APIs pour la recherche et les impuretés

<p>BIM 23052 is an analog kinase inhibitor that has been shown to have potent anticancer activity. It targets specific proteins in cancer cells and induces apoptosis, leading to cell death. BIM 23052 has been tested extensively in human urine and Chinese hamster ovary cells, demonstrating its effectiveness against a wide range of tumor types. This medicinal compound inhibits several kinases involved in cancer progression, making it a promising candidate for the treatment of various cancers. Its unique mechanism of action makes it a valuable addition to the arsenal of anticancer drugs available today.</p>

<p>Labetalol is a carboxylic acid that is used as a drug to lower blood pressure. It belongs to the group of beta-blockers and has been shown to have anti-inflammatory properties. Labetalol is a monomer that can be polymerized into homopolymers or copolymers with other monomers, such as styrene, methyl methacrylate, and acrylonitrile. Labetalol has the ability to polymerize by radical polymerization. The molecular weight of labetalol ranges from 500-2000 Da and it can be used in the preparation of phosphorylcholine which is an important constituent of cell membranes.</p>

<p>FR183998 is an anticancer drug that is derived from Chinese urine. It is a potent inhibitor of human tumor cell growth and has been shown to induce apoptosis in cancer cells. FR183998 works by inhibiting kinases, which are proteins that play a critical role in cell division and proliferation. This drug has been found to be effective against a wide range of cancers, including breast, lung, and colon cancer. Additionally, FR183998 has analogs that have been developed as kinase inhibitors for the treatment of various types of cancer. The use of FR183998 as an anticancer agent shows great promise in the development of new treatments for cancer patients.</p>

<p>Esmolol is a drug product that has been developed for the treatment of cardiac arrhythmias. It is an ester prodrug of esmolol, which is metabolized by hydrolysis to produce esmolol. Esmolol isopropyl amine hydrochloride (ESA) is an analytical standard used as a reference compound in HPLC methods. ESA is an impurity standard for API esmolol and CAS number 83356-59-6. Research on ESA has shown that it undergoes rapid metabolism to form metabolites that are detectable in plasma. Metabolism studies have shown that this drug has niche applications in the field of pharmacopoeia and high purity pharmaceuticals.</p>

<p>Brimonidine-2,3-dione is a synthetic compound that is used as an impurity standard in the research and development of drugs. It has a CAS number of 182627-95-8. The synthesis of Brimonidine-2,3-dione is not disclosed to the public. The drug product containing this substance is a high purity pharmaceutical grade. It has been shown to be metabolized in animal studies.</p>

<p>Please enquire for more information about NSC 116339 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Levofloxacin is a synthetic molecule with an asymmetric carbon atom in its heterocycle. It is synthesized by reacting chloroform with 2-fluoro-5-nitrobenzaldehyde, which reacts further with sodium hydroxide and hydrochloric acid to form the levofloxacin carboxylic acid. Impurities can be found in the reaction product due to chlorine atoms that are formed during the synthesis. The amount of impurities present in the final product can be determined using a titration method or through HPLC analysis. Levofloxacin has been shown to be effective against methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium perfringens, although is not active against acid-fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex.</p>

<p>3-[(1E)-2-[4-[[(2-Carboxyethyl)amino]carbonyl]phenyl]diazenyl] balsalazide is a white to off-white solid that is soluble in water and acidic solutions. It has an impurity level of less than 0.5%. The melting point of 3-[(1E)-2-[4-[[(2-Carboxyethyl)amino]carbonyl]phenyl]diazenyl] balsalazide is approximately 195°C. This compound has been shown to have antibiotic activity against a variety of bacteria, including methicillin resistant Staphylococcus aureus (MRSA).</p>

<p>N-Ethoxycarbonyl norfloxacin is a custom synthesis for research and development. It is an impurity standard used to determine the purity of drug product. This compound is synthesized using the chemistry of synthetic organic compounds, and it has a high purity. N-Ethoxycarbonyl norfloxacin can be used as a pharmacopoeia reference material or as a metabolite in metabolism studies.</p>

<p>1,3-Benzodioxol-5-yl[4-(2-chloroethoxy)phenyl]methanone (1,3-BDE) is a synthetic compound that is intended for use as an analytical reference standard. 1,3-BDE has been shown to inhibit the growth of Mycobacterium tuberculosis and Mycobacterium avium complex in vitro. This drug product is intended for research and development purposes only.</p>

<p>Norethindrone acetate impurity is a drug product that is used in the development and research of drugs. It is an analytical standard for norethindrone acetate, which is an impurity found in the synthesis of this drug. Norethindrone acetate impurity can be synthesized in different ways, such as natural or synthetic routes. It is also available as a custom synthesis or it can be purchased as an impurity standard. This compound's CAS number is 1175129-26-6 and it has a purity level of 99%.</p>

<p>Alloc bromoridane is a drug product that contains the active ingredient bromoridane. Bromoridane is a natural metabolite of the plant alkaloid berberine and has been shown to inhibit the activity of bacterial type IIA topoisomerases from both Gram-positive and Gram-negative bacteria. The chemical name for Alloc bromoridane is 2-[2-(4-bromobenzoyl)phenyl]dihydropyrimidine, and it has CAS number 117348-70-6. Bromoridane is an impurity standard in pharmacopoeias such as USP XXII, European Pharmacopoeia 6th Edition, Japanese Pharmacopoeia 2006, and Chinese Pharmacopoeia 2005. Alloc bromoridane is used in research and development for pharmaceuticals or as an analytical reference material.</p>

<p>Anastrozole is an aromatase inhibitor that has been used in the treatment of breast cancer. It binds competitively to the heme moiety of aromatase, blocking its access to substrate and thereby inhibiting estrogen production. Anastrozole dimer impurity is an analytical impurity found in drug products that is not a natural component of the API (active pharmaceutical ingredient). CAS No. 1216898-82-6 refers to this impurity standard as well as other synthetic analogues. This impurity is a custom synthesis with no pharmacopoeia standards for purity. The HPLC standard for this product is high purity (99%).</p>

<p>Please enquire for more information about 3-Desmethyl-3-(5-oxohexyl) pentoxifylline including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(+)-o-Desmethyl-N,N-bisdesmethyl tramadol is a synthetic opioid analgesic. It has a chemical structure that is similar to morphine, but with two methyl groups at the 3 and 6 positions of the benzene ring. (+)-o-Desmethyl-N,N-bisdesmethyl tramadol binds to mu receptors in the brain and spinal cord, which block pain signals from being sent to the brain. It also inhibits norepinephrine reuptake, leading to increased levels of this neurotransmitter in the synapse. This increased level of norepinephrine leads to an increase in pain relief.</p>

<p>Ritonavir impurity N is an impurity in Ritonavir, a drug product. It has been shown to have natural origin. Impurities are substances that are not part of the desired drug substance and may cause side effects or reduced efficacy. Analytical studies such as HPLC can be used to identify impurities in a drug product. CAS No. 202816-62-4 is the Chemical Abstracts Service Registry Number for this compound. This compound is available as an analytical standard and as a synthetic API impurity. It is also available as an impurity standard for HPLC and pharmacopoeia grade material.END&gt;</p>

<p>Trazodone Impurity A is a drug product that is an impurity standard for Trazodone. It has been classified as a synthetic metabolite and is used in analytical research studies. Trazodone Impurity A has demonstrated niche applications in the pharmaceutical industry, including metabolism studies, pharmacopoeia requirements, and HPLC standards.</p>

<p>Tetrahydrocurcumin monoglucuronide is an analog of curcumin, a natural compound found in turmeric. It has been shown to have potent anticancer properties by inhibiting kinases involved in cancer cell growth and proliferation. Tetrahydrocurcumin monoglucuronide has also been found to inhibit testosterone production, making it a potential treatment for hormone-dependent cancers such as prostate cancer. This compound induces apoptosis, or programmed cell death, in cancer cells and has been studied extensively for its potential use in Chinese traditional medicine for the treatment of various types of tumors. Tetrahydrocurcumin monoglucuronide is excreted in urine and is a promising candidate for the development of kinase inhibitors for cancer therapy.</p>

<p>4-HO-DPHP is a cyclic analog of a Chinese plant-derived compound that has been shown to have anticancer properties. It functions as an inhibitor of kinases, which are enzymes involved in the regulation of protein activity and cell signaling pathways. In vitro studies have demonstrated that 4-HO-DPHP can induce apoptosis in human cancer cells, making it a potential candidate for cancer treatment. Additionally, this compound has been found in urine samples from cancer patients, suggesting that it may play a role in the body's natural defense against tumor growth. Overall, 4-HO-DPHP shows promise as a novel anticancer agent with potential therapeutic applications.</p>

<p>BMS-986299 is a Chinese compound that acts as an inhibitor of kinases, specifically targeting cyclin-dependent kinases (CDKs). This compound has been shown to inhibit the growth of cancer cells in humans by inducing apoptosis and inhibiting tumor cell proliferation. BMS-986299 is an analog of another anticancer compound and has been found to be highly effective against various types of cancer. This inhibitor has also been shown to have a high degree of selectivity for CDKs and to be well-tolerated in clinical trials. The compound can be detected in urine samples, making it a useful biomarker for monitoring treatment efficacy. Overall, BMS-986299 shows great potential as a promising new treatment option for cancer patients.</p>

<p>This compound is a drug product that is used as an analytical standard for the identification of impurities. This compound is also a Metabolism studies, Natural, API impurity, Custom synthesis, Impurity standard, Synthetic and Drug development research chemical. The CAS number for this compound is 170570-01-1 and it has HPLC standards with high purity. This compound is also a Synthetic and Pharmacopoeia Research Chemical with a niche market.</p>

<p>((3R,5S,6E)-Methyl-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin -3-yl)-3,5-dihydroxyhept-6-enoate is a metabolite of the drug product. It is a white to off-white crystalline powder that is soluble in methanol and insoluble in water. This compound has been shown to be an impurity standard for HPLC analysis of the drug product. ((3R,5S,6E)-Methyl-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin -3-yl)-3,5-dihydroxyhept-6-enoate has been used in metabolism studies and pharmacopoeia as a reference substance for the analytical testing of drugs. It can also be synthesized for research purposes.</p>

<p>N-Desmethyltoremifene is an anti-estrogen that has been shown to have genotoxic effects. It inhibits DNA synthesis and protein synthesis in human breast cancer cells. N-Desmethyltoremifene is a potent inducer of CYP3A4, which metabolizes many drugs. This drug also binds to α1-acid glycoprotein, which can lead to reduced plasma concentrations and pharmacokinetics. N-Desmethyltoremifene has been shown to inhibit the growth of renal cell carcinoma in animals, but not normal tissue, at high doses.</p>

<p>Stafib-2 is an analog inhibitor that has shown potent anticancer activity in human cancer cell lines. It works by inhibiting kinases, which are enzymes that play a key role in regulating cell growth and division. Stafib-2 has been shown to induce apoptosis, or programmed cell death, in Chinese hamster ovary cells and human cancer cells. This drug also inhibits the activity of elastin kinase, a protein that is involved in tumor growth and metastasis. Stafib-2 has potential as a targeted therapy for cancer treatment due to its ability to selectively inhibit specific kinases involved in cancer progression. Its unique mechanism of action makes it a promising candidate for further development as an anticancer agent.</p>

<p>Paclitaxel impurity O is a synthetic drug that is used in the treatment of cancer. It is an impurity standard for use in research and development, as well as a custom synthesis. Paclitaxel impurity O has been shown to have a high purity and can be used as a metbolite or analytical standard. It has been shown to possess anti-inflammatory properties, which may be due to its ability to inhibit prostaglandin synthesis.</p>

<p>(5aR,10aR)-Tetrahydro-3H,5H,8H,10H-bisthiazolo[3,4-a:3',4'-d]pyrazine-5,10-dione is a drug product that is an impurity standard for the API (Active Pharmaceutical Ingredient) 5α-tetrahydrospiro[benzofuran-1(3H),2'(3'H)]pyrido-[2,1'-cyclohexan]-6β,7β-(1'H)-dione. It is a metabolite of this API and can be used as a research and development analytical standard for HPLC. The CAS number for this compound is 72744-67-3. This substance has been found in natural products such as the seeds of Sesamum indicum L., Cucurbita maxima Duchesne var.</p>

<p>Tametraline is a medicinal compound that has been used in Chinese traditional medicine to treat tumors. It is an analog of protein kinase inhibitors and has shown potent anticancer activity in preclinical studies. Tametraline is an inhibitor of kinases, which are enzymes involved in the regulation of cell growth and division. It induces apoptosis, or programmed cell death, in cancer cells by inhibiting the activity of these enzymes. Tametraline has also been found to be excreted in urine, indicating that it can be effectively metabolized by the human body. This compound holds great promise as a potential treatment for various types of cancer.</p>

<p>Bletilol B is a medicinal compound that has been shown to induce apoptosis in human cancer cells. It acts as a cyclin-dependent kinase (CDK) inhibitor, disrupting the cell cycle and preventing tumor growth. Bletilol B has been tested on various cancer cell lines and has demonstrated potent anticancer activity by inhibiting the proliferation of cancer cells. This compound works by binding to the active site of CDKs and blocking their activity, leading to cell cycle arrest and ultimately causing apoptosis. In addition, Bletilol B also inhibits the expression of proteins involved in cancer cell survival, making it an attractive candidate for future anticancer therapies.</p>

<p>N-Des[2-(1-methyl-2-pyrrolidinyl)ethyl] udenafil is an impurity in the drug product. It is a synthetic compound and is a metabolite of the drug product. N-Des[2-(1-methyl-2-pyrrolidinyl)ethyl] udenafil is present as a byproduct of the metabolism of the active ingredient. The CAS number for this substance is 319491-68-4. This impurity has been observed to have niche applications in research and development and analytical studies. It has also been found to be pharmacopoeia grade, which means it meets or exceeds purity standards set by regulatory authorities.</p>

<p>Benzo[b]thien-2-yl ketone (zileuton impurity) is a metabolite of the drug zileuton, which is used to treat asthma. Benzo[b]thien-2-yl ketone is formed by the oxidation of benzo[b]thiophene in the presence of cytochrome P450 enzyme system. It has been found to have anti-inflammatory properties and may be useful for treating asthma. This product is available as an analytical standard for HPLC, or as a custom synthesis for research and development.</p>

<p>Fenticonazole sulfone nitric acid salt is an analog of dabigatran, which is a protein kinase inhibitor that has shown potential in the treatment of cancer. It induces apoptosis in human cancer cells and inhibits the activity of various kinases involved in tumor growth and proliferation. Fenticonazole sulfone nitric acid salt has been studied extensively for its anticancer properties, showing promising results in Chinese hamster ovary cells and urine samples from cancer patients. This drug also exhibits inhibitory effects on protein kinases that are involved in the regulation of cell cycle progression, angiogenesis, and metastasis. Overall, Fenticonazole sulfone nitric acid salt holds great promise as a potential anticancer agent.</p>

<p>Please enquire for more information about Rosuvastatin impurity 42 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Bis(o-ethylbenzylamine) catechol dihydrochloride is a potent inhibitor of protein kinases that play a crucial role in the regulation of the cell cycle. It has been shown to induce apoptosis in various human cancer cell lines, including leukemia and Chinese hamster ovary cells. This compound inhibits the activity of several kinases, including indoleamine 2,3-dioxygenase (IDO), which is involved in tumor immune evasion. Bis(o-ethylbenzylamine) catechol dihydrochloride also acts as an inhibitor of other key proteins involved in the growth and proliferation of cancer cells. Its unique mode of action makes it a promising candidate for the development of novel anticancer therapies.</p>

<p>Solifenacin N-oxide is an anti-cholinergic agent that has been shown to be effective in the treatment of overactive bladder. Solifenacin N-oxide is a prodrug that is hydrolyzed in vivo to solifenacin, its active form. The compound reversibly binds to muscarinic receptors and inhibits the release of acetylcholine. Solifenacin N-oxide has been shown to have low levels of impurities and is highly soluble in water. It was also found to be stable when stored at room temperature for two months. This drug has a high flow rate and moderate retention time, which makes it suitable for reversed-phase liquid chromatography (RPLC). RPLC is a chromatographic technique that separates compounds by size, hydrophobicity, or charge.</p>

<p>Carbamazepine is a drug that has been used to treat epileptic seizures and trigeminal neuralgia. Impurities in the drug are removed by using chromatographic methods, such as high-performance liquid chromatography (HPLC). The rotarod test is an animal model of motor coordination and balance that can be used to assess the effects of drugs on these functions. Carbamazepine impurities may cause depression and have an epileptic effect on animals. Chronic exposure to carbamazepine can lead to drug reactions and gene polymorphisms, which may alter the metabolism of the drug. Analytical methods for determining carbamazepine impurities include HPLC, gas chromatography mass spectrometry (GC-MS), and thin-layer chromatography (TLC).</p>

<p>6-Fluoro-3-indoxyl-beta-D-galactopyranoside is an active compound used as an antituberculosis drug. It belongs to the class of rifamycins and is highly effective in treating tuberculosis infections. This drug works by inhibiting bacterial growth through its bactericidal activity. By binding to DNA-dependent RNA polymerase, it prevents transcription and replication, effectively stopping the spread of the infection. Additionally, 6-Fluoro-3-indoxyl-beta-D-galactopyranoside specifically targets Mycobacterium tuberculosis strains and inhibits their cell growth. With its various metabolic transformations and interactions with enzymes, this drug is a powerful weapon against tuberculosis.</p>

<p>Amoxicillin EP Impurity E is an impurity found in Amoxicillin EP, which is a β-lactam antibiotic. It belongs to the group of β-lactam antibiotics and has antibacterial activity. Amoxicillin EP Impurity E is found by applying validation methods to measure the concentration of this product. The analytical method used for this impurity is a wavelength measurement or a magnetic field measurement. This impurity can be determined using chromatographic or elution methods. The chromatographic methods used are high performance liquid chromatography (HPLC) and gas chromatography (GC). Method development is required for determining the level of this impurity, as well as validation procedures for measuring it with various methods.</p>

<p>6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxylic acid (CA) is an impurity found in the drug lorazepam. It is a chemical intermediate that is not active as a pharmaceutical agent, but has been studied for use in treating epilepsy and other neurological disorders. CA is an excipient used to manufacture other drugs such as salicylic acid and the surfactant sodium lauryl sulfate. It has been shown to have acidic properties and can be used as a surfactant, which is helpful in chromatographic methods to separate molecules by size. CA also binds to chloride ions, which are necessary for the proper functioning of many cellular processes. CA's molecular weight is 322 daltons and it exhibits no pharmacological activity.</p>

<p>Ezetimibe fluoro isomer is a drug product that is used to research and develop new drugs. It has a natural origin, and is an impurity standard for analytical purposes. Ezetimibe fluoro isomer can also be synthesized in the laboratory. This product can be metabolized by the body into its active form, ezetimibe, which inhibits cholesterol absorption in the gut by inhibiting intestinal ileal NPC1L1 protein. The pharmacopoeia recommends a purity of 98%, but this product contains 99% purity.</p>

<p>N-Acetyl N-descarboxyethyl retigabine (D4) is a pharmaceutical drug that is used for the treatment of epilepsy. It has been shown to be effective in patients who have not responded to other treatments. D4 binds to voltage-gated potassium channels and inhibits their opening, which leads to a decrease in neurotransmitter release from nerve cells. The mechanism by which D4 induces epileptic seizures is unclear but may be due to its ability to inhibit the activity of GABA receptors in the brain.</p>

<p>(S)-3-((R)-5-Oxopyrrolidine-2-carbonyl)thiazolidine-4-carboxylic acid is a drug product of the drug development industry. It is a metabolite of 3-(1,2,4-triazol-1-ylmethyl)thiazolidine-4-carboxylic acid and has been used as an analytical standard for HPLC methods. The compound has been shown to be naturally occurring in humans. (S)-3-(1,2,4-Triazol-1ylmethyl)thiazolidine 4 carboxylic acid is also used as the impurity standard for the API 3-(1,2,4 triazol 1ylmethyl)thiazolidine 4 carboxylic acid.</p>

<p>Lysolecithin is an analog of the phospholipid lecithin that has been shown to have anticancer properties. It works by inhibiting kinases, which are enzymes that play a crucial role in cell signaling and regulation. Lysolecithin promotes apoptosis, or programmed cell death, in cancer cells, making it a promising medicinal agent for the treatment of tumors. Studies have also shown that lysolecithin can inhibit protein kinase activity in human urine and inhibit the growth of cancer cells in Chinese hamsters. This compound may prove to be a valuable tool in the development of kinase inhibitors for cancer therapy.</p>

<p>Hydroxychloroquine N-oxide is a drug product that is an impurity of hydroxychloroquine. It is an analytical standard for the determination of hydroxychloroquine in pharmaceutical preparations and for research and development of new products. Hydroxychloroquine N-oxide is also used as an impurity standard for HPLC with UV detection, LC/MS, and GC/MS. The chemical formula of this compound is C6H7ClN3O4. The molecular weight of this compound is 231.09 g/mol. Hydroxychloroquine N-oxide has CAS No. 1449223-88-4 and natural status. br&gt;br&gt; Hydroxychloroquine N-oxide is primarily used as a synthesis intermediate in the production of drugs, such as antihypertensives, antimalarials, antidepressants, antipsychotics, immunosuppressants and immunomodulators.br&gt;br&gt; The</p>

<p>α-(4-Chlorophenyl)-2-ethyl-1,3-dioxolane-2-acetonitrile is a metabolite of the drug product α-[4-(chlorophenyl)phenoxy]ethanol. It has been used as an impurity standard for HPLC and as a pharmacopoeia.<br>!--</p>

<p>Please enquire for more information about 2-[[2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-1H-isoindole-1,3(2H)-dione including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Deterenol acetate is a drug product that is used as an analytical standard. It has been shown to be a natural metabolite of the synthetic drug deterenoic acid, which is an impurity in API preparations of the drug. Deterenol acetate has been shown to have anti-inflammatory effects and may be useful for treating cardiovascular disease, cancer, and arthritis. Deterenol acetate has also been shown to have potential as a treatment for high blood pressure.</p>

<p>Valdecoxib dimer is a drug product that has been custom synthesized to meet the customer's requirements. It is an analytical standard and is available in high purity. Valdecoxib dimer has been shown to be metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Valdecoxib dimer also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture. The drug product may also be used as a pharmacopoeia impurity standard for HPLC analysis of natural products.</p>

<p>N-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-formamide is an analytical standard that is used for the determination of formamide in pharmaceutical formulations. N-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-formamide is a synthetic compound and has a natural impurity which may be present at levels up to 10%. The CAS number for this compound is 911805-54-4. N-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-formamide is an impurity standard for HPLC analysis. It has been synthesized and characterized by the United States Drug Enforcement Agency (DEA). It can be used as a reference substance in pharmacopoeia standards.</p>

<p>Please enquire for more information about 4'-Bromo-2-(diethylamino)-2',6'-acetoxylidide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>O-Acetyl silodosin is a synthetic, natural metabolite of silodosin. It is a nicotinic acid derivate that inhibits the activity of phosphodiesterase type 5 (PDE5) and has been used as a research and development standard for PDE5 inhibitors. O-Acetyl silodosin is an impurity in the commercial drug product, Silodosin®.</p>

<p>(E)-4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobut-2-enoic acid is an organic compound that is a metabolite of the drug product. It is a synthetic chemical compound and does not occur in nature. It has been used as an analytical standard for HPLC and LC/MS. It has also been used as an impurity standard for API's. This product is typically produced synthetically, but can be obtained through metabolism studies with niche organisms such as fungi or bacteria. It should be noted that this product is not pharmacopoeia grade and cannot be used in medical devices or drugs.br&gt;br&gt;<br>This product has been classified by the International Union of Pure and Applied Chemistry (IUPAC) as a 2-(3-(aminoc</p>

<p>2-Bromo-4-chloro-N-methyl-N-phenyl-butanamide is an analog of saxagliptin, a protein inhibitor that has been shown to induce apoptosis in cancer cells. This compound has demonstrated potent anticancer activity in vitro and in vivo, inhibiting the growth of tumor cells by targeting kinases involved in cell proliferation and survival. It has also been found to be effective against a variety of human cancer types, including breast, prostate, and lung cancer. Additionally, 2-Bromo-4-chloro-N-methyl-N-phenyl-butanamide has been shown to have potential as a urine biomarker for detecting early-stage Chinese bladder cancer. Overall, this compound shows promise as a potent inhibitor of cancer cell growth and may have important applications in the development of novel anticancer therapies.</p>

<p>3-(Cyanomethyl)-N-methyl-1H-indole-5-methanesulfonamide is an analytical standard, used for HPLC analysis of impurities. It is also used as a reference in certain pharmacopoeia standards, such as the USP and EP. 3-(Cyanomethyl)-N-methyl-1H-indole-5-methanesulfonamide has a purity of 99% and can be found in the drug product Impurity Standard.</p>

<p>4-Hydroxy-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide-1,1dioxide is a drug product that is used as an analytical reference material. It is a white to pale yellow powder that is soluble in water and has a molecular weight of 343.4 g/mol. The compound has been used for the development of drugs with therapeutic potential against cancer, diabetes, and other diseases. The following are some of the impurities that may be found in 4-hydroxy-N-2-pyridinyl-2H--1,2--benzothiazine--3--carboxamide--1,1dioxide: CAS No.: 65897 - 46 - 3 Molecular weight: 343.4 g/mol Melting point: Boiling point: Density: 1.7 g/cm</p>

<p>Santhopine is a medicinal compound that has shown to be a promising anticancer agent. It is a kinase inhibitor that targets various protein kinases involved in cancer cell proliferation and survival. Santhopine has been found in the urine of Chinese cancer patients and has been shown to induce apoptosis (programmed cell death) in human cancer cells. This compound inhibits the cell cycle, preventing the uncontrolled growth of tumor cells. Santhopine's potential as an anticancer drug makes it an exciting area of research for cancer treatment.</p>

<p>4-Hydroxy mexiletine hydrochloride is a compound with a high viscosity and the presence of impurities. It forms hydrogen bonds and has been found to interact with growth factors such as epidermal growth factor (EGF). This compound has been shown to have neutralizing effects on CDK4/6 inhibitors like palbociclib, which are commonly used in cancer treatment. Additionally, 4-Hydroxy mexiletine hydrochloride binds to proteins involved in cellular processes, such as interleukin-6 (IL-6) and monoclonal antibodies. Its structure includes a chelate ring, which can be observed in its mass spectrum analysis. Furthermore, this compound has demonstrated an impact on hepatocyte growth and phycocyanin.</p>

<p>Loe 908 hydrochloride is a cytosolic calcium ionophore with a biphasic response. It activates epidermal growth factor and inhibits myosin phosphatase, inhibiting the activation of the Ras pathway. Loe 908 hydrochloride has been shown to inhibit carotid artery constriction in rats. This drug acts by binding to cation channels in blood vessel walls, which prevents the influx of calcium ions into the cells of the vessel wall. Loe 908 hydrochloride also binds to 5-HT2 receptors and activates them. The result is an increase in intracellular calcium levels and inhibition of adenylyl cyclase, which leads to a decrease in cyclic AMP levels. This leads to decreased contractility in smooth muscle cells and relaxation of arterial smooth muscle cells.</p>

Fluticasone furoate impurity K is a synthetic drug product that is used in the manufacture of pharmaceutical products. It has a CAS Number of 220589-37-7, and the purity of the compound is >98%. The compound has been synthesized using natural starting materials, and it has undergone metabolism studies to determine its pharmacological activity. Fluticasone furoate impurity K is on the list of substances that are not scheduled by the US DEA. Fluticasone furoate impurity K is an analytical standard and Metabolite for use in HPLC analysis. Fluticasone furoate impurity K can be used as a Research and Development or Pharmacopoeia standard. This compound may also be useful for niche applications such as Drug development or Custom synthesis.

<p>Please enquire for more information about 5-Deoxy-Δ5,6-8-epi-tacrolimus including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>DL-threo-Ritalinic Acid is a dopamine receptor agonist that has been shown to be effective in treating hyperactivity, or attention deficit disorder (ADHD). It has been found to be more efficacious than dextro-amphetamine, another stimulant drug used for the treatment of ADHD. DL-threo-Ritalinic Acid is believed to work by affecting the neurotransmitters in the brain and altering the balance of dopamine receptors. In a two-way crossover study, preschool children were given either 0.5mg/kg of DL-threo-Ritalinic Acid or placebo for three days. The results showed that this drug was more effective than placebo and significantly improved reaction time. DL-threo-Ritalinic Acid also increased α1 acid glycoprotein levels in plasma, which may account for its effectiveness as an antihypertensive agent.</p>

<p>Des-chloromeclozine-d9 is a research and development impurity standard. It is used as an impurity in the synthesis of meclozine, a drug product. This compound is synthesized using the organic chemistry laboratory technique called custom synthesis. The purity of this compound is high and it meets the requirements of pharmacopoeia standards for analytical use. Des-chloromeclozine-d9 has been found to be a metabolite of meclozine and may have some niche applications for metabolism studies. This synthetic compound has CAS number 16896-82-5.</p>

<p>2-Methoxyethyl-3-aminocrotonate is an impurity of a drug product. It is an analytical standard that is used to quantify the metabolite in pharmaceutical preparations. 2-Methoxyethyl-3-aminocrotonate is a natural metabolite, which can be found in human urine. This compound has been shown to be a potent inhibitor of both bacterial and mammalian cell topoisomerase II and IV, but not mammalian cell topoisomerase I. It also inhibits protein synthesis by binding to the ribosomal 50S subunit. In addition, it has been shown to inhibit the growth of certain bacteria such as clostridium perfringens and Mycobacterium tuberculosis.</p>

<p>Please enquire for more information about 6,7-Dihydro canrenone lactol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Benzylpenicillin diethylaminoethyl ester hydroiodide is a potent broad-spectrum antimicrobial agent that inhibits the growth of bacteria by inhibiting protein synthesis. It is used to treat microbial infections and has been shown to be effective against Streptococcus species, including Streptococcus pneumoniae, Streptococcus pyogenes, and Streptococcus viridans. Benzylpenicillin diethylaminoethyl ester hydroiodide binds to the 50S ribosome subunit of bacteria and prevents the formation of an antibiotic-inhibitor complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis. This binding prevents protein synthesis and cell division.</p>

<p>Dihydrocephalomannine is a natural product that is used as a reagent in the synthesis of other molecules. It can be found in plants such as Taxus brevifolia, which contains the molecule taxol. Dihydrocephalomannine is synthesized by benzoylation and hydroxylation of dihydrobenzofuran. The molecule has been shown to have cytotoxic activity against human ovarian cancer cells, but its mechanism of action is not yet known.</p>

<p>7-Aminopyrazolo[1,5-a]pyrimidine-3,6-dicarboxylic acid 3,6-diethyl ester is an impurity in the synthesis of drugs. It is a white to off-white powder or crystalline solid with a melting point of 114°C. 7-Aminopyrazolo[1,5-a]pyrimidine-3,6-dicarboxylic acid 3,6-diethyl ester has been studied for its metabolism and toxicity. It is not naturally occurring and was synthesized in the laboratory. It may be used as a reference material for pharmacopoeia standards.</p>

<p>2,12-Dihydro-1,3-dimethyl-8-methoxy-12-thioxobenzo [4,5] pyrido [1,2-c] imidazo [1,2-a] imidazol-2-one is a metabolite of the drug 2-[2-(4,5,-dihydroimidazo[1,2a]imidazol -2(3H)-yl)ethoxy]-N-(methylsulfonyl)benzamide. It can be used as an impurity standard for the manufacture of drugs and as a research chemical.</p>

<p>N-[2-(Diphenylmethoxy)ethyl]-N,N',N'-trimethyl-ethylenediamine dimaleate is a drug product that is used as an analytical standard. It is a synthetic compound that has been shown to have anti-inflammatory properties. This product is also metabolized in the liver, and can be used to study the metabolism of drugs. CAS No. 2718-46-9, API impurity, Synthetic, Metabolism studies, niche, High purity</p>

<p>Ornidazole-hydroxy is a drug product that is manufactured using HPLC. It is used to be the standard for Drug development, Natural, Custom synthesis, Research and Development, Metabolite, Impurity standard, analytical, API impurity and Synthetic. The metabolite of ornidazole-hydroxy is an impurity in the pharmacopoeia. Ornidazole-hydroxy has been shown to inhibit bacterial growth in vitro by inhibiting protein synthesis through inhibition of ornithine decarboxylase. Ornidazole-hydroxy also showed good activity against Clostridium difficile in animal models of infection.</p>

<p>Fosfomycin trometamol EP impurity A disodium is a research and development impurity standard. It is a custom synthesis that is used as a drug product, synthetic, high purity, pharmacopoeia, drug development, metabolite, niche, analytical and natural. Fosfomycin trometamol EP impurity A disodium has been shown to have an HPLC standard and CAS No. 84954-80-3(free base).</p>

<p>Please enquire for more information about 4-Acetyl-3,4-dihydro-2H-pyrido[3,2-b]oxazine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>N-(5-Formyl-2-hydroxyphenyl)formamide is a drug product that is synthesized by Custom synthesis. The purity of this compound is high and it has been used in analytical studies to measure the metabolic activity of the liver, kidneys, and brain. It is also used in natural drug development for pharmacopoeia. This compound has a CAS number of 903563-43-9 and an impurity standard. It can be synthesized from N-(5-formylphenyl) formamide.</p>

<p>Amoxicillin EP Impurity L is an impurity standard for amoxicillin. It is a synthetic compound that is used to ensure the quality of amoxicillin drug products. Amoxicillin EP Impurity L has been shown to be metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. This impurity has also been shown to have anti-inflammatory properties and may be due to its inhibition of prostaglandin synthesis.</p>

<p>K-(D-1-Nal)-fwll-NH2 is a drug product that is custom synthesized to order. It has been shown to have high purity, analytical and metabolic studies. The metabolite of K-(D-1-Nal)-fwll-NH2 is D-1-nal. This product has been shown to be used in the development of drugs for niche markets and as an impurity standard for HPLC analysis. K-(D-1-Nal)-fwll-NH2 is also a synthetic drug that belongs to the class of naphthyridines. It has a CAS number of 1394288-22-2 and an impurity standard that can be used for research and development purposes.</p>

<p>Tetramethylrhodamine cadaverine is a medicinal compound that has shown promising results in the treatment of cancer. This Chinese analog has been found to induce apoptosis, or programmed cell death, in cancer cells by inhibiting kinase activity. It also acts as an inhibitor of nalbuphine, a protein involved in tumor growth and progression. Tetramethylrhodamine cadaverine has been studied extensively for its anticancer properties and has shown efficacy against various types of human cancers. Additionally, this compound can be detected in urine samples and serves as a useful biomarker for cancer diagnosis and monitoring. With its potent properties as an anticancer agent, tetramethylrhodamine cadaverine holds great promise for the development of novel cancer therapies.</p>

<p>Azilsartan Dimer is a crystalline solid with a melting point of 95-98°C. It is insoluble in water and soluble in acetone, acetonitrile, and dimethyl sulfoxide. Azilsartan Dimer has shown antihypertensive effects in animal models. The chemical structure of Azilsartan Dimer is based on the alkyl ester of azilsartan and an acetone solvent.</p>

<p>Mono-(4-methyl-7-oxooctyl)phthalate (MMP) is a metabolite of the phthalate esters, which are synthetic chemicals used in plastics and other materials. MMP has been detected in the urine of neonates and preschool children, suggesting that it can be absorbed through skin contact. This compound is also found in wastewater, where it may cause estrogenic effects on human cells. The reaction solution of MMP with insulin-like growth factor (IGF) was studied by kinetic analysis and logistic regression to determine its binding affinity for IGF binding proteins. MMP has shown to be biodegradable under aerobic conditions.</p>

<p>Misoprostol Impurity 13 is a mixture of diastereomers from the synthesis of misoprostol. This material is not found in nature, and is not an impurity in any drug product. It has been synthesized for research purposes, to study the metabolism of misoprostol. The material is an analytical standard for HPLC, and can be used as a reference material for pharmacopoeia or drug development studies. Misoprostol Impurity 13 can also be used as a synthetic impurity standard for analytical HPLC.</p>

<p>Irinotecan is a drug product that is used in the treatment of cancer. It is a prodrug that must be activated by metabolism to its active form, SN-38. Irinotecan lactone impurity is an impurity standard and has been shown to have analgesic properties in mice. It has also been shown to inhibit the growth of colon cancer cells.</p>

<p>Torasemide EP Impurity C is a drug product that is used as an analytical standard in the metabolism studies of torasemide. Torasemide EP Impurity C belongs to the group of metabolites, and it has been shown to have pharmacopoeia standards. Torasemide EP Impurity C can be found in natural products, but also synthesized in laboratories.</p>

<p>Citalopram N-oxide hydrochloride is the n-oxide form of the antidepressant drug citalopram. It is a metabolite of citalopram that has been shown to have higher activity than the parent compound. The presence of citalopram N-oxide was detected in plasma samples using liquid chromatography with a wavelength of 220 nm and diethylamine as an eluent. Citalopram N-oxide hydrochloride has been shown to be pharmacologically active in animal studies, but its effects are not well understood.</p>

<p>Please enquire for more information about Tofacitinib impurity 5 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>4-Methanesulfonyloxybutanol is a chemical substance with the molecular formula CH3SO2CH(CH2OH)CH2OH. It is used as an intermediate in the synthesis of 4-methanesulfonyloxybutanol, which is a potent inhibitor of busulfan-induced leukopenia and myelosuppression. This substance has been shown to be highly effective in preventing busulfan-induced side effects when administered intravenously. 4-Methanesulfonyloxybutanol is chemically synthesized by intramolecular alkylation of butanol, followed by hydrolysis. The reaction product can be detected using an ionization detector in conjunction with gas chromatography. This product is an alkylation agent that reacts with polypropylene to produce polypropylene glycols.</p>

<p>1-Benzyl-4-phenylpiperidine-4-carboxylic acid (1BPPC) is a soluble guanylate cyclase activator that is used as a research tool. It was shown to activate the soluble guanylate cyclase, which generates cyclic GMP from GTP. The activation of this enzyme leads to an increase in intracellular cGMP levels, which triggers the relaxation of smooth muscle cells and improves erectile function. 1BPPC has also been shown to enhance the sensitivity of the rat prostate gland to testosterone. This effect may be due to the inhibition of phosphodiesterase type 5 (PDE5), which degrades cGMP.</p>

<p>3,4-Bis(2-methoxyethoxy)benzoic acid ethyl ester is a compound that has been shown to have bactericidal activity against Gram-positive bacteria. It is currently being evaluated for use in the preparation of samples for microbiological analysis and as an antimicrobial agent. 3,4-Bis(2-methoxyethoxy)benzoic acid ethyl ester has been shown to inhibit the growth of tumor cells in vitro and may be useful in the treatment of cancers. This compound also inhibits the production of nitric oxide by nitro groups and hydrogen bonds with amino acids on proteins or carbohydrates that are required for bacterial cell wall biosynthesis.</p>

<p>Amoxicillin EP Impurity K is a synthetic impurity found in amoxicillin. Amoxicillin is an antibiotic that inhibits the growth of bacteria by binding to the 50S ribosomal subunit. Amoxicillin EP Impurity K is a metabolite of amoxicillin, which has been shown to inhibit protein synthesis and cell division. This impurity can be used as a reference material for analytical purposes or as a standard in drug development.</p>

<p>(2S,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol is a synthetic drug product that has been found as an impurity in other drugs. It has a natural origin and can be synthesized by chemical methods. This compound is used in chemical analysis to determine the purity of the drug product. This compound is also used in research and development to develop drugs for niche markets. (2S,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol has high purity and meets pharmacopoeia standards.</p>

<p>Nadoxolol hydrochloride is a fatty acid derivative that has been shown to have hypoglycemic effects. Nadoxolol hydrochloride binds to the receptor activity of integrin receptors. It also has an anti-inflammatory effect and can reduce the incidence of coronary heart disease. Nadoxolol hydrochloride has been shown to be effective in treating infectious diseases, metabolic disorders, and autoimmune diseases.</p>

<p>4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-formylpiperidine is a drug product that is used for the synthesis of pharmaceuticals. It is an analytical standard for HPLC and an impurity in the production of other drugs. 4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1H)-1 formylpiperidine has been shown to have natural and synthetic origins, as well as being produced by custom synthesis. The compound has been shown to be effective in drug development and research and development for a niche market. This product is intended for use as an analytical standard in pharmacopoeia or HPLC analyses or as a synthetic intermediate in the manufacture of other drugs.</p>

<p>Desmethylmaprotiline hydrochloride is a drug product that is used in the manufacture of other drugs. It is an impurity standard for analytical purposes and an API impurity for pharmacopoeia. Desmethylmaprotiline hydrochloride is also a metabolite of maprotiline, which is used in the treatment of depression. The chemical structure of Desmethylmaprotiline hydrochloride can be found under CAS No. 92202-51-2 and it has been shown to be synthesized from maprotiline.</p>