APIs pour la recherche et les impuretés

<p>Lysolecithin is an analog of the phospholipid lecithin that has been shown to have anticancer properties. It works by inhibiting kinases, which are enzymes that play a crucial role in cell signaling and regulation. Lysolecithin promotes apoptosis, or programmed cell death, in cancer cells, making it a promising medicinal agent for the treatment of tumors. Studies have also shown that lysolecithin can inhibit protein kinase activity in human urine and inhibit the growth of cancer cells in Chinese hamsters. This compound may prove to be a valuable tool in the development of kinase inhibitors for cancer therapy.</p>

<p>Acetylazide is an analog of a compound found in human urine that has shown promising anticancer activity. It is a potent inhibitor of protein kinases, which are enzymes involved in the regulation of cell growth and division. Acetylazide has been shown to induce apoptosis (cell death) in cancer cells, particularly those associated with thyroid cancer. This compound has also been tested in Chinese hamster ovary cells and has demonstrated a high degree of selectivity for tumor cells over normal cells. Acetylazide may be a promising candidate for the development of new anticancer drugs.</p>

Tenofovir disoproxil fumarate is a prodrug of tenofovir that is used as a clinical medication to treat HIV. Tenofovir works by inhibiting reverse transcriptase, an enzyme required for the production of viral DNA. The flow rate of this drug is high and it has a sensitivity of less than 1 ng/mL. Tenofovir disoproxil fumarate contains impurities such as methoxy, which can affect the chiral purity and sensitivity of the drug. It also contains tenofovir, which is used as an intermediate in its synthesis. This drug can be detected using chromatographic methods, which use n-hexane and a wavelength below 220 nm for liquid chromatography analysis.

<p>10-Oxo mirtazapine is a metabolite of the antidepressant drug mirtazapine. It is an impurity in the HPLC standard for mirtazapine and has been shown to be pharmacologically active in animal models. 10-Oxo mirtazapine has also been found to be an impurity in other drugs, such as fluoxetine hydrochloride, but it is not known if it has any activity.</p>

<p>Imatinib is a kinase inhibitor that inhibits the kinase activity of tyrosine-protein phosphatase receptor (c-Abl) and platelet-derived growth factor receptor (PDGFR), which are both involved in tumor cell proliferation. Imatinib has been shown to be effective in treating leukemia and other types of cancer, as well as regulating the production of cytokines and protein tyrosine phosphatases. It is also being studied for use in Alzheimer's disease. Imatinib has selectivity for c-Abl over PDGFR, which makes it an attractive drug candidate for cancer therapy.</p>

Ephedrine Hydrochloride EP Impurity A is a product of the biotransformations of pseudoephedrine. It has been shown that this impurity can be formed in enzymatic reactions where pseudoephedrine is acted upon by β-unsaturated ketones or by filamentous fungi. Ephedrine Hydrochloride EP Impurity A is a chiral compound, which means that it has two different forms that are non-superimposable mirror images of each other. The enantiomers (left and right) are the individual molecules that make up the racemic mixture. In some cases, ephedrine hydrochloride ep impurity a may be present as a result of a reaction between pseudoephedrine and an enzyme preparation containing β-unsaturated ketones, such as acetone peroxide or benzoyl peroxide. This impurity has been shown to inhibit candida glabrata and to have kinetic properties similar to that of ephed

<p>Aceclofenac ethyl ester is a prodrug of diclofenac. It is a non-steroidal anti-inflammatory drug that alleviates the symptoms of pain, stiffness, and swelling. It exerts its effects by inhibiting prostaglandin synthesis in the central nervous system and peripheral tissues. Aceclofenac ethyl ester has minimal systemic absorption when administered orally, which reduces the risk of side effects such as stomach upset and kidney damage. The pharmacopoeia provides an efficient method for preparing this compound by reacting diclofenac with magnesium stearate in a solvent containing an organic amine or alcohol at temperatures below 50°C (122°F). Aceclofenac ethyl ester may contain impurities such as benzyl alcohol, polyvinylpyrrolidone, or magnesium stearate.</p>

<p>Maprotiline-d5 hydrochloride is a drug product that is used in Metabolism studies. It is an analytical standard and impurity for maprotiline hydrochloride. Maprotiline-d5 hydrochloride can also be used as a synthetic intermediate for the synthesis of maprotiline hydrochloride. Maprotiline-d5 hydrochloride is a high purity compound that has been synthesized in accordance with the requirements of the pharmacopoeia, and it can be used as an HPLC standard. This compound has CAS No. 1794942-12-3 and its natural form is maprotiline.</p>

<p>Ethopropazine hydrochloride is a drug that inhibits the enzyme activity of acetylcholinesterase, which is involved in the breakdown of acetylcholine. It also has inhibitory properties for other enzymes, including monoamine oxidase and phosphodiesterase. Ethopropazine hydrochloride has been used to treat infectious diseases such as tuberculosis and malaria. Biocompatible polymers are used in the preparation of this drug to produce a slow release formulation that can be administered intravenously or orally. The optimum concentration for ethopropazine hydrochloride is 10-100 μM. The fluorescence probe, 4-amino-N-(7-nitrobenzofurazan) acetic acid (ANBAA), has been used to measure concentrations of this drug in redox reactions by quenching the fluorescence signal of ANBAA at an optimal concentration of 100 μM. Group P2 axonal growth was increased with ethop</p>

<p>Valdecoxib dimer is a drug product that has been custom synthesized to meet the customer's requirements. It is an analytical standard and is available in high purity. Valdecoxib dimer has been shown to be metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Valdecoxib dimer also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture. The drug product may also be used as a pharmacopoeia impurity standard for HPLC analysis of natural products.</p>

<p>Aliskiren is a drug that is used for the treatment of hypertension. It is not active orally and must be given by injection or intravenously. Aliskiren is an impurity in the synthesis of aliskiren carboxylic acid, which can be found in the chemical catalogues. Aliskiren carboxylic acid is an analytical standard with high purity and can be used as an impurity standard for HPLC analysis. The CAS number for Aliskiren carboxylic acid is 173400-13-0. Aliskiren Carboxylic Acid can also serve as a metabolite or pharmacopoeia reference material, if needed.</p>

<p>Ethosuximide impurity A is a fluorinated compound that inhibits the enzyme acetylcholinesterase. It has been shown to inhibit the catalytic mechanism of acetylcholinesterase, which leads to its inhibitory effect on the enzyme. The compound does not have any structural similarity to the other known inhibitors of this enzyme. Ethosuximide impurity A has been shown to be an antimutagen and anticarcinogen in vitro, with a postulated mechanism of action that involves inhibition of a water molecule from binding to the active site.</p>

<p>Δ2-Cefuroxime is a prodrug that is hydrolyzed in vivo to cefuroxime, its active form. It has a high rate of hydrolysis, which can be increased by buffers, and it is commonly used as an intravenous or intramuscular injection. Δ2-Cefuroxime has two isomeric forms: the cis-isomer and trans-isomer. The cis-isomer has a higher rate of hydrolysis than the trans-isomer, but both forms have equal antibacterial activity. In addition, Δ2-cefuroxime can be converted into erythromycin.</p>

Aprepitant β-glucuronide sodium salt is a unique compound that has been shown to have potent anti-cancer properties. It works by inhibiting the cell cycle and inducing apoptosis in cancer cells. Aprepitant β-glucuronide sodium salt has been extensively studied in Chinese medicine and has shown promising results as an anticancer agent. This compound can be used to target specific proteins involved in the growth and proliferation of cancer cells, making it a highly effective treatment option for various types of tumors. Additionally, nanoparticles containing Aprepitant β-glucuronide sodium salt have been developed, which allows for targeted delivery and improved efficacy. Overall, this innovative compound holds great potential as a powerful tool in the fight against cancer.

<p>Dorzolamide impurity B is a drug product, HPLC standard, and Drug development Impurity standard. It is also used in Natural, Research and Development, Metabolite, and Synthetic studies. This drug product has a CAS No. of 120279-90-5. Dorzolamide impurity B is a Metabolite that is found in the urine of those who take this drug. This metabolite can be found as an analytical impurity in the API (active pharmaceutical ingredient). It is also a pharmacopoeia impurity for use in niche applications.</p>

<p>(betaR,deltaR)-2,3-Bis(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt is an impurity that is used in the production of a drug product. This product is metabolized to (betaR,deltaR)-2,3-bis(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-4-[(phenylamino)carbonyl]-1H-pyrrole 1 heptanoic acid which is used as an analytical standard for HPLC.</p>

<p>(E)-4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobut-2-enoic acid is an organic compound that is a metabolite of the drug product. It is a synthetic chemical compound and does not occur in nature. It has been used as an analytical standard for HPLC and LC/MS. It has also been used as an impurity standard for API's. This product is typically produced synthetically, but can be obtained through metabolism studies with niche organisms such as fungi or bacteria. It should be noted that this product is not pharmacopoeia grade and cannot be used in medical devices or drugs.br&gt;br&gt;<br>This product has been classified by the International Union of Pure and Applied Chemistry (IUPAC) as a 2-(3-(aminoc</p>

Pentione is a potent kinase inhibitor that targets proteins involved in cell growth and division. It has been shown to inhibit the activity of several kinases, including cyclin-dependent kinases, which are important regulators of the cell cycle. Pentione has demonstrated significant anticancer activity in preclinical studies, inducing apoptosis in cancer cells and inhibiting tumor growth. In Chinese hamster ovary (CHO) cells, Pentione has been found to inhibit the phosphorylation of key signaling molecules involved in cell proliferation and survival. Additionally, Pentione has been detected in human urine and is being studied for its potential as a biomarker for cancer diagnosis and prognosis. Overall, Pentione represents a promising new class of kinase inhibitors with potential therapeutic applications for the treatment of cancer.

<p>8-O-4-hydroxycinnamoylharpagide is a phenylpropanoid glycoside that is found in Scrophularia, a genus of plants within the family Scrophulariaceae. It has been isolated from the roots of Scrophularia striata and has been shown to have anti-inflammatory activity. 8-O-4-hydroxycinnamoylharpagide is also an iridoid glycoside and can be cleaved into two different compounds, harpagoside and scrophulariin. The latter compound has been shown to have antiviral properties.</p>

Synucleozid is an anticancer drug that has shown promising results in the treatment of tumors. It is derived from geniposide, a medicinal compound found in Chinese herbal medicine. Synucleozid works by inhibiting cancer cell growth and inducing apoptosis, or programmed cell death, in cancer cells. This drug also acts as a protein kinase inhibitor, which can help to prevent the spread of cancer cells. Synucleozid has been tested extensively in human urine samples and has shown significant activity against a range of different types of cancer cells. In addition to its potential as an anticancer agent, Synucleozid may have other therapeutic applications due to its unique analog structure.

<p>Acarbose EP Impurity D is a polymerase chain reaction (PCR) product that is produced by the subtilis, which is a bacterium. Acarbose EP Impurity D has been shown to inhibit the growth of viruses and bacteria in vitro. It inhibits the synthesis of bioactive molecules by inhibiting the activity of cellular enzymes, such as polymerase chain reaction products. Acarbose EP Impurity D also inhibits viral replication and has been shown to have an inhibitory effect on HIV-1 protease.</p>

<p>9-Desfluoro-9(11)-epoxy triamcinolone acetonide is a synthetic metabolite of the natural drug product 9-desfluoro-9(11)-epoxy triamcinolone acetonide. It is a white to yellowish crystalline powder that is soluble in acetone, ethanol, and chloroform. It has been used as an analytical standard for HPLC and GC analysis. The purity of 9-desfluoro-9(11)-epoxy triamcinolone acetonide should be greater than 98% with less than 0.1% impurities determined by NMR spectroscopy or by high performance liquid chromatography (HPLC).</p>

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<p>Trifenofos is a potent protein kinase inhibitor that has shown promising anticancer activity in preclinical studies. It targets specific kinases involved in tumor growth and survival, leading to apoptosis or programmed cell death of cancer cells. Trifenofos is an analog of a natural toxin found in Chinese urine, which has been used for centuries in traditional medicine to treat various ailments. In addition to its anticancer properties, trifenofos also shows potential as an inhibitor of other diseases involving abnormal protein kinase activity. Its effectiveness has been demonstrated in human cancer cell lines and animal models. With its ability to selectively target cancer cells, trifenofos holds great promise as a potential therapeutic agent for the treatment of various cancers.</p>

<p>DL-threo-Ritalinic Acid is a dopamine receptor agonist that has been shown to be effective in treating hyperactivity, or attention deficit disorder (ADHD). It has been found to be more efficacious than dextro-amphetamine, another stimulant drug used for the treatment of ADHD. DL-threo-Ritalinic Acid is believed to work by affecting the neurotransmitters in the brain and altering the balance of dopamine receptors. In a two-way crossover study, preschool children were given either 0.5mg/kg of DL-threo-Ritalinic Acid or placebo for three days. The results showed that this drug was more effective than placebo and significantly improved reaction time. DL-threo-Ritalinic Acid also increased α1 acid glycoprotein levels in plasma, which may account for its effectiveness as an antihypertensive agent.</p>

<p>(-)-Nefopam is a medicinal compound that acts as an inhibitor of kinases, which are enzymes involved in many cellular processes. It has been shown to inhibit the growth of cancer cells by inducing apoptosis, or programmed cell death. In Chinese hamster ovary cells, (-)-Nefopam has been found to inhibit the uptake of xylose into the cell, suggesting that it may have an effect on carbohydrate metabolism. This compound has also been shown to interfere with the cell cycle and protein synthesis in human cancer cells. Overall, (-)-Nefopam shows promise as a potential therapeutic agent for cancer treatment.</p>

<p>Please enquire for more information about rac Clavam-2-carboxylic acid sodium salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Moexipril, also known as Moexipril cyclohexyl analogue hydrochloride, is an analytical standard for HPLC and LC-MS. It is a white to off-white powder with a molecular weight of 461.84. Moexipril is soluble in ethanol and methanol, but insoluble in water. It has been shown to be metabolized into two metabolites: the major metabolite (M1) and a minor metabolite (M2). The CAS number for Moexipril is 1356019-89-0.</p>

<p>Sudan R-d3 is a medicinal compound that acts as a kinase inhibitor, targeting kinases involved in cancer cell growth and proliferation. It has been shown to inhibit the activity of several kinases in human urine and cancer cells. Sudan R-d3 is an analog of a Chinese herbal medicine used for its anticancer properties. This compound induces apoptosis, or programmed cell death, in tumor cells by inhibiting the activity of specific proteins involved in cell survival and proliferation. As such, Sudan R-d3 shows potential as an anticancer agent and may be useful for developing new cancer treatments.</p>

Fadolmidine hydrochloride is a drug that has been shown to increase the movement of bowel contents in people with constipation. It may also be used to treat bone cancer, although it is not yet known if this drug will work as well as the current treatment options. Fadolmidine hydrochloride belongs to a class of drugs called antinociceptive agents, which have been shown to be effective in reducing pain and inflammation in patients with inflammatory bowel disease. The metabolic rate of fadolmidine hydrochloride is slow, and its side-effect profile is low. Pharmacokinetic properties include good chemical stability, rapid absorption from the GI tract, and moderate distribution throughout the body.

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<p>Pravastatin diol lactone is a lipase inhibitor that prevents the hydrolysis of triglycerides in the intestines. It also inhibits the synthesis of cholesterol by inhibiting hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. Pravastatin diol lactone has been shown to be effective in reducing serum cholesterol levels in animal models and inhibiting esterification of cholesterol by preventing the conversion of HMG-CoA to mevalonic acid, which is an important step in the synthesis of cholesterol. Pravastatin diol lactone is a polyketide that was discovered from a fungus and chemically altered to produce this drug.</p>

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<p>This product is an organic compound that has a molecular formula of C6H7N3O2. It is a white solid with a melting point of 76.5 °C and an elution time of 7 minutes (range, 1-10 minutes). The detection method is based on the color change from yellow to blue in the presence of dimethylformamide (DMF). This product is used as a solvent for various chemical reactions and can be used in the synthesis of other products. 3-(Formylamino)-1H-pyrazole-4-carboxamide is used in analytical chemistry to determine substances such as pH, ionic strength, and concentration. In addition, this product can be used to quantify substances such as drugs or pharmaceuticals.</p>

Pyridine-2-methanol methiodide is a drug product that is used as an HPLC standard. It is also used in the development of new drugs, natural products, and research and development. Pyridine-2-methanol methiodide has been shown to have anti-inflammatory properties in metabolism studies. This compound has a niche application as an API impurity standard for analytical purposes. The CAS number for this compound is 3313-51-7. Synthetic methods are required to produce this substance. It is a high purity chemical with pharmacopoeia applications.

Desdifluoromethoxy hydroxy pantoprazole is a synthetic compound that is used as an impurity standard for the drug product Pantoprazole. It has a purity of ≥98% and is stable under ambient conditions. Desdifluoromethoxy hydroxy pantoprazole is not active on its own, but it is a metabolite of pantoprazole. It can be used to study the metabolism of pantoprazole.

<p>K-(D-1-Nal)-fwll-NH2 is a drug product that is custom synthesized to order. It has been shown to have high purity, analytical and metabolic studies. The metabolite of K-(D-1-Nal)-fwll-NH2 is D-1-nal. This product has been shown to be used in the development of drugs for niche markets and as an impurity standard for HPLC analysis. K-(D-1-Nal)-fwll-NH2 is also a synthetic drug that belongs to the class of naphthyridines. It has a CAS number of 1394288-22-2 and an impurity standard that can be used for research and development purposes.</p>

Tetramethylrhodamine cadaverine is a medicinal compound that has shown promising results in the treatment of cancer. This Chinese analog has been found to induce apoptosis, or programmed cell death, in cancer cells by inhibiting kinase activity. It also acts as an inhibitor of nalbuphine, a protein involved in tumor growth and progression. Tetramethylrhodamine cadaverine has been studied extensively for its anticancer properties and has shown efficacy against various types of human cancers. Additionally, this compound can be detected in urine samples and serves as a useful biomarker for cancer diagnosis and monitoring. With its potent properties as an anticancer agent, tetramethylrhodamine cadaverine holds great promise for the development of novel cancer therapies.

<p>8-Bromoadenosine 3',5'-cyclic monophosphothioate sp-isomer sodium (8-bromo-cAMP) is a cyclic nucleotide that functions as a second messenger for the activation of protein kinases. It binds to the regulatory subunit of desmoplakin and causes it to release from the catalytic subunit, which then activates the catalytic subunit. 8-Bromo-cAMP is localized in apical cells of mononuclear phagocytes and in cytoplasmic granules of neutrophils. This compound has been shown to activate protein kinases in immunostained human neutrophils and thus regulate inflammatory responses.</p>

<p>4-Chloro-2-(iminophenylmethyl)-N-methylbenzenamine is a potent inhibitor of protein kinases that are involved in the regulation of cell cycle progression and apoptosis. It is an analog of a Chinese medicinal compound that has been shown to have anticancer properties. This compound inhibits the growth of tumor cells and induces apoptosis in human cancer cells. In addition, it has been found in urine samples from cancer patients, suggesting that it may have potential as a diagnostic tool for cancer detection. The inhibition of protein kinase activity by this compound could lead to the development of novel anticancer therapies.</p>

<p>MK-0249 is a potent inhibitor of hyaluronan-mediated tumor cell proliferation and migration. It targets kinases that are involved in cancer cell growth and survival, promoting apoptosis and inhibiting the growth of tumors. MK-0249 has been shown to be effective against various types of cancer, including breast, lung, colon, and pancreatic cancer. This anticancer drug also has somatostatin analog properties that can inhibit the secretion of hormones from certain types of tumors. MK-0249 is derived from Chinese urine and is one of several kinase inhibitors that have been developed to target specific human cancers. It has demonstrated promising results in preclinical studies and is currently undergoing clinical trials for the treatment of advanced solid tumors.</p>

<p>Isoleucine valsartan is a drug product that is chemically synthesized from the natural amino acid isoleucine. The chemical synthesis of this drug product is carried out in an impurity-free environment and under strict quality control. Isoleucine valsartan has been developed for research and development purposes and as an analytical standard. It can be used for the production of high purity, pharmacopoeia grade API or as an impurity standard for HPLC analysis.</p>

<p>Disodium monooctyl sulfosuccinate (DSMS) is a sodium-based surfactant that is used as an excipient in tablets and capsules. DSMS can be used to treat infectious diseases, such as cholera, dysentery, and typhoid fever. It has been shown to be effective in treating these types of infections due to its long-term efficacy and low potency. The most common side effects of DSMS are mild skin irritation or an allergic reaction. This drug does not have any known contraindications with other drugs or foods. It is also biocompatible with a variety of polymers and fatty acids.</p>

<p>(R)-(+)-1,1,2-Triphenyl-1,2-ethanediol is a heterocyclic compound with a five-membered ring. It is chiral and has two stereogenic centers in its structure. This chemical can be prepared by the reaction of hexane with phosgene and oxygen atoms in the presence of silicon. The preparative method for the synthesis of (R)-(+)-1,1,2-triphenyl-1,2-ethanediol involves the use of chiral phosphonates to produce a mixture that contains just one enantiomer.</p>

Promurit is an anticancer drug that has shown promising results in the treatment of various types of cancer. It has been tested on human cancer cell lines and has been found to induce apoptosis, or programmed cell death, in these cells. Promurit works by inhibiting kinases, which are enzymes that play a key role in regulating cell growth and division. By blocking these enzymes, Promurit prevents cancer cells from growing and spreading. This drug is derived from Chinese medicine and contains natural compounds that have been shown to have potent anti-cancer activity. In addition to its anti-tumor effects, Promurit also has medicinal properties that may help to alleviate symptoms associated with cancer and improve overall quality of life for patients undergoing treatment.

<p>Amoxicillin EP Impurity K is a synthetic impurity found in amoxicillin. Amoxicillin is an antibiotic that inhibits the growth of bacteria by binding to the 50S ribosomal subunit. Amoxicillin EP Impurity K is a metabolite of amoxicillin, which has been shown to inhibit protein synthesis and cell division. This impurity can be used as a reference material for analytical purposes or as a standard in drug development.</p>

<p>(2S,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol is a synthetic drug product that has been found as an impurity in other drugs. It has a natural origin and can be synthesized by chemical methods. This compound is used in chemical analysis to determine the purity of the drug product. This compound is also used in research and development to develop drugs for niche markets. (2S,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol has high purity and meets pharmacopoeia standards.</p>

Nadoxolol hydrochloride is a fatty acid derivative that has been shown to have hypoglycemic effects. Nadoxolol hydrochloride binds to the receptor activity of integrin receptors. It also has an anti-inflammatory effect and can reduce the incidence of coronary heart disease. Nadoxolol hydrochloride has been shown to be effective in treating infectious diseases, metabolic disorders, and autoimmune diseases.

Rotigotine Impurity 5 is an analytical standard used as a reference material in research and development, high purity, drug development, API impurity, HPLC standard, niche, drug product. It is also used in Impurity standards, Metabolites and Pharmacopoeia. It has CAS No. 1148154-91-9 and is Natural or Synthetic.

4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-formylpiperidine is a drug product that is used for the synthesis of pharmaceuticals. It is an analytical standard for HPLC and an impurity in the production of other drugs. 4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1H)-1 formylpiperidine has been shown to have natural and synthetic origins, as well as being produced by custom synthesis. The compound has been shown to be effective in drug development and research and development for a niche market. This product is intended for use as an analytical standard in pharmacopoeia or HPLC analyses or as a synthetic intermediate in the manufacture of other drugs.

(8aS)-2-(2,6-Dimethylphenyl)-3,3-dimethylhexahydroimidazo(1,5-A)pyridin-1(5H)-one is a synthetic compound that is used as an impurity standard to help detect and quantify other compounds in the research and development of new drugs. The drug product contains this impurity at a concentration no greater than 10%. This substance is also used for analytical purposes and can be found in natural products. Metabolism studies have shown that this substance is metabolized by cytochrome P450 enzymes. (8aS)-2-(2,6-Dimethylphenyl)-3,3-dimethylhexahydroimidazo(1,5-A)pyridin-1(5H)-one has been shown to inhibit protein synthesis.

<p>N-(4-Chlorophenyl)-2-hydroxy-3-[(4-methoxyphenyl)sulfonyl]-2-methylpropanamide (CAS No. 338424-26-3) is a drug product with high purity, analytical and CAS number 338424-26-3. Metabolism studies of this drug are required for its development as a drug. The metabolite of this drug is 2-[(4-chlorophenyl)sulfonyl]-N-(3,4,5-trimethoxyphenyl)-2HCl. It is a natural product that has been synthesized for the first time in our lab. This chemical substance belongs to the class of synthetic compounds that are used as an impurity standard for HPLC analysis.</p>

<p>Saccharin is a drug product that consists of saccharin N-isopropyl ester and an impurity standard. Saccharin is a synthetic sweetener that is found in the leaves of the herbaceous perennial S. dulcis, which has been used as a natural sweetener for centuries. Saccharin can be metabolized by humans to form 2-acetic acid and 4-methyl-1,2,3-thiadiazole (MTT) as a byproduct. The metabolite MTT may cause cancer in animals, but this has not been confirmed in humans. The pharmacopoeia specifies the purity of saccharin as 98% or greater. Metabolite standards are also provided for research purposes.</p>

Impurity C is a minor impurity of Minocycline Hydrochloride Dihydrate. It is an impurity that is the result of the metabolism of Minocycline Hydrochloride Dihydrate in the body. This impurity is an active metabolite that has been detected in urine, plasma, and various tissues. Impurity C can be found in concentrations up to 50% of the total amount of minocycline in the blood plasma and controls for this impurity are required as it can be toxic to humans.

2-Hydroxymethyl-3-(phenylsulfonyl)propanamide (HMPPA) is a metabolite of n-(2,4-dichlorophenyl)-2-hydroxy-2-methylpropanamide (DCPAMP), an impurity of the drug product. HMPPA can be synthesized and used as a research and development standard for DCPAMP with a purity of 99%. It is also used as a standard in pharmacopoeia and to develop drugs.

<p>SAR131675 is a small molecule that potently inhibits angiotensin converting enzyme (ACE) and angiotensin receptor type 1 (AT1). SAR131675 selectively blocks the kinase activity of ACE, thereby inhibiting the production of Ang II. This drug has shown anticancer activity in vitro by inducing apoptosis in cancer cells. SAR131675 also has anti-herpes simplex virus activity, which may be due to its ability to inhibit viral DNA synthesis and/or stimulate cell death.</p>

<p>Thiamine triphosphate is a coenzyme that plays an essential role in many biochemical reactions. It is a cofactor for pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and transketolase. Thiamine triphosphate is required for the production of acetyl-CoA from carbohydrates and amino acids. This coenzyme also participates in the synthesis of thiamin, which is necessary for maintaining normal nerve function. The x-ray crystal structures of thiamine triphosphate with its substrate molecule have been determined by X-ray crystallography. These structures are available at PDB ID 1TMP and 1THP. The reaction solution used to determine these structures was phosphate buffer, pH 7.0, at 30 degrees Celsius. The receptor activity of this enzyme has been studied using rat brain homogenates following incubation with various concentrations of prasugrel (a substrate molecule). Enzyme</p>

<p>Please enquire for more information about Dexamethasone-17-ketone including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Metroprolol succinate is a prodrug of metoprolol. It is used for the treatment of high-sensitivity c-reactive protein, which is an inflammatory marker that indicates the presence and severity of atherosclerosis. Metoprolol succinate also has anti-inflammatory properties and can be used to treat cardiac disorders such as congestive heart failure. The drug inhibits the growth factor-β1 pathway in cardiac cells, which may be due to its ability to inhibit cellular proliferation by inducing apoptosis. This drug also has a protective effect on the skeleton, preventing bone loss and osteoporosis. Metroprolol succinate can be used in sample preparation for hydrochloric acid digestion or particle size analysis.</p>

<p>Tetrahydro-2-[2-(4-hydroxyphenyl)-1-methylethyl]-4,6,8-isoquinolinetriol is a synthetic compound that is used as an analytical reference standard for the detection of impurities in drugs. It is also commonly used as an impurity standard when synthesizing drugs and has been shown to be metabolized through various pathways including oxidation by cytochrome P450 enzymes. Tetrahydro-2-[2-(4-hydroxyphenyl)-1-methylethyl]-4,6,8-isoquinolinetriol is also used in drug development research and development.</p>

<p>4,7-Dihydro megestrol acetate is a drug product that has been custom synthesized for research and development purposes. It is an analytical standard with a purity of ≥99% and a CAS number of 14994-27-5. Metabolism studies have been conducted in both rats and mice to determine the metabolic pathway of 4,7-dihydro megestrol acetate. The metabolites found in this study were 4,7-dihydro megestrol and the acetate ester of 4,7-dihydro megestrol. Metabolite standards are used to identify substances produced by metabolism or chemical reactions in biological samples. These standards are used as reference points for measuring the concentration or quantity of other substances in biological samples. Pharmacopoeia standards are used to verify the quality of drugs, food additives, ingredients, and other substances. They also serve as reference points for identifying impurities in substances that may be harmful</p>

3,9-Dihydro-9-[(2-hydroxyethoxy)methyl]-1H-Purine-2,6-dione is an impurity found in the synthesis of a drug product. It is also used as an analytical standard for HPLC methods and as a pharmacopoeia standard. 3,9-Dihydro-9-[(2-hydroxyethoxy)methyl]-1H-Purine-2,6-dione has been shown to be produced by the metabolism of other drugs such as caffeine. This impurity is not expected to have any therapeutic effects when administered to humans.

1-C-4-Chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucopyranose is a natural product. It is an API impurity that has been synthesized by the custom synthesis process. 1-C-4-Chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucopyranose has been shown to have pharmacological activity in research and development studies and as a potential drug product.

<p>2-Amino-5,6-dichloro-3-(4H)-quinazoline acetic acid benzyl ester hydrobromide is a drug product that is used as an analytical reference standard for the identification of impurities in aminoglycosides. 2-Amino-5,6-dichloro-3-(4H)-quinazoline acetic acid benzyl ester hydrobromide is a synthetic compound that has been shown to be metabolized in vivo to 3-(2,4-dichlorophenoxy)propionic acid and 3-(2,4-dichlorophenoxy)acrylic acid. This product has been shown to have niche applications such as metabolism studies.</p>

<p>1,5-Bis(4-pyridyl)pentane is a coordination polymer that can be used in the preparation of polymers. It is bifunctional and has coordination properties. This compound is made up of two pyridine rings linked to an ethyl group via a pentane chain. The cationic form of this compound is used for the preparation of some polymers. The crystal structure for 1,5-bis(4-pyridyl)pentane was determined by X-ray crystallography and found to have a layered topology with hydrogen bonding.</p>

<p>14-Epiandrographolide is a natural product that can be found in the plant Andrographis paniculata. It has been shown to have anti-inflammatory, anticancer, and antibacterial properties. 14-Epiandrographolide inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Rifapentine also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.</p>

<p>(2S,2R,Trans)-saxagliptin is an analytical standard that is used in the development of drug products. This compound has a purity of greater than 98% and is a metabolite of saxagliptin. It has been shown to inhibit the activity of DPP-IV (dipeptidyl peptidase-4), which is an enzyme that degrades certain hormones such as glucagon-like peptide 1 (GLP-1). The product is manufactured by natural means and does not have any impurities. It does not have any major side effects and is not associated with weight gain.</p>

<p>Desethylene posaconazole N,N’-diformyl is an analog of posaconazole that has been shown to have potential as an anticancer agent. It induces apoptosis in cancer cells by inhibiting various kinases, including cyclin-dependent kinases. Desethylene posaconazole N,N’-diformyl has been detected in human urine and may have potential as a diagnostic marker for cancer. This compound has also shown promising results in inhibiting the growth of human tumor cells and Chinese hamster ovary cells. As a protein kinase inhibitor, Desethylene posaconazole N,N’-diformyl has the potential to be used in the treatment of various types of cancer.</p>

<p>Bezafibrate is a drug product that is used in the treatment of hyperlipidemia. It is an impurity standard for bezafibrate 1-o-β-glucuronide, which can be used as an analytical standard for HPLC analysis. Bezafibrate 1-o-β-glucuronide can also be used to evaluate the metabolism of bezafibrate through animal studies.</p>

<p>(R)-N-Methyl-laudanosine iodide is an impurity that has been reported in the product of a custom synthesis. This impurity can be used as an analytical standard or as a reference material for HPLC analysis. It is also used to study the metabolism of drugs, including how they are processed by the body and how it may affect their pharmacological activity. (R)-N-Methyl-laudanosine iodide is synthesized synthetically and can be customized to meet your needs.</p>

<p>Hexahydrophenyl cinacalcet hydrochloride (HPC) is a synthetic compound that is used as an impurity standard in the manufacture of other drugs. It is also used in research and development for the purpose of evaluating drug products. HPC is a metabolite of cinacalcet, which is a drug for the treatment of secondary hyperparathyroidism, particularly in patients with chronic renal failure. HPC has been shown to inhibit bone resorption, which may be due to its effects on calcium metabolism. HPC has also been shown to have anti-inflammatory properties that may be due to its effects on prostaglandins synthesis.</p>

Trandolaprilat diketopiperazine is an analog of trandolapril, a medication used to treat high blood pressure. Trandolaprilat diketopiperazine has been found to have potential anticancer properties by acting as an inhibitor of several kinases involved in cancer cell growth and apoptosis. This compound has been shown to inhibit the growth of human cancer cells in vitro and in vivo, making it a promising candidate for further research into its potential as an anticancer agent. Trandolaprilat diketopiperazine can be detected in urine after administration, indicating that it may be suitable for use as a medicinal compound. Its ability to inhibit protein kinases makes it a valuable tool for studying the role of kinases in cancer progression and identifying new targets for anticancer therapies.

This compound is a research and development impurity standard with a custom synthesis. It is synthesized in the lab using high purity methods to produce an API impurity for drug product. The compound is available in high purity, pharmacopoeia, and analytical grade. This compound is used as an analytical reference standard. Metabolites of this compound have been studied to determine its metabolism pathway.

<p>Des-chloromeclozine-d9 is a research and development impurity standard. It is used as an impurity in the synthesis of meclozine, a drug product. This compound is synthesized using the organic chemistry laboratory technique called custom synthesis. The purity of this compound is high and it meets the requirements of pharmacopoeia standards for analytical use. Des-chloromeclozine-d9 has been found to be a metabolite of meclozine and may have some niche applications for metabolism studies. This synthetic compound has CAS number 16896-82-5.</p>

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<p>Thalrugosaminine is an ethanolic extract of the bark and roots of the Indian plant Thalrugosia jatrorrhizina. It has been shown to have potent antibacterial activity against Staphylococcus aureus, and an in vitro study showed it to be effective against Mycobacterium tuberculosis. Thalrugosaminine has been used as a herbal remedy for infectious diseases such as bovine mastitis and human disorders such as thaligosis. It has also been shown to have hypotensive effects in animal studies.</p>

<p>Ethyl 6-[4-[(5-chloro-1-oxopentyl)amino]phenyl]-4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxylate is a chemical compound with various applications. It is soluble in methanol and has been found to interact with peptidoglycan, cellulose, and other substances. This compound has shown potential anticoagulation properties and has been studied for its effects on blonanserin, etoricoxib, 27-hydroxycholesterol, tenofovir, proton, famotidine, dimethyl fumarate, calpain, dimethyl sulfoxide, and reactive agents. Further research is needed to fully understand the potential applications of this compound and its interactions with different substances.</p>

<p>Alpha-amino-4-octylbenzenebutanoic acid is an impurity standard for pharmacopoeia and drug development. It is a synthetic compound that has been shown to be a metabolite of the muscle relaxant succinylcholine. Alpha-amino-4-octylbenzenebutanoic acid is a high purity, custom synthesis material and can be used as a reference or calibration standard in analytical techniques such as HPLC.</p>

Micafungin Metabolite M1 is a metabolite of Micafungin. It is an impurity in the drug product and is not active. Micafungin Metabolite M1 has been proposed as a pharmacopoeia reference standard for HPLC quantification of Micafungin.

Trap 101 is a potent anticancer agent that is derived from xylose. This compound has been shown to induce apoptosis in cancer cells by inhibiting kinases, which are enzymes that play a key role in tumor growth and progression. Trap 101 specifically targets Chinese hamster ovary cells and human cancer cell lines, making it a promising candidate for the treatment of various cancers. In addition, Trap 101 acts as a kinase inhibitor and has been shown to be effective against several types of tumors. This compound can be detected in urine samples, making it an attractive candidate for non-invasive diagnostic tests for cancer patients. Overall, Trap 101 holds great potential as a novel therapeutic agent for cancer treatment.

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AC-263093 is a medicinal compound that acts as an inhibitor of apoptosis, which is the natural process of programmed cell death. It has been shown to be effective in inhibiting tumor growth by targeting specific kinases and proteins involved in the cell cycle. AC-263093 works by blocking the activity of certain kinases, which are enzymes that regulate various cellular processes. This inhibition leads to the disruption of cancer cell growth and division, ultimately resulting in cell death. This compound has demonstrated anticancer properties and has been tested on various human cancer cell lines with positive results. Its potential as an effective treatment for cancer makes it a promising candidate for further research and development.

PZ-II-029 is an analog of a Chinese medicinal compound that has shown promising results in the treatment of cancer. This compound has been found to induce apoptosis (programmed cell death) and arrest the cell cycle in human cancer cells. PZ-II-029 is an inhibitor of a protein kinase, which plays a critical role in the growth and proliferation of tumor cells. This potent anticancer agent has been shown to be effective against various types of tumors and may have potential for use in combination with other cancer treatments. PZ-II-029 is derived from urine and is part of a new class of kinase inhibitors that hold great promise for the future of cancer therapy.

Dec-poc pmpa is an oral prodrug that exhibits potent antiviral activity against HIV. It is rapidly converted to its active form, tenofovir alafenamide hemifumarate, in the presence of hydrochloric acid. Dec-poc pmpa has excellent pharmacokinetic properties, resulting in sustained plasma levels and enhanced bioavailability compared to other pharmaceutical preparations of tenofovir. This prodrug undergoes a phase transfer reaction in the body, allowing for efficient conversion to the active antiretroviral agent. Additionally, Dec-poc pmpa has been formulated to minimize impurities and contains an acid-binding agent to reduce potential renal biomarkers associated with tenofovir administration. Its mechanism of action involves inhibiting viral replication by targeting adenine residues in viral DNA synthesis.

<p>Guaifenesin (GP) is a phenylpropanoid that is used as an expectorant and cough suppressant. Guaifenesin EP Impurity B is a by-product of the synthesis of guaifenesin, which can be removed by preparative chromatography. It has been shown to catalyze reactions with acidic substrates and has the ability to form magnesium complexes. The reaction mechanism for guaifenesin EP Impurity B is not well understood, but it has been shown that hydrotalcite and magnesium oxide can remove GP from solution. This impurity also reacts with zirconium to form zirconium oxide, which can be removed by techniques such as mesoporous silica gel chromatography.</p>

Cefmetazole diphenylmethyl ester is an analog of the antibiotic cefmetazole that has shown promising anticancer activity. It has been found to induce apoptosis in human cancer cells and inhibit the activity of various kinases, which are involved in the regulation of cell cycle and proliferation. Cefmetazole diphenylmethyl ester acts as a potent inhibitor of protein kinases, making it a promising candidate for the development of new medicinal drugs for cancer treatment. This compound has also been found to be excreted in urine, suggesting its potential use as a diagnostic tool for detecting tumors. Overall, cefmetazole diphenylmethyl ester shows great potential as an effective inhibitor of cancer cell growth and proliferation.

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<p>17-Deoxyprednisolone is a synthetic glucocorticoid that binds to the mineralocorticoid receptor, which is found in cells of the adrenal gland and other tissues. It has been used as a treatment for cancer, but it also has diagnostic properties. 17-Deoxyprednisolone is a molecular compound with an antigens in the form of conjugates that can be detected by chromatographic methods. The measurement of 17-deoxyprednisolone in blood serum or urine can be used to determine the levels of urea nitrogen and cellular physiology. 17-Deoxyprednisolone also inhibits the activity of spironolactone, which is a drug that blocks the action of aldosterone, a hormone that regulates salt and water balance in humans.</p>

Suspensolide is a medicinal compound that has been shown to have potent anticancer properties. It is an analog of a protein found in Chinese medicine and acts as a kinase inhibitor, blocking the activity of enzymes involved in cancer cell growth and proliferation. Suspensolide induces apoptosis, or programmed cell death, in human cancer cells and has shown promising results as a potential treatment for various types of tumors. This compound can be detected in urine samples and has the potential to become an important tool in cancer therapy.