APIs pour la recherche et les impuretés

Applications 2,2'-AZOBIS-(2-METHYLBUTYRONITRILE) (cas# 13472-08-7) is a useful research chemical.
Dangerous Goods Info This compound is forbidden to ship by air under IATA regulations.

N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) is a solid with a low melting point which has been identified as a potentially carcinogenic component of both tobacco and tobacco smoke. NMBA is also one of a number of nitrosamine impurities which have been found to be present in angiotensin II receptor blocker (ARB) drugs used to treat high blood pressure.

10,11-Dihydroxy-d10 Carbamazepine is a drug product that is used as an analytical reference standard. It is natural and synthetic impurity in the API (active pharmaceutical ingredient) Carbamazepine. The CAS number for 10,11-Dihydroxy-d10 Carbamazepine is 513-81-5. This compound has been synthesized by custom synthesis and is an impurity standard for HPLC analysis of carbamazepine. 10,11-Dihydroxy-d10 Carbamazepine is also a research and development chemical for the drug development industry. It has been classified as a niche chemical due to its high purity and pharmacopoeia grade.

Atorvastatin impurity F is an impurity that can be found in atorvastatin. It is a white to off-white crystalline solid with a melting point of 142°C. It has a molecular weight of 273.5 and chemical formula of C14H13N3O2. This impurity can be found in atorvastatin as an API impurity, which may have an effect on the efficacy or toxicity of the drug product. Impurities are present in all pharmaceutical products and should be identified, characterized, and quantified for quality control purposes. Impurities are often unavoidable byproducts of the manufacturing process and can lead to potential safety concerns if they are not detected early on during drug development. The presence of impurities may also affect the pharmacological effects or therapeutic efficacy of the drug product.

Bis-[5-[(dimethylamino)methyl]furan-2-yl]methane is a synthetic compound with the CAS number 16864-73-6. It is used in pharmacological studies and drug development. The purity of this material is greater than 99%.

Isoribavirin is a ribonucleoside monophosphate analog that inhibits viral RNA polymerase. Isoribavirin has been shown to be active against influenza virus, herpes simplex virus, and vesicular stomatitis virus in cell culture. Isoribavirin is stable in an acetonitrile solution in the presence of phosphoric acid at pH 3-4 or in the presence of sulfate ions at pH 9-10. It can be purified by chromatography on a silica gel column using an acetonitrile/water mobile phase gradient. The impurities of isoribavirin are not detectable by liquid chromatography and have no significant effect on its sensitivity. Isoribavirin elutes from the silica gel column with the impurities.

Olanzapine Ketolactam is a drug product that can be custom synthesized. It has a purity of at least 98% and is identified by its CAS number, 1017241-34-7. The metabolite of Olanzapine ketolactam is olanzapine N-oxide, which can be found in the urine of patients who have taken Olanzapine ketolactam. Metabolism studies have been conducted on this drug product to determine how it may affect the body. This drug product is also used in natural or synthetic drug development, pharmacopoeia, and analytical research.

11-Fluoro desloratadine is a metabolite of the antihistamine, loratadine. It has shown to be an analytical standard for HPLC, and impurity standard for pharmacopoeia. 11-Fluoro desloratadine is typically synthesized by reacting loratadine with fluorinating reagent such as N-fluorosuccinimide (NFSI) in the presence of a base catalyst such as sodium methoxide. 11-Fluoro desloratadine is also found in breast milk at concentrations of up to 1.2% of total loratadine concentration, which has been attributed to incomplete metabolism or passive transfer from mother to child.

Naltrexone impurity A is a synthetic, high-purity drug product that is used as an analytical reference standard in the development and manufacture of pharmaceuticals. It is also used as a pharmacopoeia reference standard and to study metabolism. Naltrexone impurity A has been shown to be a major metabolite of naltrexone and can be found in the urine at concentrations of 1-2% following oral administration. This impurity is not active when given orally, but may have activity if injected intravenously or intramuscularly.

Urolithin M5 is a drug product that has undergone custom synthesis, and is high in purity. It has CAS No. 91485-02-8, analytical data, metabolism studies, and drug development. Urolithin M5 is natural, with a metabolite pharmacopoeia and niche. There are impurities in this substance that are of synthetic origin and have an analytical HPLC standard. This substance has been researched and developed for use as an Impurity Standard.

6-Methylene progesterone acetate is a polymerase chain inhibitor that inhibits the synthesis of viral and cellular DNA. It was first isolated from infected cells in tissue culture and has been shown to inhibit the growth of a wide range of viruses, including rabies, herpes simplex, herpes zoster, cytomegalovirus, varicella-zoster virus, and vesicular stomatitis virus. 6MPAA also blocks the production of gene products in mammalian cells by preventing RNA synthesis. This drug can be used as an antiviral agent for treatment of enteritis caused by rotavirus infection. 6MPAA binds to gp2 protein on the surface of virus particles and prevents this protein from interacting with polyclonal antibodies or monoclonal antibodies to prevent antibody response.

Tacrolimus is a macrolide that is used as an immunosuppressive drug. It has been shown to bind to the FK-binding protein, which in turn inhibits calcineurin. This prevents the release of IL-2, TNF-α and other cytokines. The immunosuppressive effects of tacrolimus have been evaluated using analytical methods such as coefficients, affinity, and monitoring techniques such as immunoassays and agglutination. These techniques are used to evaluate the plasma concentration of tacrolimus. Tacrolimus also binds to proteins in the blood samples and can be detected by turbidimetric or electrochemiluminescence immunoassay reagents.

O3-Desethyl apremilast is an experimental drug product that belongs to the class of drug products. This drug product has been shown to be a natural, synthetic and analytical impurity in API. It is also an impurity standard for HPLC analysis. O3-Desethyl apremilast can be used in research and development, as well as niche applications in the pharmaceutical industry.

Atorvastatin epoxydione impurity (EPI) is a heptanoic, hydrate, diastereoisomer, racemic mixture, enantiomer and impurity of Atorvastatin. The EPI has been minimized in the formulation process by using a novel synthesis route that employs a chiral pyrrole derivative as an intermediate. This minimization has allowed for the elimination of the tautomer and other impurities present in the original compound.

Dicyclopropylamine is a molecule that has been clinically developed as a drug. It is an inhibitor of the enzyme tyrosinase, which is involved in the production of melanin, and has been shown to have anti-cancer properties. Dicyclopropylamine hydrochloride has been shown to be effective against aliphatic hydrocarbons such as hexane and cyclohexane, as well as aromatic compounds such as benzene and toluene. This drug can also bind to coordination complexes with high kinetic energy, which may be useful for tumor treatment. Dicyclopropylamine hydrochloride can be used for the clinical treatment of human epidermoid carcinoma.

N-(5-Aminopentyl) methotrexate amide is a fluorescent probe that is used to study the transport of drugs across cell membranes. It binds to the plasma membrane of cells and can be visualized with a fluorescence microscope. N-(5-Aminopentyl) methotrexate amide has been shown to bind to leukemia cells in murine leukemia models. It has a high affinity for drug-resistant cells, which makes it useful for studying drug resistance mechanisms. This probe can be used at nanomolar concentrations for imaging studies, as well as for measuring the uptake of drugs into cancer cells by flow cytometry.

Trazodone hydrochloride impurity H is an impurity of the drug product Trazodone hydrochloride. It is a natural metabolite of Trazodone hydrochloride, which is synthesized in vivo by oxidation of the parent compound. Impurity H has been identified as a potential impurity standard for HPLC-UV analysis of Trazodone hydrochloride. The purity of this compound is 98.3% and it is available on a custom synthesis basis.

Esomeprazole is a proton pump inhibitor used to treat gastroesophageal reflux disease and other conditions where there is too much stomach acid. It is available as a capsule or tablet in doses of 20, 40, and 60 mg. Esomeprazole inhibits the production of gastric acid by blocking the hydrogen/potassium adenosine triphosphate (H+/K+ ATPase) enzyme system at the secretory surface of the gastric parietal cells. Omeprazole is an acidic drug that blocks the H+/K+ ATPase enzyme system. The two drugs have been compared in two-way crossover studies using healthy volunteers who were given omeprazole magnesium for one week followed by esomeprazole sodium for another week. There was no difference in their effect on acid secretion or on heartburn relief. The plasma concentrations of both drugs increased with increasing dose, but there was no significant difference between them in terms of either

Colchicine EP Impurity B is a synthetic, impurity standard that is used in research and development for drug product development. It is also used as an analytical reagent. Colchicine EP Impurity B has been shown to be a metabolite of colchicine, which is found in the natural environment. This impurity can be synthesized by reacting 4-hydroxybenzaldehyde with nitroethane and sodium nitrite in the presence of hydrochloric acid. Analytical methods to detect this impurity include HPLC and GC-MS.

Trazodone Hydrochloride Impurity G is a synthetic compound that is an impurity found in Trazodone Hydrochloride, CAS No. 77893-17-6. This compound has the following physical properties: MW = 284.27, mp = 227-229°C, [α] D = -33.5° (c 1.0 in water), and UV max (λ max ) = 228 nm. It has been shown that this compound is not metabolized by human enzymes and is found to be natural. It can be used as a standard for HPLC analysis of Trazodone Hydrochloride Impurities A-F with the following retention times: 8.7 min for Impurity A, 9.2 min for Impurity B, 9.9 min for Impurity C, 10.4 min for Impurity D, 11.1 min for Impurity E, and 12.3 min for Impurity F.BR>BR

Terbinafine is an antifungal agent that belongs to the family of medicines. It is used to treat fungal infections of the skin, nails and scalp. Terbinafine can also be used to treat other types of fungal infections, such as tinea corporis (ringworm), tinea cruris (jock itch), tinea pedis (athlete's foot) and tinea capitis (scalp ringworm). Terbinafine dimer impurity dihydrochloride is a by-product of terbinafine hydrochloride that has been shown to have industrial applications as a dispersant or lubricant in industries such as papermaking.

Di-2-thienylmethanone is a pyrazole with an activation energy of about 10.5 kcal/mol. It has been found to be toxic and can cause cell lysis. This molecule has been used in the synthesis of a number of drugs, including thiopental, a barbiturate that is used as an anaesthetic. Di-2-thienylmethanone is also the precursor for the synthesis of fluoroquinolones, which are potent antibacterial agents. The Friedel-Crafts reaction is one way this molecule is synthesized, and it involves the addition of an alkyl halide to an unsaturated double bond. This reaction is named after Charles Friedel and James Crafts who first discovered it in 1877.

9-Oxo azithromycin B is a metabolite of azithromycin. It is an analytical standard for the HPLC analysis of azithromycin and its metabolites. 9-Oxo azithromycin B has been shown to bind to the ribosomes of bacteria, and inhibit protein synthesis. This drug also has antibiotic activity against Mycobacterium avium and Mycobacterium tuberculosis. 9-Oxo azithromycin B can be used in niche research or as an API impurity.br>
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Tirzepatide impurity.

Decitabine Impurity 12 is an analytical standard that is used in the research and development of drug products. It is a high purity, HPLC-grade impurity that complies with USP/NF requirements. Decitabine Impurity 12 has been shown to be a metabolite of decitabine, which is an anti-cancer drug used in the treatment of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This impurity has also been shown to have pharmacopoeia value as an impurity standard for drug products.

6-Epi pravastatin sodium salt is a synthetic compound with the same molecular formula and chemical structure as the natural product. It has been used in pharmacological studies, drug development, and research. 6-Epi pravastatin sodium salt is a metabolite of pravastatin.