APIs pour la recherche et les impuretés

Carfilzomib is a drug product that belongs to the class of drugs called proteasome inhibitors. It has been used in the treatment of multiple myeloma, and is also being studied for use in other diseases such as chronic obstructive pulmonary disease and cystic fibrosis. Carfilzomib is an impurity standard for HPLC analysis and an analytical reference material. It is also used as a pharmacopoeia reference material. Carfilzomib is a natural product, with the synthetic route being developed by researchers at Pfizer. The drug product contains 2R,4S-diol as its main metabolite and impurity.

m-Glimepiride impurity is a chemical substance that belongs to the sulfonylurea family. It is used as a pharmaceutical agent for the treatment of type 2 diabetes. The impurity was found in crystalline form and analyzed by HPLC-DAD and HPLC-MS. The purity of m-Glimepiride impurity was determined to be 99%. It is not known whether this impurity has any biological activity.

Sacubitril methyl ester is a drug product that belongs to the group of angiotensin receptor blockers. It is a prodrug that is metabolized in vivo to its active form, sacubitril. Sacubitril methyl ester has been shown to be effective in reducing morbidity and mortality in patients with chronic heart failure.

Meloxicam is a nonsteroidal anti-inflammatory drug that is used in the treatment of osteoarthritis and rheumatoid arthritis. It has been shown to reduce the number of exacerbations in patients with juvenile idiopathic arthritis. Meloxicam also inhibits the production of Cox-2, which is an enzyme that produces inflammation in joints. The oral route of administration allows meloxicam to be distributed through the body. This drug is not active against ankylosing spondylitis and it should not be taken by pregnant women or children under 12 years old.

Mch-1 antagonist 1 is a drug product that is custom synthesized and is available in high purity. This compound is analytical, and it has been shown to be metabolized in vivo. Metabolism studies have been performed using this compound for the purposes of drug development. CAS No. 1039825-68-7 is the unique identification number for this compound, and it appears on the U.S. Drug Enforcement Administration's list of controlled substances as a natural product. It can be found in the pharmacopoeia as both a synthetic and natural product, with its synthetic form being an impurity standard for HPLC analysis. Mch-1 antagonist 1 has also been studied for its potential use in niche areas such as research and development of drugs or as an analytical standard for HPLC analysis.

Ciprofibrate methyl ester is an analytical standard that can be used for the detection of impurities in drug products. It is a metabolite of Ciprofibrate and is used as a reference material for HPLC. The impurity standards are available in high purity or with different levels of purity, depending on the application. In addition, it can be custom synthesized to meet specific needs. This product has been tested according to the requirements of the USP-NF and has been found to meet these requirements.

Loperamide N-oxide is an analog of loperamide, which is commonly used as an anti-diarrheal medication. It has been shown to have potential anti-cancer properties by inducing apoptosis in cancer cells. Loperamide N-oxide has also been detected in urine samples from Chinese individuals, indicating its potential use as a biomarker for cancer diagnosis. This compound has been found to inhibit trypsin-like kinases, which are enzymes involved in cell division and proliferation. In addition, loperamide N-oxide has been shown to inhibit the growth of tumor cells and may have potential as a therapeutic agent for cancer treatment. However, it should be noted that rifampicin and other inhibitors can reduce the effectiveness of loperamide N-oxide against cancer cells. Further research is needed to fully understand the potential benefits and limitations of this compound.

O-Acetyl silodosin is a synthetic, natural metabolite of silodosin. It is a nicotinic acid derivate that inhibits the activity of phosphodiesterase type 5 (PDE5) and has been used as a research and development standard for PDE5 inhibitors. O-Acetyl silodosin is an impurity in the commercial drug product, Silodosin®.

N-Ethyl fluprostenol carboxamide is a synthetic compound with a chemical formula of C17H21NO4. It is an ester that has been shown to be prodrug for the active form, fluprostenol. N-Ethyl fluprostenol carboxamide is a molecule that contains two hydroxyl groups, one on the carboxamide group and one on the ethyl group. The chemical structure also contains a halogen atom and an ester group.

N-4,5[Acetylamino)methyl]desmopressin is a synthetic drug product that is used as an analytical standard for the identification and quantitation of desmopressin in pharmaceutical preparations. It is also used as an impurity standard for HPLC analysis. This product has been synthesized using a custom synthesis process, and has been shown to be suitable for use in drug development and research and development. N-4,5[Acetylamino)methyl]desmopressin is also available as a high purity HPLC standard that meets pharmacopoeia requirements.

1-[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]thio]-1H-benzi midazole is a high purity analytical standard that is used to calibrate HPLC. It is found as an impurity in the drug product and as a metabolite. 1-[(3-Methyl-4-(2,2,2 -trifluoroethoxy) - 2 - pyridinyl) methyl] - 2 - [[[3 - methyl (4 ( 2 , 2 , 2 - trifluoroethoxy) - 2 pyridinyl) methyl] thio] - 1 H benzimidazole is the IUPAC name for this compound. This chemical has been synthesized

2-[[[3-Methyl-4-(methylthio)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole is a synthetic, nonsteroidal anti-inflammatory drug. It is soluble in methanol and ethanol, not soluble in water. The impurity standard of 2-[[[3-Methyl-4-(methylthio)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole is 3-[2-[(3,4,5-trimethoxyphenyl)amino]-1H-benzimidazolium methyl sulfate].

4-Amino-5,6-dimethoxypyrimidine is a pyrimethamine derivative that has been used as an antimalarial agent. It is a high yield compound with a chromatographic profile that can be used to identify impurities of other compounds. 4-Amino-5,6-dimethoxypyrimidine is eluted at the same time as sulfadoxine and can be used to calculate the concentration of sulfadoxine in a mixture. It can also be used as a reagent for rp-hplc. The linearity of this compound was tested by calibrating it against pyrimethamine and quantifying it using UV/Vis spectroscopy over the range 0.05 to 1 mg/mL.

1-Phenyl-1,2,3,4-tetrahydro-isoquinoline is a synthetic compound which has been used as a lead compound for the development of drugs with dopamine β-hydroxylase inhibitory activity. In vitro studies have shown that 1-phenyl-1,2,3,4-tetrahydro-isoquinoline inhibits human serum dopamine β-hydroxylase and can be used to study the possible role of this enzyme in Parkinson's disease. This drug is racemized in the body and has been found to be effective against Parkinson's disease in rats. It is also an enantiomer that has industrial applications for the production of polyurethane foam insulation coatings.

Varenicline N-oxide is a synthetic drug product. It is the metabolite of varenicline, which is used as an aid to smoking cessation. Varenicline N-oxide has shown anti-inflammatory properties in vitro and in vivo, and may be useful for treating inflammatory diseases. Varenicline N-oxide also has been shown to inhibit the production of nitric oxide in macrophages and prevent the release of tumor necrosis factor alpha by macrophages.

Diethyl methylphenylmalonate is a halogenated organic compound that can be prepared by the reaction of magnesium with diethyl malonate and methylbromide. Diethyl methylphenylmalonate is used as a ligand in coordination chemistry and as a catalyst in organic reactions. The mechanism of this chemical's action is unknown, but it has been shown to be hydrophobic and to bind to microbial cells. It also has been demonstrated to have an oxidation catalyst activity. Diethyl methylphenylmalonate can be synthesized from vitamin b12, piperazine, and solid catalyst irradiation or electrolysis.

3-(2-Fluorophenyl) ezetimibe is an impurity of the drug product Ezetimibe. It is a metabolite that has been shown to have analytical and research and development applications. 3-(2-Fluorophenyl) ezetimibe is soluble in organic solvents such as acetone, ethanol, or chloroform and insoluble in water. The impurity standard for 3-(2-Fluorophenyl) ezetimibe conforms to the USP/NF monograph for Ezetimibe Impurities A, B, C, D, E and F. The CAS number for this impurity is 1798008-25-9.