APIs pour la recherche et les impuretés

Applications An intermediate for the synthesis of Labelled Ketoprofen.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Derewenda, Z., et al.: J. Mol. Biol., 227, 818 (1992), Grochulski, P., et al.: J. Biol. Chem., 268, 12843 (1993).

Applications 1-Acetyl-2,2,5,5-tetramethyl-3-pyrroline-3-carboxamide (cas# 887352-22-9) is a compound useful in organic synthesis.

Applications 3,4-Difluoroaniline-2,6-d2 (CAS# 1061566-62-8) can be used in its derivative form as an antiviral agent for Hepatitis B.
References Qiu, Y.L., et.al., U.S. Pat. Appl. Publ., 187,(2019);

Applications N2-[1-Deoxy-2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranos-1-yl]-L-asparagine (cas# 794477-75-1) is a compound useful in organic synthesis.

Applications An intermediate in the synthesis of the metabolite of Nitazoxanide.
References Honma, K., et al.: Chem. Pharm. Bull., 24, 394 (1976),

Applications Α hydroxylated metabolite of Vitamin D2 (V676040); a synthetic analog of Vitamin D.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Matsuoka, M. et al.: J. Nutrit. Sci. Vitaminol., 35, 253 (1989); Jones, G. et al.: Arch. Biochem. Biophys., 202, 450 (1980); Goff, J. et al.: J. Nutrit., 112, 1387 (1982);

Applications (R,S)-Fmoc-3-amino-3-(naphthalen-2-yl)-propionic acid

Applications An intermediate in the preparation of HIV-integrase inhibitors
References Summa, V., et al.: J. Med. Chem., 51, 5843 (2008),

Applications 1,3-Dihydro-N-nitro-1,3-dioxo-2H-isoindole-2-carboximidothioic acid Methyl Ester is an intermediate in the synthesis of Dinoteturan (D482100), a neonicotinoid insecticide.
References Wakita, T., et al.: J. Pesticide. Sci., 29, 348 (2004);

Applications A metabolite of Rosiglitazone.The ratio of the diastereomers will be quite variable due to the acidic proton at one chiral centre.
References Balton, G.C., et al.: Xenobiotica, 26, 6, 627 (1996),

Applications A labelled intermediate of Pioglitazone (P471000).
References Amir, M., et al.: Eur. J. Med. Chem., 39, 535 (2004), Zarghi, A., et al.: Bioorg. Med. Chem. Lett., 15, 1863 (2005),

Applications Dl-Metanephrine:Hcl (A,B,B-D3, 98%) (cas# 1085333-94-3) is a useful research chemical.

Applications 5,7-Dichloroimidazo[1,2-a]pyrimidine (cas# 57473-32-2) is a compound useful in organic synthesis.

Applications The major human labelled metabolite of Flurazepam. Controlled substance.
References Ochs, H.R. , et al.: Pharmacology, 36, 166 (1988), Capello, S., et al.: Drug Metab. Dispos., 18, 190 (1990),

Applications 3-Acetoxy-3-methylpentane-1,5-dioic Acid Anhydride (cas# 87894-65-3) is a compound useful in organic synthesis.
References Gordon, E., et al.: Bioorg. Med. Chem. Lett., 1, 161 (1991),

Stability Hygroscopic
Applications Phosphinothricin metabolite.
References Komossa, D. et al.: Pestic. Biochem. Phys. 43, 95 (1992)

Applications Intermediate for the preparation of Neophytadiene.
References Marson, C.M., et al.: Bioorg. Med. Chem. Lett., 12, 255 (2002).

Applications A derivative of 6-Chlorotryptophan.

Stability Hygroscopic
Applications Guanethidine Monosulfate acts as an antihypertensive; antiglaucoma
References Al-Shora, H., et al.: Int. J. Pharm., 47, 209 (1988), Golander, Y., et al.: J. Pharm. Sci., 77, 902 (1988),

Applications PYRENE-4,5-QUINONE (cas# 6217-22-7) is a useful research chemical.

Applications 4-Piperidine-d9-carboxylic Acid (CAS# 1219798-43-2) is a useful isotopically labeled research compound.

Applications p-(Dimethyl-d6-amino)nitrosobenzene is labelled p-(Dimethylamino)nitrosobenzene (D2907600 which is an intermediate in the synthesis of Meldola Blue (M215120), a biosensor for the measurement of lactate in serum.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Vinothkumar, S.P., et al.: J. Pharma. Res., 3, 1371 (2010); Huang, R., et al.: Chem. Res. Toxicol., 21, 659 (2008);

Applications 9-Bromononanoic Acid is an intermediate in synthesizing Rumenic Acid (R701590), a trans fatty acid that may potentially reduce the risk of cancer and cardiovascular diseases. It may also prevent disease processes that lead to chronic inflammation, atherosclerosis, and diabetes.
References Baer, D. J.: Am J Clin Nutr 95, 267 (2012); Gebauer, S. K., et al.:  Adv Nutr 2, 332 (2011); Duffy, P. E., et al.: Tetrahedron 62, 4838 (2006)

Applications α-Phenyloxiranepropanenitrile is used in the preparation of CC-1065 and its analogs.
References Bryson, T.A., et al.: Synlett, 9, 723 (1992),

Impurity Agomelatine Impurity 2
Stability Light Sensitive
Applications (E)-N-[2-(3,4-Dihydro-7-methoxy-1(2H)-naphthalenylidene)ethyl]acetamide is an impurity of Agomelatine (A430000) which is a melatoninergic agonist and selective antagonist of 5-HT2C receptors and used in the treatment of major depressive disorder. Agomelatine Impurity 2
References Yous, S., et al.: J. Med. Chem., 35, 1484 (1992), Zhdanova, I., et al.: J. Clin. Endocrinol. Metab., 86, 4727 (2001), Cajochen, C., et al.: J. Pineal Res., 35, 149 (2003),

Applications 4-Androsten-11beta-ol-3,17-dione-2,2,4,6,6,16,16-d7 is a useful isotopically labeled compound of 4-Androsten-11β-ol-3,17-dione (A637705)

Applications 1,1-Cyclopropane-2,2,3,3-d4-dicarboxylic Acid (CAS# 136503-99-6) is a useful isotopically labeled research compound.

Applications (L)-Suberyl Carnitine Trifluoroacetic Acid Salt is a metabolite of L-Carnitine (C184110).
References Millington, D., et al.: J. Inherit. Metab. Dis., 13, 321 (1990), Chace, D., et al.: Clin. Chem., 49, 1797 (2003),

Applications 1-Chloro-2,4-dinitrobenzene-d3 (CAS# 347840-12-4) is a useful isotopically labeled research compound.

Applications N-​(3-​Dibenzofuranyl)-​5-​nitro-2-​furancarboxamide is synthesized from Dibenzo[b,d]furan-3-amine (D418205), which is a building block used as a reactant in the preparation of dibenzofuryl(phosphonomethyl)alanines as endothelin converting enzyme inhibitors.
References De Lombaert, S., et al.: J. Med. Chem., 43, 488 (2000);

Applications 21-Acyloxycorticosteroid derivative. Antiinflammatory.
References Ko, D. et al.; Steroids 67, 211 (2002)

Applications Labelled tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter.
References Klerman, G.L., et al.: Pharmacol. Rev., 17, 101 (1965), Checkley, S.A, et al.: Br. J. Psychiatry, 138. 248 (1981), Zhu, M.Y., et al.: J. Neurochem., 70, 1547 (1998), Okugawa, G., et al.: J. Neuroindocrinol., 11, 887 (1999), Torres, G.E., et al.: Nat. Rev. Neurosci., 4, 13 (2003),

Applications Protected 4-Hydroxy Toremifene (H954500), a metabolite of Toremifene (T547500). 4-Pivaloyloxy Toremifene is used in the preparation of Tamoxifen (T006000) analogs with improved binding selectivity towards the orphan estrogen-related receptor γ and the classical estrogen receptor α.
References Chao, E. et al.: Bioorg. Med. Chem. Lett., 16, 821 (2006)

Stability Hygroscopic
Applications An impurity of Torsemide.

Applications Nim-Trityl-D-histidine is used as a reagent in solid-phase synthesis and screening of peptides as catalysts for asymmetric induction of desymmetrization of bis(phenol)s.
References Lewis, C. A., et al.: J. Am. Chem. Soc., 130, 16358 (2008); Keith, J., et al.: Adv. Synth. Catal, 5, 343 (2001)

Applications Steviol-13CD2 is the isotope labelled analog of Steviol (S686720) which is an aglycone of the natural sweetener Stevioside (90%, S686730) and is found to be highly mutagenic compared to Stevioside.
References Toskulkac, C., et al.: Drug Chem. Toxicol., 20, 31 (1997); Pezzuto, J.M., et al.: P. Natl. Acad. Sci. USA, 82, 2478 (1985); Matsui, M., et al.: Mutagenesis, 11, 573 (1996); Koyama, E., et al.: Food Chem. Toxicol., 41, 875 (2003)

Applications 5-(2-Bromo-1-oxobutyl)-8-hydroxy-2(1H)-quinolinone is an intermediate in the synthesis of metabolites of procaterol hydrochloride (Meptin) (P155490), a β2-adrenergic agonist used in the treatment of asthma.
References Yoshizaki, S., et al.: Chem. Pharma. Bull., 26, 1611 (1978);

Applications 6β-Naltrexol Hydrochloride is a neutral opioid antagonist that has shown minimal withdrawal symptoms in patient with opioid-dependence.
References J. Addict. Res. Ther., 2, 108 (2011)