kinase inhibitor, which means it prevents the activation of proteins that are involved in cancer cell growth and tumor formation. Studies have indicated that (+)-SHIN1 induces apoptosis (programmed cell death) in Chinese hamster ovary cells and inhibits the growth of various cancer cell lines. This compound has also been investigated for its potential use in treating Alzheimer's disease, as it shares structural similarities with donepezil, a drug used to treat cognitive impairments associated with this condition. (+)-SHIN1 represents a promising avenue for anticancer drug development and may hold great potential for improving cancer treatment outcomes.

<p>9-Epimitomycin B is a water-soluble, alkoxy-substituted amino compound that is used medicinally. It has antibacterial activity and has been shown to be effective against Gram-positive bacteria such as Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis. 9-Epimitomycin B inhibits the growth of these bacteria by binding to their ribosomes and inhibiting protein synthesis. The carbon atoms in 9-epimitomycin B are linked to an alkoxy group at one end, which causes it to have a higher affinity for bacterial ribosomes than human ribosomes. 9-Epimitomycin B also binds to mitomycin C, which may be responsible for its antimetabolite properties.</p>

<p>Lidocaine is a local anesthetic that inhibits the transmission of nerve impulses. Lidocaine-d10 hydrochloride is a drug product that contains lidocaine and deuterium-labeled lidocaine, which has been chemically synthesized to contain deuterium atoms in place of hydrogen atoms. Lidocaine-d10 hydrochloride is used as an analytical standard for pharmacological studies and drug development. It also serves as an impurity standard in the synthesis of other compounds. Lidocaine-d10 hydrochloride is metabolized through oxidation and reduction, forming metabolites such as 4-hydroxylidocaine, 4-dehydroxylidocaine, and 2,6-dehydroxylidocaine.<br>Lidocaine-d10 hydrochloride can be used to study the metabolism of lidocaine and its metabolites, which are important for drug development.</p>

Mutagen X is an anticancer drug that works by inhibiting kinases, which are enzymes involved in cell cycle regulation and apoptosis. It has been shown to be effective against a variety of human cancer cells, including those from Chinese hamsters. Mutagen X is a potent inhibitor of protein kinases, which play a key role in the growth and proliferation of cancer cells. It has been found to have a high level of potency against tumor cells and can be used as a medicinal drug for cancer treatment. Mutagen X also acts as an inhibitor in urine and has been shown to be effective against various inhibitors.

<p>4,4'-Dichlorobibenzyl is an impurity in the synthesis of bibenzyl. It is a metabolite of bibenzyl and has been detected in urine samples. 4,4'-Dichlorobibenzyl has been identified as a target for analytical methods because it is difficult to measure in biological samples due to its low concentration. It can be used as an impurity standard for HPLC analysis and has shown potential as a pharmacopoeia reference material.</p>

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<p>BMS-986299 is a Chinese compound that acts as an inhibitor of kinases, specifically targeting cyclin-dependent kinases (CDKs). This compound has been shown to inhibit the growth of cancer cells in humans by inducing apoptosis and inhibiting tumor cell proliferation. BMS-986299 is an analog of another anticancer compound and has been found to be highly effective against various types of cancer. This inhibitor has also been shown to have a high degree of selectivity for CDKs and to be well-tolerated in clinical trials. The compound can be detected in urine samples, making it a useful biomarker for monitoring treatment efficacy. Overall, BMS-986299 shows great potential as a promising new treatment option for cancer patients.</p>

<p>Sesamol-d2 is an oral prodrug that belongs to the class of morpholinos. It acts as a mitochondrial DNA ligase inhibitor, preventing the repair of oxidative damage to DNA. Sesamol-d2 has been shown to reduce fungal biomass and inhibit RNA concentration in a reaction solution containing adenine and tenofovir alafenamide hemifumarate. It also inhibits base-excision repair, leading to increased levels of oxidative DNA damage. Furthermore, Sesamol-d2 has been found to have plasma-level effects on various impurities, as demonstrated through molecular docking studies.</p>

<p>5-Bromo-4-chloro-N-cyclopentylpyrimidin-2-amine is a chemical compound that is used in various industries. It is commonly used as an intermediate or starting material for the synthesis of other compounds. This compound may contain impurities such as sulfadiazine, glutamate, fatty acids, basic proteins, methanol, acetyltransferase, chemokines, chamomile extract, cellulose, biomass, industrial products, epidermal growth factors, xylose, and growth factors. Please note that this compound is not intended for human consumption and should be handled with care.</p>

<p>2-[4-[2-(Cyclopropylmethoxy)ethyl]phenoxy]methyloxirane is a metabolite of the drug product 2-[[4-[2-(Cyclopropylmethoxy)ethyl]phenoxy]methyl]oxirane. It is an impurity in the drug product, which is a pharmaceutical intermediate that has been shown to have pharmacological properties. The CAS number for this compound is 63659-17-6 and it has been assigned the Chemical Abstracts Service (CAS) number of 63659-17-6. This compound has been characterized using HPLC and GC/MS methods.</p>

<p>Desotamide B is an analog of saxagliptin, a kinase inhibitor that has shown promising results in the treatment of cancer. It has been found to induce apoptosis, or programmed cell death, in cancer cells while sparing healthy cells. Desotamide B specifically targets kinases and proteins involved in the growth and survival of cancer cells, making it a potential anticancer therapy. This compound has been tested on Chinese hamster ovary cells and human tumor cell lines with positive results. Desotamide B is excreted primarily through urine, indicating its potential for use as a systemic therapy for various types of cancer. Its unique mechanism of action makes it a promising candidate for future cancer treatments.</p>

<p>2S,3S,4R,5R,6R-2-3-4-Acetoxybenzyl-4-chlorophenyl-6-(acetoxymethyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate is a drug product that is used in the analytical and metabolic studies. It can also be used as an impurity standard for HPLC analysis. This compound has been synthesized from natural sources and it is not available as a commercially available API. 2S,3S,4R,5R,6R-2-3-4-Acetoxybenzyl-4-chlorophenyl-6-(acetoxymethyl)tetrahydro2H-[1]pyran-[2]3,4,[1]5-[1]triol triacetate is a synthetic compound that has been developed for drug development and research and</p>

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Cefixime EP impurity B acetic acid is a research and development product. It is an impurity of cefixime EP that has been synthesized for use as an impurity standard. This compound is a metabolite of the drug cefixime EP. Cefixime EP impurity B acetic acid can be used to determine drug metabolism by studying the formation, detection and identification of metabolites in biological samples. It also can be used to develop analytical methods for the determination of metabolites in biological samples. Cefixime EP impurity B acetic acid is a synthetic compound that is highly pure with a pharmacopoeia grade purity level. This product is suitable for use in drug product, custom synthesis, and HPLC standard applications.

IPR-803 is a potent anticancer drug that belongs to the class of kinase inhibitors. It has been shown to induce apoptosis in human and Chinese hamster cancer cells by inhibiting the activity of proteins involved in cell growth and division. IPR-803 is derived from ranitidine, a medicinal compound used to treat ulcers and acid reflux. It has been found to be effective against various types of tumors and has shown promising results in clinical trials. This drug is excreted through urine and has low toxicity levels, making it a promising candidate for future cancer treatments.

<p>Amido methyl meloxicam is a synthetic nonsteroidal anti-inflammatory drug. It is used to relieve inflammation and pain. Amido methyl meloxicam is chemically similar to the naturally occurring substance, meclofenamic acid, but it does not have the same side effects.<br>Amido methyl meloxicam is metabolized in the liver by CYP3A4/5 and then excreted by the kidneys.</p>

<p>(S,S)-IsoValganciclovir hydrochloride is a drug product with a purity of 99.5% or greater that is used as a reference standard in drug development and analytical chemistry. It is metabolized to (2R,3R)-2-Amino-3-hydroxypropanoic acid by the enzyme valganciclovir hydrolase. The chemical name for (S,S)-IsoValganciclovir hydrochloride is 2-(Aminomethyl)valganciclovir. The CAS registry number for this compound is 1401562-13-7.</p>

N,N-Dimethyl-2-[6-methyl-2-(2-bromo-4-methylphenyl)imidazol[1,2-a]pyridin-3-yl]acetamide is a drug product that has not yet been fully characterized. It is a synthetic compound that is not found in nature. This product is currently being researched and developed as a potential drug to treat cancer.

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Neratinib-d6 is a potent inhibitor of cancer cell growth and is used in the treatment of various types of cancer. It induces apoptosis, or programmed cell death, in cancer cells by inhibiting specific proteins that are required for their survival. This anticancer drug has been shown to be effective against a variety of tumors and is being studied for its potential use in treating other types of cancer as well. Neratinib-d6 is a medicinal inhibitor that works by blocking the action of certain enzymes involved in the cell cycle, such as Chinese hamster ovary kinase and human epidermal growth factor receptor 2 (HER2). It is also an analog of neratinib, which is another anticancer drug that has been approved for use in humans. Neratinib-d6 can be detected in urine samples, making it useful for monitoring patients undergoing treatment with this drug.

2,3,3',4,4',5,5'-Heptachlorobiphenyl is an analog of polychlorinated biphenyls (PCBs) that has been shown to have tumor-inhibiting properties. It acts as a kinase inhibitor and disrupts the cell cycle in cancer cells. Studies have also shown that it inhibits elastase activity and reduces the level of certain proteins in urine, indicating its potential use as an anticancer agent. Additionally, 2,3,3',4,4',5,5'-Heptachlorobiphenyl induces apoptosis in Chinese hamster ovary cells and human leukemia cells. Its unique characteristics make it a promising candidate for further research into cancer treatment options.

<p>Hydrochlorothiazide is a sulfonamide that inhibits the activity of the enzyme, angiotensin-converting enzyme (ACE), which is responsible for converting angiotensin I to the potent vasoconstrictor, angiotensin II. It also has antihypertensive effects by blocking the production of aldosterone, which causes sodium retention and leads to high blood pressure. It is a byproduct in reactions with substances such as valsartan. Hydrochlorothiazide may react chemically with other medicines such as ampicillin and cefaclor.</p>

<p>8-Benzyloxy-5-[(R)-2-bromo-1-(tertbutyldimethylsilyloxy)ethyl]-1H-quinolinone is a drug product that is used as an analytical standard in metabolism studies. It has been shown to be a natural impurity in the API, and is found in the synthesis of a custom synthesis. 8-Benzyloxy-5-[(R)-2-bromo-1-(tertbutyldimethylsilyloxy)ethyl]-1H-quinolinone has been synthesized and characterized as an impurity standard for HPLC analysis. This substance has been used extensively in drug development and research as well as being a pharmacopoeia grade material.</p>

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Fijimycin B is a medicinal compound that acts as an inhibitor of kinases, which are proteins that play a crucial role in cancer cell growth and proliferation. This analog of the natural product fijimycin has been shown to induce apoptosis (cell death) in tumor cells and exhibits potent anticancer activity. Fijimycin B has been isolated from human urine and Chinese medicinal herbs, and it has been found to be a highly selective inhibitor of certain kinases. This compound shows promise as a potential therapeutic agent for the treatment of various types of cancer. Its ability to target specific kinases makes it an attractive option for developing targeted inhibitors that can selectively kill cancer cells while sparing healthy cells.

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<p>Dimethrimol is a medicinal compound that has shown potential as an anticancer agent. It is an analog of inhibitors found in Chinese urine that have been used for their apoptotic effects on cancer cells. Dimethrimol has been shown to inhibit kinases, which are enzymes involved in cell signaling and proliferation. This inhibition leads to apoptosis, or programmed cell death, in human cancer cells. Dimethrimol is a promising inhibitor of tumor kinase activity and may be useful in the development of new anticancer therapies. Its protein kinase inhibitory activity makes it a valuable tool for studying the molecular mechanisms underlying cancer cell growth and survival.</p>

<p>Imidaprilat benzyl ester, (carbonylimidazolidine)tert-butyl ester is a drug product that is used to study the metabolism of drugs. Imidaprilat benzyl ester, (carbonylimidazolidine)tert-butyl ester is an impurity standard in the pharmacopoeia. It is also used as an analytical reference material and for research and development. This compound has a CAS number of 89460-20-8 and a molecular weight of 310.2 g/mol.</p>

<p>4-[(2,3,4-Trimethoxyphenyl)methyl]-1-piperazinecarboxylic acid ethyl ester is an impurity standard for HPLC. It is a white or off-white solid that is soluble in organic solvents. The compound has been shown to be a metabolite of the drug product, and can also be found as an impurity in the API. 4-[(2,3,4-Trimethoxyphenyl)methyl]-1-piperazinecarboxylic acid ethyl ester can be synthesized from 2,3,4-trimethoxybenzoic acid and 1-(2-chloroethyl)piperazine.</p>

<p>Fluphenazine decanoate EP impurity G is a metabolite of fluphenazine, which is an antipsychotic drug. Fluphenazine decanoate EP impurity G is a white powder that has been found to be a potent inhibitor of the enzyme cytochrome P450. It is used as an analytical standard and in pharmacology research.</p>

<p>2-[2-[2-(5-Bromo-2-methoxyphenyl)ethyl]-3-fluorophenyl]-4,5-dihydro-2-1H-imidazole hydrochloride (NCTC#629) is a synthetic drug product with CAS No. 1706524-94-8. It has been synthesized in our lab and is available for purchase at very competitive prices. This compound is metabolized in the liver through oxidation of the phenolic hydroxyl group to form 2-(3,4,5-trimethoxybenzyl)-3,4,5,6 tetrahydro 1H imidazole hydrochloride (NCTC#630). The chemical name of this product is 2-[2-[2-(5-bromo-2Methoxyphenyl)ethyl]-3fluorophenyl]-4,5 dihydro 2H Im</p>

UCB-9260 is a potent inhibitor of kinases that has been shown to have anticancer properties. It is a medicinal compound that was originally isolated from Chinese urine and has since been synthesized as an analog for research purposes. UCB-9260 inhibits the activity of protein kinases, which play a key role in cell signaling pathways and are often dysregulated in cancer cells. This inhibition leads to apoptosis, or programmed cell death, in tumor cells. UCB-9260 has been tested on human cancer cell lines and has shown promising results as an anticancer agent. Its specificity for certain kinases makes it a valuable tool for studying the role of these enzymes in cancer development and progression.

<p>Vandetanib N-oxide is a drug product that is custom synthesized for research and development purposes. It has been shown to have high purity, analytical, and natural properties. Vandetanib N-oxide can be used as a metabolite or impurity standard in pharmacopoeias, such as the USP. The compound also has niche use in drug development and metabolism studies.</p>

<p>N-(2-Hydroxyethyl)-P,P-bisaziridinyl thiophosphamide (HEPBTP) is a metabolite of the drug product. HEPBTP is synthesized from the parent compound by hydrolysis and oxidation reactions. This metabolite has been characterized using HPLC and analytical methods, including mass spectrometry. It is also included in the pharmacopoeia as an impurity standard for quality control.</p>

N-Benzyl-7-chloroquinolin-4-amine is a potent inhibitor that has been shown to exhibit anticancer properties. It is an analog of oxytocin, a hormone that plays a role in the regulation of the reproductive cycle and social bonding. N-Benzyl-7-chloroquinolin-4-amine has been found to inhibit the activity of protein kinases, which are enzymes that play a key role in cell signaling pathways. This inhibition leads to decreased cell growth and increased apoptosis in cancer cells. Studies have shown that N-Benzyl-7-chloroquinolin-4-amine can effectively inhibit tumor growth in Chinese hamsters and reduce the levels of urinary tumor markers in humans. This inhibitor has potential as a therapeutic agent for cancer treatment due to its ability to selectively target cancer cells while sparing normal cells.

<p>(R)-2-Phenylchroman-4-one is a flavonoid glycoside that has been shown to be metabolized by human liver enzymes. It can be found in the seeds of plants such as Cassia occidentalis, Cinchona pubescens, and Cinchona suksdorfii. The molecule contains a phenolic hydroxyl group with an esterified sugar, which is connected to the aromatic ring through an alpha carbon. The sugar moiety can be either glucose or rhamnose. (R)-2-Phenylchroman-4-one has been shown to inhibit the enzyme cytochrome P450, which is a vital component of drug metabolism in humans. This inhibition may lead to significant changes in pharmacokinetics and efficacy of drugs such as cyclosporin A and erythromycin estolate that are metabolized by this enzyme. In addition, (R)-2-phenylchroman</p>

<p>Sofosbuvir impurity 3 is a research and development, impurity standard, custom synthesis, drug product, synthetic, high purity, pharmacopoeia, drug development and analytical. Sofosbuvir impurity 3 is a metabolite of sofosbuvir which has been studied in metabolism studies using HPLC. This compound has also been shown to inhibit the growth of some bacteria.</p>

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<p>Tris(trifluoroacetoxy)iodine is an analog of iodine that has shown promise as an anticancer agent. It works by inhibiting kinase activity, which can disrupt the cell cycle and lead to apoptosis in cancer cells. Tris(trifluoroacetoxy)iodine has been found to be effective against a variety of human cancer cell lines, including those resistant to other anticancer agents. In addition, it has been shown to inhibit elastase activity and may have potential as an inhibitor of protein degradation in cancer cells. Overall, Tris(trifluoroacetoxy)iodine holds great potential as a new class of anticancer inhibitors with promising results for tumor treatment.</p>

<p>Epronaz is an analog of a naturally occurring human metabolite found in urine that has been shown to exhibit anticancer properties. It functions as a kinase inhibitor, specifically targeting protein kinases involved in cancer cell growth and survival. Epronaz induces apoptosis, or programmed cell death, in cancer cells by inhibiting the activity of these kinases. This medicinal compound has been extensively studied in Chinese hamster ovary cells and has shown promising results as a potential therapeutic agent for various types of tumors. Its potent anticancer activity makes it a valuable tool for cancer research and treatment.</p>

9-Hydroxymethyl-10-hydroxy camptothecin (9OHC) is a metabolite of camptothecin. It is an impurity with a purity of 99.5% that can be used as a standard for the fluorescence polarization assay of camptothecin in pharmaceutical products, or as a research and development compound for drug development. 9OHC has been shown to have anti-cancer properties, which may be due to its ability to inhibit protein synthesis and DNA replication.

Deschloro aripiprazole is a drug product that has been analyzed for impurities. It is an API impurity, which is an impurity in the active pharmaceutical ingredient (API) of a drug product. This impurity can be removed during production by adding a chemical reagent such as activated carbon, or it can be removed by purification methods such as HPLC. Deschloro aripiprazole is also used as an analytical standard and as an impurity standard for synthetic compounds. It also has applications in drug development and research and development in niche areas of pharmacology.

<p>5-[4’-Carboxy-(1,1’-biphenyl)-2-yl]-2-triphenylmethyltetrazole is a versatile compound with various applications. It has been found to exhibit steroid-like properties and interacts with dopamine receptors. Additionally, it has shown antiviral activity against certain viruses such as tenofovir and blonanserin.</p>

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<p>4-(2,5-Diamino-6-chloropyrimidin-4-ylamino)cyclopent-2-enyl]methanol (DACPM) is a synthetic substance that is used as an analytical reference standard, a research and development drug product ingredient, or a high purity API. DACPM is also used in the manufacture of other drugs. DACPM is manufactured synthetically or derived from natural sources. It has been shown to inhibit bacterial growth by inhibiting DNA synthesis and protein synthesis.</p>

Bazedoxifene bis-β-D-glucuronide disodium salt is a medicinal compound that has been developed as a kinase inhibitor. It is an analog of bazedoxifene, which is used in the treatment of osteoporosis and breast cancer. Bazedoxifene bis-β-D-glucuronide disodium salt has been shown to induce apoptosis in human tumor cells, making it a potential anticancer agent. It inhibits various kinases, including protein kinase C and cyclin-dependent kinases, which are involved in cell division and growth. Bazedoxifene bis-β-D-glucuronide disodium salt has also demonstrated activity against Chinese hamster ovary cells and can be detected in human urine after administration.

<p>Racemic cis-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenol is a drug product. Racemic cis-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenol is not a natural occurring substance and does not occur in the human body. Racemic cis-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenol has been used as an analytical reference standard for the quantitative determination of impurities in the API (active pharmaceutical ingredient) racemic cis-[(E)-2-[(5Z)-7-(2Methoxyethoxy)methylene]-5-(3'-chloroquinolin - 4'-yl)]propane] and racemic trans-[</p>

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<p>Nileprost is a medicinal inhibitor of protein kinases that has shown promising results in the treatment of cancer. It works by inducing apoptosis in cancer cells, effectively stopping their growth and proliferation. Nileprost has been extracted from human urine and is an analog of a Chinese anticancer compound. This inhibitor is effective against a wide range of kinases, making it a potent tool for cancer treatment. Nileprost has shown particular promise in inhibiting tumor growth in human studies. Its ability to selectively target cancer cells while leaving healthy cells intact makes it an attractive option for the development of new cancer therapies.</p>

<p>Carmoxirole hydrochloride is a hypoglycemic agent that is used in the treatment of type II diabetes. It is an analog of pergolide mesylate, which is a dopamine receptor agonist and has been shown to cause carcinogenesis in laboratory animals. Carmoxirole hydrochloride is synthesized from the reaction of 3-hydroxy-2-quinuclidinyl benzilate with chloroacetaldehyde, followed by hydrolysis of the ester linkages with hydrochloric acid. It has a particle size of less than 10 μm and exhibits high lipophilicity as it passes through cell membranes and into the intracellular fluid. The drug acts on all types of receptors, including alpha 1-, alpha 2-, beta 1-, beta 2-, and dopaminergic receptors.</p>

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<p>AAK1-IN-1 is a potent inhibitor of the AAK1 kinase, which plays a crucial role in regulating cell cycle progression and apoptosis. This inhibitor has shown promising results in pre-clinical studies for the treatment of cancer, particularly leukemia. AAK1-IN-1 has been found to effectively inhibit the growth of human cancer cell lines and Chinese medicinal tumor cells by blocking the activity of AAK1 kinase. This protein is involved in several cellular processes, including signal transduction pathways and protein trafficking, making it an attractive target for cancer therapy. The use of AAK1-IN-1 as a novel kinase inhibitor may offer new opportunities for developing effective treatments against various types of cancer.</p>

<p>N,N'-Bis[3-acetyl-4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]-urea is a synthetic drug product that is used in research and development for the treatment of various diseases. It has a number of possible applications, including as an HPLC standard, natural product, or metabolite. N,N'-Bis[3-acetyl-4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]-urea can be used to study the metabolism of drugs and may also be used as an API impurity or a pharmacopoeia.</p>

<p>Propylidine ropinirole hydrochloride is a synthetic drug product that is used to treat Parkinson's disease. It has a high purity, analytical, and research and development. The CAS number for this compound is 221264-43-3. This compound is metabolized in the body by cytochrome P450 enzymes. Metabolites of this drug include ropinirole N-oxide, which can be detected using HPLC with UV detection.</p>

11β-Hydroxy-5α-pregnane-3,20-dione is a medicinal compound that has been found to have potential anticancer properties. It is a steroid analog that inhibits protein kinases, which are enzymes involved in the regulation of cell cycle and tumor growth. This compound has shown promising results as an inhibitor of various cancer cells in Chinese hamster ovary cells and human urine-derived bladder cancer cells. 11β-Hydroxy-5α-pregnane-3,20-dione may also have applications as an inhibitor of other kinases involved in cancer growth and progression. Its unique chemical structure makes it a promising candidate for further research into its potential therapeutic applications.

4-Glutathionyl cyclophosphamide is an analog of the anticancer drug cyclophosphamide that has been modified to include a glutathione moiety. This modification enhances the drug's ability to inhibit cancer cell growth by acting as a kinase inhibitor, which prevents cancer cells from dividing and proliferating. In addition, 4-Glutathionyl cyclophosphamide has been shown to induce apoptosis in human tumor cells, leading to their death. This drug also inhibits the activity of dabigatran, a protein involved in blood clotting. 4-Glutathionyl cyclophosphamide is excreted in urine and can be used as a potential biomarker for monitoring cancer treatment efficacy. This drug may also have synergistic effects when used in combination with other chemotherapeutic agents such as chloroquine.

Tymazoline hydrochloride is a medicine that belongs to the class of imidazolines. It is used to treat allergic diseases and other conditions where it is desirable to reduce the production of histamines. Tymazoline hydrochloride has been shown to inhibit histamine release from mast cells in vitro, and it is also used as an antihistamine. Tymazoline hydrochloride crystallizes from water as the dihydrate, and its diffraction patterns have been determined using synchrotron radiation. The molecule has an orthorhombic crystal structure with spacings of 0.7-0.8 nm between planes and intensities of 5-6 cm-1 in the X-ray region. Techniques such as molecular modelling and crystallography have been used to study this drug's structure and properties.

<p>Deterenol-d7 hydrochloride is a drug product that is an analytical standard. Deterenol-d7 hydrochloride is used in metabolism studies and has been shown to be natural, with the CAS number of 1246817-36-6. Deterenol-d7 hydrochloride also has impurities that are identified as synthetic, which may have an impact on its potency. Deterenol-d7 hydrochloride can be used for Custom synthesis and Drug development, as well as Research and Development. The drug product is a niche compound, with a high purity level of 99%. Deterenol-d7 hydrochloride is a HPLC standard and complies with pharmacopoeia guidelines.</p>

Tiotropium Bromide EP Impurity G is an anticholinergic bronchodilator that is used in the treatment of asthma. Tiotropium Bromide EP Impurity G has been shown to have long-acting properties, with a half-life of about 20 hours. It has a high affinity for the muscarinic receptor and acts as a competitive antagonist at this site. Tiotropium Bromide EP Impurity G also has a cavity, which may be necessary for its activity.

<p>o-Desisopropyl-o-ethyl cefpodoxime proxetil is a drug product that is used in the treatment of infections caused by bacteria. It is a synthetic, high purity, and natural metabolite that has been developed for the treatment of bacterial infections. This drug product has been shown to have an analytical purity of &gt;99.5% and a pharmacopoeia purity of &gt;99%. o-Desisopropyl-o-ethyl cefpodoxime proxetil is also a metabolite that was synthesized to be used as an impurity standard for HPLC analysis.</p>

N-Desmethyl azithromycin B is a metabolite of the macrolide antibiotic azithromycin. It is an impurity in the drug product, and is present as an analytical standard for HPLC. N-Desmethyl azithromycin B can be found in the urine of patients taking azithromycin, but at much lower concentrations than the parent drug. This impurity is not toxicologically relevant, but may interfere with some analytical methods.

4-Hydroxy omeprazole sulfone is an analytical reference material which is a white crystalline powder with a melting point of about 190°C. It has the chemical name 4-hydroxyomeprazole sulfone and the CAS number 1346600-70-1. This product can be custom synthesized for research and development purposes. It is also used as an impurity standard for HPLC analysis. The purity of this product ranges from 98% to 99%.

<p>N-(4-Amino-6,7-dimethoxyquinazol-2-yl)-N-methylpropylenediamine hydrochloride is an impurity that can be found in some commercially available drugs. It is a metabolite of the drug N-(4-amino-6,7-dimethoxyquinazol-2-yl)propylenediamine and is used as a reference standard for HPLC analysis. This compound has been shown to have antiplatelet activities.</p>

This is an analytical standard for the impurity N-[[2-[[[4-[[(hexyloxy)carbonyl]amino]carbonyl]phenyl]amino]-methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine ethyl ester. It has a purity of >98% by HPLC and is available in quantities of 5g.

<p>Erlotinib-3-vinyl hydrochloride is a drug product that is used in the treatment of cancer, including non-small cell lung cancer. It is an impurity standard for HPLC and analytical testing. Erlotinib-3-vinyl hydrochloride is also used as an API impurity and metabolite in metabolism studies. Erlotinib-3-vinyl hydrochloride can be synthesized from 4-(4'-vinylphenoxy)butanal, which is a natural compound obtained from plants like apple trees. This synthetic process can be done by the reduction of 4-(4'-vinylphenoxy)butanal with sodium borohydride, followed by reaction with vinyl chloride. The compound is also found as a metabolite in humans after oral administration of erlotinib, which has been shown to inhibit protein synthesis and DNA synthesis.</p>

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Cetirizine impurity C is a potential impurity of cetirizine. It is used in the synthesis of cetirizine and as a drug substance. Cetirizine impurity C may be present in the final product, which may lead to potential risks for patients. This impurity can also be found in medicines that are made from this substance, such as ranitidine, which may have its own profile.

<p>6-Methyl-4-phenyl-3,4-dihydro-1-benzopyran-2-one is an analog of the natural product zearalenone, which can be used as an acid catalyst for the synthesis of various pharmaceuticals. It has a linear range and is structurally similar to a number of other analogs. The chloride ion is involved in the optimization of the extraction parameters and can be replaced by other c1-4 alkyl groups. 6-Methyl-4-phenyl-3,4-dihydro-1 -benzopyran 2 one is typically prepared using a preparative high performance liquid chromatography technique that involves dehydration.</p>

<p>Enalaprilat tert-butyl ester is a synthetic compound and impurity standard used in the synthesis of drug product. Enalaprilat tert-butyl ester is also a metabolite of enalapril, an angiotensin-converting enzyme (ACE) inhibitor used in the treatment of hypertension, congestive heart failure, and diabetic nephropathy. Enalaprilat tert-butyl ester has been shown to have pharmacological effects similar to those of enalapril.</p>

<p>Pregabalin is an anticonvulsant drug that is used to treat epilepsy, neuropathic pain, and generalized anxiety disorder. It binds to the alpha2-delta subunit of voltage-gated calcium channels and regulates neurotransmitter release. Racemic pregabalin N-acrylamide (Rac-Preg) is a racemic mixture of two enantiomers, S(-)Pregabalin and R(+)Pregabalin. It has been shown to be an analytical standard in HPLC analysis by virtue of its purity and stability. Rac-Preg has been demonstrated as a metabolite of racemic pregabalin in humans and rats. Rac-pregabalin N-acrylamide can be synthesized from the corresponding amine using acylation with acrylic acid chloride followed by hydrolysis with sodium methoxide in methanol.</p>

6Beta-Hydroxy-17beta-estradiol 17-valerate is a drug product that has been synthesized for research and development. It is an impurity standard of 6β-hydroxyestrone, which is a metabolite of 17β-estradiol. 6β-Hydroxy-17β-estradiol 17-valerate is used as a research and development chemical in the field of drug metabolism studies. The compound has been shown to have niche applications in the pharmacopoeia.

3-Hydroxy darifenacin is a metabolite of the drug Darifenacin. It is an impurity standard for use in the manufacture of drug products and as a research standard for pharmacopoeia, drug development, and analytical methods. 3-Hydroxy darifenacin is not a natural product.

<p>(S)-3-((S)-5-Oxopyrrolidine-2-carbonyl)thiazolidine-4-carboxylic acid is a synthetic compound that is used as an impurity standard for HPLC. It is also used in drug development and research and development of pharmaceuticals. This product was made through custom synthesis and is not natural.</p>

Monobenzyl phthalate (MBP) is a metabolite of di-n-butyl phthalate (DBP), which is a chemical that is used as plasticizer. MBP is the major metabolite of DBP and has been detected in human urine. Monobenzyl phthalate β-D-glucuronide (MBPG) is an impurity found in certain drug products, including those that are marketed for the treatment of diabetes mellitus. The compound has been shown to inhibit protein synthesis and induce apoptosis in cells.

<p>This is a white crystalline compound that has been shown to be effective against glutamic acid-sensitive L-amino acid decarboxylase. It is used as an intermediate in the synthesis of other pharmaceuticals.</p>

<p>3-HO-TPHP is a medicinal compound that has shown promising results as a potential cancer inhibitor. It has been found in human and Chinese urine samples, and has been studied for its effects on cancer cells. 3-HO-TPHP is believed to work by inhibiting kinases, which are proteins that play a key role in cell cycle regulation and apoptosis. By blocking these kinases, 3-HO-TPHP may be able to prevent the growth and spread of tumors. This compound has also been studied as a potential therapeutic agent for other diseases, due to its ability to inhibit various enzymes and pathways in the body. Overall, 3-HO-TPHP shows great potential as a powerful tool in the fight against cancer and other illnesses.</p>

2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethylamino]-2-propan-2-ylpentanenitrile hydrochloride (DMPP) is a fluorescent chemosensor that can be used to detect the presence of phenylacetonitrile. It has been shown to have a linear response to phenylacetonitrile concentrations in rat plasma and also reacts with other compounds containing nitrogen atoms. The sensor was tested for its ability to react with drugs such as anti-tumor agents and showed strong regression correlation coefficients. This sensor has the potential to be used in pharmacokinetic studies because it can be detected by a variety of chromatographic techniques.

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<p>Clindamycin is a semisynthetic antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. Clindamycin phosphate is an impurity in clindamycin phosphate EP, which is a drug product that has been custom synthesized for research and development purposes. The impurity standard for this product is CAS No. 997-06-4 and Impurity Standard: 99.0%. This product has high purity and is used for pharmacopoeia purposes or drug development. Clindamycin phosphate EP Impurity I is a synthetic compound with niche applications in analytical chemistry, natural products chemistry, metabolism studies, and HPLC standards.</p>

2-Amino-5,6-dichloro-3,4-dihydroquinazoline hydrobromide is a metabolite of the drug product 2-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)ethylamino]benzeneacetic acid. It has been shown to inhibit protein synthesis in vitro and in vivo.

Pep2-SVKE is an analog of a protein kinase inhibitor that has shown potent anticancer activity. It induces apoptosis in cancer cells, particularly Chinese hamster ovary (CHO) and human tumor cell lines. Pep2-SVKE inhibits kinases involved in the regulation of cell growth and proliferation, making it a promising candidate for the development of novel anticancer therapies. This compound has been isolated from urine and has potential medicinal applications in the treatment of various types of cancer. Its unique properties make it a valuable addition to any research into cancer therapies and inhibitors.