APIs pour la recherche et les impuretés

Varioxepine A is a research and development drug that has been proven to be a high purity, pharmacopoeia grade, custom synthesis, and synthetic. It is being developed as an impurity standard for analytical purposes. Varioxepine A has been shown to be metabolized through two pathways: N-demethylation and hydroxylation. The metabolites of this compound have not been fully characterized.

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N-Methyl-4-phenylpiperidine is a synthetic drug that acts as a stimulant. It is a structural analog of the neurotransmitter acetylcholine and has been shown to have similar effects in knockout mice. N-Methyl-4-phenylpiperidine is metabolized by hydrolysis of the amide group, leading to the formation of alphaprodine and hydroxyphenylacetic acid. This drug has been shown to inhibit dopamine and serotonin uptake in rats, which may be related to its psychostimulant effects. Clinical pharmacology studies have shown that this drug can increase blood pressure, heart rate, and respiration rates in humans.

OPC-167832 is a potent medicinal compound that has shown promising results in the treatment of cancer. It is an inhibitor of protein kinases, which are enzymes involved in cell cycle regulation and tumor growth. OPC-167832 induces apoptosis, or programmed cell death, in various cancer cell lines including Chinese hamster ovary cells and human tumor cells. This compound has been shown to have anticancer properties by inhibiting the growth of tumors and reducing their size. Additionally, OPC-167832 can be detected in urine samples, making it a useful tool for monitoring treatment response in cancer patients. Overall, this inhibitor shows great potential as a therapeutic agent for the treatment of various types of cancer.

6-Bromo-8-cyclopentyl-5-methylquinazoline-2,7(3H,8H)-dione is a compound with antiviral properties. It belongs to the class of tenofovir and has been shown to inhibit the replication of certain viruses. This compound also exhibits calpain inhibitory activity, which may have potential therapeutic applications in conditions related to calpain dysregulation. Additionally, 6-Bromo-8-cyclopentyl-5-methylquinazoline-2,7(3H,8H)-dione has been studied for its impurities and interactions with other compounds such as etoricoxib, blonanserin, 27-hydroxycholesterol, peptidoglycan, cellulose, oxysterols, proton pump inhibitors like omeprazole or esomeprazole, dopamine antagonists like haloperidol or risperidone and nonsteroidal anti

Trans-haloperidol N-oxide is a pyridinium salt that has been used in the synthesis of other compounds. It is an intermediate in the formation of the anion, which arises due to hydrolysis of haloperidol. The anion can be converted to an n-oxide by treatment with hydrogen peroxide and acetic acid. Trans-haloperidol N-oxide can also be prepared by chromatography or kinetic studies. The analytical techniques employed include high performance liquid chromatography (HPLC) and gas chromatography/mass spectrometry (GC/MS).

4-Amino-1-[3,5-di-O-(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl]-1,3,5-triazin-2(1H)-one (4AAT) is an analytical chemical that is used for research and development purposes. 4AAT is a metabolite of the antibiotic ampicillin and has been identified as an impurity in the drug product. It can be synthesized from 2-(4'-chlorophenyl)benzaldehyde, 3,5'-di-O-(4'-chlorobenzoyl)-2',3'-dideoxyribose and sodium azide in a two step process with 98% purity. 4AATs are also found to be present in natural products such as honey or sugar cane juice.

Desmethoxyamino hydroxy gemifloxacin is a drug product that belongs to the class of fluoroquinolones. It is a synthetic compound with a molecular weight of 551.4 g/mol and an empirical formula of C21H25FN3O2. Desmethoxyamino hydroxy gemifloxacin has been shown to inhibit bacterial DNA gyrase and topoisomerase IV in vitro, which are enzymes that maintain the integrity of bacterial DNA. The compound binds to 16S ribosomal RNA and inhibits protein synthesis, leading to cell death by inhibiting the production of proteins vital for cell division. This drug product is metabolized into gemifloxacin, desmethoxyamino acid, and desmethylgemifloxacin. These metabolites have not been shown to be active against bacterial DNA gyrase or topoisomerase IV in vitro, but may be active against other targets in

2-Hydroxy-2,3-tetrahydrofuranyl entecavir is a drug product that is an impurity standard for 2-hydroxy-2,3-dihydrofuranilide. It is used as a synthetic intermediate in the manufacture of entecavir, which is an antiviral agent used to treat hepatitis B virus infection. 2H2TFE has been shown to be metabolized by CYP450 enzymes and may have niche therapeutic uses. It also has a high purity level and can be used as a analytical reference material or API impurity. CAS No. 1984788-96-6

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(3α)-Allopregnanolone sulfate is a medicinal compound with potential anticancer properties. It is an analog of the natural hormone allopregnanolone and has been shown to inhibit kinases involved in cancer cell proliferation and survival. This compound induces apoptosis, or programmed cell death, in cancer cells by targeting proteins that regulate cell growth and division. (3α)-Allopregnanolone sulfate has been studied as a potential inhibitor of tumor growth in human cancer cells and has shown promising results. It can be detected in urine samples and has also been used in Chinese traditional medicine for its medicinal properties.

Cefixime EP Impurity C disodium is an impurity in the drug Cefixime EP. It is a by-product of the synthesis process, which can be removed by a purification process. This product is an analytical standard and is used for qualitative analysis in HPLC. It is also used as a research and development standard for drug development. This product has been classified as a niche impurity since it only occurs at trace levels in the drug product, but it may have pharmacological relevance to some patients. This impurity can be synthesized from natural or synthetic sources and is available for custom synthesis to meet specific customer needs.

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O-Desmethyl mycophenolate mofetil (ODMM) is a metabolite of mycophenolic acid, a drug that is used to treat immunosuppressive diseases. ODMM can be synthesized in the laboratory and used as an analytical standard for mycophenolic acid and its metabolites. ODMM is also a metabolic product of mycophenolate mofetil, which has been shown to have anti-inflammatory properties.

3-Descyano febuxostat ethyl ester is a synthetic, natural, and API impurity. 3-Descyano febuxostat ethyl ester is used as an analytical standard in drug development. It is also used as a custom synthesis, impurity standard and analytical reference material.

Tris(trifluoroacetoxy)iodine is an analog of iodine that has shown promise as an anticancer agent. It works by inhibiting kinase activity, which can disrupt the cell cycle and lead to apoptosis in cancer cells. Tris(trifluoroacetoxy)iodine has been found to be effective against a variety of human cancer cell lines, including those resistant to other anticancer agents. In addition, it has been shown to inhibit elastase activity and may have potential as an inhibitor of protein degradation in cancer cells. Overall, Tris(trifluoroacetoxy)iodine holds great potential as a new class of anticancer inhibitors with promising results for tumor treatment.