APIs pour la recherche et les impuretés

<p>(S)-Rabeprazole sodium is an anticancer drug that acts as a kinase inhibitor. It is an analog of Rabeprazole and has been shown to inhibit the growth of cancer cells in vitro and in vivo. (S)-Rabeprazole sodium inhibits the activity of kinases, which are enzymes that play a key role in cell signaling pathways. This inhibition leads to apoptosis, or programmed cell death, in cancer cells. (S)-Rabeprazole sodium has been tested against various types of cancer, including Chinese hamster ovary cells and tumor xenografts in mice. It has also been shown to inhibit elastin degradation, which is important for preventing metastasis of cancer cells. (S)-Rabeprazole sodium may be a promising candidate for the development of new anticancer drugs that target specific kinases and proteins involved in cancer cell growth and survival.</p>

<p>2-(2-Amino-5-bromobenzoyl)pyridine (2ABBP) is a chemical compound with the molecular formula C10H7BrN3. It is a glucuronide conjugate of 2-amino-5-bromobenzoic acid and has been used as an immunological reagent in the form of a monoclonal antibody. 2ABBP binds to dryopteris, which is a plant species that contains polyphenols called pteridines. 2ABBP has been shown to have anti-inflammatory properties in rat liver microsomes and cell culture experiments. The mechanism of action may involve inhibition of cyclooxygenase enzymes, which are involved in prostaglandin synthesis. 2ABBP also binds to human serum albumin and chaperones, proteins that bind other proteins or small molecules. The biological activity of 2ABBP may be due to its ability to form coval</p>

Salbutamol EP Impurity F is a drug impurity that is an analytical standard and pharmacopoeia reference material. It is used in the manufacture of pharmaceuticals to ensure that the product meets quality standards. Salbutamol EP Impurity F has been shown to be a metabolite of salbutamol, which is produced as a result of oxidative metabolism by cytochrome P450 enzymes such as CYP3A4. The compound has also been observed in human urine and plasma.

3-Indoxyl β-D-galactopyranoside, 6-fluoro-3-indoxyl β-D-galactopyranoside, Tilmicosin, 3-Desacetylcefotaxime potassium, Gatifloxacin, Vortioxetine Impurity 19

<p>Simvastatin acid is the active form of simvastatin, a drug used to lower blood cholesterol levels. Simvastatin acid inhibits HMG-CoA reductase, the enzyme that converts HMG-CoA to mevalonate. This conversion is a rate-limiting step in the synthesis of cholesterol and other lipids. Simvastatin acid binds to polymerase chain and drug transporter proteins, which leads to cell lysis. The concentration–time curve for simvastatin acid is linear and the half-life is approximately 12 hours. When simvastatin acid is administered with drugs that are potent inducers of CYP3A4 or UGT1A1 enzymes, there may be an increased risk for drug interactions. Simvastatin acid has shown no significant human pharmacokinetic interactions with food or grapefruit juice at doses up to 200 mg/day. There are limited data on the pharmacokinetics of simvastatin</p>

Please enquire for more information about ethyl 6-(4-aMinophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>Please enquire for more information about Mycophenolate mofetil EP Impurity C including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Sar-[D-Phe8]-des-Arg9-bradykinin is a selective Bradykinin B1 receptor agonist that exhibits resistance to aminopeptidase cleavage. This peptide plays a crucial role in various physiological processes, including inflammation, pain perception, and angiogenesis. Sar-[D-Phe8]-des-Arg9-bradykinin has been shown to have potent hypotensive effects and can stimulate the release of prostaglandins and nitric oxide. It is resistant to endopeptidase cleavage, making it an ideal candidate for therapeutic applications. Additionally, this peptide has been found to possess antibacterial properties against certain bacteria strains. Sar-[D-Phe8]-des-Arg9-bradykinin is available in pure form with minimal impurities, ensuring its efficacy and safety for use in research and medical applications.</p>

<p>Chlorthalidone is a drug product that contains the impurity J. Chlorthalidone is an antihypertensive drug that belongs to the class of thiazides. It is used in the treatment of hypertension, congestive heart failure, and edema. Chlorthalidone is metabolized by the liver and eliminated through urine; it has been shown to be excreted unchanged in urine as well as in bile. The impurity J can be found in human urine, which may be due to metabolism by microorganisms or renal clearance.</p>

<p>Pseudomonic acid D sodium is a chemical compound that is found in coal tar. It has antimicrobial properties and can be used to inhibit the growth of bacteria and fungi. Pseudomonic acid D sodium has been shown to inhibit the growth of gram-positive bacterial strains, including Bacillus cereus, Clostridium perfringens, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus faecalis. It also inhibits the growth of yeast such as Candida albicans. Pseudomonic acid D sodium is soluble in water at low concentrations and insoluble in water at high concentrations. This chemical exhibits acidic properties with an acidic pH range from 2-4. Pseudomonic acid D sodium does not dissolve calcium carbonate or hydroxide solution due to its weakly acidic nature.</p>

<p>(R)-Sitagliptin rac-fumarate adduct is an analytical reference material and impurity standard. It is a natural product that is synthesized using a custom synthesis with analytical data available. The impurities of the synthetic process are well defined, with the exception of (1) an unknown peak at retention time 9.7 min and (2) a peak at retention time 12.5 min that may be due to the presence of fumaric acid or its derivatives. This product can be used for drug development research and development, as well as for establishing HPLC standards for pharmacopoeia testing.</p>

<p>Pitavastatin N-oxide is a drug product that is an analytical standard and natural API impurity. It is used in the synthesis of other drugs, such as pitavastatin, which is a statin drug used to lower cholesterol levels. Pitavastatin N-oxide has been shown to be a potent inhibitor of HMG-CoA reductase, the enzyme that catalyzes the conversion of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) to mevalonate. This inhibits cholesterol production and lowers levels of low density lipoprotein (LDL) cholesterol in the blood.</p>

<p>5-methyl-2-oxo-1,3-dioxo-4-[(4-[2-(trityl)phenyl]phenyl)methylimidazo]-5-carboxylate is a drug that belongs to the group of angiotensin II receptor antagonists. The main human metabolite is the product of N-dealkylation at the nitrogen atom of the imidazole ring. It has been shown to inhibit rat liver microsomes at concentrations of 2.5 and 5 μM. This compound is also found as an impurity in cilexetil and olmesartan, which are other drugs belonging to this class. Impurities can be detected by using metal hydroxides, amines and biphenyl as reagents, or with gas chromatography/mass spectrometry (GC/MS), liquid chromatography/mass spectrometry (LC/MS), or high performance liquid chromatography/mass</p>

Ruxolitinib is a drug product that belongs to the class of small molecule drugs. It is an impurity standard for HPLC and other analytical techniques. Ruxolitinib Impurity 5 is a synthetic drug product, which has been custom synthesized for research and development purposes. This impurity standard is used as a pharmacopoeia in high-purity form.

Please enquire for more information about Mycophenolate mofetil EP impurity B oxalate including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>Sumatriptan EP Impurity A is a metabolite of sumatriptan, a drug product that is used for the treatment of migraine headaches. Sumatriptan EP Impurity A is a natural metabolite of sumatriptan and has been found to be an analytical impurity in the drug product. It has been shown to have anti-inflammatory properties and may be useful for treating arthritis. This impurity can also be synthesized by chemical synthesis or recombinant DNA technology.</p>

(3R,4S)-Tofacitinib is a synthetic compound that is being researched for the treatment of rheumatoid arthritis. It is a potent inhibitor of Janus Kinase 3 (JAK3) and Janus Kinase 1 (JAK1), which are important enzymes in cytokine signaling pathways that play a role in inflammation. (3R,4S)-Tofacitinib is metabolized to an impurity standard for the drug product. The metabolite has not been characterized and its concentration cannot be determined from analytical data.

Clarithromycin EP impurity B is a natural impurity in clarithromycin. Clarithromycin EP impurity B is synthesized by the metabolism of clarithromycin, and its chromatographic retention time is 13.5 minutes. It has been shown to have anti-inflammatory and immuno-suppressive effects, which may be due to its inhibition of prostaglandin synthesis. Clarithromycin EP impurity B has been shown to inhibit the growth of bacteria that are resistant to penicillin, ampicillin, and erythromycin.

Ivermectin Impurity K is an impurity in Ivermectin, a drug product. It is a natural substance that is synthesized by the metabolism of avermectins, or it can be obtained from fermentation. It has been shown to have anti-inflammatory properties in mice and rats. Ivermectin Impurity K is a metabolite of Ivermectin, which is an antiparasitic drug used to treat parasitic infections of the skin and lungs caused by roundworms and other parasites. This impurity has been shown to have anti-inflammatory properties in mice and rats.

Orlistat is a lipase inhibitor that is used as a weight-loss drug. It works by inhibiting the absorption of dietary fats and their subsequent conversion into triglycerides in the intestines, thereby limiting the calories absorbed. Orlistat has been shown to be effective in lymphatic and fatty acid transport, but oral bioavailability is low due to extensive first-pass metabolism. Orlistat inhibits pancreatic lipase, which may lead to reduced intestinal fat absorption and decreased systemic exposure. This drug also inhibits long-chain fatty acids from being absorbed through the intestinal wall and prevents them from being metabolized, thereby reducing lipid formulations in the blood.

Melphalan dimer is an anticancer drug that belongs to the class of kinase inhibitors. It works by inhibiting kinases, which are enzymes that play a critical role in cancer cell growth and survival. This medicinal compound has been shown to induce apoptosis or programmed cell death in human cancer cells. The analog of melphalan dimer has also been found in urine protein, indicating its potential as a biomarker for cancer diagnosis and treatment. Melphalan dimer is effective against various types of tumors, including Chinese hamster ovary cells and human melanoma cells. Its potent anticancer activity makes it a promising candidate for cancer therapy.

<p>Atorvastatin is a drug product with an impurity of atorvastatin cyclic sodium salt (isopropyl). The synthesis of this compound can be found in the natural and synthetic routes. Impurity standard is used to identify impurities in drugs and is necessary for pharmacopoeia, research and development, and analytical work. This compound has been shown to have high purity, analytical, metabolism studies, natural, drug development, and pharmacopoeia. CAS No. 1316291-19-6 is the impurity standard for this compound.</p>

Quetiapine hemifumarate is an antipsychotic drug that blocks receptors for dopamine, serotonin, and adrenergic neurotransmitters. It is used to treat schizophrenia and other disorders such as bipolar disorder. Quetiapine has been shown to be effective in clinical trials. The fumarate salt of quetiapine is the form of the drug that is used in these trials. Serum prolactin levels were found to be significantly lower in patients who received the fumarate salt than those who received a placebo. Quetiapine hemifumarate may potentiate the effects of other drugs by inducing their metabolism via CYP3A4 or CYP2D6 enzymes, which are also responsible for its own metabolism. This drug can interact with other drugs such as risperidone, olanzapine, and clozapine due to its atypical nature. Quetiapine hemifumarate has side effects

5''''-Methyl-apixaban is a drug product that is synthesized in the laboratory. It has been shown to be metabolized by cytochrome P450 enzymes, which are found in the liver, and eliminated by glucuronidation. This compound has been shown to have antiplatelet activity and is used for the prevention of stroke in patients with atrial fibrillation who cannot tolerate warfarin or those who need a higher dose of warfarin than can be achieved with standard doses. 5''''-Methyl-apixaban also inhibits platelet aggregation, leading to decreased blood clot formation. 5''''-Methyl-apixaban has been shown to have a number of metabolites including apixaban, which is formed through oxidation; apixanone, which is formed through hydrolysis; and apixanol, which is formed through conjugation with glucuronic acid. Apixanone has been shown to have more potent antiplatelet activity

Isopropyl 2-hydroxy-2-phenylacetate is an inorganic acid that is used as a solvent and as a reagent for sample preparation. It has been shown to be able to dissolve hydroxy methyl cellulose, which is a common component of membranes. In addition, it can be used as an electrospray ionization source and has been shown to have a phase transition temperature of -24 degrees Celsius. Isopropyl 2-hydroxy-2-phenylacetate has also been shown to inhibit the action of cholic acid on kinetics in high-performance liquid chromatography. This chemical compound also contains an ethyl group, which may be due to its derivation from acetone.

N-Boc Linagliptin is a drug product that is an analytical standard. It is a synthetic, impurity free API with high purity and pharmacopoeia grade. The CAS No. 668273-75-4 denotes this compound as an N-Boc protected form of Linagliptin. This compound has been developed for its potential use in the treatment of type 2 diabetes mellitus, obesity and related disorders.

<p>Gentamicin Impurity</p>

<p>Atorvastatin lactam phenanthrene calcium salt impurity is a high purity, custom synthesis drug product. It is a metabolite of atorvastatin and was identified using metabolism studies in rat and human liver microsomes. This impurity has been shown to be an analytical standard for HPLC. Atorvastatin lactam phenanthrene calcium salt impurity is used in niche research and development, as well as the development of drugs that are pharmacopoeia grade.</p>

Cefdinir impurity F is an impurity of cefdinir that has been identified in some batches. It is a triethylamine derivative and has been found to be ultralow. Cefdinir impurity F has been studied for its use in laboratories.

<p>Amoxicillin EP Impurity C is a metabolite of amoxicillin that is formed by oxidation. It can be used as an impurity standard for the detection of amoxicillin in HPLC and LC-MS analyses. Amoxicillin EP Impurity C has been found to be a natural metabolite of amoxicillin in human urine. This impurity also exhibits anti-inflammatory activity, which may be due to its ability to inhibit prostaglandin synthesis.</p>

Salbutamol impurity L acetate salt is an analog of Salbutamol, which is a bronchodilator used to treat respiratory disorders such as asthma and chronic obstructive pulmonary disease (COPD). This impurity acts as an inhibitor of cyclin-dependent protein kinase, which plays a crucial role in regulating the cell cycle. It has been shown to have anticancer properties by inducing apoptosis in cancer cells. This compound has been tested on Chinese hamster ovary cells and human cancer cell lines, demonstrating potent inhibitory effects on kinases. Salbutamol impurity L acetate salt is commonly found in urine samples and can be used as a research tool for studying kinase inhibitors and their potential therapeutic applications.

Ertapenem Ring Open Impurity is an impurity standard for research and development. It is a synthetic metabolite that is not present in the drug product. Ertapenem Ring Open Impurity is used as a standard to measure the purity of drugs, and it can be used as a reference material in pharmacopoeia and drug development. This impurity is also used in metabolism studies to determine the extent of conversion of ertapenem into its metabolites.

<p>Ivermectin impurity I is an analytical standard that is used for pharmacopoeia and custom synthesis. It is a natural metabolite of the drug Ivermectin, which has been shown to have anti-inflammatory properties in mice. Ivermectin impurity I binds to nicotinic acetylcholine receptors, leading to muscle paralysis and death. This compound is found in high purity for research and development purposes.</p>

OMDM-5 is a potent vanilloid receptor type 1 (TRPV1, EC50 = 75 nM) agonist, showing weak ligand activity at cannabinoid type 1 receptor (CB1, Ki=4.9 μM).

<p>Stigmastanol is a phytosterol isolated from Hypericum riparium, which is a Cameroonian medicinal plant.</p>

N-Hydroxy sertraline is a metabolite of the antidepressant drug, sertraline. It is formed by the action of cytochrome P450 enzymes in the liver. N-Hydroxy sertraline is not active as an antidepressant, but it may have some activity against bacterial infections. There are no pharmacopoeia standards for this compound.

<p>Oxytocin impurity</p>

Quetiapine ep impurity P is a metabolite of quetiapine. It is a synthetic compound with pharmacopoeia and analytical standards available. Quetiapine ep impurity P is used in research and development to study the metabolism of quetiapine, but it also has niche uses in drug product development. Quetiapine ep impurity P can be synthesized by high-purity custom synthesis or natural methods, such as from plants.

6-Oxo mometasone furoatemometasone furoate impurity F is a drug product that is an impurity standard for the synthesis of 6-oxo mometasone furoatemometasone furoate. This impurity has been shown to have a metabolite profile similar to that of 6-oxo mometasone furoatemometasone furoate, but with a different retention time in HPLC analysis. It has also been shown to be present in natural products and to inhibit metabolism studies. This impurity should be used as an analytical standard for HPLC analysis of 6-oxo mometasone furoatemometasone furoate.

<p>7'-Methyl-2'-propyl-2,5'-bi-1H-benzimidazole (7'-MPB) is a benzimidazole derivative that is used as a medicine. It is made from recycled chemicals and has shown to have industrial applications as a catalyst for cyclization reactions. 7'-MPB is also used in the production of benzenesulfonic acid, which is an organic solvent. This chemical has been shown to be effective against high blood pressure, but has not been tested on humans yet. Telmisartan, which belongs to the angiotensin II receptor blocker class of drugs, can inhibit the synthesis of prostaglandins.</p>

<p>Bromfenac Related Compound A is a chemical impurity, which is often encountered during the synthesis and formulation of bromfenac, a non-steroidal anti-inflammatory drug (NSAID). This compound arises as a byproduct in the chemical synthetic pathway utilized in the production of bromfenac, necessitating stringent analytical methods to ensure product purity and compliance with pharmaceutical standards.The mode of action for Bromfenac Related Compound A itself is not typically characterized, as it is primarily the parent compound, bromfenac, that is pharmacologically active. Bromfenac works by inhibiting cyclooxygenase enzymes (COX-1 and COX-2) that mediate inflammatory processes. However, the related compound is investigated to understand the synthesis intricacies and to refine processes that limit its formation.Understanding and controlling the levels of Bromfenac Related Compound A is crucial in pharmaceutical applications, as the presence of impurities can affect the efficacy, safety, and overall quality of the drug product. Analytical chemists and pharmaceutical scientists study this compound extensively using chromatographic and spectroscopic techniques to ensure drug safety and compliance with regulatory guidelines.</p>

2-(Methoxymethyl)-5-(phenylthio)-1H-benzimidazole is a drug product that is used in research and development. It is an analytical standard for the impurity 2-(Methoxymethyl)-5-phenylthio-1H-benzimidazole, which has a natural origin. The impurity standard can be used to assess the purity of the API by HPLC. This drug product is also used as a Metabolism studies and Natural standards. These standards are used to study the metabolism of drugs, which can lead to new insights into their therapeutic action and toxicity. 2-(Methoxymethyl)-5-(phenylthio)-1H-benzimidazole can be synthesized in custom synthesis or synthetic methods. It has been shown to have niche uses in drug development, research and development, and analytical chemistry.

<p>Sitagliptin impurity E is an inhibitor of dipeptidyl peptidase-4 (DPP-IV) that is used as a hypoglycemic agent. Sitagliptin impurity E has been shown to increase the glucose-lowering effect in diabetic patients with type 2 diabetes mellitus. It is also effective in reducing postprandial glucose and insulin levels. Sitagliptin impurity E has been shown to increase the concentration of insulin in plasma for up to 24 hours after administration, which suggests that it may be useful for the treatment of metabolic disorders such as obesity and type 2 diabetes mellitus.</p>

<p>Fluoroquinolones are a class of antibiotics that are used to treat bacterial infections. Desfluoro ciprofloxacin hydrochloride is a fluorinated derivative of ciprofloxacin and is an ultra-fast synthetic compound. It has been shown to be more potent than the parent molecule. This drug is considered to be impure because it contains other chemical compounds, such as isomers and back-pressure products. The particle size distribution of desfluoro ciprofloxacin hydrochloride is usually very broad with diameters ranging from 5 nm to 1 micron. It can be separated by particle size in a phase liquid chromatography column because the particles have different hydrodynamic diameters. Desfluoro ciprofloxacin hydrochloride can also be separated by phase chromatography on an oligosaccharide column, which produces more efficient separation than traditional high-performance liquid chromatography (HPLC).</p>

Please enquire for more information about Sumatriptan 3-hydroxy-2-oxo impurity including the price, delivery time and more detailed product information at the technical inquiry form on this page

14-Hydroxy clarithromycin is an analog of clarithromycin that has been shown to have anticancer properties. It is excreted in urine and has been found to inhibit several kinases, including cyclin-dependent kinases and protein kinase C. This drug induces apoptosis in cancer cells and inhibits tumor growth in Chinese hamsters. 14-Hydroxy clarithromycin has also been studied as a potential inhibitor of the human kinase, which may have implications for the development of new cancer therapies. Overall, this drug shows promise as an effective anticancer agent with potential for further research and development.

<p>4-[(2RS)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-benzaldehyde hydrochloride is a drug product. It is used as an analytical standard and in the development of drugs. The metabolite of 4-[(2RS)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-benzaldehyde hydrochloride, 4-[(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy]-N-(4-nitrophenyl)benzamide, has been shown to inhibit the production of cytokines IL6 and TNFα by human monocytes, macrophages, and dendritic cells. Metabolism studies have shown that 4-[(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy]-N</p>

<p>Chlorthalidone impurity E is an analytical standard for the HPLC analysis of chlorthalidone in pharmaceutical drug products and is a metabolite of chlorthalidone. Chlorthalidone impurity E is an API impurity that can be found in the synthesis of chlorthalidone, and it has been detected as a minor component in certain drug products. It is important to have an accurate specification for this compound, since it can affect the pharmacological properties of the drug product. The purity level of this compound must be at least 98% or greater to ensure that there are no contaminants present. This compound is also a metabolite of chlorthalidone and is used as a pharmacopoeia reference substance for testing equipment calibration.END&gt;</p>

Acarbose EP Impurity H is an impurity of acarbose, a drug product used in the treatment of type II diabetes. Acarbose is a natural product and its synthesis starts from a chemical called alpha-D-glucopyranosyl-3-O-[2,4,6-trichloro-3-(trifluoromethyl)phenyl]pyridine. Acarbose is metabolized by the liver to form Acarbose EP Impurity H. The metabolism studies of this impurity have shown that it has niche pharmacological properties. Acarbose EP Impurity H can be used as an analytical or API impurity for HPLC standard or as a synthetic intermediate for pharmaceutical research and development.

<p>Etofenamate impurity</p>