APIs pour la recherche et les impuretés

Applications An intermediate in the syntheis of a metabolite of the anti-cancer drug Tamoxifen.

Applications 4-Pregnen-17alpha,21-diol-3,20-dione-21,21-d2 (CAS# 1271728-08-5) is a useful isotopically labeled research compound.

Applications Labelled rac-Nicotine (N412420). Nicotine is an alkaloid isolated from plants. Nicotine is an active stimulant, having both addictive and carcinogenic properties. Nicotine can be absorbed through the alimentary canal, respiratory tract and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ferretti, G., et al.: J. Med. Chem., 45, 4724 (2002), Guillen, M., et al.: J. Agric. Food Chem., 53, 1093 (2005), Ramunno, A., et al.: Bioorg. Med. Chem. Lett., 15, 3237 (2005), Alburges, M., et al.: Eur. J. Pharmacol., 573, 124 (2007),

Applications The major human labelled metabolite of Flurazepam. Controlled substance.
References Ochs, H.R. , et al.: Pharmacology, 36, 166 (1988), Capello, S., et al.: Drug Metab. Dispos., 18, 190 (1990),

Applications A possible metabolite of Ranolazine (R122500).

Applications (3R,4S)-3,4,7,8-Tetrahydro-3,4-dihydroxy-1(2H)-azocinecarboxylic Acid Phenylmethyl Ester is an intermediate in the synthesis of Loline (I707255), an alkaloid isolated from fungal endophytes, an endosymbiont that lives within a plant.
References Cakmak, M., et al.: Nature. Chem., 3, 543 (2011);

Applications A triphenylalkene derivative with anti-estrogenic, and anti-tumor properties.

Stability Hygroscopic
Applications 2,4-Dithiouridine (cas# 13239-96-8) is a compound useful in organic synthesis.

Applications 4-Androsten-11beta-ol-3,17-dione-2,2,4,6,6,16,16-d7 is a useful isotopically labeled compound of 4-Androsten-11β-ol-3,17-dione (A637705)

Stability Hygroscopic
Applications (R)-isopropyl 2-(((R)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate is an impurity of Tenofovir (T018500) which is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.
References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);

Applications 21-Acyloxycorticosteroid derivative. Antiinflammatory.
References Ko, D. et al.; Steroids 67, 211 (2002)

Applications α-Phenyloxiranepropanenitrile is used in the preparation of CC-1065 and its analogs.
References Bryson, T.A., et al.: Synlett, 9, 723 (1992),

Applications 2R, 3S-Dihydroxy-4-oxo-butanoic Acid is synthesized from D-Ribonolactone (R416000), which is a sugar lactone as inhibitor of β-galactosidase of E. coli.
References Zhang, B., et al.: Science, 284, 974 (1999), Zimmet, P., et al.: Nature, 414, 782 (2001), Verspohl, E., et al.: Planta Med., 68, 581 (2002), Thompson, K., et al.: Science, 300, 936 (2003), Thompson, K., et al.: J. Inorg. Biochem., 98, 683 (2004),

Applications 3,4-Dihydro-2H-1,4-benzoxazine-7-boronic acid pinacol ester is a useful intermediate for the synthesis of naphthamides which functions as VEGFR-2 kinase inhibitors for cancer treatment.
References Lv, Y., et al.: ACS Med. Chem. Lett., 5, 592 (2014)

Applications A compound closely related to Enterolactone (E558950). A metabolite of sesame lignans (sesamin, sesamolin). Inhibits colonic cancer cell growth by inducing cell cycle arrest and apoptosis. Possible relationship between exposure and reduced risk of breast cancer.
References Hirano, T. et al.: Res. Com. Chem. Path. Pharmac., 64, 227 (1989); Ayella, A. et al.: Nut. Res., 30, 762 (2010); Pianjing, P. et al.: J. Agric. Food Chem., 59, 212 (2011); Buck, K. et al.: Am. J. Clinic. Nut., 92, 141 (2010);

Applications N2,N5-Dibenzoyl-4-oxo-L-ornithine Methyl Ester is an intermediate in the preparation of L-(+)-Ergothioneine (E600000).

Applications 3-(4-tert-Butylbenzene)propionic Acid Methyl Ester (cas# 1211-99-0) is a compound useful in organic synthesis.

Applications An intermediate in the preparation of HIV-integrase inhibitors
References Summa, V., et al.: J. Med. Chem., 51, 5843 (2008),

Stability Moisture and Temperature Sensitive
Applications (R,S)-Equol 4’-Sulfate is a sulfated metabolite of isoflavone Daidzein (D103500).
References Heinonen, S., et al.: Anal. Biochem., 274, 211 (1999), Setchell, K., et al.: J. Nutr., 132, 3577 (2002), Thigpen, J., et al.: Comp. Med., 53, 607 (2003), Yee, S., et al.: Food Chem. Toxicol., 46, 2713 (2008),

Applications A useful synthetic intermediate.

Applications [1,2,4]triazolo[1,5-a]pyridine-6-carboxylic acid (cas# 1043903-19-0) is a useful research chemical.

Applications N,​N-​Diethylethanol-1,1,2,2-d4-amine is deuterium labelled of 2-diethylaminoethanol, which is an inactive metabolite of 2-Chloroprocaine (HCl: C380265) and commonly used for epidural analgesia in obstetrics. It is also hypothesized to cause onset-asthma to humans following brief exposure. 2-Diethylaminoethanol also has the ability to inhibit growth of tomato roots.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Boll, W.: Science, 129, 330 (1959); Cornish, H.: Am. Ind. Hyg. Assoc. J., 26, 479 (1965); Foldes, F. & McNall, P.: Anasthesiology, 13, 287 (1952); Reisner, L., et al.: Anast. Analg., 59, 452 (1980)

Applications (-)-OSU is a weak dopamine D2 receptor antagonist.
References Carlsson, M., et al.: Curr. Med. Chem., 11, 267 (2004); Natesan, S., et al.: J. Pharmacol. Exp. Ther., 318, 810 (2006); Seeman, P., et al.: Eur. J. Pharmacol., 557, 151 (2007);

Applications 2-Des(5-methyl-1,3,4-oxadiazole-2-carboxamide) (E)-2-(N,N-Dimethylformimidamide) Raltegravir is an impurity of Raltegravir (R100300), a potent human immunodeficiency virus (HIV) integrase inhibitor. A novel anti-AIDS drug.
References Wade, K., et al.: J. Pharmacol. Biomed. Anal., 8, 401 (1990), Hazuda, D., et al.: Science, 287, 646 (2000), Williams, J., et al.: Drug Metab. Dispos., 32, 1201 (2004), Duckett, C., et al.: Xenobiotica, 36, 59 (2006), Miners, J., et al.: Biochem. Pharmacol., 71, 1531 (2006), Summa, V., et al.: J. Med. Chem., 49, 6646 (2006),

Applications A metabolite of Aprepitant.
References Ballard, T., et al.: Eur. J. Pharmacol., 412, 255 (2001), Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001), Severini, C., et al.: Pharmacol. Rev., 54, 285 (2002),

Applications 2-Bromo-4-chloro-6-nitrophenol

Impurity Solifenacin EP Impurity D
Applications ((R)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)((S)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)methanone is a possible impurity of solifenacin (S676700) which is a muscarinic M3 receptor antagoinst. Solifenacin is used in treatment of urinary incontinence.
References Ikeda K., et al.: Arch. Pharmacol., 366, 97, (2002); Chapple, C.R., et al.: Br. J. Urol., 93, 303 (2004); Ohtake, A., et al.: Eur. J. Pharmacol., 492, 243 (2004); Brunton, S., et al.: Curr. Med. Res. Opin., 21, 71 (2005); Habb, F., et al.: Eur. Urol. 47, 376 (2005); Payne, C.K., et al.: Drugs, 66, 175 (2006)

Applications A fluorescent labeling reagent for the reversed-phase HPLC separation and detection of carboxylic acids.
References Sasamoto, et al.: Analytical Sciences, 12(2), 189 (1996)

Applications Diiododifluoromethane is useful for the synthetic preparation of alpha,omega-diiodoperfluoroalkanes.
References Martin, S. J., et al.: PCT Int. Appl. (2014), WO 2014062450 A2

Applications 7-Despropyl 7-Methyl Vardenafil is an impurity of Vardenafil (V098001, 2HCl); a selective phosphodiesterase type 5 (PDE5) inhibitor.
References Bischoff, E., et al.: J. Urol., 165, 1316 (2001); Kim, N.N., et al.: Life Sci., 69, 2249 (2001); Kendirci, M., et al.: Expert Opin. Pharmacother., 5, 923 (2004)