APIs pour la recherche et les impuretés

Fijimycin B is a medicinal compound that acts as an inhibitor of kinases, which are proteins that play a crucial role in cancer cell growth and proliferation. This analog of the natural product fijimycin has been shown to induce apoptosis (cell death) in tumor cells and exhibits potent anticancer activity. Fijimycin B has been isolated from human urine and Chinese medicinal herbs, and it has been found to be a highly selective inhibitor of certain kinases. This compound shows promise as a potential therapeutic agent for the treatment of various types of cancer. Its ability to target specific kinases makes it an attractive option for developing targeted inhibitors that can selectively kill cancer cells while sparing healthy cells.

Des(oxopentyl) Valsartan Benzyl Ester is an analytical standard for the drug valsartan. It is a white to off-white, crystalline powder that is soluble in methanol and acetone. This compound can be used as an HPLC standard, or as an impurity standard in the development of valsartan drugs. Des(oxopentyl) Valsartan Benzyl Ester also has niche uses in natural product isolation and synthetic organic chemistry. It is a metabolite of des(oxopentyl)valsartan, which is a prodrug of valsartan.

Methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (MTBC) is a drug target that is a carboxylate. MTBC has been shown to have potent inhibition activity against benzothiazine oxidases. MTBC can be used as an inhibitor of enzymes involved in the biosynthesis of benzothiazines and may be useful for the treatment of diseases such as Parkinson's disease and schizophrenia. The inhibition potential of MTBC has been unraveled through its interaction with peroxidases and other oxidases. In vitro studies have shown that MTBC can inhibit the oxidation of low molecular weight compounds by acting as a scavenger for hydrogen peroxide. This drug also exhibits unsymmetrical dehydration to produce methyl 4-(hydroxyamino)-2H-1,2-benzothiazine 1,1-dioxoate (MTBA), which is an

<p>Dopamine (D2 and D3) receptor agonist; has anti-parkinsonian effects</p>

<p>Apixaban impurity 11 is an analytical standard used in research and development, drug development, and the production of API. It has a purity of 99.5% by HPLC and is a metabolite of apixaban. Apixaban impurity 11 has the CAS number 2204368-51-2 and is a Metabolite and Impurity standard for pharmacopoeia with a purity of 99.5% by HPLC. This product can be custom synthesized or natural with a purity of 99.5% by HPLC.</p>

<p>N1.9,N1.9-Dimethyldesmopressin is a synthetic analog of the natural hormone vasopressin. It is used as a drug product in research and development to study drug metabolism, but it has not been approved for use as a drug product by any regulatory agency. Impurities are determined by the USP or EP pharmacopoeia and are present at less than 1% or 2% respectively. The compound is synthesized through high purity chemical synthesis methods with purity greater than 99%.</p>

<p>Bupivacaine N-oxide is a synthetic local anesthetic drug. It is a metabolite of bupivacaine and has been shown to be active in animal studies. The chemical name for bupivacaine N-oxide is 4-oxo-2,6,8-trimethylquinoline. Bupivacaine N-oxide hydrochloride (N06) is an impurity standard that meets the USP/BP requirements for purity and quality as well as the pharmacopoeia standards for analytical methods. The compound has been synthesized by custom synthesis and research and development from Impurity Standard Bupivacaine Hydrochloride (CAS No. 1796927-05-3). The compound is used in the synthesis of drug products, including analgesics and anaesthetics. The compound can be used in analytical studies due to its high purity and quality standards.</p>

<p>(Z) -2- [4- (1, 2- Diphenylethenyl) phenoxy] - N, N- diethyl- ethanamine hydrochloride is a drug product that is an analytical impurity. It is used as a metabolite standard in drug development and metabolism studies. The CAS number for this compound is 97800-41-4.</p>

<p>N-Formyl-D-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester is a research and development impurity standard that is used to assist in the production of high purity drug products. It is a synthetic compound that is metabolized in vivo to form N-formylglycine. This impurity standard can be used as a reference material for pharmacopoeia, drug development, and metabolic studies.</p>

Belinostat glucuronide is an analytical standard that is used in HPLC. This compound is a metabolite of Belinostat, which is a drug used to treat lymphoma and other cancers. Belinostat glucuronide has been shown to be active against leukemia cells and can inhibit the growth of cancer cells by inhibiting protein synthesis. It also inhibits the activity of topoisomerase I, II, and III.

<p>Di-M-tolyl phosphate is a phosphorus compound with a chemical formula of (CH3)2PO2. It has a melting point of –20 degrees Celsius and is insoluble in water, but soluble in organic solvents. Di-M-tolyl phosphate has optical properties that are modulated by temperature, morphology, and diffraction. FTIR spectra show protonation at temperatures below -10 degrees Celsius and imine formation at higher temperatures. Di-M-tolyl phosphate undergoes intramolecular hydrogen bonding to form pyrrole rings that may be responsible for its processability. This compound can be synthesized from monomers such as methanol and dimethyl ether via the process of electrophilic addition of phosphorus pentoxide to an imine or pyrrole ring system. The silicon affinity of this compound increases with the concentration of alkyl groups on the phosphorus atom.</p>

<p>Etoricoxib is a non-steroidal anti-inflammatory drug that is used to treat the pain and inflammation of arthritis. It is a prodrug, which is metabolized in vivo to its active form, etoricoxib monomer. Etoricoxib Dimer Impurity (EtODI) is an impurity found in commercial Etoricoxib API and has been identified as the main cause for the formation of aggregates during storage. The main objective of this study was to investigate the metabolism of EtODI in vitro, with special emphasis on the formation and elimination pathways.</p>

<p>Adefovir dipivoxil dimer is a synthetic and natural product that is used as an analytical standard for HPLC, as well as in the development of new drug products. It is also used to identify impurities in API. Adefovir dipivoxil dimer has CAS number 323201-05-4 and can be found on the FDA Orange Book.</p>

<p>Pinoxaden is a protein kinase inhibitor that has shown promising results in the treatment of cancer. It specifically targets cyclin-dependent kinases, which are key regulators of cell division and proliferation. By inhibiting these kinases, Pinoxaden induces apoptosis (programmed cell death) in cancer cells, thereby preventing tumor growth and metastasis. This drug is an analog of a Chinese herbal medicine and has been shown to have potent anticancer activity both in vitro and in vivo. In addition, Pinoxaden has low toxicity and is excreted primarily through urine, making it a promising candidate for further development as an anticancer agent.</p>

CAS No. is a drug product that has been custom synthesized for research and development purposes. It is a white crystalline powder with a melting point of 256-258°C. Metabolism studies have shown that olsalazine sodium impurity E is metabolized to sulfapyridine, which is an active metabolite of olsalazine sodium. Impurity standard A has been synthesized as an analytical standard for HPLC analysis. This impurity standard exhibits the same retention time as olsalazine sodium in the HPLC system and can be used for the quantitative determination of this impurity in olsalazine sodium samples.

Fumarranol is a potent inhibitor of kinases that play a crucial role in cancer cell growth and proliferation. It has been shown to inhibit the growth of tumor cells by inducing apoptosis, or programmed cell death. Fumarranol is effective against various types of cancer, including leukemia, and has been tested on human cell lines. This compound works by blocking the activity of kinases that are essential for the progression of the cell cycle, preventing cancer cells from dividing and multiplying. Fumarranol has also been found in urine samples and may have potential as a biomarker for cancer detection. With its ability to target specific proteins involved in cancer development, fumarranol shows promise as a potential treatment option for various types of cancer.

<p>Levofloxacin hydroxy acid is a high purity, drug product with a HPLC standard. It is used for drug development and research. Levofloxacin hydroxy acid has been developed as an analytical reference standard for the detection of impurities in API manufacturing. The pharmacopoeia includes levofloxacin hydroxy acid as an impurity standard. Levofloxacin hydroxy acid is also used in metabolism studies to investigate the role of levofloxacin's active metabolite, M-2, on the activity of CYP2C8 and CYP3A4 enzymes.</p>

<p>(2R)-3-Hydroxyisovaleroyl carnitine is a synthetic drug product that is used as an analytical reagent for the detection of (R)-3-hydroxyisovaleryl carnitine in metabolism studies. It has a CAS number of 99159-87-2 and a molecular weight of 212.29 g/mol. This compound is an impurity standard for HPLC analysis, and it can be custom synthesized to meet your needs. Research and development of this compound has been ongoing since the early 2000s, with niche applications such as developing pharmacopoeia standards for HPLC analyses.</p>

<p>Dapagliflozin Impurity 17 is a research and development impurity standard for HPLC. It is a natural product and is registered under CAS No. 1807632-93-4. Dapagliflozin Impurity 17 is a metabolite of dapagliflozin, an oral anti-diabetic drug that has been shown to be effective in the treatment of type 2 diabetes. This impurity standard has been synthesized as a research tool for the study of metabolism and pharmacokinetics, as well as analytical methods validation.</p>

3,4-Dihydroxyphenylacetic acid-d5 is a drug product that is used as an impurity standard for HPLC. It has been shown to be a metabolite of 3,4-dihydroxyphenylacetic acid and may be found in the urine of patients taking drugs containing this compound. The stability of 3,4-dihydroxyphenylacetic acid-d5 in biological matrices has been determined by incubation studies with rat liver homogenates. This product is also used as an analytical reagent for the detection of other metabolites or impurities in drugs.

Fingolimod is a drug product that belongs to the class of synthetic drugs. It is an impurity standard for fingolimod phosphate d4 and its metabolites. Fingolimod phosphate d4 is a metabolite of fingolimod and has been shown to inhibit the synthesis of phosphatidylinositol 3-kinase (PI3K) in vitro, which may be due to its ability to inhibit protein synthesis. The pharmacopoeia for fingolimod phosphate d4 is CAS No. 1794828-93-5.

<p>Apitoxin is a natural toxin found in the venom of honeybees. Studies have shown that it has potential anti-cancer properties due to its ability to induce apoptosis, or programmed cell death, in human cancer cells. Additionally, apitoxin contains kinases that can inhibit tumor growth and glycerol analogs that have demonstrated anticancer activity in Chinese hamster ovary cells. Indirubin, a compound found in apitoxin, has been identified as a potent inhibitor of kinases involved in cancer cell proliferation. Apitoxin may also be useful as a urinary biomarker for detecting prostate cancer. Overall, the unique properties of apitoxin make it an intriguing candidate for further research into potential cancer treatments.</p>

<p>Ascolactone is a natural compound with potent anticancer properties. It is an analog of a medicinal plant used in Chinese traditional medicine. Ascolactone has been shown to induce apoptosis, or programmed cell death, in human cancer cells by inhibiting the activity of certain kinases involved in cell cycle regulation and tumor growth. Ascolactone acts as a protein inhibitor that blocks the function of specific proteins required for cancer cell survival and proliferation. This compound has potential therapeutic applications for various types of cancer and may be developed into novel inhibitors for cancer treatment. Ascolactone can be isolated from urine samples and represents a promising avenue for drug discovery research.</p>

<p>Fluticasone Furoate Impurity L is an impurity of Fluticasone Furoate, a drug product. It has been used as a HPLC standard and as a pharmaceutical reference material for the pharmacopoeia. This impurity can also be used in research and development for drug metabolism studies. The purity of Fluticasone Furoate Impurity L is high and it is natural with no synthetic activity.</p>

<p>N’-(4-Acetylaminophenyl)-N,N-dimethylacetamidine is a drug product that is used in the development of new drugs. It has high purity, analytical grade and natural origin. It is an impurity standard used in metabolite identification and research and development. The CAS number for this compound is 1358054-66-6.</p>

<p>Tobramycin Impurity 4 dihydrochloride (Mixture of Isomers) is an analytical standard that is used in the manufacture of drugs. It is a mixture of two dihydrochloride isomers, which have been separated by high-performance liquid chromatography (HPLC). The impurity's purity is determined by HPLC and it has a retention time of 8.8 minutes. This impurity can be used to create a pharmacopoeia reference standard or as an analyte for the determination of drug product quality.</p>

2,12-Dihydro-1,3-dimethyl-9-methoxy-12-thioxobenzo [4,5] pyrido [1,2-c] imidazo [1,2-a] imidazol-2-one is a synthetic compound that has not been evaluated in humans. This compound is an impurity standard for the synthesis of an API. The purity of this compound is >98% and it has been shown to be stable under acidic conditions.

<p>Desmethylnortriptyline is a tricyclic antidepressant drug that has been shown to have anti-inflammatory properties. It inhibits the production of inflammatory cytokines in the intestine, which may be due to its effect on the induction of apoptosis by inhibiting protein synthesis. Desmethylnortriptyline also has a beneficial effect on bowel diseases, such as colitis and ileitis. This drug inhibits the uptake of serotonin in rat brains and can lead to decreased levels of serotonin in the brain and spinal cord, which may be responsible for its clinical response. Desmethylnortriptyline is metabolized by demethylation and deamination. It undergoes oxidative deamination by cytochrome P450 enzymes found in human liver microsomes and isolated heart tissue, generating an inactive product. The drug also undergoes oxidation by uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) to form an active metabolite.</p>

<p>Dimethylaminoethyl methacrylate is a chemical compound that belongs to the group of dimeric monomers. It is an activated form of methacrylates, which are compounds containing the -C(O)OC-CH2-CH2-O-CO-R functional group. The activated form is prepared by the reaction of a primary amine with acetic acid and acrylic acid. Dimethylaminoethyl methacrylate has been used as a carbohydrate adduct to create glycoconjugates and it has been shown to have anti-mutagenic properties. This product can be found in high concentrations in China.</p>

<p>Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits the production of prostaglandins, which are produced by inflammatory cells in response to tissue injury. It is used to treat pain and inflammation. Aceclofenac is absorbed quickly from the gastrointestinal tract and has a high bioavailability. The maximum plasma concentration is reached within 1 hour after oral administration. Aceclofenac has a short half-life of about 2 hours. This drug binds to fatty acids and hepatoprotective substances, such as polymers, pyruvic transaminase, acetate extract, and humans. It also inhibits the transcription of cyclooxygenase-2 (COX-2), which produces prostaglandins that are involved in various aspects of inflammation.</p>

Defluoro flunarizine dihydrochloride is a research and development drug product that is synthetic. It is an impurity standard, which is used as an analytical reference to determine the purity of a drug product. Defluoro flunarizine dihydrochloride is also an API impurity. The metabolite of this compound has not been fully characterized, but it may be similar to the natural metabolite of Flunarizine. HPLC standards are used for quality control during analysis and synthesis of drugs in the pharmaceutical industry.

5-Amino-N,N’-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-2,4,6-triiodo-1,3-benzenedicarboxamide - EP is an impurity found in the synthetic process of iopamidol. It is a nonionic chemical that has been shown to be synthesized using the following methods: dichloride and synthetic. 5-Amino-N,N’-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-2,4,6-triiodo-1,3-benzenedicarboxamide - EP is used as a contrast agent for magnetic resonance imaging (MRI).

<p>4-Desfluoro-4-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-3,6-dihydropyridin-1(2H)-yl] droperidol is a research chemical that belongs to the class of drugs. The 4DDRP is an analytical standard for impurities in droperidol and also has been used as an API impurity in HPLC standards. The chemical is also used for drug development and drug product synthesis. 4DDRP has been shown to be metabolized into oxalic acid, benzeneacetic acid, and benzoic acid.</p>

Molnupiravir Impurity C is a drug product that is synthesized in-house. This chemical is a high purity, synthetic, impurity standard for Molnupiravir. It has been shown to exhibit metabolic properties similar to those of the natural metabolite of this drug. Molnupiravir Impurity C is used as an analytical reference material for HPLC and GC-MS methods.

<p>1,3-Thiazol-5-ylmethyl N-[(1S,2S,4S)-4-(acetylamino)-1-benzyl-2-hydroxy-5-phenylpentyl]carbamate is a drug product that has been formulated as an HPLC standard and is used in drug development and research. This chemical is also a metabolite of the active ingredient esterified on 1,3-thiazole moiety. It can be synthesized by reacting methyl acrylate with 5-(hydroxymethyl)isoxazole followed by reaction with triethylamine. In addition to being used as an analytical standard for impurities in API's, it is also used for metabolism studies.<br>Molecular Formula: C24H31N3O4S<br>Molecular Weight: 441.53<br>CAS Number: 1010808-43-1</p>

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1-[(1-Methylethyl)amino]-3-phenoxy-2-propanol is an organic compound that belongs to the class of phenoxyethanol derivatives. It has been used in milligram amounts to assist in the separation of racemic mixtures by countercurrent chromatography. The compound is a racemate and the enantiomers are separated by chiral high performance liquid chromatography. The β-adrenergic agonist activity of 1-[(1-methylethyl)amino]-3-phenoxy-2-propanol has been shown in rats.

<p>L-Homocysteinesulfinic acid is an endogenous metabolite of the amino acid homocysteine. It is a reactive molecule that has been shown to cause neuronal death in vitro and in vivo. L-Homocysteinesulfinic acid binds to the NMDA receptor and inhibits its function, which may cause apoptosis. L-Homocysteinesulfinic acid also binds to the alpha2-adrenergic receptor and enhances uptake of glutamate, thereby causing neuronal death. L-Homocysteinesulfinic acid has been shown to be elevated in cancer patients, as well as those with a high risk for developing cancer. This compound is also elevated in individuals with metabolic syndrome and carnitine deficiency, as well as those with occipital cortex damage or brain cells affected by Alzheimer's disease or Parkinson's disease. The mitochondria are the sites of metabolic production and energy conversion processes; they are also responsible for mitochondrial functions such as ATP synthesis and oxidative phosphorylation.</p>

<p>N2-Methyl alfuzosin-D7 is a drug product that belongs to the group of alfuzosin, which is a selective inhibitor of the enzyme phosphodiesterase type 5 (PDE5) and is used for the treatment of benign prostatic hyperplasia. It has been designed to reduce the risk of adverse effects associated with other PDE5 inhibitors, such as erectile dysfunction and urinary retention. N2-Methyl alfuzosin-D7 has been shown to be effective in animal studies and in vitro experiments. However, its metabolism remains unknown.</p>

<p>This product is a synthetic impurity of Allopurinol. It is a cyclization reaction product of dimethylhydrazine and allopurinol in the presence of an organic solvent such as DMF.</p>

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<p>2,3-Dimethylphenyl mefenamic acid is a synthetic drug product. It is used as an impurity standard for the HPLC analysis of N-(2,3-dimethylphenyl)mefenamic acid carboxamide, and is also a custom synthesis intermediate. 2,3-Dimethylphenyl mefenamic acid has been shown to be metabolized by liver microsomes in vitro and to inhibit prostaglandin synthesis. In vivo studies have shown that the primary route of elimination of 2,3-dimethylphenyl mefenamic acid is through the urine.<br>2,3-Dimethylphenyl mefenamic acid has been shown to be effective in inhibiting prostaglandin synthesis in vitro and in vivo studies. It has also been shown to be active against gram positive bacteria such as Bacillus subtilis and Staphylococcus aureus (ATCC 25923).</p>

<p>4’-(7-Dechloroquinolinyl) piperaquine is an inhibitor of tumor kinases and has shown potent anticancer activity against various cancer cells. This compound is a derivative of piperaquine, which is commonly used as an antimalarial drug. 4’-(7-Dechloroquinolinyl) piperaquine has been found to induce apoptosis in human cancer cells by inhibiting the activity of protein kinases that are essential for cell growth and division. It has also been shown to have synergistic effects with capsaicin, a natural compound found in chili peppers, in inhibiting the growth of cancer cells. Additionally, this analog has been detected in human urine after administration, indicating its potential use as a therapeutic agent for cancer treatment.</p>

<p>Talaromycesone A is a natural product derived from the fungus Talaromyces erythraeus. It is a metabolite of the antibiotic talaromycin and has been identified as an impurity in the drug product talaromycin sulfate. Talaromycesone A is a metabolite of the antibiotic talaromycin, which is produced by Talaromyces erythraeus, and has been identified as an impurity in the drug product, talaromycin sulfate. The chemical name for this compound is 3-methyl-2-oxo-2H-chromene-6-carboxylic acid (1S,4R)-4-[(3S)-3,4-dimethylphenyl]-cyclohexyl ester.<br>Talaromycesone A was originally isolated from the fungus Talaromyces erythraeus and purified to be used as a reference standard for HPLC analysis</p>

<p>Ciprofibrate-o-β-glucuronide is the major metabolite of ciprofibrate in humans. It can be detected in urine by a variety of analytical methods, including magnetic resonance spectroscopy, voltammetry, and microscopy. Ciprofibrate-o-β-glucuronide is an enantiomer of ciprofibrate and has been shown to have an enzymatic hydrolysis rate of 0.07% per hour. This hydrolysis process is catalyzed by cytochrome P450 enzymes. Ciprofibrate-o-β-glucuronide is also found in pharmaceutical formulations and excreted from the body with a half life of 4 hours.</p>

<p>Tiagabine is an ester hydrochloride that is used to treat the symptoms of Parkinson's disease. Tiagabine inhibits GABA transaminase, which converts GABA into its active form, and thus prevents the breakdown of GABA in the brain. This drug also has inhibitory properties against HIV infection and has been shown to reduce neuronal death in vitro. Tiagabine has shown a positive response in clinical trials with human subjects with Parkinson's disease. Tiagabine can be taken orally or intravenously, but should not be taken with food or grapefruit juice due to increased bioavailability of the drug. This medication does not have any clinically significant pharmacokinetic interactions and does not affect hepatic function.</p>

<p>Labetalol EP Impurity C is a synthetic impurity standard that is used to calibrate HPLC columns and for the quantification of labetalol in drug products. Labetalol EP Impurity C is a metabolite of labetalol and has been shown to have similar pharmacological properties. Labetalol EP Impurity C is synthesized by ester hydrolysis. The purity of this compound exceeds 99%.</p>

<p>a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-propyl-benzeneacetonitrile is a drug product that is custom synthesized and has been shown to have high purity. It is also used in analytical studies, metabolism studies, and natural drug development. This compound can also be found as an impurity standard for HPLC or as an API impurity.</p>

<p>Desloratadine is a drug that belongs to the group of antihistamines and is indicated for the treatment of allergic rhinitis. It has been shown to be as effective as loratadine, cetirizine, and fexofenadine in clinical trials. Desloratadine is metabolized by cytochrome P450 enzymes including CYP2D6 to its active form, desloratadine N-oxide. The metabolites are excreted in the urine.</p>

Des[2-[(2-hydroxyethyl)amino]ethyl] mitoxantrone is a research and development impurity standard for synthesis. It is a synthetic, high purity compound with a CAS number of 89991-52-6. The chemical is not found in nature and does not have any natural metabolites. Des[2-[(2-hydroxyethyl)amino]ethyl] mitoxantrone has been shown to be metabolized by the liver into various metabolites that have been identified through analysis of urine samples. The metabolite of des[2-[(2-hydroxyethyl)amino]ethyl] mitoxantrone may be used as an analytical standard for HPLC methods.

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<p>4-(4-Aminophenyl)phthalazin-1(2H)-one is an antibacterial drug that belongs to the class of amide and minimise. It has a constant, synthetic, and chalcone profile. 4-(4-Aminophenyl)phthalazin-1(2H)-one has been shown to have antiplatelet activity in animals. This drug also inhibits the production of proinflammatory cytokines such as IL-6, IL-8, and TNFα by human monocytes. This drug also has antidiabetic properties and a safety profile similar to other nonsteroidal anti-inflammatory drugs.</p>

WAY 181187 oxalate is a metabolite of WAY-361507, a drug that has been studied for the treatment of cancer. The chemical structure of WAY 181187 oxalate is shown below.

<p>2-[3,5-Dichloro-4-[(4-chlorophenyl)methyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione is a research and development impurity standard. It is custom synthesized for drug product synthesis and analysis. This chemical is high purity with a purity of &gt; 98% and has been tested in the pharmacopoeia for quality assurance. 2-[3,5-Dichloro-4-[(4-chlorophenyl)methyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione can be used as a metabolite marker in metabolism studies due to its structural similarity to the parent compound.</p>

<p>The N-(4-hydroxyphenyl)propionamide (HPPA) is a synthetic drug that binds to the human liver. It has been shown to be effective in preventing implantation of fertilized eggs, and can be used as a diagnostic agent for determining the presence of HPPA in human liver tissue. HPPA is also used as a diluent for other drugs. The HPPA binds to chromatographic components and can be detected using electrochemical detection, which allows it to be used as a targetable probe for cancer research. HPPA is also used to study iontophoretic transport of ions across reconstituted membranes in vitro.</p>

<p>(S)-Aspartimide is a drug product that is used in the synthesis of pharmaceuticals. Its purity should be greater than 99% and it should be free from detectable impurities. (S)-Aspartimide is metabolized by esterases, glutathione reductase, cytochrome P450 enzymes, and conjugation with glucuronic acid. It has been shown to inhibit the growth of bacteria that are resistant to penicillin, ampicillin, erythromycin, and gatifloxacin. (S)-Aspartimide has been found to have an anti-inflammatory effect due to its inhibition of prostaglandin synthesis.</p>

Tortoside A is a potent inhibitor of protein kinases and has been found to have anticancer properties. It is an analog of a compound originally isolated from a Chinese medicinal plant. Tortoside A has been shown to induce apoptosis in cancer cells by inhibiting the activity of specific kinases that are involved in tumor growth and progression. This compound has also demonstrated promising results as an anticancer agent, with studies showing its ability to inhibit the growth of various human cancer cell lines. Tortoside A can be detected in urine, making it a potential biomarker for monitoring cancer treatment efficacy. Its unique properties make it an exciting candidate for further research and development as a potential cancer therapy.

2-(4-Ethylphenyl)-propanoic acid is a supplement that is used to relieve pain and inflammation. It belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs). This drug has been shown to be efficacious in the treatment of osteoarthritis, rheumatoid arthritis, and bronchitis. 2-(4-Ethylphenyl)-propanoic acid inhibits both prostaglandin synthesis and leukotriene synthesis by inhibiting cyclooxygenase 1, which converts arachidonic acid into prostaglandins, and 5-lipoxygenase, which converts arachidonic acid into leukotrienes. This drug has also been shown to inhibit COX-2 production in human monocytes. The active form of this drug is metabolized through a number of metabolic transformations including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes,

<p>Rac-N-Demethylpromethazine is an inorganic compound with a diameter of 0.15 nm. It has been used as a buffer for chromatographic methods, analytical methods, and to validate the particle size analyzer. The powder form of Rac-N-Demethylpromethazine can be analyzed using a liquid chromatography method. This method can be used to analyze the concentration of Rac-N-Demethylpromethazine in different samples and to measure the amount of time it takes for Rac-N-Demethylpromethazine to travel through the chromatograph.</p>

9-Glycine Desmopressin is a drug product that has been custom synthesized for use in research and development. This compound is an impurity standard that is used to identify the 9-glycine desmopressin impurities in the HPLC method. It is also used as a synthesis intermediate for the manufacture of the API. The CAS number for this compound is [CAS NO.]. This compound was manufactured using synthetic methods and has demonstrated high purity.

4-Hydroxy-α1-[[[6-(3-phenylpropoxy)hexyl]amino]methyl]-1,3-benzenedimethanol (4OHBZ) is a metabolite of the drug product 4OHBZ. It is an impurity standard for HPLC analysis of the drug product 4OHBZ. The impurity has been characterized by LCMS and MS studies. The purity of this compound is >99%.

<p>N-Desmethyl phenyltoloxamine hydrochloride is a white crystalline powder that is soluble in water and slightly soluble in ethanol. It has an analytical purity of greater than 99% with a melting point of 188-190°C. This compound is a metabolite of phenyltoloxamine, which is used as an analgesic and anti-inflammatory drug. N-Desmethyl phenyltoloxamine hydrochloride can be used as a pharmacopoeia reference standard for the analysis of this metabolite and also as a research and development starting material for the synthesis of other compounds.</p>

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4-Methyl-N-(5-methyl-2-pyridinyl)benzamide is a birefringent, crystalline compound that is soluble in organic solvents. This compound exhibits liquid crystal composition and can be synthesized by the reaction of 2,4-dimethylbenzoyl chloride with 5-methylpyrimidine. It has been used in the production of photolytic materials such as fluorine. 4-Methylbenzamide has been shown to have a skeleton that is composed of two fused pyridine rings and an amide group. The impurities found in this product are mainly methyl benzoate and methyl pyridine.

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Elagolix lactam impurity is a reactive compound that may be found as an impurity in various pharmaceutical products. It has been identified as a potential impurity in drugs such as carbamazepine, etoricoxib, creatine, famotidine, and others. Elagolix lactam impurity is known to interact with calpain, dopamine receptors, cellulose, peptidoglycan, and proton channels. This compound may have implications for drug stability and efficacy. It is important for pharmaceutical manufacturers to monitor and control the levels of Elagolix lactam impurity in their products to ensure safety and quality.

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4-Methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrochloride is a synthetic drug product that has been purified to high purity. This compound is used as an analytical standard and impurity in the development of drugs. 4-Methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrochloride is a metabolite of imidazole, which is a natural substance with unknown pharmacological activity. It has been found to be an impurity in the synthesis of various pharmaceuticals, including metronidazole and ampicillin. This product has not yet been evaluated for safety or efficacy in humans.

<p>Quetiapine is a drug that belongs to the class of sulfoxides. It is usually administered orally, but can also be given intravenously or intramuscularly. Quetiapine has been studied for its clinical use in the treatment of schizophrenia and bipolar disorder. The plasma concentrations of quetiapine are determined by high-performance liquid chromatography (HPLC) with tandem mass spectrometry (LC-MS/MS) detection. Validation studies have shown that the HPLC-MS/MS method is accurate and precise, with good linearity over a range of concentrations. Analysis was performed on plasma samples from healthy volunteers who were administered either 2 mg or 10 mg doses of quetiapine by intravenous injection. Concentrations were calculated and compared to those found in patients with schizophrenia and bipolar disorder who had been given oral doses of 300 mg per day for four weeks, yielding a therapeutic plasma concentration range from 100 to 300 ng/mL.</p>

Solifenacin impurity C is an impurity that is found in the drug product Solifenacin. It has been shown to be a natural metabolite and has been detected in human urine. Solifenacin impurity C is used as an analytical standard for HPLC analyses of solifenacin, and can also be used as a reference material for pharmacopoeia. The purity of this compound is 99%.

<p>(Z)-Fluvoxamine-EP is a drug product that is used as an analytical standard. It is a synthetic metabolite of fluvoxamine, which is a drug used for the treatment of depression. The synthesis of (Z)-fluvoxamine-EP is based on the asymmetric synthesis of fluvoxamine and the use of chiral chromatography to purify the product. This synthetic process allows for the production of high-purity (Z)-fluvoxamine-EP with a purity greater than 99%.</p>

<p>[1-Hydroxy-3-(methylisopentylamino)propylidene] bisphosphonic acid monosodium (ibandronic acid impurity) is a metabolite of ibandronate, which is used in the treatment of osteoporosis. It is an impurity found in ibandronate drug products and can be detected using HPLC.</p>

<p>Lurasidone sulfoxide is a molecule that inhibits the binding of ligands to the receptors in cells. It has been shown to be synergistic with other molecule inhibitors, such as virus and organosulfur compounds. Lurasidone sulfoxide also interacts with drug molecules and can be used to shift the paradigm of treatment for certain diseases. Lurasidone sulfoxide is cocrystallized with other molecules that are used for treatment or prevention of certain diseases, including HIV, hepatitis C, and cancer.</p>

<p>Isoginsenoside Rh3 is a metabolite of the natural product ginseng. It has been reported to have anti-inflammatory properties in vitro and in vivo, but it has not been studied extensively. Isoginsenoside Rh3 is not found in the human body, but it is an impurity of Ginseng extract that is routinely measured by HPLC. The concentration of this metabolite can be used as a quality control measure for Ginseng extracts.</p>

<p>Indoxacarb is a racemic compound that is used as an insecticide. It belongs to the class of carbamate insecticides and is marketed under the trade name of "Provaunt". Indoxacarb inhibits acetylcholinesterase, which leads to increased acetylcholine in the synapse, resulting in death. The production of indoxacarb has been optimized to yield a high-level of stereoselectivity. This optimization was achieved through a biocatalytic process that uses a strain of Escherichia coli with high stereoselectivity. This strain produces indoxacarb with a high level of stereoselectivity, which can be confirmed by NMR analysis.</p>

<p>(-)-Cloprostenol is an analog of prostaglandin F2α and a potent inhibitor of protein kinase C. It has been shown to induce apoptosis in human cancer cells, making it a potential anticancer agent. (-)-Cloprostenol has also demonstrated inhibitory effects on tumor growth in Chinese hamster ovary cells and has been investigated for its medicinal uses in cancer treatment. This compound works by binding to the prostaglandin receptor and activating downstream signaling pathways that lead to cell death. Its ability to inhibit kinases makes it a promising candidate for the development of kinase inhibitors as a new class of anticancer drugs.</p>

<p>Olopatadine methyl ester is a non-sedating antihistamine that is used to treat allergic symptoms. It has a rapid onset of action and is effective for 24 hours. Olopatadine methyl ester blocks the effects of histamine by inhibiting its binding to H1 receptors in the body. This drug also inhibits the release of prostaglandins and leukotrienes, which are mediators of inflammation, thereby providing relief from allergy symptoms.</p>

<p>Cinacalcet is a drug product that is used for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease. It is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. Cinacalcet impurity E hydrochloride (CIN-E) is an analytical standard for use in HPLC as an impurity of cinacalcet. This compound has not been found to be pharmacologically active and its effects are unknown.</p>

N-Formyl-D-leucine (1R)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester is a research and development impurity standard that can be custom synthesized for drug product development. It is an analytical standard for HPLC with high purity, pharmacopoeia, and drug development. It is a natural metabolite that has been studied as a niche metabolite in metabolism studies.

a-(Aminocarbonyl)-4-[2-(5-ethyl-2-pyridinyl)ethoxy]benzeneethanesulfonic acid is an analytical standard that is used in the drug development process. It has a purity of 99.9% and is used as an HPLC standard, niche product, and pharmacopoeia impurity. This chemical can also be custom synthesized or found in nature.

<p>Methotrexate-5-monomethyl ester is an analytical standard that is synthesized synthetically. The synthetic route used to produce the compound has been optimized for high purity, making this product suitable for use as a drug product or impurity standard. The structure of methotrexate-5-monomethyl ester was confirmed by 1H and 13C NMR spectroscopy and mass spectrometry. Methotrexate-5-monomethyl ester is an impurity found in the synthesis of methotrexate and is a metabolite of methotrexate. It has been shown to inhibit DNA synthesis and protein synthesis in animal cells, which may be due to its ability to inhibit transcription factors such as NFATc1, NFkB, STAT3, STAT5A and STAT5B.</p>

Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) that is used for the relief of inflammation and pain in osteoarthritis and rheumatoid arthritis. It is a stable, water-soluble prodrug of methylated meloxicam. The drug is metabolized to its active form, which is an inhibitor of cyclooxygenase-2 (COX-2). Meloxicam has been shown to be effective against COX-1, but not COX-2. This agent can be administered as an oral tablet or as a slurry in ethyl acetate and dimethyl sulfoxide.

Ml 10302 hydrochloride is a drug that has anxiolytic-like effects in animals. Ml 10302 hydrochloride binds to the GABAA receptor and enhances its sensitivity to the neurotransmitter GABA. It also binds to the benzodiazepine site on the GABAA receptor and inhibits a variety of ligands, including benzodiazepines, barbiturates, and alcohols. Ml 10302 hydrochloride was shown to have anxiolytic-like effects in humans and it is thought that this effect may be due to its ability to increase the sensitivity of GABAA receptors. Studies suggest that Ml 10302 hydrochloride increases the affinity of GABA for its binding site on the GABAA receptor, which is thought to be mediated through an allosteric mechanism.

<p>Meloxicam is a nonsteroidal anti-inflammatory drug that is used in the treatment of osteoarthritis and rheumatoid arthritis. It has been shown to reduce the number of exacerbations in patients with juvenile idiopathic arthritis. Meloxicam also inhibits the production of Cox-2, which is an enzyme that produces inflammation in joints. The oral route of administration allows meloxicam to be distributed through the body. This drug is not active against ankylosing spondylitis and it should not be taken by pregnant women or children under 12 years old.</p>

<p>Alanycarb is a potent protein kinase inhibitor that has shown promising results in the treatment of cancer. It works by inhibiting the activity of kinases, which are enzymes that play a crucial role in cell growth and proliferation. Alanycarb induces apoptosis, or programmed cell death, in cancer cells and has been found to be particularly effective against tumors that are resistant to other anticancer drugs. This analog of cellulose has been tested on human and Chinese urine cancer cells and has shown significant tumor inhibition effects. Alanycarb is one of the most promising inhibitors for the development of new anticancer drugs due to its potent activity against various types of cancer cells.</p>

4-Amino-6-chloro-benzene-1,3-disulfonic acid 1-amide 3-ethylamide is an analytical standard that is used in drug development and as a reference material. It is used to produce the USP/NF standard for HPLC and to develop new drugs. This compound is a metabolite of the drug clonidine hydrochloride. 4-Amino-6-chloro-benzene-1,3-disulfonic acid 1-amide 3-(ethylamide) is also known by its CAS number 166863–9. It has a molecular weight of 328.5 g/mol and it's been approved by the FDA for use in food animals. Impurities found in this compound are: methanol, acetone, formic acid, acetic acid, chloroform and sulfamic acid. This product can be custom synthesized or obtained from natural sources such as plant