APIs pour la recherche et les impuretés

Cycrimine hydrochloride is a molecule that is used as an anticholinergic drug. It has been shown to be effective in humans, with a half life of 3 hours and a duration of action of 8 hours. Cycrimin hydrochloride is also used as a diagnostic agent for irritant contact dermatitis and may be useful in the diagnosis of other allergic reactions. The molecule is also used as a diagnostic aid for cardiac arrhythmias.

Polyethylene glycol monoisotridecyl ether (PEG-DTAE) is a polymer that can be used as an antimicrobial agent. It is active against Gram-positive bacteria but not against Gram-negative bacteria. PEG-DTAE has anti-angiogenic effects, which may be due to its ability to inhibit the growth of new blood vessels and thereby prevent the spread of infection. In vitro assays have shown that PEG-DTAE can induce cell lysis and hemolysis in test samples. PEG-DTAE has been shown to have hemolytic activity in vivo in rats, with histology sections showing inflammation and necrosis in the spleen and liver. This polymer also causes symptoms such as fever, chills, rigors, and hypotension in patients with chronic renal failure who are undergoing dialysis.

Despropylrotigotine is a dopamine agonist that is used to treat Parkinson's disease. It is structurally related to rotigotine, which is an active metabolite of the drug. Despropylrotigotine has a long half-life and high potency, making it suitable for once-daily dosing. It has been shown to be well tolerated and effective in clinical trials for the treatment of Parkinson's disease. The pharmacokinetic profile of this drug is similar to that of other drugs in the same class, with despropylrotigotine being able to cross the blood-brain barrier and bind to dopamine receptors in the brain, thereby increasing dopamine levels in Parkinson's patients.

Please enquire for more information about (R)-3-((1-Methylpyrrolidin-2-yl)methyl)-5-vinyl-1H-indole including the price, delivery time and more detailed product information at the technical inquiry form on this page

Descyclopropyl-2-oxopropyl prasugrel is a metabolite of the prodrug prasugrel. It is a synthetic compound that has been shown to have pharmacological activity similar to its parent drug. Descyclopropyl-2-oxopropyl prasugrel has a purity of >98% and is available as an API standard in impurity grade and as custom synthesis. The chemical name for descyclopropyl-2-oxopropyl prasugrel is 2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2- yl)butoxy]-N-(3S)-(3aR*,8aS*)-octahydroindole-1,3(2H)-dione.

6β-Phthalimidopenicillanic acid is an analog of penicillin that acts as an inhibitor of cyclin-dependent kinases (CDKs). It has been shown to have potent anticancer activity and induce apoptosis in tumor cells. This medicinal compound specifically targets CDKs, which are important regulators of the cell cycle and have been implicated in cancer development. 6β-Phthalimidopenicillanic acid has been tested in Chinese hamster ovary cells and human cancer cell lines, where it has demonstrated significant inhibition of CDK activity. This inhibitor also exhibits potential as a protein kinase inhibitor, making it a promising candidate for further development as an anticancer agent.

Benzenesulfonamide is a drug product that is used as an analytical standard. It is a synthetic drug that has been shown to be metabolized by the liver, forming metabolites such as hydroxybenzenesulfonamide and sulfamethoxazole. Benzenesulfonamide is not under any pharmacopoeia guidelines or regulations. The CAS number for this drug product is 20778-16-9.

2,6,6-Trimethyl-2-cyclohexen-1-one is an analog of uridine and cysteamine that has been studied for its potential anticancer properties. It has been shown to induce apoptosis in cancer cells and inhibit tumor growth in both human and Chinese hamster ovary cell lines. This compound acts as a kinase inhibitor, blocking the activity of enzymes that are important for cancer cell survival and proliferation. Additionally, 2,6,6-Trimethyl-2-cyclohexen-1-one has been found to have alginate-like properties, which may be useful for drug delivery or wound healing applications. Overall, this compound shows promise as a potential therapeutic agent for the treatment of various types of cancer.

L-Isoleucine orlistat is a drug product that is an analytical standard and a natural product. It is used in research and development for the study of drug metabolism, and as an impurity standard for synthetic L-isoleucine. L-Isoleucine orlistat has CAS number 1072902-75-0 and Impurity Standard Number (ISN) 910.
L-Isoleucine orlistat is not a registered active pharmaceutical ingredient (API). It can be custom synthesized to meet the requirements of a particular application, such as high purity, pharmacopoeia grade, or USP HPLC grade.

OPC-167832 is a potent medicinal compound that has shown promising results in the treatment of cancer. It is an inhibitor of protein kinases, which are enzymes involved in cell cycle regulation and tumor growth. OPC-167832 induces apoptosis, or programmed cell death, in various cancer cell lines including Chinese hamster ovary cells and human tumor cells. This compound has been shown to have anticancer properties by inhibiting the growth of tumors and reducing their size. Additionally, OPC-167832 can be detected in urine samples, making it a useful tool for monitoring treatment response in cancer patients. Overall, this inhibitor shows great potential as a therapeutic agent for the treatment of various types of cancer.

2-(Naphthalen-2-ylmethyl)-4,5-dihydro-1H-imidazole is a medicinal compound that has shown promising results in cancer research. It works as an inhibitor of cyclin-dependent kinases, which are essential for cancer cell proliferation. This compound induces apoptosis in cancer cells by inhibiting the activity of certain proteins involved in tumor growth. Studies have shown that 2-(Naphthalen-2-ylmethyl)-4,5-dihydro-1H-imidazole analogs have potent anticancer activity and can inhibit the growth of human cancer cells. This compound has also been found to be present in urine samples from Chinese patients with cancer. Further research on this compound may lead to the development of new and effective treatments for various types of cancers.

N-Desmethyl-4-hydroxy tamoxifen β-D-glucuronide is a drug product that is used as an analytical reference for the identification and quantification of Metabolites in drug metabolism studies. It is synthesized from 4-hydroxytamoxifen, which has been shown to have antiestrogenic effects and inhibit the growth of estrogen receptor (ER)-positive breast cancer cells. N-Desmethyl-4-hydroxy tamoxifen β-D-glucuronide has been shown to be a metabolite of 4-hydroxytamoxifen. This impurity standard is available in both powder and liquid form with purity levels up to 99%. It can be custom synthesized upon request, with a lead time of 5 weeks.
NDA: N/A

ML604440 is a potent inhibitor of cyclin-dependent kinases (CDKs) and has shown anti-cancer activity in various human cancer cell lines. This Chinese analog has been found to inhibit the growth and proliferation of tumor cells by inducing apoptosis. ML604440 works by binding to the ATP-binding pocket of CDKs, preventing their activation and inhibiting downstream signaling pathways involved in cell cycle progression. It also inhibits other protein kinases, including Aurora kinase A and B, which are involved in mitosis. ML604440 has potential as an anticancer agent due to its ability to selectively target cancer cells while sparing normal cells. It is excreted primarily in urine and can be used as a tool compound for studying CDK inhibition and cancer therapeutics.

Cis-1,2-dihydroperillic acid is an endogenous metabolite of perillyl alcohol. It is formed in the liver from perillyl alcohol and is excreted in the urine. Cis-1,2-dihydroperillic acid has been shown to inhibit cell growth and induce cancer in animals and humans. Its mechanism of action may be due to its ability to inhibit the production of a growth factor called growth factor β (GFβ). This hormone stimulates the proliferation of mammary carcinomas and may also be involved in carcinogenesis. Cis-1,2-dihydroperillic acid is present in plasma at low concentrations, which have been measured using a human bioassay.

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