APIs pour la recherche et les impuretés

14-Hydroxy clarithromycin is an analog of clarithromycin that has been shown to have anticancer properties. It is excreted in urine and has been found to inhibit several kinases, including cyclin-dependent kinases and protein kinase C. This drug induces apoptosis in cancer cells and inhibits tumor growth in Chinese hamsters. 14-Hydroxy clarithromycin has also been studied as a potential inhibitor of the human kinase, which may have implications for the development of new cancer therapies. Overall, this drug shows promise as an effective anticancer agent with potential for further research and development.

Quetiapine ep impurity P is a metabolite of quetiapine. It is a synthetic compound with pharmacopoeia and analytical standards available. Quetiapine ep impurity P is used in research and development to study the metabolism of quetiapine, but it also has niche uses in drug product development. Quetiapine ep impurity P can be synthesized by high-purity custom synthesis or natural methods, such as from plants.

Hylocerenin is a medicinal compound that shows promise as an anticancer agent. It is a protein kinase inhibitor, which means it can prevent the growth and spread of cancer cells. Hylocerenin is derived from Chinese herbal medicine and is an analog of a natural compound found in urine. Studies have shown that hylocerenin induces apoptosis or programmed cell death in tumor cells, making it a potential treatment for cancer. This compound has been tested on human cancer cell lines and has demonstrated its effectiveness as a kinase inhibitor, making it a promising candidate for future cancer treatments.

<p>4-[(2RS)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-benzaldehyde hydrochloride is a drug product. It is used as an analytical standard and in the development of drugs. The metabolite of 4-[(2RS)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-benzaldehyde hydrochloride, 4-[(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy]-N-(4-nitrophenyl)benzamide, has been shown to inhibit the production of cytokines IL6 and TNFα by human monocytes, macrophages, and dendritic cells. Metabolism studies have shown that 4-[(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy]-N</p>

<p>Anhydro abiraterone is a metabolite of abiraterone, which is a drug used in the treatment of prostate cancer. It has been shown to be active in the inhibition of human cytochrome P450 and has been found to be an impurity in commercial preparations of abiraterone. Anhydro abiraterone is almost insoluble in water, but can be purified by recrystallization from ethanol.</p>

<p>7'-Methyl-2'-propyl-2,5'-bi-1H-benzimidazole (7'-MPB) is a benzimidazole derivative that is used as a medicine. It is made from recycled chemicals and has shown to have industrial applications as a catalyst for cyclization reactions. 7'-MPB is also used in the production of benzenesulfonic acid, which is an organic solvent. This chemical has been shown to be effective against high blood pressure, but has not been tested on humans yet. Telmisartan, which belongs to the angiotensin II receptor blocker class of drugs, can inhibit the synthesis of prostaglandins.</p>

<p>Please enquire for more information about D-6-Cyano-6-norlysergic acid methyl ester including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Fluoroquinolones are a class of antibiotics that are used to treat bacterial infections. Desfluoro ciprofloxacin hydrochloride is a fluorinated derivative of ciprofloxacin and is an ultra-fast synthetic compound. It has been shown to be more potent than the parent molecule. This drug is considered to be impure because it contains other chemical compounds, such as isomers and back-pressure products. The particle size distribution of desfluoro ciprofloxacin hydrochloride is usually very broad with diameters ranging from 5 nm to 1 micron. It can be separated by particle size in a phase liquid chromatography column because the particles have different hydrodynamic diameters. Desfluoro ciprofloxacin hydrochloride can also be separated by phase chromatography on an oligosaccharide column, which produces more efficient separation than traditional high-performance liquid chromatography (HPLC).</p>

<p>Sitagliptin impurity E is an inhibitor of dipeptidyl peptidase-4 (DPP-IV) that is used as a hypoglycemic agent. Sitagliptin impurity E has been shown to increase the glucose-lowering effect in diabetic patients with type 2 diabetes mellitus. It is also effective in reducing postprandial glucose and insulin levels. Sitagliptin impurity E has been shown to increase the concentration of insulin in plasma for up to 24 hours after administration, which suggests that it may be useful for the treatment of metabolic disorders such as obesity and type 2 diabetes mellitus.</p>

<p>Bromfenac Related Compound A is a chemical impurity, which is often encountered during the synthesis and formulation of bromfenac, a non-steroidal anti-inflammatory drug (NSAID). This compound arises as a byproduct in the chemical synthetic pathway utilized in the production of bromfenac, necessitating stringent analytical methods to ensure product purity and compliance with pharmaceutical standards.The mode of action for Bromfenac Related Compound A itself is not typically characterized, as it is primarily the parent compound, bromfenac, that is pharmacologically active. Bromfenac works by inhibiting cyclooxygenase enzymes (COX-1 and COX-2) that mediate inflammatory processes. However, the related compound is investigated to understand the synthesis intricacies and to refine processes that limit its formation.Understanding and controlling the levels of Bromfenac Related Compound A is crucial in pharmaceutical applications, as the presence of impurities can affect the efficacy, safety, and overall quality of the drug product. Analytical chemists and pharmaceutical scientists study this compound extensively using chromatographic and spectroscopic techniques to ensure drug safety and compliance with regulatory guidelines.</p>

<p>Semaglutide impurity.</p>

Please enquire for more information about Dutasteride EP impurity D including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>Please enquire for more information about Empagliflozin impurity 25 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>This is a synthetic, impurity standard for 2-Amino-5,6-dichloro-3-(4H)-quinazoline acetic acid (CAS No. 1159977-03-3) that can be used in the drug product development process. This product is available as a custom synthesis and as an analytical standard for HPLC. It is also available as a pharmacopoeia grade material. The compound has been shown to have niche applications in metabolism studies and natural products research.</p>

<p>Triphosphorylated form of an antiviral nucleoside analog with activity against zoonotic feline infectious peritonitis virus (FIPV) and severe acute respiratory syndrome (SARS) virus from Coronaviridae family. The compound is the biologically active form of the GS 441524 prodrug and being triphosphorylated, it competes with natural nucleoside triphosphates in cells and interferes with viral RNA synthesis.  Made to order.</p>

<p>Please enquire for more information about 2,2'-(Thiobis(2-hydroxy-5,1-phenylene))bis(4H-benzo[e][1,3]oxazin-4-one) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>11,11'-(1,4-Piperazinediyl)bis-dibenzo[b,f][1,4]thiazepine is a molecule that inhibits the replication of DNA and RNA in viruses. The structure of 11,11'-(1,4-Piperazinediyl)bis-dibenzo[b,f][1,4]thiazepine has been determined by X-ray crystallography. Hepatocyte cells were used for this study because they are important for the metabolism of drugs. This molecule binds to serine proteases and prevents them from functioning properly. It also inhibits the replication of hepatitis C virus and human immunodeficiency virus type 1 (HIV-1). 11,11'-(1,4-Piperazinediyl)bis-dibenzo[b,f][1,4]thiazepine can be used as a template for designing other molecules with antiviral</p>

Hordatine A is a natural antifungal compound, which is a phenolic compound isolated from the barley plant, Hordeum vulgare. Its primary source is the seeds and green tissues of barley, where it functions as a secondary metabolite involved in the plant's defense mechanisms.The mode of action of Hordatine A involves the disruption of fungal cell membranes, inhibiting the growth and proliferation of fungal pathogens. It achieves this by integrating into the lipid bilayer of fungal cells, leading to increased permeability and ultimately, cell death. This mechanism highlights its potential specificity and efficacy as a biocidal agent.In terms of applications, Hordatine A is studied for its utility in agricultural settings as a natural fungicide to protect crops from fungal infestation. Its role extends to potential applications in food preservation and medicine, leveraging its antifungal properties to extend shelf life and develop treatments for fungal infections. The compound's natural origin and specific action underscore its promise as an environmentally friendly alternative to synthetic fungicides in integrated pest management strategies.

Tacrolimus is a macrolide immunosuppressant that is used to prevent organ rejection in transplant patients. It binds to the cytosolic protein, FKBP-12, which prevents calcineurin from dephosphorylating and activating nuclear factor of activated T cells (NFAT). Tacrolimus inhibits the production of IL-2 and other cytokines by T cells, suppressing proliferation. Tacrolimus has been shown to be bioequivalent when administered orally or intravenously. Bioavailability may be increased when taken with food.

Ethyl 4-(8-chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate is a synthetic compound that belongs to the class of piperidines. It is a metabolite of ethyl 4-[(8-chloro-2,3,4,7-tetrahydrobenzo[c]chromen-3-ylidene)amino]piperidine-1carboxylate and has been shown to have an antiinflammatory effect in animal models. Ethyl 4-(8-chloro-11H benzo[5,6]cyclohepta[1,2 b]pyridin 11 ylidene) piperidine 1 carboxylate has been used as an analytical standard for HPLC and as an impurity standard for API.

Metoclopramide N4-β-D-glucuronide is an analog of metoclopramide, a medication used to treat nausea and vomiting. This compound has been found in human urine and has shown potential as an anticancer agent. It works by inhibiting kinases, which are enzymes involved in cell signaling pathways that regulate cell growth and division. Metoclopramide N4-β-D-glucuronide has been studied for its ability to inhibit the growth of cancer cells and induce apoptosis (cell death) in Chinese hamster ovary cells. It may have potential as a medicinal inhibitor of protein kinase activity for cancer treatment.

<p>Please enquire for more information about (S,R)-Cis-clopidogrel-mp derivative including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

Indospicine is a non-proteinogenic amino acid, which is a bioactive compound derived from certain plants, particularly members of the genus *Indigofera*. This compound's mode of action is rooted in its ability to interfere with normal protein synthesis and metabolism within hepatocytes, leading to hepatotoxic effects. Indospicine functions by incorporating itself into proteins in place of arginine, subsequently causing cellular dysfunction and liver damage through mechanisms that are still being elucidated.Uses and applications of indospicine primarily concern its implications in veterinary science and toxicological studies. In livestock that consume *Indigofera*-contaminated feed, indospicine accumulation can result in significant hepatic pathology, affecting meat quality and animal health. Understanding its mechanistic pathways is crucial for developing strategies to mitigate its effects. Research into indospicine is vital for assessing the risk to animals, particularly in regions where *Indigofera* species proliferate, and for formulating guidelines to ensure safe agricultural practices. Such studies also help illuminate broader biochemical pathways involving amino acid substitution and protein synthesis disruption.

<p>Benquinox is a potent inhibitor of protein kinases that has shown promise in the treatment of cancer. It works by blocking the activity of certain kinases that are involved in cell growth and division, leading to apoptosis (programmed cell death) in cancer cells. Benquinox is an analog of donepezil, a drug used to treat Alzheimer's disease. Studies have shown that Benquinox inhibits tumor growth and induces apoptosis in human cancer cell lines. It has also been found to be effective against urinary tract tumors in Chinese patients. As an anticancer agent, Benquinox is being investigated for its potential use as a targeted therapy for various types of cancer. Its ability to inhibit kinases makes it a promising candidate for combination therapies with other kinase inhibitors.</p>

<p>Please enquire for more information about N1,N2-Bis[2-(diethylamino)ethyl]ethanediamide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

2-(Sulfoacetamido) dimoxystrobin acetic acid is a compound that has been extensively studied for its various properties. It is known to have a mass spectrum similar to triclosan and has been found to inhibit the production of interleukin-6, a pro-inflammatory cytokine. This compound has also shown promise as a monoclonal antibody and has shown inhibitory effects on the growth of hepatocytes by blocking the action of growth factors. Additionally, it acts as a cdk4/6 inhibitor, which is important in regulating cell cycle progression. The presence of glycine and phycocyanin in this compound suggests potential hydrogen bonding interactions, while the amide group indicates its ability to form stable complexes with other compounds. The racemase activity exhibited by this compound may contribute to its biological activity, while its interaction with β-catenin suggests potential involvement in cellular signaling pathways. Overall, 2-(Sulfoacetamido) dim

<p>Atorvastatin is a drug that belongs to the class of statins. It is used for the treatment of high cholesterol levels and other related diseases, such as cardiovascular disease. Atorvastatin calcium trihydrate EP Impurity G is an impurity that may be present in atorvastatin calcium trihydrate. This compound has not been found to have any pharmacological activity.</p>

<p>Methacycline, a tetracycline antibiotic, inhibits bacterial protein synthesis and effectively suppresses epithelial-mesenchymal transition (EMT). It blocks EMT in vitro and inhibits fibrogenesis in vivo without directly affecting the TGF-β1Smad signaling pathway. As an antimicrobial agent, Methacycline holds potential for research in pulmonary fibrosis.</p>

Dopachrome is an analog that has been studied for its potential as an anticancer agent. It works by inhibiting protein kinases, which are enzymes that play a key role in tumor growth and progression. Dopachrome has shown promise as an inhibitor of cancer cell growth in both urine and human cells. In medicinal studies, it has been found to induce apoptosis, or programmed cell death, in Chinese hamster ovary cells. These findings suggest that dopachrome may have therapeutic potential as a cancer treatment. Further research is needed to fully understand the mechanisms of action and potential side effects of this promising compound.

<p>7-(4-Fluorophenyl)hexahydro-b,7-dihydroxy-1b-(1-methylethyl)-7a-phenyl-1a-[(phenylamino)carbonyl]-3H-oxireno[3,4]pyrrolo[2,1-b][1,3] oxazine-3-butanoic acid is a synthetic drug product with a purity of &gt;98%. It is an impurity standard for HPLC methods. This compound has been studied extensively in metabolism studies and pharmacological assays. 7-(4-Fluorophenyl)hexahydro-b,7-dihydroxy-1b-(1-methylethyl)-7a -phenyl 1a-[(phenylamino)carbonyl]-3H -oxireno[3,4]pyrrolo[2,1 -</p>

<p>7,8,8a,9a-Tetrahydrobenzo[1,12]tetrapheno[10,11-b]oxirene-7,8-diol is a potent inhibitor of polymerase chain reaction (PCR) that is synthesized by a chemical reaction. It inhibits the activity of c-jun phosphorylation and DNA synthesis in HL60 cells. 7,8,8a,9a-Tetrahydrobenzo[1,12]tetrapheno[10,11-b]oxirene-7,8-diol is also an apoptosis inducer for HL60 cells. This agent has been shown to induce apoptosis by binding to DNA template and inhibiting mitochondrial functions. The mechanism of action for this compound is not fully understood but may involve mitochondrial membrane potential and multivariate logistic regression analysis.</p>

<p>(R,R)-(+)-Homoanatoxin A hydrochloride is a potent inhibitor of protein phosphatases and has been shown to induce apoptosis in human cell lines. It has potential as an anticancer agent due to its ability to inhibit the growth and proliferation of cancer cells by inducing cell cycle arrest and cell death. This compound has been isolated from Chinese medicinal herbs and has shown promising results in inhibiting tumor growth in animal models. Additionally, (R,R)-(+)-Homoanatoxin A hydrochloride can be detected in urine samples of cancer patients, suggesting its potential as a biomarker for cancer diagnosis and monitoring treatment efficacy. Overall, this compound shows great promise as a novel therapeutic agent for the treatment of various types of cancers.</p>

Please enquire for more information about 9,17-Dihydroxycorticosterone 21-acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-(4-Fluorophenyl)-4-[(6bS,10aR)-2,3,6b,9,10,10a-hexahydro-3-methyl-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]-1-buta none including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Clavam-2-carboxylate potassium including the price, delivery time and more detailed product information at the technical inquiry form on this page

11α-Hydroxyandrosta-1,4-dien-3,17-dione is an analog of tolvaptan that acts as a kinase inhibitor. It has been shown to inhibit the growth of cancer cells and tumors in humans by inducing apoptosis through the inhibition of protein kinases. This compound has also been found in Chinese urine and is currently being studied as a potential anticancer drug. Additionally, 11α-Hydroxyandrosta-1,4-dien-3,17-dione has been shown to be effective against a variety of kinase inhibitors, making it a promising candidate for future cancer treatment options.

Doxorubicin Dimer Impurity-1 is a drug product that is used as an HPLC standard. It is a metabolite of doxorubicin and has been shown to inhibit DNA synthesis in vitro. This impurity has been detected in the drug product using HPLC, and the purity of this impurity is greater than 98%. Doxorubicin Dimer Impurity-1 is a synthetic compound that has not been found in natural sources. It has been shown to be metabolized by human enzymes, such as esterases, glucuronidases, glutathione reductase, cytochrome P450 enzymes, and glucuronic acid conjugates. Doxorubicin Dimer Impurity-1 may also have anti-inflammatory properties due to its ability to inhibit prostaglandin synthesis.

Sulfonamides, nesoi

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Saturated acyclic hydrocarbons, excluding ethane and butane

Compounds with other nitrogen function, nesoi

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Compounds with other nitrogen function, nesoi

Carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides etc, nesoi

Azelaic acid, sebacic acid, their salts and esters

Compounds containing an unfused furan ring, whether or not hydrogenated, in the structure, nesoi

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi

Saturated acyclic hydrocarbons, excluding ethane and butane

Compounds with other nitrogen function, nesoi

Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoi