APIs pour la recherche et les impuretés

<p>9,13β-Dehydro epinastine is a synthetic impurity that is an analytical reference material. It is a metabolite of the drug epinastine and has been shown to have pharmacological activity.</p>

2-[(E)-[(4-Fluorophenyl)imino]methyl]phenol is a synthetic substance that is used as an analytical reagent, research and development, drug development, and impurity standard. It is an impurity of certain drugs, such as furosemide, which are metabolized to 2-[(E)-[(4-fluorophenyl)imino]methyl]phenol. 2-[(E)-[(4-Fluorophenyl)imino]methyl]phenol is also a metabolite of the drug product erythromycin. This chemical has been identified in the National Institute for Standards and Technology (NIST) mass spectral library. The CAS number for this substance is 252573-77-6.

<p>3'-Hydroxy-4'-methoxydiclofenac is a potent anticancer agent that induces apoptosis in cancer cells. It has been shown to inhibit the growth of tumor cells in both human and Chinese hamster models. This compound acts as an inhibitor of kinases, including indirubin and glycerol kinase, which are involved in cell proliferation and survival. 3'-Hydroxy-4'-methoxydiclofenac is an analog of diclofenac, a nonsteroidal anti-inflammatory drug (NSAID) used for pain relief. However, this compound does not exhibit any anti-inflammatory properties and has been found to be excreted mainly through urine. The unique structure of 3'-Hydroxy-4'-methoxydiclofenac makes it a promising candidate for further development as an effective cancer treatment.</p>

<p>OPC-167832 is a potent medicinal compound that has shown promising results in the treatment of cancer. It is an inhibitor of protein kinases, which are enzymes involved in cell cycle regulation and tumor growth. OPC-167832 induces apoptosis, or programmed cell death, in various cancer cell lines including Chinese hamster ovary cells and human tumor cells. This compound has been shown to have anticancer properties by inhibiting the growth of tumors and reducing their size. Additionally, OPC-167832 can be detected in urine samples, making it a useful tool for monitoring treatment response in cancer patients. Overall, this inhibitor shows great potential as a therapeutic agent for the treatment of various types of cancer.</p>

Tetrabromobisphenol A dimethyl ether is a high yield, biotransformed product that is synthesized from brominated phenols. It has been shown to be radiation-resistant and can be used as an extender for polymers in the hydroponic industry. Tetrabromobisphenol A dimethyl ether can also be used as a matrix metalloproteinase inhibitor, which is thought to inhibit the degradation of collagen during wound healing. This product has also been shown to have enzymatic activity in human serum.

<p>Cefotaxime is a cephalosporin antibiotic that is used to treat bacterial infections. Cefotaxime sodium impurity G is an impurity of the drug product. The impurity has been shown to be a metabolite of cefotaxime and is not known to have any biological activity.</p>

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<p>3,4-Dimethoxy-N,N-dimethyl-benzeneethanamine hydrochloride is a drug product that is used as an analytical standard. This drug development chemical is not found in nature and has been synthesized in the laboratory. The chemical's structure closely resembles that of amphetamine and methamphetamine. 3,4-Dimethoxy-N,N-dimethyl-benzeneethanamine hydrochloride is used to develop analytical methods for determining impurities in APIs such as 3,4-dimethoxyamphetamine (DMA). It is also used to help identify metabolites of amphetamines. 3,4-Dimethoxy-N,N-dimethyl-benzeneethanamine hydrochloride has been shown to have a half life of approximately 12 hours and is excreted through the urine.</p>

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<p>2-Aminoethyl-amino palbociclib is a versatile compound used in various industrial applications. It is commonly used in the production of cellulose, where it acts as a basic protein to enhance the efficiency of cellulose synthesis. Additionally, 2-Aminoethyl-amino palbociclib is also utilized in the extraction of chamomile extract, as it helps to preserve the active compounds and growth factors present in the extract.</p>

<p>Please enquire for more information about (S)-Carisbamate β-D-o-glucuronide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1-(2-Deoxy-a-D-ribofuranosyl)-5-azacytosine is a DNA methylation inhibitor that is used to treat cancer. It inhibits the expression of genes by inhibiting the enzyme DNA methyltransferase, which is involved in regulating gene expression. 1-(2-Deoxy-a-D-ribofuranosyl)-5-azacytosine has been shown to be effective against squamous cell carcinoma cells and has significant cytotoxicity against these cancer cells. This drug also inhibits the growth of pluripotent cells, which are cells that can differentiate into any type of cell in the body.</p>

Decarboxy ciprofloxacin is a prodrug that is active against bacteria and other microorganisms. It has been shown to have an affinity for the fluoroquinolone binding site on the bacterial ribosome, inhibiting protein synthesis and cell division. Decarboxy ciprofloxacin has been used in animals to treat infections caused by Escherichia coli, Klebsiella pneumoniae, Salmonella enterica, Proteus mirabilis, and Pseudomonas aeruginosa. Decarboxy ciprofloxacin is administered orally in the form of tablets or capsules. The drug binds to metal ions and can be detected with a biosensor that uses an aptamer-coated electrode. This sensor can be used for the detection of both metal ions and fluoroquinolones. Decarboxy ciprofloxacin is also used as a research tool to

Cortisol 21-M-maleimidobenzoate is a synthetic analog of the human hormone cortisol. It is commonly used as a kinase inhibitor in cancer research and medicinal chemistry. This compound has been shown to induce apoptosis in tumor cells by targeting specific proteins involved in cell cycle regulation, making it a promising candidate for anticancer therapy. Cortisol 21-M-maleimidobenzoate has demonstrated potent activity against various kinases and inhibitors, making it a valuable tool for studying their roles in cancer progression. Its unique chemical structure allows for precise targeting of specific proteins, making it an ideal choice for researchers seeking to develop new treatments for cancer. Additionally, this compound can be detected in urine samples, which makes it useful for monitoring disease progression and response to treatment.

<p>Teopranitol is a potent inhibitor of kinases, which are enzymes that play a critical role in cellular signaling pathways. It belongs to the class of protein kinase inhibitors and has been shown to have inhibitory activity against a wide range of kinases. Teopranitol has been tested on various cell lines, including human cancer cells and Chinese medicine-derived cell lines. It has been found to be effective in inhibiting the growth of mutant cancer cells by blocking the activity of specific kinases. This inhibitor shows promise as a potential treatment for cancer and tumors due to its ability to target specific pathways involved in cancer progression.</p>

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(±)-3',4'-Dihydro-1'-hydroxy-7'-methoxy-spiro[cyclopentane-1,2'(1'H)-naphthalene]-1'-acetonitrile is an impurity standard that is used as a research and development (R&D) chemical. It can be custom synthesized and is available as a drug product. This compound is synthetically derived and has high purity. It is also listed in the pharmacopoeia and can be used for drug development. Metabolite studies have been done on this compound, including metabolism studies that were conducted with HPLC standards.

<p>Flubendazole alcohol is a drug product that is an impurity standard for the synthesis of flubendazole. It is also used as a metabolite and an analytical reference material in drug development, natural product research and development, and metabolism studies. Flubendazole alcohol is considered to be high purity, with 98% purity by HPLC standards. The CAS number for this product is 82050-12-2.</p>

1,1'-[(1-Methylethyl)imino]bis[3-[4-(2-methoxyethyl)phenoxy]-2-propanol] is a synthetic drug product that has been custom synthesized for testing purposes. It is one of the metabolites of the drug product 1,1'-[(1-Methylethyl)imino]bis[3-[4-(2-hydroxypropyl)phenoxy]-2-propanol]. The metabolite has not been found in nature and its structure is unknown. Metabolism studies have been performed on this metabolite to determine its metabolic pathway. This metabolite is an impurity standard for HPLC analysis.

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2-Ethoxy-1-[2'-[1-(trityl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-4-carboxylic acid methyl ester is an impurity in the drug product, which is a synthetic drug for research and development. The impurity standard for 2-ethoxy-1-[2'-[1-(trityl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H benzimidazole 4 carboxylic acid methyl ester is available in quantities of 10g. The CAS number for the impurity is 150058-29-0. This compound has an API purity of 99.9%. Impurities are not expected to be present at greater than 1% by weight.

<p>Tolterodine S-enantiomer is a drug product that belongs to the class of prodrugs. It is metabolized in vivo to the active form, tolterodine. Tolterodine S-enantiomer has been shown to have a natural origin and can be found in plants and animals. Metabolism studies of this compound have been conducted in human liver microsomes, with the major metabolite being tolterodine. Tolterodine S-enantiomer also has pharmacopoeia standards, including an analytical standard and an impurity standard, as well as an HPLC standard for research and development purposes.</p>

rac-Parconazole oxalate is a drug product that is synthesized in the laboratory for research and development. It can be custom synthesized to meet specific needs. rac-Parconazole oxalate has a high purity, analytical data, and natural origins. Metabolism studies have been performed on rac-parconazole oxalate as well as its metabolites. Pharmacopoeia standards have also been developed for rac-parconazole oxalate. Rac-parconazole oxalate has shown to be effective in drug development and has been used for niche purposes in research and development. HPLC standards have also been developed for rac-parconazole oxalate.br>br>

2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol N-oxide is a peroxide that is used in pharmaceutical preparations as an antioxidant. It is a white solid that is insoluble in water and has a molecular weight of 168.13. 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol N-oxide has been shown to be effective against the development of cholesterol gallstones and can be used as a prophylactic agent against cardiovascular disease. This compound also inhibits the oxidation of drugs by hydrogen peroxide and other oxidizing agents. 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)eth

<p>Asenapine 11-hydroxysulfate is a metabolite of asenapine. It is a synthetic drug that can be synthesized from asenapine by reacting with hydrogen sulfide. Asenapine 11-hydroxysulfate may be used for the production of asenapine, or it may be used in analytical research to determine the purity and identity of asenapine.</p>

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<p>Dehydronitrosonisoldipine is a pyridine-containing compound that has been synthesized from dehydronitrosodiphenylamine. It is an ionic liquid with a melting point of 114°C and a boiling point of 272°C. Dehydronitrosonisoldipine has been shown to be active against some bacterial strains, but not others. It is effective for the treatment of infectious diseases such as H. influenzae, M. tuberculosis, and Listeria monocytogenes in animal studies. This compound also shows efficacy against some bacteria that are resistant to antibiotics such as penicillin and erythromycin in vitro. The molecular weight of dehydronitrosonisoldipine is 262.2 g/mol and its molecular formula is C12H14N2O4S2D6N2O6.</p>

Neratinib-d6 is a potent inhibitor of cancer cell growth and is used in the treatment of various types of cancer. It induces apoptosis, or programmed cell death, in cancer cells by inhibiting specific proteins that are required for their survival. This anticancer drug has been shown to be effective against a variety of tumors and is being studied for its potential use in treating other types of cancer as well. Neratinib-d6 is a medicinal inhibitor that works by blocking the action of certain enzymes involved in the cell cycle, such as Chinese hamster ovary kinase and human epidermal growth factor receptor 2 (HER2). It is also an analog of neratinib, which is another anticancer drug that has been approved for use in humans. Neratinib-d6 can be detected in urine samples, making it useful for monitoring patients undergoing treatment with this drug.

Sm21 is a 5-HT1A receptor antagonist that can be used to treat symptoms of Parkinson's disease. It binds to the 5-HT1A receptor and prevents the release of proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α). Sm21 has also been shown to have antinociceptive effects in animals by acting as a 5-HT1A agonist. This drug can also be used for treatment of neuropathic pain because it inhibits the release of serotonin from nerve endings. The drug may exacerbate dyskinesia and cause neuropathic pain when it is used with dopamine antagonists.

<p>Spirolaxine is a coumarin derivative that has been shown to have anti-cancer properties. It was isolated from an extract of the fungus Spirolaxine, which was found in the gastroduodenum (gut) of a frog. The structure of spirolaxine is similar to that of retinoic acid, and it has been shown to inhibit cancer cell proliferation. Spirolaxine also inhibits the production of proinflammatory cytokines in mice with colitis. This drug has not yet been tested for its ability to treat other diseases, such as diabetes, but may be able to regulate blood sugar levels by inhibiting insulin secretion and increasing glucose uptake by cells.</p>

10-{3-[4-(2-Chloro-ethyl)-piperazin-1-yl]-propyl}-2-trifluoromethyl-10H-phenothiazine is a nonselective, competitive antagonist of glutamate and quinpirole. It has been shown to block the glutamate receptors in the brain and reduce dopamine release. 10-[3-[4-(2-Chloro-ethyl)-piperazin-1-yl]-propyl]-2-trifluoromethylphenothiazine has a high affinity for the ryanodine receptor, which is found in the sarcoplasmic reticulum of striatal neurons. This drug also binds to calmodulin with high affinity, which may account for its ability to inhibit covalent adducts of dopamine to proteins. 10-[3-[4-(2-Chloro-ethyl)-piperazin-1-yl

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Butanilicaine hydrochloride is a molecular weight heparin that is structurally related to the natural pentasaccharide sequence of heparin. Its anticoagulant activity is due to its ability to form a coordination complex with calcium in the presence of magnesium and other cations. Butanilicaine hydrochloride has been shown to have anti-inflammatory and angiogenic properties, which may be due to its inhibition of pro-inflammatory factors such as TNF-α and IL-1β. It also inhibits production of angiogenic factors, such as VEGF and HGF.

2,3,3',4,4',5,5'-Heptachlorobiphenyl is an analog of polychlorinated biphenyls (PCBs) that has been shown to have tumor-inhibiting properties. It acts as a kinase inhibitor and disrupts the cell cycle in cancer cells. Studies have also shown that it inhibits elastase activity and reduces the level of certain proteins in urine, indicating its potential use as an anticancer agent. Additionally, 2,3,3',4,4',5,5'-Heptachlorobiphenyl induces apoptosis in Chinese hamster ovary cells and human leukemia cells. Its unique characteristics make it a promising candidate for further research into cancer treatment options.

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4-Methyl trans-Doxercalciferol is a synthetic drug product that is used as an analytical reference material for the study of metabolism. It is a natural, API impurity, and synthetic metabolite that has been prepared as an impurity standard for HPLC analysis. 4-Methyl trans-Doxercalciferol has not been evaluated in living systems, but it may be useful in research and development of drugs, such as those used to treat cardiovascular disease. 4-Methyl trans-Doxercalciferol has shown no adverse effects in pharmacological studies.

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<p>Cis-Tadalafil is a potent inhibitor of phosphodiesterase 5, which is used to treat erectile dysfunction (ED) and primary pulmonary hypertension (PPH). It works by increasing blood flow to the penis, allowing men with ED to achieve and maintain an erection. Cis-Tadalafil is also used to treat symptoms of prostatic hyperplasia (enlarged prostate) in men. This drug has been shown to be effective in treating PPH by reducing pulmonary arterial pressure and improving exercise capacity. Cis-Tadalafil belongs to the carboline class of drugs and is a phosphodiesterase 5 inhibitor that selectively inhibits cGMP-specific phosphodiesterase type 5 (PDE5). This drug has been shown to be highly effective in treating both ED and PPH with minimal side effects.</p>

<p>(S)-4-(2-Methylpropyl)-2-pyrrolidinone is a lactam that has been synthesized in the laboratory. It is an organic solvent that is used in the synthesis of other compounds. The compound has a potential for producing impurities, such as isopropyl and phosphite, during synthesis. (S)-4-(2-Methylpropyl)-2-pyrrolidinone can be synthesized by reacting 2-methylpropionic acid with one equivalent of methylamine. This reaction takes place in an organic solvent and requires kinetic control to avoid side reactions.</p>

nicotinic acetylcholine receptor antagonist

<p>Applications epi-Glycochenodeoxycholic Acid Sodium Salt-d7 is a labelled epimer analogue of Glycochenodeoxycholic Acid Sodium Salt (G641255), which is a bile salt formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic.<br>References Ollila, F., et al.: Langmuir, 17, 7107 (2001); Uekama, K., et al.: Chem. Pharm. Bull., 52, 900 (2004); Tongiani, S., et al.: J. Pharm. Sci., 94, 2380 (2005);<br></p>

<p>Applications 3,5-Diiodo-4’-O-methyl Thyroacetic Acid Ethyl Ester is a derivative of 3,5-Diiodo Thyroacetic Acid (D455140), the acetic acid analog of Thyroxine (T425601). It is a reactant in the preparation of bifunctional thyrointegrin inhibitors, thyroxine (T425601) and triiodothyronine (T795380).<br>References Bridoux, A. et al.: J. Enz. Inh. Med. Chem., 26, 871 (2011); Wilkinson, J.: Biochem. J., 63, 601 (1956); Wilkinson, J.: Chem. Ind., 1352 (1955)<br></p>

<p>2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine is a cytosine analog that is used as an industrial chemical. It is prepared by the reaction of 5'-deoxycytidine with acetic anhydride in the presence of sodium bicarbonate, followed by a purification procedure. 2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine reacts with toluene and trifluoromethanesulfonic acid to form 2',3'-di-O-acetyl 5'-deoxyfluorocytidine. This compound can be converted to 5'-deoxyfluorocytosine by heating in the presence of sodium tetrachloride. The yield for this process is high.</p>

Glycopyrrolate related B is a drug product that belongs to the class of drugs for research and development. It is a natural metabolite of glycopyrrolate and is used as an analytical standard. The metabolite can also be used as a synthetic intermediate or impurity standard in pharmaceutical production. It has been shown that glycopyrrolate related B has niche applications in drug development and metabolism studies. Glycopyrrolate related B is not found in the pharmacopeia, but it can be synthesized by reacting the corresponding amine with pyrrole-2-carboxaldehyde.

<p>5,6-Dehydro-tigecycline is a synthetic antibiotic that is used for the treatment of multi-drug resistant bacterial infections. 5,6-Dehydro-tigecycline binds to the 30S ribosomal subunit and blocks protein synthesis by inhibiting peptidyl transferase activity. This drug has been shown to be effective in treating methicillin resistant Staphylococcus aureus (MRSA) infections. 5,6-Dehydro-tigecycline also inhibits the growth of Mycobacterium tuberculosis and Mycobacterium avium complex, although it is not active against acid-fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex. Metabolism studies have shown that 5,6-Dehydro-tigecycline undergoes oxidative metabolism via CYP450 enzymes to form reactive metabolites like N2-[(</p>

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N-Succinyl-L-tyrosine is a synthetic compound that is used as an impurity standard for the determination of the purity and quality of drug products. It is also used in research and development to study metabolism. N-Succinyl-L-tyrosine is a metabolite of tyrosine, which has been shown to be an important intermediate in the biosynthesis of some neurotransmitters and hormones. This product can be used in HPLC assays to provide a standard curve for quantification.

<p>Descarboxyl febuxostat is a synthetic drug that is metabolized to its active form, febuxostat. This drug product has been custom synthesized and is of high purity. Descarboxyl febuxostat has been used in the development of drugs for hypertension, hypercholesterolemia, and gout. It has also been used as a research tool for studying the metabolism of drugs in humans.</p>