APIs pour la recherche et les impuretés

Applications 6-Benzyloxy Warfarin (cas# 30992-68-8) is a compound useful in organic synthesis.
References Barker, W., et al.: J. Med. Chem., 14, 167 (1971),

Applications Used for clinical pharmacokinetic studies.
References Kyte, J., et al.: J. Mol. Biol., 157, 105 (1982), Kamo, M., et al.: Eur. J. Biochem., 255, 162 (1998), Wu, C., et al.: Nat. Biotechnol., 21, 532 (2003),

Applications [18O] Cholesterol can be used as a practical tracer for studies of cholesterol metabolism in humans.
References Hudgins, L.C., et al.: Biomed. Environ. Mass Spect., 17, 463 (1988),

Applications A metabolite of Ethacrynic Acid (E676000) that is a potent inhibitor of sodium-potassium-chloride cotransporter and bumetanide binding. Also an inhibitor of human hepatic glutathione S-transferase isozymes.
References Palfrey, H. et al.: Am. J. Physiol., 264, C1270 (1993); Klaassen, C.D. et al.: J. Pharmacol. Exp. Therap., 191, 548(1974); Takamatsu, Y. et al.: Toxicol. Lett., 62, 241 (1992);

Applications 1-Chloro-2,4-dinitrobenzene-d3 (CAS# 347840-12-4) is a useful isotopically labeled research compound.

Applications PHNO precursor. Used for the preparation of radiolabeled amines, which are useful in Positron Emission Tomog. (PET) and Single Photon Emission Computed Tomog. (SPECT), and hence, can be utilized for imaging neuro-receptors with radiolabeled agonists.
References Seiler, M., et al.: J. Med. Chem., 29, 912 (1986), Halldin, et al.: J. Nuclear Med., 36, 1275 (1995), Hwang, D., et al.: Nuclear Med. Biol., 27(6), 533 (2000),

Applications N,​N-​Diethylethanol-1,1,2,2-d4-amine is deuterium labelled of 2-diethylaminoethanol, which is an inactive metabolite of 2-Chloroprocaine (HCl: C380265) and commonly used for epidural analgesia in obstetrics. It is also hypothesized to cause onset-asthma to humans following brief exposure. 2-Diethylaminoethanol also has the ability to inhibit growth of tomato roots.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Boll, W.: Science, 129, 330 (1959); Cornish, H.: Am. Ind. Hyg. Assoc. J., 26, 479 (1965); Foldes, F. & McNall, P.: Anasthesiology, 13, 287 (1952); Reisner, L., et al.: Anast. Analg., 59, 452 (1980)

Stability Hygroscopic
Applications Antihypertensive; antiglaucoma
References Al-Shora, H., et al.: Int. J. Pharm., 47, 209 (1988), Golander, Y., et al.: J. Pharm. Sci., 77, 902 (1988),

N-(Diphenoxymethylene)-methanesulfonamide is a potent cancer kinase inhibitor that has been shown to induce apoptosis in human cancer cells. It is an analog of the anticancer drug staurosporine and inhibits a wide range of kinases, including cyclin-dependent kinases (CDKs) and protein kinase C. N-(Diphenoxymethylene)-methanesulfonamide has demonstrated significant activity against various tumor types in Chinese hamster ovary cells and has been shown to be effective in inhibiting the growth of several different cancer cell lines. This inhibitor can also be found in urine samples, indicating its potential use as a biomarker for cancer diagnosis and treatment monitoring. Overall, N-(Diphenoxymethylene)-methanesulfonamide represents a promising new class of anticancer agents with broad-spectrum kinase inhibition activity.

Acyclovir Impurity K is a drug product that is used as an analytical reference standard for metabolism studies. Acyclovir Impurity K is a natural product and an impurity of acyclovir, which has CAS No. 1797131-64-6. The chemical name of this drug is 3-hydroxy-2,5,6,7-tetrahydro-1H-[1]benzopyran-2,4(3H)-dione. It can be synthesized in the laboratory by custom synthesis or it can be obtained from a commercial supplier as an impurity standard. This product is used to help with drug development and research and development in the pharmaceutical industry. It can also be used as a high purity HPLC standard for pharmacopoeia testing purposes.

Methiotepa is a potent anticancer drug that has been used for the treatment of various types of tumors. It is a Chinese hamster ovary (CHO) cell-derived analog of chitin, which inhibits the activity of protein kinase C. Methiotepa induces apoptosis in cancer cells by inhibiting DNA synthesis and repair, leading to cell death. This drug has also been shown to be a potent inhibitor of heparin-induced platelet aggregation in human blood. Methiotepa has been found to be effective against a wide range of cancers, including breast, lung, ovarian, and bladder cancer, among others. Its use as an anticancer agent may be due to its ability to inhibit the activity of various kinases and other enzymes involved in cancer cell proliferation and survival.

Please enquire for more information about (3R)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazin-7(8H)-yl]-4-(2,3,5-trifluorophenyl)-1-butanone including the price, delivery time and more detailed product information at the technical inquiry form on this page

ML604440 is a potent inhibitor of cyclin-dependent kinases (CDKs) and has shown anti-cancer activity in various human cancer cell lines. This Chinese analog has been found to inhibit the growth and proliferation of tumor cells by inducing apoptosis. ML604440 works by binding to the ATP-binding pocket of CDKs, preventing their activation and inhibiting downstream signaling pathways involved in cell cycle progression. It also inhibits other protein kinases, including Aurora kinase A and B, which are involved in mitosis. ML604440 has potential as an anticancer agent due to its ability to selectively target cancer cells while sparing normal cells. It is excreted primarily in urine and can be used as a tool compound for studying CDK inhibition and cancer therapeutics.

Please enquire for more information about rac-7-Oxo-pramipexole hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

L-Allysine is an analog of L-lysine and a potent inhibitor of kinases. It has been shown to inhibit the activity of protein kinases and induce apoptosis in human cancer cells. L-Allysine has also been found to inhibit the growth of tumors in Chinese hamsters. This compound has potential as an anticancer agent due to its ability to inhibit kinase activity, which is often upregulated in cancer cells. Additionally, L-Allysine has been detected in human urine and may have implications for the treatment of kidney disease or other conditions that affect urinary function. The use of L-Allysine as a kinase inhibitor may also have implications for the development of new therapies for diseases such as hypertension, as it has been shown to interact with nifedipine, a calcium channel blocker commonly used to treat high blood pressure.