APIs pour la recherche et les impuretés

Applications 2-tert-Butyl-5-methyl-1,3-dioxane-5-carboxylic Acid Vinyl Ester-d3 (cas# 1189464-68-3) is a compound useful in organic synthesis.

Applications cyclohexyl 4-methylbenzenesulfonate (cas# 953-91-3) is a useful research chemical.

Stability Temperature sensitive
Applications Labelled Glycidyl Linolenate. An inhibitor of monoacylglycerol lipase and fatty acid amide hydrolase.
References Karlsson, M., et al.: J. Biol. Chem., 272, 27218 (1997), de Lago, E., et al.: Biochem. Pharmacol., 70, 446 (2005), Romero, F., et al.: J. Med. Chem., 50, 1058 (2007),

Applications Protected 4-Hydroxy Toremifene (H954500), a metabolite of Toremifene (T547500). 4-Pivaloyloxy Toremifene is used in the preparation of Tamoxifen (T006000) analogs with improved binding selectivity towards the orphan estrogen-related receptor γ and the classical estrogen receptor α.
References Chao, E. et al.: Bioorg. Med. Chem. Lett., 16, 821 (2006)

Applications 1-Cyclopropyl-1,4-dihydro-7-fluoro-6-methoxy-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester (cas# 1391052-97-3) is a compound useful in organic synthesis.

Applications 2-Chloro-2’,3’-O-isopropylideneadenosine-5’-N-ethylcarboxamide is a potent and selective adenosine receptor agonist (1). It is also used to prepare photoreactive 2-​phenethylamine derivatives (2).
References (1) Hutchison, A.J., et al.: J. Med. Chem., 33, 1919 (1990)(2) Murai, Y., et al.: Eur. J. Org. Chem 2013, 2428 (2013)

Applications Used in the preparation of substituted oxazolidinones, useful in the treatment of disorders associated with blood coagulation.

Applications Safinamide-d4 is a labelled analogue of Safinamide. Safinamide is a potent and selective MAO-B inhibitor, and is used as an add-on treatment to treat Parkinson’s disease.
References Finberg, J.P.M., et al.: Front Pharmacol., 7, 340-54 (2016);

Applications 1,5-Dichloro-2-methoxy-4-(4-nitrophenoxy)benzene, is used for the synthesis of three major ring-hydroxylated metabolites of Diclofop-methyl, acting as herbicide.
References Tanaka, F. S., et al.: J. Agri. Food Chem., 38, 553 (1990);

Applications A metabolite of Alpidem.
References Padovani, P., et al.: Eur. J. Drug Metab. Pharmacokinetics, 12, 295 (1987).

Stability temperature Sensitive
Applications Δ2-Cefoxitin is a derivative of Cefoxitin (C243200), a semi-synthetic antibiotic derived from Cephamycin C, possessing high resistance to β-lactamase inactivation. An antibacterial.
References Wallick, H., et al.: Antimicrob. Agents Chemother., 5, 25 (1974), Brenner, G.S., et al.: Anal. Profiles Drug Subs., 11, 169 (1982),

Applications Chlorosulfates were used to esterify several carboxylic acids.
References Binderup, E., et al.: Synth. Commun., 14, 857 (1984).

Applications 1-Palmitoyl-3-O-benzyl-rac-glycerol (cas# 1487-51-0) is a compound useful in organic synthesis.

Applications Steviol-13CD2 is the isotope labelled analog of Steviol (S686720) which is an aglycone of the natural sweetener Stevioside (90%, S686730) and is found to be highly mutagenic compared to Stevioside.
References Toskulkac, C., et al.: Drug Chem. Toxicol., 20, 31 (1997); Pezzuto, J.M., et al.: P. Natl. Acad. Sci. USA, 82, 2478 (1985); Matsui, M., et al.: Mutagenesis, 11, 573 (1996); Koyama, E., et al.: Food Chem. Toxicol., 41, 875 (2003)

Applications α-Phenyloxiranepropanenitrile is used in the preparation of CC-1065 and its analogs.
References Bryson, T.A., et al.: Synlett, 9, 723 (1992),

Applications 1-Ethyl-1,4-dihydro-4-oxo-7-(4-pyridyl)quinoline-3-carboxylic Acid Ethyl Ester is an intermediate in the synthesis of Rosoxacin (R693580), an antibacterial agent used against Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae.
References Koba, M., et. al.: J. Mol. Modeling, 16, 327 (2010)

Applications PYRENE-4,5-QUINONE (cas# 6217-22-7) is a useful research chemical.

Applications 1,3-Dihydro-N-nitro-1,3-dioxo-2H-isoindole-2-carboximidothioic acid Methyl Ester is an intermediate in the synthesis of Dinoteturan (D482100), a neonicotinoid insecticide.
References Wakita, T., et al.: J. Pesticide. Sci., 29, 348 (2004);

Applications Labelled Hydroxyurea. An anti-neoplastic - inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide.
References Ratcliffe, W., et al.: Lancet, 339, 164 (1992), Roodman, G., et al.: Cancer, 80, 1557 (1997), Horwitz, M., et al.: J. Clin. Endocrinol. Metab., 2003, 88, 1603 (2003),

Applications An intermediate in the preparation of HIV-integrase inhibitors
References Summa, V., et al.: J. Med. Chem., 51, 5843 (2008),

Applications 4-Chlorosulfonylcinnamic Acid (cas# 17641-30-4) is a compound useful in organic synthesis.

Applications A useful synthetic intermediate in the preparation of Rosuvastatin (R700500) and its derivatives

Applications A triphenylalkene derivative with anti-estrogenic, and anti-tumor properties.

Applications N2-t-Boc-N6-(biotinamido-6-N-caproylamido)lysine (cas# 102910-26-9) is a compound useful in organic synthesis.

Applications (2S,3R)-3-Hydroxynorleucine is an analogue of DL-6-Hydroxy Norleucine (H948855) which is an intermediate for antiviral and antihypertensive drugs.
References Kaufman, S., et al.: J. Biol. Chem., 257, 14667 (1982), Hanson, R., et al.: Bioorg. Chem., 18, 116 (1990), Oshima, T., et al.: J. Bacteriol., 173, 3943 (1991), Oshima, T., et al.: Eur. J. Biochem., 222, 305 (1994), Robl, J., et al.: J. Med. Chem., 40, 1570 (1997)

Applications 1-(2-tert-Butyl-4-bromophenyl)pyrrolidin-2-one is an intermediate in the preparation of [1,1':3',1'']terphenyl-4-carboxylic acid and esters as ligands modulating retinoic acid receptors (RAR).
References Biadatti, Thibaud, et al.: PCT Int. Appl., WO 2006066978 A1 20060629 (2006)

Applications 7-Despropyl 7-Methyl Vardenafil is an impurity of Vardenafil (V098001, 2HCl); a selective phosphodiesterase type 5 (PDE5) inhibitor.
References Bischoff, E., et al.: J. Urol., 165, 1316 (2001); Kim, N.N., et al.: Life Sci., 69, 2249 (2001); Kendirci, M., et al.: Expert Opin. Pharmacother., 5, 923 (2004)

Applications A fluorescent labeling reagent for the reversed-phase HPLC separation and detection of carboxylic acids.
References Sasamoto, et al.: Analytical Sciences, 12(2), 189 (1996)

Applications 2-Bromo-4-chloro-6-nitrophenol

Applications A metabolite of Aprepitant.
References Ballard, T., et al.: Eur. J. Pharmacol., 412, 255 (2001), Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001), Severini, C., et al.: Pharmacol. Rev., 54, 285 (2002),

Applications 2-Bromo-1,4-dichlorobenzene is a reactant used in the synthesis of C-13 and C-14-labeled versions of the investigational proteasome inhibitor MLN9708.
References Plesescu, M., et. al.: J. Labelled Compd. Rad., 56, 464 (2013)

Applications (αR)-α-[(Methylamino)methyl]-3-(phenylmethoxy)-benzenemethanol is a reagent used to synthesize degradation products of Phenylephrine (P320635 Hydrochloride salt) in over-the-counter products.
References Chan, T., et al.: Synth. Commun., 38, 2252 (2008); Wong., J., et al.: Anal. Chem., 78, 7891 (2006)

Applications 3-Methyl-3-azetidinecarboxylic Acid is a useful reagent for the synthesis of PD-1/PD-L1 inhibitors for treatment of cancer.
References Aktoudianakis, E., et al.: PCT Int. Appl. (2020), WO 2020014643 A1

Applications Fmoc-alpha-methyl-L-phenylalanine

Applications 2-hydroxy-5-[2-(4-hydroxyphenyl)propan-2-yl]benzoic acid (cas# 101949-49-9) is a useful research chemical.