APIs pour la recherche et les impuretés

<p>Applications Cardioselective β-adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).<br>References Cuthbert, O.A., et al.: Br. J. Pharmacol., 43, 639 (1971), Singh, B.N., et al.: Drugs, 29, 531 (1985), Foster, R.T., et al.: Anal. Profiles Drug Subs., 19, 1 (1990),<br></p>

<p>Impurity Loratadine EP Impurity H<br>Applications N-Carbethoxy-4-piperidone (Loratadine EP Impurity H) is used in the preparation of 3-hydrazinopyridazines as antihypertensive agents as well as γ-carboline derivatives as potential serotonergic agents. N-Carbethoxy-4-piperidone is also an impurity of Loratadine (L469575).<br>References Schenker, E. et al.: Arsneim.-Forsch., 29, 1835 (1979); El-Kader, A. et al.: Mans. J. Pharm. Sci., 6, 1 (1989); Albu, M. et al.: J. Liq. Chrom. Rel. Technol., 32, 2569 (2009);<br></p>

<p>Applications Labelled Torsemide (T548750). Used as a diuretic.<br>References Lesne, M., et al.: In. J. Clin. Pharmacol. Ther. Toxicol., 20, 382 (1982), Brater, D.C., et al.: Clin. Pharmacol. Ther., 42, 187 (1987),<br></p>

<p>Applications m-Toluidine is a reagent that is used in the synthesis of torsemide and its derivatives which are used as a diuretic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lesne, M., et al.: In. J. Clin. Pharmacol. Ther. Toxicol., 20, 382 (1982), Brater, D.C., et al.: Clin. Pharmacol. Ther., 42, 187 (1987),<br></p>

<p>Applications Labelled Tetrahydrocortisone (T293375). A normal mammalian metabolite of Cortisone (C696500).<br>References Schneider, et al.: J. Biol. Chem., 183, 365 (1950), Barkemeyer, et al.: Appl. Microbiol., 8, 237 (1960),<br></p>

<p>Applications The main basic metabolite of Diethylpropione.<br>References Banci, F., et al.: Arzneim.-Forsch., 21, 1616 (1971), Mikhailova, D., et al.: Eur. J. Med. Chem., 13, 49 (1978),<br></p>

<p>Applications Daidzein-3',5',8-d3 is labelled Daidzein (D103500) which is an inactive analog of Genistein (Cat. #G350000). It blocks the G1 phase of the cell cycle in Swiss 3T3 cells by inhibiting casein kinase II activity.<br>References Jones, P., et al.: J. Biol. Chem., 274, 32008 (1999), Hassan, M., et al.: Anticancer Res., 19, 5657 (1999), Salti, G., et al.: Eur. J . Cancer, 36, 796 (2000).<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Daidzin, Daidzein and Puerarin.<br>References Griffiths, L., et al.: Biochem. J., 130, 141 (1972), Zhu, X., et al.: Acta Pharm. Sin., 14, 349 (1979), Powell, G., et al.: Drug Metab. Drug Interact., 6, 203 (1988), Bamforth, K., et al.: Eur. J. Pharmacol., 228, 15 (1992), Walle, T., et al.: Biochem. Pharmacol., 50, 731 (1995),<br></p>

<p>Applications Indazolone derivative.<br></p>

<p>Applications rac-1, 2-Didecanoyl-3-chloropropanediol belongs to a group of 3-Chloropropanediol fatty acid esters, which are contaminants found in edible oils and other food sources.<br>References Z. Zelinková, et al.: Food Addi. &amp; Conta., 23:12, 1290-1298 (2006)<br></p>

<p>Applications Labelled Cefuroxime (C248050). Antibacterial.<br>References O’Callaghan, C.H., et al.: Antimicrob. Agents Chemother., 9, 511 (1976), Norrby, R., et al.: J. Antimicrob. Chemother., 3, 355 (1977), Brogden, R.N., et al.: Drugs, 17, 233 (1979), Wozniak, J.R., et al.: Anal. Profiles Drug Subs., 20, 209 (1991),<br></p>

<p>Applications A metabolite of Torsemide (T548750).<br>References Besenfelder, E., et al.: J. Pharm. Biomed. Anal., 5, 259 (1987), Vormfelde, S., et al.: Clin. Pharmacol. Ther., 76, 557 (2004),<br></p>

<p>Impurity Cefuroxime Sodium Impurity B (EP)<br>Applications Cefuracetime is an impurity of Cefuroxime, which is an antibacterial.<br>References O’Callaghan, C.H., et al.: Antimicrob. Agents Chemother., 9, 511 (1976), Norrby, R., et al.: J. Antimicrob. Chemother., 3, 355 (1977), Brogden, R.N., et al.: Drugs, 17, 233 (1979), Wozniak, J.R., et al.: Anal. Profiles Drug Subs., 20, 209 (1991),<br></p>

<p>Applications 6β-Hydroxy-3α,5α-cycloandrostan-17-one is a degredation product of Dehydroepiandrosterone Sodium Sulfate (S673250), an active agent in the preparation of a pharmaceutical for the treatment of asthma or other respiratory diseases.<br>References Ishihara, T., et al.: Drug. Develop. Indust. Pharmacy., 5, 263 (1979); Sollman, P.B., et al.: J. Org. Chem., 28, 3559 (1963); Van Renterghem, P., et al.: Steroids., 75, 1047 (2010);<br></p>

<p>Applications 2-Hydroxyglutarate-13C5,d8 is used in the 13C NMR detection of 2-hydroxyglutarate in tissue extracts from isocitrate dehydrogenase-mutated gliomas.<br>References Pichumani, K., et al.: Anal. Biochem., 481, 4 (2015)<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Azelastine (A808250).<br>References Heinemann, U. et al.: J. Chrom. B Anal. Tech. Biomed. Life Sci., 793, 389 (2003); Tasaka, K., et al.: Arzneim.-Forsch., 29, 488 (1979);<br></p>

<p>5-Methoxy-2-[(4-chloro-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-5-methoxy-1H benzimidazole is a synthetic drug product. It has been used as a positive control in metabolism studies and as an impurity standard. 5-Methoxy 2-[(4-chloro 3,5 dimethyl 2 pyridinyl)methyl]sulfinyl]-5 methoxy 1H benzimidazole is also a metabolite of the active pharmaceutical ingredient (API) which is used to develop drugs. This chemical is synthesized by custom synthesis and can be obtained at high purity levels. The metabolite of this compound is 5 methoxy 2-[(4 chloro 3,5 dimethyl 2 pyridinyl)methyl]sulfonyl]-5 methoxy 1H benzimidazole.</p>

<p>(-)-9-Hydroxyrisperidone is a metabolite of risperidone that is structurally related to the neurotransmitter dopamine. This compound has been found to be a potent antagonist of serotonin and adrenergic receptors, which may contribute to its therapeutic effects in schizophrenia. (-)-9-Hydroxyrisperidone also has been shown to have a high affinity for human liver plasma proteins, which suggests it may be responsible for the long half-life seen with risperidone. The (+) form of the drug has been shown to be more potent than (-)-9-hydroxyrisperidone, while (-)-9-hydroxyrisperidone is more selective in terms of receptor binding.</p>

<p>(+/-)-N-Benzyl-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-propylamine hydrochloride is a synthetic drug product with the chemical name of (+/-)-N-Benzyl-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-propylamine hydrochloride. It is an analytical standard, and its CAS No. is 660414-56-2. It has the purity of 99% and a molecular weight of 377.5. The impurities in this product are less than 1%. This product can be used as an analytical reference in HPLC, as well as a drug development and natural standard for pharmacopoeia. This product was synthesized by a process that included: (1) 3,4-(trifluoromethyl)benzaldehyde; (2) A mixture of</p>

<p>3,4-Dihydroxybenzoic acid 3-O-sulfate sodium salt is an active compound that has been shown to have potential as a cancer inhibitor. It acts by inhibiting the activity of mutant cells and cancer cells, making it a promising candidate for cancer treatment. This compound has been tested on human cell lines and analogs, demonstrating its ability to inhibit tumor growth and prevent the progression of cancer cells. Additionally, 3,4-Dihydroxybenzoic acid 3-O-sulfate sodium salt has been identified as one of the active agents in Chinese medicine that can regulate protein expression and cell cycle progression by targeting kinases. Its potent anti-cancer properties make it a promising therapeutic agent for the treatment of various forms of cancer.</p>

<p>1,2,3,4-Tetrahydroisoquinoline-4,6,7-triol is an analytical standard that has been synthesized using a custom synthesis. It is used to determine the purity of the drug product and as an impurity in the synthesis of other compounds. 1,2,3,4-Tetrahydroisoquinoline-4,6,7-triol is a product of natural origin and is found in plants such as licorice roots. This compound can be used for drug development research and development purposes.</p>

<p>Bis-[[2-[(diaminomethylene)amino]thiazol-4-yl]methyl]disulfide is a disulfide derivative of famotidine. It has been used as an analytical reagent for the determination of impurities in famotidine and other related compounds. Bis-[[2-[(diaminomethylene)amino]thiazol-4-yl]methyl]disulfide is soluble in methanol, ethanol and water, but not in acetone. The compound can be prepared by reacting 4-(dimethylamino)-1H-1,2,3-benzothiadiazole with 2-[(diaminomethylene)amino]-4-(N'-methoxycarbonylthio)benzaldehyde and then reductive amination with sodium bisulfite.</p>

<p>N-((-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)methyl) acetamide is a custom synthesis, drug product, niche, Metabolite, Drug Development, CAS No. 224323-50-6. It is a natural compound and has pharmacopoeia and API impurity. It is an analytical standard for HPLC and research and development. It is a high purity synthetic with impurity standard.</p>

<p>N,N'-Bis(4-chlorobenzylidene)hydrazine is an organic nitrogen compound that is used as a reagent in organic chemistry. It can be used to synthesize hydrazones, toluenes, and carbonyls. This reagent also has the ability to catalyze olefinations. N,N'-Bis(4-chlorobenzylidene)hydrazine can be crystallized from its aryldiazomethanes.</p>

<p>Dihydroxy diketo atorvastatin impurity is a synthetic impurity that is generated by the metabolism of atorvastatin. This drug product is an analytical standard for the determination of purity, and can also be used to develop high purity drugs.</p>

<p>Atorvastatin methyl ester is a statin drug that inhibits the synthesis of cholesterol and other lipids in the body. It is used to reduce high levels of low-density lipoprotein (LDL) cholesterol, which may lead to heart disease or stroke. Atorvastatin methyl ester has been shown to be effective in reducing the uptake of LDL cholesterol into cells by preventing the formation of LDL particles. This drug also decreases the production of biphosphate-containing phospholipids, which are essential for dendritic cell maturation. The crystalline polymorphs have been characterized by X-ray diffraction and microscopy. Impurities can be detected using ultraviolet spectroscopy, infrared spectroscopy, or nuclear magnetic resonance spectroscopy.</p>

<p>Naltrexone impurity A is a synthetic, high-purity drug product that is used as an analytical reference standard in the development and manufacture of pharmaceuticals. It is also used as a pharmacopoeia reference standard and to study metabolism. Naltrexone impurity A has been shown to be a major metabolite of naltrexone and can be found in the urine at concentrations of 1-2% following oral administration. This impurity is not active when given orally, but may have activity if injected intravenously or intramuscularly.</p>

<p>3-(4-(4-Morpholinyl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one is an impurity in the drug development process. It is used as a standard for HPLC testing and a synthetic intermediate. It has been shown to have niche use in the pharmaceutical industry. 3-(4-(4-Morpholinyl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one has been found to be metabolized through oxidation and reduction reactions, leading to the formation of metabolites such as 2,6-dihydroxypyridine (DHP). Further metabolism studies are required for this substance.</p>

<p>Methotrexate dimethylamide is a research and development impurity standard with high purity. It is a synthetic drug product that can be custom synthesized to meet the needs of the customer. Methotrexate dimethylamide has been used as an analytical standard for HPLC analysis and as a natural metabolite in metabolism studies. This compound is also known as 71074-44-7, CAS No. 71074-44-7, or Metabolite.</p>

<p>Dimethyl-2-ene-3-(4-methylbenzoyl)propionamide is an impurity that is found in N,N-dimethyl-3-(4-methylbenzoyl)-propionamide. It is a white solid and has a melting point of 132°C. Dimethyl-2-ene-3-(4-methylbenzoyl)propionamide is not soluble in water or ethanol. This compound is used as a high purity, API impurity, HPLC standard, niche, pharmacopoeia, Custom synthesis, Drug development, analytical and Synthetic drug product. Dimethyl-2-ene-3-(4-methylbenzoyl)propionamide can be metabolized by the liver to 2-[(2E)-1H-[1]benzopyran--5(6H)-ylidene]-N,N'-dimethylethane--3(2H)-carbox</p>

<p>Please enquire for more information about 2-[[1-(Methylamino)-2-nitroethenyl]amino]-ethanethiol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Lansoprazole N-oxide is a prodrug that is converted to lansoprazole sulfone in vivo. Lansoprazole N-oxide is used as a diluent in chromatographic experiments. It has been shown to be more sensitive than the parent compound, lansoprazole, for the diagnosis of reflux oesophagitis. Lansoprazole N-oxide also has a validation wavelength of 240 nm and can be detected by liquid chromatography. The active form of lansoprazole, lansoprazole sulfone, can be detected by gas chromatography mass spectrometry (GCMS).</p>

<p>O3-Desethyl apremilast is an experimental drug product that belongs to the class of drug products. This drug product has been shown to be a natural, synthetic and analytical impurity in API. It is also an impurity standard for HPLC analysis. O3-Desethyl apremilast can be used in research and development, as well as niche applications in the pharmaceutical industry.</p>

<p>N,N-dimethyl-2-(1-phenyl-1-(pyridin-2-yl)methoxy)ethanamine is a drug impurity that is produced as a result of the metabolism of the drug 1-[(2R)-2-phenylethyl]pyrrolidin-2-one. It is an analytical standard and an impurity in pharmaceutical products. It has been shown to be metabolized by CYP3A4, CYP1A2, and CYP2C19 and excreted unchanged in urine.</p>

<p>Topiramate is a drug used to treat epilepsy and weight loss. The N-methyl impurity is a synthetic compound that is an impurity in the drug product. The impurity was synthesized by reacting 4-hydroxybenzaldehyde with methylamine in the presence of triethylamine. It has been shown to be not metabolized, but excreted unchanged in urine.</p>

<p>4-(1-Hydroxy-1-methylethyl)-2-propyl-1[4-[2-(trityltetrazol-5-yl)phenyl]phenyl]methylimidazol-5-caboxylic acid (4MPPC) is a water soluble, clear liquid that is used as a solvent. It can be prepared by the reaction of sodium carbonate with an organic or inorganic salt solution in acetonitrile. The solvents are then removed using filtration and the final product is obtained by evaporation of the solvent. 4MPPC has been used in the preparation of medoxomil, which is an antibiotic that inhibits bacterial growth by binding to DNA gyrase and topoisomerase IV.</p>

<p>NLRP3i is a molecule that is orally administered and has been shown to have anti-inflammatory effects in the heart. NLRP3i reduces pro-inflammatory cytokines and protects against cardiac dysfunction in mice with chronic kidney disease. It also protects against heart failure caused by ischemia reperfusion. This drug has been shown to be effective as a therapy for cancer, with some patients being resistant to chemotherapy, although it is not yet approved for this use.</p>

<p>N-Hydroxy riluzole N-b-D-glucuronide (NHRG) is a drug product that has been used as an analytical reference standard in metabolism studies. It is a natural impurity found in the API Rilutek (riluzole), which is used to treat ALS and related diseases. NHRG exhibits a retention time of 9.5 minutes on HPLC, and its purity should be at least 98%. NHRG can also be custom synthesized to order, and it can be used as an impurity standard in drug development research and development, or for pharmacopoeia testing.</p>

<p>2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone is a synthetic building block which can undergo reaction with nucleophilic carbon species to afford C-ribosides (via the corresponding hemiacetal).  Treatment of 2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone with stronger reducing agents, such as sodium borohydride, affords ring opened products with a stereo-defined poly-oxygenated carbon chain backbone.</p>

<p>Atorvastatin diepoxide is an analytical standard for the drug atorvastatin that is used in the development of pharmaceuticals. It is synthesized by reacting atorvastatin with epichlorohydrin, which produces a diepoxide derivative. This synthetic molecule can be used as an impurity standard for HPLC analysis. The CAS number for atorvastatin diepoxide is 887470-43-1.</p>

<p>(R,S)-N-Methyl 3-benzylamino-1-phenyl-1-propanol is an impurity standard for the drug product (R,S)-N-methyl 3-(benzylamino)-1-phenylpropanol. It is a synthetic, analytical and HPLC standard. This compound has shown to possess pharmacopoeia standards and can be custom synthesized for your needs.</p>

<p>Olmesartan medoxomil is a prodrug that is hydrolyzed to olmesartan, its active form. It is a member of the angiotensin II receptor antagonists and it is used for the treatment of hypertension and heart failure. Olmesartan medoxomil reduces the risk of cardiovascular events in patients with resistant hypertension or heart failure. The drug binds to the angiotensin II type 1 receptor, thereby blocking the binding of angiotensin II to this receptor. This prevents activation of downstream signaling pathways, including phospholipase C, protein kinase C, and mitogen-activated protein kinases. Olmesartan medoxomil also blocks the formation of new blood vessels and vascular remodeling in animal models.</p>

<p>Calcipotriol EP Impurity H is an impurity found in calcipotriol EP. It is a metabolite of calcipotriol EP, which is the active ingredient in Dovonex. Calcipotriol EP Impurity H can be detected by HPLC with a retention time of 11.5 minutes and its purity can be determined by UV spectroscopy at 254 nm with a purity of &gt;98%. Calcipotriol EP Impurity H can also be synthesized from natural or synthetic sources.</p>

<p>Empagliflozin R-furanose is a drug product that belongs to the class of drugs for treatment of type II diabetes. It is a synthetic derivative of Empagliflozin, which is a natural compound found in plants. Empagliflozin R-furanose has been shown to inhibit the activity of dipeptidyl peptidase 4 (DPP-4) and reduce postprandial glucose levels in healthy subjects. This drug product has also been shown to be safe and effective in lowering blood sugar and hemoglobin A1c levels in patients with type II diabetes mellitus or impaired glucose tolerance.</p>

<p>Trazodone is a psychotropic agent that belongs to the group of antidepressants. Trazodone hydrochloride impurity C is a metabolite of trazodone and can be used as an impurity standard for the drug product in pharmacopoeia. Trazodone hydrochloride impurity C has been found in urine, blood, and saliva after administration of trazodone. It is also found in the plasma of pregnant women who are taking trazodone to treat depression or anxiety during pregnancy. <br>Trazodone hydrochloride impurity C is synthesized using a custom synthesis with high purity. It has been shown to have a niche market as an analytical reference material for HPLC standards.</p>

<p>5,6-Dichloro-1,4-dihydro-2-quinazolinamine (5,6-DCQ) is a small molecule that has been used in vitro to study postnatal development. 5,6-DCQ binds to magnesium and forms a cation complex. This binding inhibits the activity of various enzymes such as phosphodiesterase and acetylcholinesterase. 5,6-DCQ also blocks the proliferation of cancer cells in vitro by inhibiting colony-stimulating factor and other proteins required for cell division. 5,6-DCQ has been shown to be safe in clinical trials and may be an effective treatment for cancer.</p>

<p>Fluoxetine is a selective serotonin reuptake inhibitor that is used to treat major depressive disorder, obsessive-compulsive disorder (OCD), bulimia nervosa, panic disorder, premenstrual dysphoric disorder (PMDD), and social anxiety disorder. It is also used as an appetite suppressant in some countries. Fluoxetine inhibits the neuronal uptake of serotonin by blocking the presynaptic transporter protein. The most common adverse effects are nausea, diarrhea, drowsiness, dry mouth, blurred vision and sexual dysfunction.</p>

<p>2,6-Dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester (DMPD) is an enzyme inhibitor that belongs to the group of metabolic inhibitors. This agent is used for the preparation of samples for analysis by chromatography and mass spectrometry. DMPD inhibits the activity of enzymes involved in drug metabolism, including CYP2C8, CYP2C9, CYP2D6, and CYP3A4. The matrix effect can be minimized by using a more acidic sample preparation. The immunosuppressant properties of DMPD have been shown in mice by inhibiting T cell activation and proliferation in vitro.</p>

<p>Methyl 2-deoxy-3,4-di-O-toluoyl-D-ribopyranoside is a synthetic impurity standard for the drug product. It has been used in studies on metabolism and as an analytical reference material. Methyl 2-deoxy-3,4-di-O-toluoyl-D-ribopyranoside is also available as a custom synthesis at high purity.</p>

<p>The synthesis of N,N-dimethyl-2-(1-phenyl-1-(pyridin-4-yl)ethoxy)ethanamine is a two step process. It involves the reaction of pyridine with 2,6-dichloroacetophenone in the presence of excess potassium carbonate followed by the elimination of diethyl ether to produce the desired product. The yield for this reaction is high and it is selective when compared to other reactions that use organic solvents. This product can also be quantified using various analytical methods such as thin layer chromatography and gas chromatography.</p>

<p>(R)-5-Hydroxymethyl tolterodine is a prodrug that is metabolized by cytochrome P450 3A4 (CYP3A4) in the liver to its active form, tolterodine. This drug can be used as an alternative for gabapentin in the treatment of detrusor muscle overactivity associated with neurogenic bladder dysfunction. The pharmacokinetic properties of (R)-5-hydroxymethyl tolterodine are similar to those of gabapentin, including the elimination half-life and volume of distribution. However, unlike gabapentin, which has been shown to increase the glomerular filtration rate (GFR) and renal blood flow, there is no evidence that this drug has any effect on GFR or renal blood flow. There is also no evidence that (R)-5-hydroxymethyl tolterodine causes any symptoms that may be attributed to</p>

<p>Intermediate for tiotropium bromide synthesis</p>

<p>2-Hydroxy-2,2-bis(2-thienyl) acetic acid is a long-acting bronchodilator that can be administered by inhalation. It has been used in the clinical development of medicines for the treatment of asthma and chronic obstructive pulmonary disease. 2-Hydroxy-2,2-bis(2-thienyl) acetic acid is chemically related to pyridinium compounds. It is a potent inhibitor of muscarinic receptors and has an anticholinergic profile similar to atropine. The safety profile of this drug seems to be favourable in humans with no major side effects reported so far.</p>

<p>(RS)-Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate is a drug product with an analytical purpose. This compound is metabolized by the liver and excreted in the urine. It has been shown that this compound is not present in natural sources. The CAS number for this compound is 1316606-40-2 and it's API impurity is less than 0.0001%. This drug product has been synthesized from a custom synthesis and it is an impurity standard for HPLC analyses. It has also been used as a research and development tool to develop drugs or study metabolism studies. This compound is pure enough to be used as a pharmacopoeia standard</p>

<p>Cisplatin impurity A is a platinum-based chemotherapeutic agent that binds to DNA and inhibits the synthesis of cellular proteins. Cisplatin impurity A has been shown to inhibit the growth of cancer cells in vitro and in vivo. This compound also inhibits the production of epidermal growth factor, which may be due to its ability to bind dna at tetrazolium dye adducts. The coordination geometry of cisplatin impurity A is octahedral with two axial bidentate chelating ligands, which allows it to bind both DNA and tubule cells.</p>

<p>[(2-Butoxyethoxy)ethyl] 2-[(trifluoromethyl)phenylamino]benzoate is a synthetic chemical that is an impurity in the synthesis of the drug product, [(2-butoxyethoxy)ethyl] 2-[(trifluoromethyl)phenylamino]-benzoate. It is a white to off-white solid with a melting point of 53°C. The purity of this compound is high and it has been used as an analytical standard for HPLC. This compound also has niche application in pharmacopoeia and drug development.</p>

<p>Fluticasone furoate impurity I is a drug product that is custom synthesized for research and development. It is an analytical standard that is used in metabolism studies. The metabolite of this impurity has been identified as the natural product, 4-fluoro-5-hydroxybenzoic acid. Fluticasone furoate impurity I is a synthetic standard for HPLC that can be used to calibrate the equipment and prepare stock solutions.</p>

<p>Calcipotriol EP Impurity E is a synthetic impurity that is found in the calcipotriol EP API. Calcipotriol EP Impurity E is an impurity standard for HPLC and can be used in drug development, research and development, and pharmacopoeia. It has been shown to have no significant effect on the pharmacological activity of calcipotriol EP.</p>

<p>22-Oxo-vincaleukoblastine 6'-oxide is a synthetic drug with no known clinical use. It is an impurity of the vinca alkaloid drug vinblastine and may be found in small amounts in other vinca alkaloid drugs. 22-Oxo-vincaleukoblastine 6'-oxide is a metabolite of the vinca alkaloids, which are used as anticancer drugs. This substance has been shown to inhibit the metabolism of some cancer cells, leading to increased cell proliferation.</p>

<p>3'-N,N-Didesmethyl-N-(methoxycarbonyl) azithromycin is a research and development impurity standard. It is synthesized by reacting 3-desacetylazithromycin with methoxycarbonyl chloride in the presence of triethylamine. This product has been tested for purity by HPLC. CAS No. 16892-65-2</p>

<p>Aztreonam impurity D is a metabolite of aztreonam. Aztreonam impurity D is an impurity standard for the pharmacopoeia and API industry, as well as for drug development and research. It has been shown that this compound inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Aztreonam impurity D also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.</p>

<p>N4-Acetyl sulfadoxine is a drug that is used to treat urinary tract infections in women and children. It is also used to treat bacterial infections of the skin, lungs, and joints. N4-Acetyl sulfadoxine may be effective against prostatitis caused by E. coli or Mycoplasma pneumoniae by inhibiting the production of prostaglandins. This drug works by binding to dihydropteroate synthase, which prevents folic acid from being incorporated into the bacterial cell wall, thereby inhibiting bacterial growth.</p>

<p>Naltrexone impurity E is an analytical standard that is used to calibrate high-performance liquid chromatography (HPLC) instruments. This substance is a natural metabolite of naltrexone, which is an opioid receptor antagonist, and has the chemical name of 4-hydroxy-3-methoxy-N-(5α,6β)-dimethyl-2-[(1R)-1-(3-methyloxetan-3-yl)piperidin-4-yl] benzeneacetamide. Naltrexone impurity E is a pharmacopoeia grade compound that can be used in the synthesis of drug products. Custom synthesis and natural or synthetic sources are available.</p>

<p>Isotopically labelled metabolite of telmisartan</p>

<p>Amoxicillin trihydrate impurity N is a drug product that is an impurity in amoxicillin trihydrate. It is a natural, API impurity, which has been synthesized and tested for use as an impurity standard for HPLC analysis of amoxicillin trihydrate. The CAS number for Amoxicillin trihydrate impurity N is 592-84-1.</p>

<p>2'-Deoxy-2',2'-difluorocytidine 5'-triphosphate sodium, 10 mM aqueous solution is an analytical standard that is used in metabolism studies and as an impurity in some pharmaceuticals. This chemical is also used to develop drugs, such as antiviral and anti-inflammatory agents. 2'-Deoxy-2',2'-difluorocytidine 5'-triphosphate sodium, 10 mM aqueous solution has a CAS number of 1440537-37-0 and the molecular weight of 463.88 g/mol. This compound is soluble in water, ethanol, DMSO, acetone and acetonitrile at room temperature. The purity for this compound is &gt; 99%.</p>

<p>The product is an impurity that is used as a standard in HPLC analysis. It is a natural metabolite of olmesartan, which is a drug marketed for the treatment of hypertension. The purity levels are high and the material has been shown to be stable with respect to decomposition in the presence of light, heat, or alkali. This compound has also been used in metabolism studies and as an analytical reference material.</p>

<p>Methyl 2-deoxy-3,5-di-O-(4-chlorobenzoyl)-a-D-ribofuranoside is a research and development impurity standard for the synthesis of drug products. This chemical is used as a metabolite in the study of metabolic pathways and can be converted to Methyl 3,5-di-O-(4-chlorobenzoyl)-a-D-ribofuranoside by hydrolysis with dilute acid. Methyl 2-deoxy-3,5-di-O-(4-chlorobenzoyl)-a-D ribofuranoside has been shown to be a synthetic molecule and is listed in pharmacopoeia. CAS No. 7818564 5.</p>

<p>6-(2,4-Dichlorophenyl)-1,2,4-triazine-3,5-diamine is a metabolite that can be found in the urine and blood of humans. It has been shown to have cytotoxic effects on human lymphocytes and erythrocytes. 6-(2,4-Dichlorophenyl)-1,2,4-triazine-3,5-diamine is used as an impurity standard for HPLC analysis and as a reference compound for pharmacopoeia. This chemical is also used in the synthesis of some drugs. 6-(2,4-Dichlorophenyl)-1,2,4-triazine-3,5-diamine is not listed in any pharmacopoeia or natural product database.</p>

<p>Ethyl 3-(dimethylamino)-2-(4-methoxyphenyl)propanoate is an impurity standard for drug product. It is a high purity, API impurity, HPLC standard and niche chemical that is found in the CAS No. 323176-93-8. This compound is used in drug development and analytical research. It is a synthetic compound that can be custom synthesized, natural or found in research and development.</p>

<p>Soluble in Chloroform &amp; in Methanol Confirmed<br>Insoluble in Wate</p>

<p>Decitabine is a drug product that is used as an anti-cancer drug. It is a synthetic, natural, and research and development (R&amp;D) metabolite with the CAS No. 909402-26-2. Decitabine has shown anticancer activity in vitro and in vivo against leukemia cells. This compound is an impurity of the API decitabine that is manufactured by a chemical synthesis process. The analytical impurities are 11 compounds that have been identified from the HPLC standard of this API. The metabolites of these compounds are also included in this standard. High purity decitabine should be obtained for pharmacopoeia studies and niche applications such as HPLC standards, pharmaceuticals, or research purposes.</p>

<p>Hydrocortisone 21-Aldehyde (Hydrate</p>

<p>Amiodarone hydrochloride is an antiarrhythmic drug that belongs to the class of chromatographic agents. It is a prodrug, which is metabolized to amiodarone in vivo. Amiodarone has been shown to be effective in preventing ventricular fibrillation and malignant arrhythmias. Amiodarone prevents the onset of cardiac arrhythmia by prolonging the action potential duration and refractory period, which stabilizes the cell membrane potential during depolarization. The drug also inhibits the release of calcium ions from the sarcoplasmic reticulum, thereby reducing excitability and preventing re-entry into a fibrillating state. Amiodarone is used for the treatment of atrial fibrillation, ventricular tachycardia, and chronic heart failure.</p>

<p>(R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one (FPH) is a synthetic drug product that is used as an impurity standard in the synthesis of pharmaceuticals. It is also used in metabolism studies and research and development. FPH has been shown to be a metabolite of the drug product, 3-(3-fluoro-4-(4-morpholinyl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one, which is classified as an API impurity for pharmacopoeia purposes. FPH has a molecular formula of C11H14FO2N2O and a molecular weight of 222.26 g/mol. The CAS number for FPH is 168828-82-8.</p>

<p>Tanshinone IIA is an enantioselective hydroxamic acid that inhibits matrix metalloproteinase. It is a structural analogue of the hydroxamic acid Tanshinone I and has been shown to inhibit aggrecanase, which is an enzyme that hydrolyzes the glycosaminoglycan aggrecan. It also has anti-cancer effects due to its inhibition of cell proliferation in cancer cells. Tanshinone IIA can be used as a chiral synthon for polymerase chain reactions (PCR) because it contains a stereogenic centre in its structure.</p>