APIs pour la recherche et les impuretés

<p>CAS No. is a drug product that has been custom synthesized for research and development purposes. It is a white crystalline powder with a melting point of 256-258°C. Metabolism studies have shown that olsalazine sodium impurity E is metabolized to sulfapyridine, which is an active metabolite of olsalazine sodium. Impurity standard A has been synthesized as an analytical standard for HPLC analysis. This impurity standard exhibits the same retention time as olsalazine sodium in the HPLC system and can be used for the quantitative determination of this impurity in olsalazine sodium samples.</p>

<p>Fumarranol is a potent inhibitor of kinases that play a crucial role in cancer cell growth and proliferation. It has been shown to inhibit the growth of tumor cells by inducing apoptosis, or programmed cell death. Fumarranol is effective against various types of cancer, including leukemia, and has been tested on human cell lines. This compound works by blocking the activity of kinases that are essential for the progression of the cell cycle, preventing cancer cells from dividing and multiplying. Fumarranol has also been found in urine samples and may have potential as a biomarker for cancer detection. With its ability to target specific proteins involved in cancer development, fumarranol shows promise as a potential treatment option for various types of cancer.</p>

<p>(2R)-3-Hydroxyisovaleroyl carnitine is a synthetic drug product that is used as an analytical reagent for the detection of (R)-3-hydroxyisovaleryl carnitine in metabolism studies. It has a CAS number of 99159-87-2 and a molecular weight of 212.29 g/mol. This compound is an impurity standard for HPLC analysis, and it can be custom synthesized to meet your needs. Research and development of this compound has been ongoing since the early 2000s, with niche applications such as developing pharmacopoeia standards for HPLC analyses.</p>

<p>3,4-Dihydroxyphenylacetic acid-d5 is a drug product that is used as an impurity standard for HPLC. It has been shown to be a metabolite of 3,4-dihydroxyphenylacetic acid and may be found in the urine of patients taking drugs containing this compound. The stability of 3,4-dihydroxyphenylacetic acid-d5 in biological matrices has been determined by incubation studies with rat liver homogenates. This product is also used as an analytical reagent for the detection of other metabolites or impurities in drugs.</p>

<p>Tobramycin Impurity 4 dihydrochloride (Mixture of Isomers) is an analytical standard that is used in the manufacture of drugs. It is a mixture of two dihydrochloride isomers, which have been separated by high-performance liquid chromatography (HPLC). The impurity's purity is determined by HPLC and it has a retention time of 8.8 minutes. This impurity can be used to create a pharmacopoeia reference standard or as an analyte for the determination of drug product quality.</p>

<p>Molnupiravir Impurity C is a drug product that is synthesized in-house. This chemical is a high purity, synthetic, impurity standard for Molnupiravir. It has been shown to exhibit metabolic properties similar to those of the natural metabolite of this drug. Molnupiravir Impurity C is used as an analytical reference material for HPLC and GC-MS methods.</p>

<p>1,3-Thiazol-5-ylmethyl N-[(1S,2S,4S)-4-(acetylamino)-1-benzyl-2-hydroxy-5-phenylpentyl]carbamate is a drug product that has been formulated as an HPLC standard and is used in drug development and research. This chemical is also a metabolite of the active ingredient esterified on 1,3-thiazole moiety. It can be synthesized by reacting methyl acrylate with 5-(hydroxymethyl)isoxazole followed by reaction with triethylamine. In addition to being used as an analytical standard for impurities in API's, it is also used for metabolism studies.<br>Molecular Formula: C24H31N3O4S<br>Molecular Weight: 441.53<br>CAS Number: 1010808-43-1</p>

<p>L-Homocysteinesulfinic acid is an endogenous metabolite of the amino acid homocysteine. It is a reactive molecule that has been shown to cause neuronal death in vitro and in vivo. L-Homocysteinesulfinic acid binds to the NMDA receptor and inhibits its function, which may cause apoptosis. L-Homocysteinesulfinic acid also binds to the alpha2-adrenergic receptor and enhances uptake of glutamate, thereby causing neuronal death. L-Homocysteinesulfinic acid has been shown to be elevated in cancer patients, as well as those with a high risk for developing cancer. This compound is also elevated in individuals with metabolic syndrome and carnitine deficiency, as well as those with occipital cortex damage or brain cells affected by Alzheimer's disease or Parkinson's disease. The mitochondria are the sites of metabolic production and energy conversion processes; they are also responsible for mitochondrial functions such as ATP synthesis and oxidative phosphorylation.</p>

<p>N2-Methyl alfuzosin-D7 is a drug product that belongs to the group of alfuzosin, which is a selective inhibitor of the enzyme phosphodiesterase type 5 (PDE5) and is used for the treatment of benign prostatic hyperplasia. It has been designed to reduce the risk of adverse effects associated with other PDE5 inhibitors, such as erectile dysfunction and urinary retention. N2-Methyl alfuzosin-D7 has been shown to be effective in animal studies and in vitro experiments. However, its metabolism remains unknown.</p>

<p>This product is a synthetic impurity of Allopurinol. It is a cyclization reaction product of dimethylhydrazine and allopurinol in the presence of an organic solvent such as DMF.</p>

<p>Please enquire for more information about 1-[[2-[(2-Aminophenyl)amino]-5-methyl-3-thienyl]carbonyl]-4-methyl-piperazine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ethyl(1-methylbutyl)malonuric acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-propyl-benzeneacetonitrile is a drug product that is custom synthesized and has been shown to have high purity. It is also used in analytical studies, metabolism studies, and natural drug development. This compound can also be found as an impurity standard for HPLC or as an API impurity.</p>

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<p>4-(4-Aminophenyl)phthalazin-1(2H)-one is an antibacterial drug that belongs to the class of amide and minimise. It has a constant, synthetic, and chalcone profile. 4-(4-Aminophenyl)phthalazin-1(2H)-one has been shown to have antiplatelet activity in animals. This drug also inhibits the production of proinflammatory cytokines such as IL-6, IL-8, and TNFα by human monocytes. This drug also has antidiabetic properties and a safety profile similar to other nonsteroidal anti-inflammatory drugs.</p>

<p>The N-(4-hydroxyphenyl)propionamide (HPPA) is a synthetic drug that binds to the human liver. It has been shown to be effective in preventing implantation of fertilized eggs, and can be used as a diagnostic agent for determining the presence of HPPA in human liver tissue. HPPA is also used as a diluent for other drugs. The HPPA binds to chromatographic components and can be detected using electrochemical detection, which allows it to be used as a targetable probe for cancer research. HPPA is also used to study iontophoretic transport of ions across reconstituted membranes in vitro.</p>

<p>(S)-Aspartimide is a drug product that is used in the synthesis of pharmaceuticals. Its purity should be greater than 99% and it should be free from detectable impurities. (S)-Aspartimide is metabolized by esterases, glutathione reductase, cytochrome P450 enzymes, and conjugation with glucuronic acid. It has been shown to inhibit the growth of bacteria that are resistant to penicillin, ampicillin, erythromycin, and gatifloxacin. (S)-Aspartimide has been found to have an anti-inflammatory effect due to its inhibition of prostaglandin synthesis.</p>

<p>2-(4-Ethylphenyl)-propanoic acid is a supplement that is used to relieve pain and inflammation. It belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs). This drug has been shown to be efficacious in the treatment of osteoarthritis, rheumatoid arthritis, and bronchitis. 2-(4-Ethylphenyl)-propanoic acid inhibits both prostaglandin synthesis and leukotriene synthesis by inhibiting cyclooxygenase 1, which converts arachidonic acid into prostaglandins, and 5-lipoxygenase, which converts arachidonic acid into leukotrienes. This drug has also been shown to inhibit COX-2 production in human monocytes. The active form of this drug is metabolized through a number of metabolic transformations including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes,</p>

<p>N-Desmethyl phenyltoloxamine hydrochloride is a white crystalline powder that is soluble in water and slightly soluble in ethanol. It has an analytical purity of greater than 99% with a melting point of 188-190°C. This compound is a metabolite of phenyltoloxamine, which is used as an analgesic and anti-inflammatory drug. N-Desmethyl phenyltoloxamine hydrochloride can be used as a pharmacopoeia reference standard for the analysis of this metabolite and also as a research and development starting material for the synthesis of other compounds.</p>

<p>Please enquire for more information about 2-Cyclopropyl-1-nitro-naphthalene including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Quetiapine is a drug that belongs to the class of sulfoxides. It is usually administered orally, but can also be given intravenously or intramuscularly. Quetiapine has been studied for its clinical use in the treatment of schizophrenia and bipolar disorder. The plasma concentrations of quetiapine are determined by high-performance liquid chromatography (HPLC) with tandem mass spectrometry (LC-MS/MS) detection. Validation studies have shown that the HPLC-MS/MS method is accurate and precise, with good linearity over a range of concentrations. Analysis was performed on plasma samples from healthy volunteers who were administered either 2 mg or 10 mg doses of quetiapine by intravenous injection. Concentrations were calculated and compared to those found in patients with schizophrenia and bipolar disorder who had been given oral doses of 300 mg per day for four weeks, yielding a therapeutic plasma concentration range from 100 to 300 ng/mL.</p>

<p>Solifenacin impurity C is an impurity that is found in the drug product Solifenacin. It has been shown to be a natural metabolite and has been detected in human urine. Solifenacin impurity C is used as an analytical standard for HPLC analyses of solifenacin, and can also be used as a reference material for pharmacopoeia. The purity of this compound is 99%.</p>

<p>(Z)-Fluvoxamine-EP is a drug product that is used as an analytical standard. It is a synthetic metabolite of fluvoxamine, which is a drug used for the treatment of depression. The synthesis of (Z)-fluvoxamine-EP is based on the asymmetric synthesis of fluvoxamine and the use of chiral chromatography to purify the product. This synthetic process allows for the production of high-purity (Z)-fluvoxamine-EP with a purity greater than 99%.</p>

<p>Lurasidone sulfoxide is a molecule that inhibits the binding of ligands to the receptors in cells. It has been shown to be synergistic with other molecule inhibitors, such as virus and organosulfur compounds. Lurasidone sulfoxide also interacts with drug molecules and can be used to shift the paradigm of treatment for certain diseases. Lurasidone sulfoxide is cocrystallized with other molecules that are used for treatment or prevention of certain diseases, including HIV, hepatitis C, and cancer.</p>

<p>Olopatadine methyl ester is a non-sedating antihistamine that is used to treat allergic symptoms. It has a rapid onset of action and is effective for 24 hours. Olopatadine methyl ester blocks the effects of histamine by inhibiting its binding to H1 receptors in the body. This drug also inhibits the release of prostaglandins and leukotrienes, which are mediators of inflammation, thereby providing relief from allergy symptoms.</p>

<p>Cinacalcet is a drug product that is used for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease. It is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. Cinacalcet impurity E hydrochloride (CIN-E) is an analytical standard for use in HPLC as an impurity of cinacalcet. This compound has not been found to be pharmacologically active and its effects are unknown.</p>

<p>a-(Aminocarbonyl)-4-[2-(5-ethyl-2-pyridinyl)ethoxy]benzeneethanesulfonic acid is an analytical standard that is used in the drug development process. It has a purity of 99.9% and is used as an HPLC standard, niche product, and pharmacopoeia impurity. This chemical can also be custom synthesized or found in nature.</p>

<p>Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) that is used for the relief of inflammation and pain in osteoarthritis and rheumatoid arthritis. It is a stable, water-soluble prodrug of methylated meloxicam. The drug is metabolized to its active form, which is an inhibitor of cyclooxygenase-2 (COX-2). Meloxicam has been shown to be effective against COX-1, but not COX-2. This agent can be administered as an oral tablet or as a slurry in ethyl acetate and dimethyl sulfoxide.</p>

<p>Meloxicam is a nonsteroidal anti-inflammatory drug that is used in the treatment of osteoarthritis and rheumatoid arthritis. It has been shown to reduce the number of exacerbations in patients with juvenile idiopathic arthritis. Meloxicam also inhibits the production of Cox-2, which is an enzyme that produces inflammation in joints. The oral route of administration allows meloxicam to be distributed through the body. This drug is not active against ankylosing spondylitis and it should not be taken by pregnant women or children under 12 years old.</p>

<p>5α,6α-Epoxycholestanol-d7 is an impurity of a cholestatic drug product. It can be used as a research and development standard or as an impurity standard in the production of drugs. 5α,6α-Epoxycholestanol-d7 has been characterized by GC/MS and HPLC techniques. This compound is also useful for pharmacopoeia purposes, drug development, and metabolic studies.</p>

<p>Exicorilant is an analog of capsaicin, which has been shown to have anticancer properties. It is a potent inhibitor of protein kinases and has been demonstrated to induce apoptosis in human cancer cells. Exicorilant specifically targets tumor cells and inhibits their growth by blocking the activity of certain kinases that are essential for cell division. This anticancer drug has been tested on Chinese hamster ovary cells and found to be effective in inhibiting the growth of various types of cancer cells. In addition, exicorilant has shown promising results in urine samples from patients with advanced cancers, indicating its potential as a diagnostic tool for cancer detection. Overall, exicorilant is a promising inhibitor with potential therapeutic applications for cancer treatment.</p>

<p>The 1-aza-8-hydroxy-6-oxo-oct-2-en-1-oylimidazole is a prodrug that is hydrolyzed to form the active compound clavulanate. It can be used for the treatment of infections caused by beta lactamase producing bacteria such as penicillinase producing staphylococci and beta lactamase producing streptococci. The 1-(4-Aza)8-(6-oxo)oct-(2)en-(1)-oylimidazole binds to penicillin binding proteins, which prevents the formation of an antibiotic inhibitor complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division. The clavulanic acid moiety in this drug also inhibits beta lactamases produced by bacteria, resulting in increased efficacy against these organisms.</p>

<p>Tirofiban impurity 8 is an analytical standard for HPLC. It is a research-grade, high purity, impurity standard for the drug product. Tirofiban impurity 8 is a metabolite of tirofiban that has been shown to be pharmacologically active in animal models and in vitro. Tirofiban impurity 8 has a natural or synthetic origin and its CAS number is 2250244-25-6.</p>

<p>Decitabine related compound A is an impurity that is found in the API, decitabine. It is an analytical standard for HPLC measurements and a reference material for impurity testing. It is also used as a pharmacopoeia standard for pharmacopoeias such as European Pharmacopoeia, USP, and Japanese Pharmacopoeia. Decitabine related compound A has been synthesized from natural sources such as plant-derived alkaloids and synthetically produced in the laboratory. CAS No. 1019659-87-0</p>

<p>Tovinontrine is a potent Chinese anticancer drug that targets the kinase pathway in cancer cells. It has been shown to inhibit cell cycle progression and induce apoptosis in cancer cells, making it a promising candidate for cancer treatment. Tovinontrine also has protein kinase inhibitory activity and can be used as an inhibitor of tumor growth. This drug is highly effective against various types of human cancers, including breast, lung, prostate, and colon cancer. Additionally, Tovinontrine has been shown to have synergistic effects with other anticancer drugs such as betamethasone and vitamin D3. The urine concentration of Tovinontrine can be used as a biomarker for the diagnosis and monitoring of cancer patients undergoing treatment with this drug.</p>

<p>N-[(2E)-6,6-Dimethyl-2-hepten-4-ynyl]-1-naphthalenemethanamine (DHEA) is a human metabolite and an endogenous hormone. DHEA has been shown to have antifungal activity against Candida albicans in vitro. It also possesses an inhibitory effect on the growth of some fungi that are resistant to azole drugs, such as Coccidioides immitis, Cryptococcus neoformans and Blastomyces dermatitidis. DHEA has been used in the treatment of pediatric patients with chronic granulomatous disease and is currently being evaluated for use in other pediatric conditions.</p>

<p>BGC 20-1531 is a synthetic drug product that is an impurity standard for the API, with a purity of 99.7%. BGC 20-1531 is also used as an analytical reference material and has been shown to be metabolized in both rats and humans. It can be used to study metabolism in animals and humans. The chemical name for this compound is 3-(2,4-dichlorophenyl)-5-[(1R,2S)-2-hydroxypropyl]-thiophene-2-carbonitrile hydrochloride.</p>

<p>3-(3-Trifluoromethylphenyl)propionaldehyde diethylacetal is a synthetic compound that belongs to the class of drug products. It is used for research and development, as well as for developing analytical standards for HPLC. This product has been shown to be metabolized in the rat liver by hydrolysis of the acetal group and oxidation of the alcohol.</p>

<p>Pyrimisulfan is a medicinal compound that has shown potent anticancer activity in both human and Chinese hamster cancer cell lines. It is an analog of pyrimidine, a naturally occurring compound found in urine. Pyrimisulfan works by inhibiting the activity of protein kinases, which are enzymes that regulate cell cycle progression and promote cell growth. This inhibition leads to apoptosis, or programmed cell death, in cancer cells. Pyrimisulfan has been shown to be a highly selective inhibitor of certain protein kinases, making it a promising candidate for the development of targeted cancer therapies. Its unique mechanism of action and specificity make it a valuable addition to the arsenal of anticancer inhibitors currently available.</p>

<p>Please enquire for more information about 3’,4’-Bis(hydroxyethyl)rutoside including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Threo ifenprodil hemitartrate is a drug product that has been synthesized and analyzed. It is an impurity standard for the synthesis of ifenprodil HCl. The purity of this product is greater than 99% and meets the requirements of the USP-NF, EP, BP, JP, and the pharmacopoeias of other countries. This product can be used in drug development research and development to develop drugs for niche markets.</p>

<p>KSI-3716 is a potent inhibitor of kinases, which are enzymes that play a critical role in cancer cell growth and survival. This inhibitor has been shown to be effective against Chinese and human kinases, making it a promising candidate for the treatment of various types of cancer. KSI-3716 is an analog of oseltamivir, a drug used to treat influenza. It has been found to induce apoptosis in tumor cells by inhibiting the activity of protein kinases. KSI-3716 also shows anticancer activity in vivo, as demonstrated by its ability to inhibit tumor growth in mice models. This inhibitor may have potential therapeutic applications for the treatment of cancer and other diseases related to kinase dysregulation.</p>

<p>Atorvastatin is a potent inhibitor of the enzyme HMG-CoA reductase, which is responsible for the conversion of HMG-CoA to mevalonate. This inhibition reduces the production of cholesterol and other lipids in the liver. Metabolism studies have shown that atorvastatin undergoes extensive presystemic metabolism by cytochrome P450 enzymes, primarily CYP3A4 and CYP2C9. The drug is converted to inactive metabolites that are eliminated primarily through renal excretion. Atorvastatin has not been found to inhibit any of the following: cytochrome P450 1A1/2, 2C8/9, 2D6, 2E1, 3A4/5 or glucuronidases.</p>

<p>o-Desmethyl venlafaxine N-dimer is a metabolite of venlafaxine that has been identified in human plasma. It is a white to off-white crystalline powder with a melting point of about 175°C. The purity of the product is more than 98%. It is soluble in methanol and ethanol, but insoluble in water. The o-desmethyl venlafaxine N-dimer was developed as an analytical reference standard for use in HPLC analysis of venlafaxine and its metabolites and impurities.</p>

<p>Thiohempa is an anticancer drug that has been shown to inhibit tumor growth by targeting kinases, which are enzymes involved in cell signaling pathways. This drug induces apoptosis, or programmed cell death, in cancer cells by inhibiting the activity of these kinases. Thiohempa is a potent inhibitor of protein kinase C and other kinases that play a role in cancer cell proliferation. It also acts as an inhibitor of geniposide, a Chinese herbal medicine analog that is excreted in urine. Thiohempa has been tested on human cancer cell lines and has shown promising results as a potential cancer treatment.</p>

<p>Please enquire for more information about (3R,4Z)-4-Ethylidenetetrahydro-5-oxo-3-furanacetaldehyde including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>9,13β-Dehydro epinastine is a synthetic impurity that is an analytical reference material. It is a metabolite of the drug epinastine and has been shown to have pharmacological activity.</p>

<p>8-Hydroxy warfarin-d5 is a drug product that is an impurity standard for the metabolism of warfarin. It is an analytical standard that can be used to determine the concentration of warfarin in a sample. The CAS number for 8-Hydroxy warfarin-d5 is 94820-66-3, and it has a molecular weight of 318.83 g/mol. This compound can be synthesized from natural sources or by chemical synthesis. 8-Hydroxy warfarin-d5 may also be used as a research and development tool in pharmacology, drug development, and toxicology studies.</p>

<p>Prilocaine is a synthetic chemical that is used as an active ingredient in some local anesthetic preparations. It is a metabolite of lidocaine and has been shown to be more potent than lidocaine in animal studies. Prilocaine hydrochloride is the free base form of prilocaine, which is soluble in water and alcohol. This product can be used as a reference standard for quality control purposes or as an analytical impurity standard for the analysis of drug products containing prilocaine.</p>

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<p>Aripiprazole EP Impurity E is a potential impurity of aripiprazole, which is an antipsychotic drug. It has been detected as a major impurity in the drug. Aripiprazole EP Impurity E has been found to be present in human plasma and it is thought that this impurity may have pharmacological effects on humans similar to those of aripiprazole. The detection of this impurity has been achieved using LC-MS/MS methods. This method can be used for wastewater treatment due to the matrix effect of nitrogen atoms. Aripiprazole EP Impurity E may have significant implications in the diagnosis, prevention, and treatment of obesity and other metabolic disorders.</p>

<p>Propafenone beta-D-glucuronide is a drug product that is used as an analytical reference standard. It has been shown to be metabolized in the rat, dog, and human by hydrolysis of the glucuronide group. The natural form of propafenone is found in various plants and fruits. Research and Development includes the synthesis of Propafenone beta-D-glucuronide from synthetic precursors. CAS No. 91411-76-6 is a Metabolite impurity standard for API Impurities testing which is found in pharmaceuticals, including propafenone, as an impurity.</p>

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<p>Alverine EP Impurity D is a synthetic impurity that is the result of the synthesis of Alverine EP. It is a metabolite that can be found in blood plasma and urine. This substance has been shown to have pharmacological activity, but its exact function is unknown. It is not present in natural sources and it does not have pharmacopoeia listing. Alverine EP Impurity D has been detected by HPLC analysis.END&gt;</p>

<p>N,N-Bis[2-(2-hydroxyethoxy)ethyl] quetiapine chloride is a synthetic drug product with a purity of &gt;98% and low impurity content, which is used in research and development. It can be custom synthesized to meet the needs of a particular research or development project. This compound has an analytical purity of &gt;98% and low impurity content, making it suitable for use as an API impurity standard. N,N-Bis[2-(2-hydroxyethoxy)ethyl] quetiapine chloride is not currently regulated by any pharmacopoeia.</p>

<p>Adenosine cyclic 2',3'-phosphate 5'-phosphate is an inhibitor that has been shown to induce apoptosis in cancer cells. It is a urinary metabolite of nifedipine, an anti-hypertensive drug. Adenosine cyclic 2',3'-phosphate 5'-phosphate has anticancer activity and can inhibit protein kinase A, which plays a role in tumor growth and progression. This compound is an analog of cyclic adenosine monophosphate (cAMP) and can compete with cAMP for binding to regulatory subunits of protein kinases. Adenosine cyclic 2',3'-phosphate 5'-phosphate has been shown to inhibit the activity of several kinases, including protein kinase C, GSK-3β, and ERK1/2 in human cancer cells. It may have therapeutic potential as a targeted therapy for certain types of cancer.</p>

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<p>Mdl 72832 hydrochloride is a ligand that modulates the activity of nerve cells. It has been shown to activate and synergistically enhance the effects of nerve growth factor (NGF) and acetylcholine on neurons. Mdl 72832 hydrochloride also increases the synthesis and release of melanocortins, which are neurotransmitters that are involved in regulating appetite, mood, and pain sensation. Mdl 72832 hydrochloride may be a potential nootropic agent for the treatment of neurodegenerative diseases such as Alzheimer's disease or Parkinson's disease.</p>

<p>9-(1,3-Dioxolan-2-ylmethyl)-3,9-dihydro-1,3-dimethyl-1H-purine-2,6-dione is a metabolite of the drug 9-(1,3-Dioxolan-2-ylmethyl)-1,3,9 dihydrobenzo[g]pteridine. It is an impurity in the synthesis of 9-(1,3 Dioxolan 2 ylmethyl)-3,9 dihydrobenzo [g]pteridine. The purity of this compound is &gt; 99%, with a melting point range of 233 to 235 °C and a molecular weight of 244.24 g/mol. It is soluble in methanol and acetonitrile. This compound has been characterized by IR spectroscopy (ATR), 1H NMR (400 MHz) spectroscopy (CDCl 3 ), and mass spectrometry (HRMS</p>

<p>Hydrocotarnine hydrochloride is a medicinal compound that has been found to have anticancer properties. It is an inhibitor of protein kinases, which are enzymes that play a key role in regulating cell cycle progression and apoptosis. Hydrocotarnine hydrochloride has been shown to induce apoptosis in cancer cells, making it a promising candidate for the development of novel cancer therapies. This compound has also been identified as a potential inhibitor of tumor growth in Chinese medicine. In vitro studies have demonstrated that hydrocotarnine hydrochloride inhibits the proliferation of various cancer cell lines, suggesting its potential as a therapeutic agent for the treatment of cancer.</p>

<p>Tryptoquivaline D is a metabolite of tryptoquivaline A, which is an impurity in the drug product. Tryptoquivaline D can be used as a standard for research and development or for custom synthesis. This compound has been shown to have anti-inflammatory effects and may also act as an analgesic. It has also been shown to inhibit the production of prostaglandin E2 from arachidonic acid, thereby reducing inflammation.</p>

<p>Ethylene terephthalate cyclic heptamer-d28 is a member of the class of drugs that are used to treat or prevent diseases. Ethylene terephthalate cyclic heptamer-d28 is synthesized by an unspecific method of polymerization. The molecule has been shown to have a chemical structure that can be metabolized by human liver enzymes and excreted in urine as metabolites. Metabolism studies have demonstrated that ethylene terephthalate cyclic heptamer-d28 is rapidly hydrolyzed, mainly by esterases, with the formation of a carboxylic acid derivative and a pyrrolidone derivative.</p>

<p>Dehydrodeoxy donepezil is an analytical standard that is used in the manufacture of pharmaceuticals. It is a synthetic drug impurity, and its CAS number is 120013-45-8. Dehydrodeoxy donepezil can be found in the API impurity grade of various drugs, including those that are manufactured by Custom synthesis and natural synthesis. The pharmacopoeia states that dehydrodeoxy donepezil has a purity level of 98% or greater. This product can also be found as a metabolite in humans, with its half-life being approximately 40 minutes.</p>

<p>(2S, 4’R, 8’S)-α-Tocopherol is a vitamin E compound that has been shown to have various health benefits. It acts as an antioxidant and protects cells from oxidative damage. Additionally, it has been found to inhibit the growth of cancer cells by inducing apoptosis, inhibiting protein kinase C activity, and blocking the cell cycle. Studies have shown that (2S, 4’R, 8’S)-α-Tocopherol is a potent inhibitor of tumor growth in Chinese hamster ovary cells and human breast cancer cell lines. This vitamin has also been detected in urine samples of individuals who consume a diet rich in vitamin E. Overall, (2S, 4’R, 8’S)-α-Tocopherol is an important anticancer agent with promising therapeutic potential for cancer treatment.</p>

<p>2-[[4-(2-Pyridylsulfamoyl)phenyl]azo]hydroxybenzene is an impurity found in sulfasalazine. It is a metabolite that is formed by the P450 system in the liver. The metabolic process of 2-[[4-(2-Pyridylsulfamoyl)phenyl]azo]hydroxybenzene has been studied in detail and has been shown to be a major contributor to the pharmacokinetic profile of sulfasalazine. This substance also exhibits antimicrobial activity and inhibits the growth of bacteria, fungi, and viruses.</p>

<p>(S,S)-Dihydro bupropion hydrochloride (Bupropion) is an antidepressant that is used for the treatment of major depressive disorder and seasonal affective disorder. It is a racemic mixture of the two enantiomers, (S,S) and (R,R), with the former being more active than the latter. The drug product contains a racemic mixture of (S,S) and (R,R) in a ratio of approximately 97:3. The analytical impurity in this product is N-desmethyl-bupropion. This impurity has not been found to be pharmacologically active. Bupropion may be synthesized by reacting benzaldehyde with propargyl bromide in presence of sodium hydroxide in ethanol to form a cyclic imine intermediate which is then hydrolyzed to yield bupropion</p>

<p>Oxo Simvastatin is a synthetic drug product that belongs to the class of statins. It is used as a research and development impurity standard in pharmacopoeia, and as a high-purity analytical standard in niche applications. Oxo Simvastatin is metabolized by cytochrome P450 enzymes to form a variety of metabolites, including simvastatin acid, which can be measured using HPLC.</p>

<p>(S)-2-Amino-3-(3,5-diiodo-4-(4-methoxyphenoxy)phenyl propanoic acid is a synthetic compound that is used as an impurity standard. It has been shown to be metabolized by cytochrome P450 enzyme system and its metabolites are excreted in the urine. This chemical can also act as an analytical reference for HPLC analysis of other compounds.</p>

<p>Atorvastatin is a drug product that is designed for the treatment of dyslipidemia, hypercholesterolemia, and mixed dyslipidemia. It is an impurity in the drug product Atorvastatin EP. Impurity B is a natural metabolite that has been found to have a niche market as an analytical standard for HPLC. The metabolite can be synthesized with high purity and quality standards, which are suitable for use in pharmacopoeia and research and development.</p>

<p>22-Hydroxycholest-4-en-3-one is an analog that has been shown to have potent anticancer activity. It works by inhibiting kinase activity, which plays a key role in the regulation of cell cycle and apoptosis. This inhibitor has been found to induce apoptosis in cancer cells, leading to tumor regression. 22-Hydroxycholest-4-en-3-one has also been shown to inhibit protein synthesis and inhibit the growth of human cancer cell lines. In Chinese medicine, it is used for its medicinal properties and is present in urine as a natural metabolite. Its potential as an anticancer agent makes it a promising candidate for further research and development of cancer therapies.</p>

<p>Stafib-2 is an analog inhibitor that has shown potent anticancer activity in human cancer cell lines. It works by inhibiting kinases, which are enzymes that play a key role in regulating cell growth and division. Stafib-2 has been shown to induce apoptosis, or programmed cell death, in Chinese hamster ovary cells and human cancer cells. This drug also inhibits the activity of elastin kinase, a protein that is involved in tumor growth and metastasis. Stafib-2 has potential as a targeted therapy for cancer treatment due to its ability to selectively inhibit specific kinases involved in cancer progression. Its unique mechanism of action makes it a promising candidate for further development as an anticancer agent.</p>

<p>Solifenacin is an anti-cholinergic drug that has been shown to have a potent antagonistic effect on muscarinic receptors. It is used in the treatment of overactive bladder, urinary incontinence, and irritable bowel syndrome. Solifenacin succinate is a metabolite of solifenacin and it has been found to be an antagonist of M3 muscarinic receptors. The presence of solifenacin and its metabolites in wastewater can interfere with treatment processes by inhibiting the removal of other organic chemicals such as tamsulosin hydrochloride. Optimisation studies for solifenacin production have shown that famotidine can be used as a process aid to reduce solifenacin impurities. Famotidine is also an antagonist of M3 muscarinic receptors and can be used to remove solifenacin from wastewater. Analytes detected in wastewater samples include solifenacin, famot</p>

<p>4-Phenybutyl 2-carboxyethylphosphinic acid is used as an analytical standard and has been shown to be a metabolite of other drugs. It is also used as an impurity standard for HPLC, and provides a niche for drug product development.</p>

<p>Bletilol B is a medicinal compound that has been shown to induce apoptosis in human cancer cells. It acts as a cyclin-dependent kinase (CDK) inhibitor, disrupting the cell cycle and preventing tumor growth. Bletilol B has been tested on various cancer cell lines and has demonstrated potent anticancer activity by inhibiting the proliferation of cancer cells. This compound works by binding to the active site of CDKs and blocking their activity, leading to cell cycle arrest and ultimately causing apoptosis. In addition, Bletilol B also inhibits the expression of proteins involved in cancer cell survival, making it an attractive candidate for future anticancer therapies.</p>

<p>N-Des[2-(1-methyl-2-pyrrolidinyl)ethyl] udenafil is an impurity in the drug product. It is a synthetic compound and is a metabolite of the drug product. N-Des[2-(1-methyl-2-pyrrolidinyl)ethyl] udenafil is present as a byproduct of the metabolism of the active ingredient. The CAS number for this substance is 319491-68-4. This impurity has been observed to have niche applications in research and development and analytical studies. It has also been found to be pharmacopoeia grade, which means it meets or exceeds purity standards set by regulatory authorities.</p>

<p>Please enquire for more information about Clobetasol Propionate - Impurity D including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Solifenacin N-oxide is an anti-cholinergic agent that has been shown to be effective in the treatment of overactive bladder. Solifenacin N-oxide is a prodrug that is hydrolyzed in vivo to solifenacin, its active form. The compound reversibly binds to muscarinic receptors and inhibits the release of acetylcholine. Solifenacin N-oxide has been shown to have low levels of impurities and is highly soluble in water. It was also found to be stable when stored at room temperature for two months. This drug has a high flow rate and moderate retention time, which makes it suitable for reversed-phase liquid chromatography (RPLC). RPLC is a chromatographic technique that separates compounds by size, hydrophobicity, or charge.</p>

<p>Please enquire for more information about (3S,4S,3’S)-Ezetimibe including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(2S,2R,Trans)-saxagliptin is an anti-diabetic drug that belongs to the thiazolidinedione class of drugs. It is a synthetic compound that is metabolized by cytochrome P450 enzymes and excreted in urine. (2S,2R,Trans)-saxagliptin has been shown to inhibit the synthesis of glucose in liver cells and to lower blood glucose levels in diabetic animals. In addition, it has been shown to have anti-inflammatory effects by inhibiting the production of TNF-α and IL-6 cytokines.</p>

<p>2-O-[4-[[(2-Carboxyethyl)amino]carbonyl]phenyl] balsalazide is a drug product that has been custom synthesized and purified to high purity. It is an analytical standard for metabolism studies. This compound is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. 2-O-[4-[[(2-Carboxyethyl)amino]carbonyl]phenyl] balsalazide is also used as a pharmacopoeia impurity standard and as a research and development HPLC standard.</p>

<p>Oseltamivir is an antiviral drug that prevents the replication of influenza viruses in the body. It is a prodrug, which means it must be converted to its active form in vivo by hydrolysis. Oseltamivir is metabolized to oseltamivir acid by the enzyme amidase, which is found in the gastrointestinal tract. Oseltamivir acid inhibits the neuraminidase enzyme, which allows viral particles to attach to and invade cells. Oseltamivir acid has a low dosage, so it can be taken orally with or without food and does not require intravenous administration. This drug also has a low toxicity profile and can be given at low dosages for long periods of time without significant side effects such as kidney problems or bone marrow suppression.</p>

<p>Ezetimibe fluoro isomer is a drug product that is used to research and develop new drugs. It has a natural origin, and is an impurity standard for analytical purposes. Ezetimibe fluoro isomer can also be synthesized in the laboratory. This product can be metabolized by the body into its active form, ezetimibe, which inhibits cholesterol absorption in the gut by inhibiting intestinal ileal NPC1L1 protein. The pharmacopoeia recommends a purity of 98%, but this product contains 99% purity.</p>

<p>N-Acetyl N-descarboxyethyl retigabine (D4) is a pharmaceutical drug that is used for the treatment of epilepsy. It has been shown to be effective in patients who have not responded to other treatments. D4 binds to voltage-gated potassium channels and inhibits their opening, which leads to a decrease in neurotransmitter release from nerve cells. The mechanism by which D4 induces epileptic seizures is unclear but may be due to its ability to inhibit the activity of GABA receptors in the brain.</p>

<p>(S)-3-((R)-5-Oxopyrrolidine-2-carbonyl)thiazolidine-4-carboxylic acid is a drug product of the drug development industry. It is a metabolite of 3-(1,2,4-triazol-1-ylmethyl)thiazolidine-4-carboxylic acid and has been used as an analytical standard for HPLC methods. The compound has been shown to be naturally occurring in humans. (S)-3-(1,2,4-Triazol-1ylmethyl)thiazolidine 4 carboxylic acid is also used as the impurity standard for the API 3-(1,2,4 triazol 1ylmethyl)thiazolidine 4 carboxylic acid.</p>

<p>(3R,5R)-Pitavastatin Calcium Salt is a drug product that is used in the development of pharmaceuticals. It is a synthetic compound with an impurity standard and a metabolite impurity. The CAS number for this product is 254452-96-5. (3R,5R)-Pitavastatin Calcium Salt has been shown to be metabolized by CYP2C9 and CYP2C8 enzymes, which may result in a decrease in potency or activity. This product also has been shown to have anti-inflammatory properties and inhibit the production of inflammatory mediators such as prostaglandins and leukotrienes. (3R,5R)-Pitavastatin Calcium Salt was prepared by solid phase synthesis using a fluorous biphasic approach.</p>

<p>Abiraterone dimer impurity is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs. It is also a metabolite of abiraterone and has been detected in the urine of patients receiving the drug. Abiraterone dimer impurity is found in trace amounts in abiraterone acetate but its pharmacological significance is not known. This impurity has been detected in the urine of patients receiving abiraterone acetate therapy.</p>

<p>5'-O-Acetyl ribavirin is an impurity of ribavirin, a drug product that belongs to the group of antiviral drugs. It is used in the treatment of chronic hepatitis C and influenza. 5'-O-Acetyl ribavirin is found in natural products such as plants, honey, and wine. The CAS number for this impurity is 58151-87-4. This compound can be synthesized through custom synthesis or by using a high purity HPLC standard as an impurity standard.</p>