APIs pour la recherche et les impuretés

Applications A fluorescent labeling reagent for the reversed-phase HPLC separation and detection of carboxylic acids.
References Sasamoto, et al.: Analytical Sciences, 12(2), 189 (1996)

Applications Safinamide-d4 is a labelled analogue of Safinamide. Safinamide is a potent and selective MAO-B inhibitor, and is used as an add-on treatment to treat Parkinson’s disease.
References Finberg, J.P.M., et al.: Front Pharmacol., 7, 340-54 (2016);

Applications Itraconazole Desethylene-seco-piperazine Mono-N-formyl Impurity of Itraconazole (I937500). Itraconazole is an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.
References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993),

Applications A triphenylalkene derivative with anti-estrogenic, and anti-tumor properties.

Applications A Trimethoprim (T795615) derivative.
References Manius, G.J., et al.: Anal. Profiles Drug Subs., 7, 445 (1978); Roth, B., et al.: J. Med. Chem., 23, 379 (1980); Brogden, R.N., et al.: Drugs, 23, 405 (1982);

Applications A useful synthetic intermediate in the preparation of Rosuvastatin (R700500) and its derivatives

Applications An intermediate in the preparation of HIV-integrase inhibitors
References Summa, V., et al.: J. Med. Chem., 51, 5843 (2008),

Applications Labelled Triazolam (T767380(M)). Triazolam in an hypnotic drug used in the short term treatment of insomnia.
References Lomen, P., et al.: J. Int. Med. Res., 4, 55 (1976), Allens, G.S., et al.: J. Int. Med. Res., 6, 343 (1978), Pakes, G.E., et al.: Drugs, 22, 81 (1981).

Applications 1-Acetyl-2,2,5,5-tetramethyl-3-pyrroline-3-carboxamide (cas# 887352-22-9) is a compound useful in organic synthesis.

Applications Inhibitor for the treatment of Parkinson's disease.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Biggs, S., et al.: Eur. J. Pharmacol., 299, 83 (1996), Mannisto, P., et al.: Pharmacol. Rev., 51(4), 593 (1999), Fisher, A., et al.: Neuroscience, 95(1), 97 (2000),

Applications N-(3-Mercapto-2-methylpropanoyl)glycine (cas# 89021-98-7) is a compound useful in organic synthesis.

Applications 2-Bromoethyl benzoate (cas# 939-54-8) is a useful research chemical.

Applications (2S)-3-{[tert-Butyl(dimethyl)silyl]oxy}-2-methylpropan-1-yl Tosylate (cas# 222539-29-9) is a compound useful in organic synthesis.

Applications Lys-SMCC-DM1 is designed to eradicate cancer cells that express the target antigen on their cell surface.
References Erickson, H., et al.: Bioconjugate Chem., 21, 84 (2010)

Applications 7-Ethyl-10-(4-[[benzylcarbamoyl]amino]-1-piperidino)carbonyloxycamptothecin (cas# 1217686-49-1) is a compound useful in organic synthesis.

Applications [1,2,4]triazolo[1,5-a]pyridine-6-carboxylic acid (cas# 1043903-19-0) is a useful research chemical.

Applications (2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetic acid (cas# 4113-97-7) is a useful research chemical.

Applications 2-Desmethylene-2-hydroxymethyl Ethacrynic Acid is a degradation product of Ethacrynic Acid (E676000), a diuretic used to treat high blood pressure and swelling caused by congestive heart failure, liver failure and kidney failure.
References Yarwood, R. J., et. al.: J. Pharmaceut. Sci., 74, 220 (1985); Beyer, et al.: J. Pharmacol. Exp. Ther., 147, 1 (1965); Kim., et al.: Am. J. Cardiol., 27, 407 (1971); Williamson, H.E., et al.: J. Clin. Pharmacol., 17, 663 (1977)

Applications Carvedilol (C184625) derivative.

Applications Maintains anti-proliferative activity against human malignant cell strains.
References Pratsinis, H. et al.: J. Med. Food, 13, 286 (2010);

Applications 3,4-Difluoroaniline-2,6-d2 (CAS# 1061566-62-8) can be used in its derivative form as an antiviral agent for Hepatitis B.
References Qiu, Y.L., et.al., U.S. Pat. Appl. Publ., 187,(2019);

Applications A possible metabolite of Ranolazine (R122500).

Applications Butachlor ESA Sodium Salt (cas# 1173022-75-7) is a compound useful in organic synthesis.

Applications The major human labelled metabolite of Flurazepam. Controlled substance.
References Ochs, H.R. , et al.: Pharmacology, 36, 166 (1988), Capello, S., et al.: Drug Metab. Dispos., 18, 190 (1990),

Applications N-[(2R)-2-Hydroxy-2-(3-hydroxyphenyl)ethyl]-N-methyl-glycine is an impurity of Phenylephrine (P320640), an α-Adrenergic agonist. Mydriatic; decongestant.
References Warren, M.R., et al.: J. Pharmacol. Exp. Ther., 86, 284 (1946), Gaglia, C.A., et al.: Anal. Profiles Drug Subs., 3, 483 (1974)

Applications Dl-Metanephrine:Hcl (A,B,B-D3, 98%) (cas# 1085333-94-3) is a useful research chemical.

Applications 2-Phenyl-d5-propane (CAS# 97095-85-7) is a useful isotopically labeled research compound.

Applications Intermediate for the preparation of Neophytadiene.
References Marson, C.M., et al.: Bioorg. Med. Chem. Lett., 12, 255 (2002).

Stability Hygroscopic
Applications Phosphinothricin metabolite.
References Komossa, D. et al.: Pestic. Biochem. Phys. 43, 95 (1992)

Applications 3-Acetoxy-3-methylpentane-1,5-dioic Acid Anhydride (cas# 87894-65-3) is a compound useful in organic synthesis.
References Gordon, E., et al.: Bioorg. Med. Chem. Lett., 1, 161 (1991),

Applications A novel phosphorylcholine ester for probes in immunological studies.
References Isakson, P.C., et al.: J. Immunol. Methods, 25, 89 (1979),

Applications (-)-(2R,5S)-1-Allyl-2,5-dimethylpiperazine (cas# 155836-78-5) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bishop, M., et al.: Bioorg. Med. Chem. Lett., 5, 1311 (1995), Bishop, M., et al.: J. Med. Chem., 46, 623 (2003),

Applications Saroglitazar, is a drug for the treatment of diabetic dyslipidemia and hypertriglyceridemia with Type 2 diabetes mellitus not controlled by statin therapy. Its trade name is Lipaglyn. It is also a 1,2-Diarylpyrroles derivative, which can be used in the preparation of Nonsteroidal anti-inflammatory drugs (NSAIDs).
References Khanna, I. K., et al.: J. Med. Chem., 40, 1619 (1997);

Applications 2-Cyanopyridine-d4 (CAS# 1219795-17-1) is a useful isotopically labeled research compound.

Applications Methyl 2-cyanobenzoate

Applications PHNO precursor. Used for the preparation of radiolabeled amines, which are useful in Positron Emission Tomog. (PET) and Single Photon Emission Computed Tomog. (SPECT), and hence, can be utilized for imaging neuro-receptors with radiolabeled agonists.
References Seiler, M., et al.: J. Med. Chem., 29, 912 (1986), Halldin, et al.: J. Nuclear Med., 36, 1275 (1995), Hwang, D., et al.: Nuclear Med. Biol., 27(6), 533 (2000),

Applications 2-Nitrocodeine is an intermediate in the synthesis of 3-O-(Codein-2-yl)morphine (C634500), an impurity of Codeine (C634075).
References Chatterjie, N., et al.: Syn. Commun., 9, 647 (1979);