APIs pour la recherche et les impuretés

<p>Analogue of sildenafil</p>

<p>Des(2-methylbutyryl)pavastatin sodium is a synthetic analog of the natural product, pravastatin. It is the methyl ester of the active metabolite of pravastatin and has been shown to be an effective inhibitor of cholesterol biosynthesis. Des(2-methylbutyryl)pavastatin sodium is used in drug development as an analytical standard and as a research and development impurity standard for HPLC. This compound's CAS number is 151061-28-8, making it a niche product that does not require extensive synthesis.</p>

<p>3-Bromo-N,N-dimethyl-3-(4-methylbenzoyl)propionamide is a natural metabolite of the drug 3-(2,6-dichlorobenzoyl)-1,2,3,4-tetrahydroisoquinoline. It is an impurity found in the synthesis of 3-(2,6-dichlorobenzoyl)-1,2,3,4-tetrahydroisoquinoline and has been shown to be a metabolite of this compound. 3-Bromo-N,N-dimethyl-3-(4-methylbenzoyl)propionamide is also used as an analytical reference material for HPLC. This chemical can be synthesized from commercially available starting materials or custom synthesized with your specifications.</p>

<p>6-Epi pravastatin sodium salt is a synthetic compound with the same molecular formula and chemical structure as the natural product. It has been used in pharmacological studies, drug development, and research. 6-Epi pravastatin sodium salt is a metabolite of pravastatin.</p>

<p>3-O-Methyl L-DOPA monohydrate is a chromatographic method that is used to diagnose Parkinson's disease. The method separates the catechol-o-methyltransferase (COMT) from plasma samples, which converts dopamine to 3-O-methyl dopamine. The 3-O-methyl dopamine reacts with an electrochemical detector and overlapped peaks can be seen on the chromatogram. This analytical method can be used to detect low levels of dopamine in the blood and diagnose Parkinson's disease.</p>

<p>D-Asp(9)-Semaglutide is a semaglutide impurity. The amino acid at position 9 has been replaced by the D-form of the amino acid D-aspartic acid (D-Asp). Semaglutide impurities are structurally related compounds that arise during synthesis, purification, or storage of semaglutide, a long-acting GLP-1 receptor agonist for managing type 2 diabetes and obesity.</p>

<p>Lercandipine Impurity A is a metabolite of the drug lercandipine. It is synthesized in the body by oxidation at the benzylic position of the cinnamoyl moiety. This impurity may be present in lercandipine-containing drugs and products, as well as in other drugs and products containing lercandipine. Lercandipine Impurity A has been shown to inhibit the metabolism of lercandipine and may also have anti-inflammatory properties. It is used as an analytical standard for HPLC, pharmacopoeia, drug development, and metabolism studies. Lercandipine Impurity A is found in the following: -Impurities of Lercandipine -Custom synthesis -Lercandipine Drug Product -Synthetic -High purity -Pharmacopoeia -Drug development</p>

<p>Cefpodoxime proxetil impurity H is an impurity of cefpodoxime proxetil, which is a prodrug that has been shown to be metabolized by esterases to the active form cefpodoxime. Cefpodoxime proxetil impurity H was found in the elution fraction when using liquid chromatography with reversed-phase as the separation method. It is thought that this impurity may arise from the use of methanol in the process of preparing cefpodoxime proxetil, although other mechanisms have not been ruled out. The mass spectrum for cefpodoxime proxetil impurity H shows peaks at m/z 812 and 682, which correspond to the parent drug and its hydrolysis product, respectively. The fragmentation pattern observed for cefpodoxime proxetil impurity H corresponds to that seen for cephalosporins.</p>

<p>Leflunomide is a drug that belongs to the class of pyridones. It is used in the treatment of rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, and ankylosing spondylitis. Leflunomide inhibits ATP-binding cassette transporter A1 (ABCA1) and P-glycoprotein (Pgp) which are membrane proteins involved in the transport of lipophilic molecules across cellular membranes. Leflunomide also has been shown to inhibit 5-hydroxytryptamine2 receptors (5HT2 receptors). This inhibition may be responsible for leflunomide's effect on water retention. Leflunomide is metabolized into leflunic acid by cytochrome P450 enzymes, mainly CYP3A4. The activity of leflunic acid is similar to that of leflunomide.</p>

<p>The product is an impurity that is used as a standard in HPLC analysis. It is a natural metabolite of olmesartan, which is a drug marketed for the treatment of hypertension. The purity levels are high and the material has been shown to be stable with respect to decomposition in the presence of light, heat, or alkali. This compound has also been used in metabolism studies and as an analytical reference material.</p>

<p>5-Benzamidolevulinic acid is an ethylamine derivative that inhibits the enzyme carbonic anhydrase. It is used as a synthetic intermediate in the production of other drugs, such as dopamine and remoxipride. 5-Benzamidolevulinic acid can be found as a metabolite in the urine of humans exposed to this chemical. The major urinary metabolites are 5-benzamidolevulinate, 5-benzamidoethanol, and 2,5-dihydroxybenzoic acid.</p>

<p>7α-Hydroxyhydrocortisone</p>

<p>2,4-Dicyano-3-(3,4-dihydroxy-5-nitrophenyl)-N1,N1,N5,N5-tetraethylpentanediamide is a white crystalline solid that is used as an analytical reference standard in HPLC. It is used for the determination of purity and impurities in pharmaceuticals and drug products. This compound can be custom synthesized or obtained from natural sources. It can be found in the USP Drug Impurity Standards and the European Pharmacopoeia.</p>

<p>(RS)-Di-(2-methoxyethyl) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate is an impurity standard for the API (Active Pharmaceutical Ingredient) Impurity Standard. It may be used as a reference compound in HPLC analyses of analytical samples. This compound has been evaluated by the National Institute of Standards and Technology (NIST) to be a niche HPLC standard. It is also a metabolite of the drug product Metaxalone.</p>

<p>N-[(1R)-1-(1-Naphthalenyl)ethyl]carbamic acid 3-[3-(trifluoromethyl)phenyl]propyl] ester is a drug product. It is a synthetic substance that is used in the development of new drugs and for research and development. This impurity standard is used as an analytical reference in the testing of other compounds. N-[(1R)-1-(1-Naphthalenyl)ethyl]carbamic acid 3-[3-(trifluoromethyl)phenyl]propyl] ester has been shown to be a metabolite of CAS No. 915979-44-1, which is also known as N-[(2S)-2-[[5-[3-(Trifluoromethoxy)phenoxy]-2-pyridinyl]methyl]-2,5-dioxopyrrolidin-1-yl]-3,</p>

<p>Daunomycinone is a chemical compound that belongs to the group of antitumor agents. It is used in cancer therapy and has been shown to inhibit protein synthesis, leading to cell death. Daunomycinone can be synthesized by reacting adriamycin with trifluoroacetic acid in the presence of an organic base. This reaction produces a daunomycinone molecule that has a hydroxyl group at one end and a carbonyl group at the other. The binding constants between daunomycinone and human serum proteins have been determined experimentally using molecular modeling techniques. Hydrogen bonding interactions are also present in this complex, which may account for its high affinity for proteins found in human serum.</p>

<p>(S)-N2-(Methoxymethyl)-N6-proply-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6 diamine) is an API impurity. CAS No. for this product is not available. This product is a custom synthesis and can be purchased as a research and development product. It has been shown to inhibit the activity of bacterial DNA gyrase and topoisomerase IV, which maintains the integrity of bacterial DNA. The chemical name for this product is (S)-N2-(Methoxymethyl)-N6-proply-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6 diamine).</p>

<p>Ene sacubitril is an impurity in the drug product sacubitril. It is a synthetic compound that belongs to the class of drugs called angiotensin II receptor antagonists. This impurity can be used as a research and development standard, custom synthesis, or drug product impurity standard. Ene sacubitril is also a metabolite of sacubitril and can be used for metabolism studies or HPLC standard.</p>

<p>Atorvastatin diepoxide is an analytical standard for the drug atorvastatin that is used in the development of pharmaceuticals. It is synthesized by reacting atorvastatin with epichlorohydrin, which produces a diepoxide derivative. This synthetic molecule can be used as an impurity standard for HPLC analysis. The CAS number for atorvastatin diepoxide is 887470-43-1.</p>

<p>N,N',N''-Tris(4-chlorobenzylideneimino)guanidine hydrochloride is an analytical standard used to determine the purity of a drug product. It is also used as a pharmacopoeia standard and in research and development. N,N',N''-Tris(4-chlorobenzylideneimino)guanidine hydrochloride is synthesized from 4-chlorobenzaldehyde and 1,2,3-triazole. It has been shown that this chemical can be metabolized by CYP1A2, CYP2D6, CYP3A4, and CYP3A5 enzyme systems. This chemical has not been found to have any impurities.</p>

<p>11-(1-Piperazinyl)dibenzo[b,f][1,4]thiazepine hydrochloride is a drug product that is used as an impurity standard in the manufacture of 11-aminoundecanoic acid. It is also used to study the metabolism of this compound. This drug product is not intended for use in humans or animals.</p>

<p>Please enquire for more information about 8-Chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-[[1-(Methylamino)-2-nitroethenyl]amino]-ethanethiol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>3-(3-(Trifluoromethl)phenyl-N-(R)-1-(naphthalen-1-yl)ethyl)prop-2-en-1-amine is a synthetic compound, which is not found in nature. It is an API impurity and a metabolite of the drug product. It can be synthesized in high purity and with a custom synthesis. 3-(3-(Trifluoromethl)phenyl-N-(R)-1-(naphthalen-1-yl)ethyl)prop-2-en-1-amine has been found to be involved in metabolism studies and research and development, as well as analytical purposes. This compound can also serve as an impurity standard for HPLC analysis.</p>

<p>Hydrocortisone 21-Aldehyde (Hydrate</p>

<p>2-Nitroacetamide sodium salt is an impurity of the drug N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-2-nitroacetamide, a synthetic chemotherapeutic agent for the treatment of cancers. This compound has been shown to have metabolism studies and natural properties. It has a CAS number of 112251-56-6 and is found in the pharmacopoeia. 2-Nitroacetamide sodium salt is a custom synthesis that can be used as a reference standard for HPLC analysis. It can also be used as a drug product or metabolite in drug development.</p>

<p>Biotin impurity E is a metabolite of biotin that is produced by the metabolism of biotin in humans. It can be detected in urine, saliva, and blood. Biotin impurity E has been shown to be naturally occurring and is a metabolite of biotin found as an impurity in pharmaceutical products. The purity of this drug product was determined to be 98% by HPLC analysis with a detection limit of 0.1%.</p>

<p>Risedronate sodium hydrate is a polymorphic, water-soluble salt of risedronate. It has been used in the treatment of osteoporosis and Paget's disease of bone. Risedronate sodium hydrate binds to calcium ions in the body and prevents them from being deposited in bone tissue. This drug also cross-links collagen fibers in the bone matrix, which increases mineralization and decreases the risk of fracture by strengthening the bones. The monosodium salt form of risedronate is soluble in water and is used as an analytical reagent for determining ionic strength or pH. It has been shown to inhibit ionotropic gelation, which may be due to its polyphosphoric acid content. Risedronate sodium hydrate is a polymorphic, water-soluble salt of risedronate that has been used in the treatment of osteoporosis and Paget's disease of bone. Risedronate sodium hyd</p>

<p>Atorvastatin is a statin drug that inhibits the enzyme HMG-CoA reductase, which is responsible for cholesterol synthesis. Atorvastatin is used to lower LDL cholesterol and total cholesterol levels in the blood. It also lowers triglyceride levels and raises HDL cholesterol levels. Atorvastatin has been shown to inhibit fibrinogen production, reduce TNF-α production, and improve body mass index (BMI) in obese patients. This drug has been shown to be effective in reducing the size of atherosclerotic lesions by decreasing the amount of cholesteryl esters transferred from high-density lipoprotein (HDL) to low-density lipoprotein (LDL). It has also been shown to inhibit collagen production and stimulate muscle cell proliferation.</p>

<p>3,4-Dihydroxybenzoic acid 3-O-sulfate sodium salt is an active compound that has been shown to have potential as a cancer inhibitor. It acts by inhibiting the activity of mutant cells and cancer cells, making it a promising candidate for cancer treatment. This compound has been tested on human cell lines and analogs, demonstrating its ability to inhibit tumor growth and prevent the progression of cancer cells. Additionally, 3,4-Dihydroxybenzoic acid 3-O-sulfate sodium salt has been identified as one of the active agents in Chinese medicine that can regulate protein expression and cell cycle progression by targeting kinases. Its potent anti-cancer properties make it a promising therapeutic agent for the treatment of various forms of cancer.</p>

<p>2-(N-Methyl-propanamine)-3-(2-naphthyl) thiophene is a synthetic compound that has been used as an impurity standard for the drug product and API. It has also been used for the pharmacopoeia, research and development, and analytical purposes. This compound is a metabolite of erythromycin.</p>

<p>Olsalazine sodium impurity D is a natural substance that is present as an impurity in the drug Olsalazine sodium. It is used as an analytical standard for Olsalazine sodium and its metabolites, which are involved in drug development. The purity of this substance can be customized by our research and development team. This product has CAS number 93964-55-7 and is available at a reasonable price.</p>

<p>D-Arg(28)-Semaglutide is a semaglutide impurity. The amino acid at position 28 has been replaced by the D-form of the amino acid D-arginine (D-Arg). Semaglutide impurities are structurally related compounds that arise during synthesis, purification, or storage of semaglutide, a long-acting GLP-1 receptor agonist for managing type 2 diabetes and obesity.</p>

<p>(+)-9-Hydroxyrisperidone is an active metabolite of risperidone, which is an atypical antipsychotic. It functions as a dopamine (D2) receptor antagonist and serotonin (5-HT2A) receptor antagonist. The (+)-9-hydroxyrisperidone binds to the D2 receptor in the brain and prevents dopamine from binding, thereby blocking dopamine D2 receptors. This blocks the action of dopamine on postsynaptic cells, which results in a decrease in dopaminergic effects such as extrapyramidal symptoms and akathisia. In addition, (+)-9-hydroxyrisperidone binds to serotonin 5-HT2A receptors and blocks serotonin from binding, thereby blocking serotonin effects such as hallucinations and suicidal thoughts.</p>

<p>Chlorthalidone impurity H is an impurity standard for chlorthalidone. It is a synthetic chemical and its CAS number is 2200280-98-2. It has the molecular formula C14H14ClN4O4S, molecular weight of 336.36 g/mol, and melting point of 174°C. Chlorthalidone impurity H is soluble in water and ethanol, but insoluble in ether or chloroform. It can be used as an analytical standard for HPLC and as an API impurity in the pharmacopoeia. This drug can also be used in drug development, natural product synthesis, metabolism studies, and drug product manufacturing.</p>

<p>N,N-Dimethyl-3-(4-methylbenzoyl)propionamide is a metabolite of the antihistamine drug diphenhydramine. It is a natural impurity and an impurity standard for this drug. N,N-Dimethyl-3-(4-methylbenzoyl)propionamide can be used in pharmacopoeia to test for purity and quality of drugs, as well as for analytical purposes. It has also been used in drug development and metabolism studies.</p>

<p>5-Aminolevulinic acid hexyl ester hydrochloride is a cytotoxic drug that inhibits the growth of cancer cells. It is used to diagnose and treat certain cancers, including squamous cell carcinoma, skin cancer, and some types of lung cancer. 5-Aminolevulinic acid hexyl ester hydrochloride can be used in conjunction with fluorescein angiography to detect blood vessels in the skin or other tissues. This drug has also been shown to have anti-inflammatory properties that may be useful for the treatment of autoimmune diseases.</p>

<p>Caspofungin impurity C is a high-purity, chromatographically pure, caspofungin impurity. It was isolated by chromatography and was found to have a retention time of 12.5 minutes on the chromatogram. The impurity is thought to be an organic compound with a molecular weight of 437.2 and may be due to the presence of an acetyl group or hydroxyl group.</p>

<p>Please enquire for more information about D-Ser32-Tirzepatide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Soluble in Chloroform &amp; in Methanol Confirmed<br>Insoluble in Wate</p>

<p>Adefovir Dipivoxyl Impurity I is a white crystalline powder with a melting point of 232–234 °C. It is soluble in water, and insoluble in organic solvents. Adefovir Dipivoxyl Impurity I is used as an impurity standard for Adefovir Dipivoxyl and has been shown to be metabolized by CYP3A4 and UGT1A9. This impurity also has the potential to inhibit DNA synthesis in cells.</p>

<p>Raloxifene N-oxide is a synthetic drug product that is used in the treatment of osteoporosis. It belongs to the family of selective estrogen receptor modulators (SERM). Raloxifene N-oxide has been shown to inhibit bone resorption and reduce the risk of vertebral fractures. It also has anti-estrogenic effects, which have been shown to be beneficial for prostate cancer patients who are receiving androgen deprivation therapy. Raloxifene N-oxide is an impurity in the synthesis of raloxifene, which is a drug product with CAS number 195454-31-0. The purity of this compound should be at least 99%.</p>

<p>N-[4-Amino-3-(trifluoromethyl)phenyl-3-[(4-fluorophenyl)-(R,S)-sulphinyl]- (R,S)-2-hydroxy-2-methylpropanamide is a sulfoxide that was designed to inhibit cancer cell proliferation. It has been shown to have anticancer activity in different models. The synthesis of this compound begins with the chlorination of 4-aminophenol, which produces 4-(chloromethyl)benzenesulfonyl chloride. This is then reacted with (R,S)-α-(4-Fluorophenyl)acetic acid and the resulting product is purified by column chromatography to give N-[4-(chloromethyl)phenyl]-3-[(4-fluorophenyl)(R,S)-sulphinyl]propaneamide. The final step in the synthesis is achieved by reacting the amide</p>

<p>Duloxetine succinamide is a chromatographic, solid, acidic compound. It has been synthesized by reacting (S)-duloxetine hydrochloride with succinic anhydride in the presence of triethylamine and acetonitrile. The reaction mixture was purified by high-performance liquid chromatography to produce the desired product. The purity of the compound was confirmed by postulating that it should have a reversed-phase HPLC profile similar to that of duloxetine succinate. Duloxetine succinamide is not soluble in water and is insoluble in organic solvents such as acetone, chloroform, ether, or benzene. The compound is stable at room temperature but decomposes when heated at higher temperatures.<br>!--</p>

<p>N-Despropyl ropinirole hydrochloride is a synthetic drug product that is used as a research and development impurity standard. It is also used in the synthesis of other drugs and has been shown to have an analytical purity of 99%. N-Despropyl ropinirole hydrochloride is not active against bacteria, fungi, or viruses.</p>

<p>6-(2,4-Dichlorophenyl)-1,2,4-triazine-3,5-diamine is a metabolite that can be found in the urine and blood of humans. It has been shown to have cytotoxic effects on human lymphocytes and erythrocytes. 6-(2,4-Dichlorophenyl)-1,2,4-triazine-3,5-diamine is used as an impurity standard for HPLC analysis and as a reference compound for pharmacopoeia. This chemical is also used in the synthesis of some drugs. 6-(2,4-Dichlorophenyl)-1,2,4-triazine-3,5-diamine is not listed in any pharmacopoeia or natural product database.</p>

<p>Phytofluene is a natural compound that has been found to have potential as an anticancer agent. It acts as an inhibitor of cancer cell growth and induces apoptosis, or programmed cell death, in tumor cells. Phytofluene has been shown to inhibit the activity of several important proteins involved in cancer development, including chitinase and heparin-binding protein. It is derived from Chinese medicinal plants and has been used for centuries for its anti-inflammatory and antioxidant properties. In addition to its anticancer effects, phytofluene has also been found to inhibit the activity of kinases in human urine, suggesting a potential role in the treatment of other diseases such as diabetes and cardiovascular disease.</p>

<p>[(2-Butoxyethoxy)ethyl] 2-[(trifluoromethyl)phenylamino]benzoate is a synthetic chemical that is an impurity in the synthesis of the drug product, [(2-butoxyethoxy)ethyl] 2-[(trifluoromethyl)phenylamino]-benzoate. It is a white to off-white solid with a melting point of 53°C. The purity of this compound is high and it has been used as an analytical standard for HPLC. This compound also has niche application in pharmacopoeia and drug development.</p>

<p>2-Ethoxy-4-[2-[[(1R)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzoic acid ethyl ester is a drug product that has been custom synthesized for use in research and development. This chemical has analytical properties, which can be used to study the metabolism of this compound. It is also used as a pharmacopoeia impurity standard and an API impurity. 2-Ethoxy-4-[2-[[(1R)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzoic acid ethyl ester is metabolized in vivo to form metabolites with different spectra of activity. These metabolites are used as analytical standards for HPLC analysis.</p>

<p>Cetirizine glycerol ester impurity is a drug product that is an analytical impurity. It is a natural, API impurity, and synthetic. The CAS number for this impurity is 1243652-36-9. Research and Development (R&amp;D) of cetirizine glycerol ester impurity is required for the manufacture of pharmaceutical products. High purity cetirizine glycerol ester impurity can be used as a pharmacopoeia standard for HPLC analyses.</p>

<p>Rac-N-Demethylpromethazine hydrochloride is a racemic mixture of promethazine. It is an analytical reference material that is offered as a high purity API impurity standard, which can be used for HPLC analysis. Rac-N-Demethylpromethazine hydrochloride is also offered as a drug development and drug product impurity standard for the manufacture of drugs. The racemic mixture of promethazine has been shown to inhibit the growth of bacteria by competitive inhibition of bacterial enzymes. Rac-N-Demethylpromethazine hydrochloride acts on bacterial DNA gyrase and topoisomerase IV, which maintain the integrity of bacterial DNA by inhibiting the production of proteins vital for cell division. Rac-N-Demethylpromethazine hydrochloride has also been shown to have antiinflammatory properties in animal studies.</p>

<p>Cefdinir impurity E is a research and development, impurity standard, custom synthesis, drug product, synthetic, high purity, pharmacopoeia, drug development and analytical standard. CAS No. 946573-41-7 is the metabolite of cefdinir. It is used to study metabolism of cefdinir in vitro and in vivo. HPLC standards are available for this compound.</p>

<p>25-Hydroxytachysterol is a drug product that is manufactured by natural and synthetic means. The natural form of the compound is found in the urine of pregnant women, while the synthetic form is produced by chemical synthesis. 25-Hydoxytachysterol has been shown to be an analytical standard, impurity standard, and API impurity. It also has been used extensively in metabolism studies and pharmacopoeia research.<br>25-Hydroxytachysterol can be synthesized from cholesterol or obtained from animal sources such as bile acids or piglets. The compound is metabolized by cytochrome P450 enzymes to produce 7alpha,24-dihydroxycholesterol, which has progesterone-like properties.</p>

<p>3-Amino-4-carbamoylpyrazole hemisulfate is a white to yellowish crystalline powder that is soluble in water and methanol. It is a condensation product of allopurinol and ethyl orthoformate with a molecular weight of 312.4. 3-Amino-4-carbamoylpyrazole hemisulfate can be used as an anti-inflammatory agent, but it has not been approved for medical use in the United States.</p>

<p>Remdesivir impurity 2 is an analytical standard used in the development of drugs. It is a metabolite found in the drug Remdesivir. It is a natural product that can be synthesized or isolated from natural sources. Remdesivir impurity 2 is soluble in water and acetonitrile, and it has a melting point of 80-81 degrees Celsius. It has a molecular weight of 208.3 g/mol and CAS number 249712-00-1. This compound is not listed on the current edition of the USP Pharmacopoeia.</p>

<p>Topiramate is a drug used to treat epilepsy and weight loss. The N-methyl impurity is a synthetic compound that is an impurity in the drug product. The impurity was synthesized by reacting 4-hydroxybenzaldehyde with methylamine in the presence of triethylamine. It has been shown to be not metabolized, but excreted unchanged in urine.</p>

<p>6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione is a chlorinating agent that converts alcohols to alkyl chlorides. It is used for the conversion of diazotizable aromatic compounds to diazo compounds. This compound has been shown to be neuroprotective in animal models and provides protection against glutamate excitotoxicity. 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione also reacts with nitrite ions to form the corresponding nitroso derivatives. These derivatives can cause DNA damage and are mutagenic. 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione has been shown to react with aminoguanidine to produce a chromat</p>

<p>2,5-Pyrazinedipropionic acid is a pyrazine derivative with two carboxylic acid groups. It has been shown to be effective in the stabilization of bladder tissue and as a treatment method for bladder cancer. 2,5-Pyrazinedipropionic acid can also be used in the diagnosis of cutaneous melanoma and mesoporous silica nanoparticles that are used in cancer detection. The compound has been found to have a high melting point and water absorption capacity, which makes it suitable for use as an aminolevulinic acid precursor for photodynamic therapy. The compound also has vibrational spectral characteristics that make it suitable for nucleophilic attack on DNA</p>

<p>The synthesis of N,N-dimethyl-2-(1-phenyl-1-(pyridin-4-yl)ethoxy)ethanamine is a two step process. It involves the reaction of pyridine with 2,6-dichloroacetophenone in the presence of excess potassium carbonate followed by the elimination of diethyl ether to produce the desired product. The yield for this reaction is high and it is selective when compared to other reactions that use organic solvents. This product can also be quantified using various analytical methods such as thin layer chromatography and gas chromatography.</p>

<p>Tirzepatide impurity.</p>

<p>Tirzepatide Impurity</p>

<p>D-Ser(12)-Semaglutide is a semaglutide impurity. The amino acid at position 12 has been replaced by the D-form of the amino acid D-serine (D-Ser). Semaglutide impurities are structurally related compounds that arise during synthesis, purification, or storage of semaglutide, a long-acting GLP-1 receptor agonist for managing type 2 diabetes and obesity.</p>

<p>Cetirizine is a drug product that is metabolized to cetirizine propanediol ester. This impurity has been identified in the drug and is not expected to cause any adverse effects in humans. Cetirizine propanediol ester can be synthesized and purified through high-purity, analytical, and natural methods. The pharmacopoeia defines cetirizine propanediol ester as a metabolite of cetirizine. It can also be used as an impurity standard for HPLC analysis.</p>

<p>Nisoxetine is a norepinephrine (NE) reuptake inhibitor that is used as an antidepressant. It has been shown to be a potent and selective NE reuptake inhibitor with a high affinity towards the NE transporter in rat brain synaptosomes, with potency several times higher than that of tricyclic antidepressants. Nisoxetine's major advantage over other antidepressants is its high efficiency, which makes it suitable for large-scale production. The synthesis of nisoxetine involves two steps: 1) reaction of 3-[methyl(phenylmethyl)amino]-1-phenyl-1-propanone hydrochloride with toluene to form the corresponding methyl ester and 2) hydrogenation of the methyl ester to form nisoxetine. This synthesis is efficient, stable, and chiral due to the use of bimetallic catalysts.</p>

<p>Bis-[[2-[(diaminomethylene)amino]thiazol-4-yl]methyl]disulfide is a disulfide derivative of famotidine. It has been used as an analytical reagent for the determination of impurities in famotidine and other related compounds. Bis-[[2-[(diaminomethylene)amino]thiazol-4-yl]methyl]disulfide is soluble in methanol, ethanol and water, but not in acetone. The compound can be prepared by reacting 4-(dimethylamino)-1H-1,2,3-benzothiadiazole with 2-[(diaminomethylene)amino]-4-(N'-methoxycarbonylthio)benzaldehyde and then reductive amination with sodium bisulfite.</p>

<p>Trimethoxy dobutamine hydrochloride is a custom synthesis with CAS No. 51062-14-7, drug product and Metabolite. It is developed for niche, Drug development and Natural. Trimethoxy dobutamine hydrochloride is an API impurity with analytical and HPLC standard. The Impurity standard of it is Synthetic, while the high purity of this compound can be Research and Development or Synthetic.</p>

<p>Esomeprazole impurity 12 is a drug product that belongs to the class of organic compounds. It is a metabolite of esomeprazole, an API impurity. The CAS number for Esomeprazole impurity 12 is 537-19-9 and it has been classified as an analytical standard for HPLC. This compound is not found in any pharmacopoeia and does not have any niche applications.</p>

<p>Olsalazine sodium impurity G is an API impurity. It is an important impurity in the production of Olsalazine Sodium, which is a drug for the treatment of inflammatory bowel disease and ulcerative colitis. This compound has been shown to have a high purity level and a pharmacopoeia grade. The CAS number for this compound is 1209-03-9. This compound can be synthesized using organic chemistry methods, or it can be extracted from natural resources such as plants or animal tissues.</p>

<p>Atorvastatin lactone is a prodrug for atorvastatin. It is an inhibitor of the enzyme HMG-CoA reductase, which is involved in cholesterol synthesis and reduces LDL cholesterol levels. Atorvastatin lactone is absorbed from the gut into the bloodstream and then converted to atorvastatin, which has a higher potency than atorvastatin lactone. This conversion occurs in the liver by cytochrome P450 enzymes, including cytochrome CYP3A4. The pharmacokinetics of atorvastatin lactone are influenced by drugs that inhibit these enzymes. Atorvastatin and its metabolites are excreted in human serum as glucuronide or sulfate conjugates.</p>

<p>Epirubicin impurity G is a synthetic research and development impurity standard that is used in the manufacture of drug products, as well as in the development of new drugs. Epirubicin impurity G is a metabolite of epirubicin and has been shown to be an active inhibitor of DNA synthesis. Epirubicin impurity G may also have potential as an analytical standard for HPLC analysis.</p>

<p>Dehydrocorybulbine chloride salt is a medicinal compound that has shown potential as an anticancer agent. It is an analog of the Chinese herb Corydalis yanhusuo and has been found to inhibit protein kinases, which are enzymes that play a key role in cancer cell growth and proliferation. Dehydrocorybulbine chloride salt has been shown to induce apoptosis (programmed cell death) in various types of cancer cells, including bladder, lung, and breast cancer cells. This compound also exhibits low toxicity towards normal human cells and has shown promise as a possible treatment for certain types of cancer.</p>

<p>Cephalosporin impurity is an industrial by-product that is generated during the production of cephalosporins. It is a white powder that has no known toxicological effects. Cephalosporin impurity can be used as a supplement in inoculated soil to increase the yield of cephalosporium, which is a fungus that produces cephalosporins.</p>

<p>(+/-)-N-Benzyl-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-propylamine hydrochloride is a synthetic drug product with the chemical name of (+/-)-N-Benzyl-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-propylamine hydrochloride. It is an analytical standard, and its CAS No. is 660414-56-2. It has the purity of 99% and a molecular weight of 377.5. The impurities in this product are less than 1%. This product can be used as an analytical reference in HPLC, as well as a drug development and natural standard for pharmacopoeia. This product was synthesized by a process that included: (1) 3,4-(trifluoromethyl)benzaldehyde; (2) A mixture of</p>

<p>Terbutaline Impurity D is a synthetic drug with the CAS number 94109-61-2. This product has been developed as an impurity standard for Terbutaline, which is a drug product that has been approved by the United States Pharmacopoeia (USP). Terbutaline Impurity D can be used to study the metabolism of Terbutaline in animals. It is also used to develop new drugs by chemists and other scientists.</p>

<p>Please enquire for more information about L-138,037 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>N-(Cyclohexylcarbamoyl)-4-(2-((cyclohexylcarbamoyl)amino)ethyl)benzenesulfonamide is a drug product that is an analytical standard. It is metabolized in the body to 4-aminobenzenesulfonamide and cyclohexylurea. This product has been shown to have antibacterial activity against Mycobacterium tuberculosis, Mycobacterium avium, and other bacteria. It also has analgesic properties, which may be due to its ability to inhibit prostaglandin synthesis.</p>

<p>Allopurinol impurity C is a product of the reaction between allopurinol and n-butyl alcohol, which occurs in the presence of sodium hydroxide solution and dimethylformamide. The reaction condition is heated to reflux for 12 hours, after which the mixture is filtered and concentrated under reduced pressure. The resultant crude product is purified by column chromatography with ethyl acetate and then recrystallized from methanol. The synthesis scheme can be found in Figure 1.</p>

<p>Chlorhexidine digluconate impurity K dihydrochloride is a drug product that is an analytical standard. It is a natural metabolite of chlorhexidine digluconate, which is a synthetic compound. Chlorhexidine digluconate impurity K dihydrochloride has been shown to have anti-inflammatory properties and to inhibit the production of prostaglandins in animal studies. The pharmacopoeia designation for this drug product is USP/NF.</p>

<p>Bis-[5-[(dimethylamino)methyl]furan-2-yl]methane is a synthetic compound with the CAS number 16864-73-6. It is used in pharmacological studies and drug development. The purity of this material is greater than 99%.</p>

<p>4-[(2,4-Dihydroxy-3,3-dimethylbutanoyl)amino]-butanoic acid is a white to off-white solid that is soluble in water. It is used as an impurity standard for drug product and as a custom synthesis for research and development. This compound is metabolized by oxidation to form an alcohol and carboxylic acid. The oxidation products are excreted in the urine. 4-[(2,4-Dihydroxy-3,3-dimethylbutanoyl)amino]-butanoic acid has been used for metabolism studies with human liver microsomes.</p>

<p>Calcipotriol EP Impurity H is an impurity found in calcipotriol EP. It is a metabolite of calcipotriol EP, which is the active ingredient in Dovonex. Calcipotriol EP Impurity H can be detected by HPLC with a retention time of 11.5 minutes and its purity can be determined by UV spectroscopy at 254 nm with a purity of &gt;98%. Calcipotriol EP Impurity H can also be synthesized from natural or synthetic sources.</p>

<p>Atorvastatin is a drug used for the treatment of hypercholesterolemia and cardiovascular diseases. Atorvastatin lactam, which is an impurity formed during the synthesis of atorvastatin, has been shown to inhibit cholesterol biosynthesis in a rat model. The in vivo metabolism of atorvastatin lactam was studied by HPLC-MS/MS and was found to be identical to that of the parent molecule. This impurity may be useful as a research and development or custom synthesis product, or as an impurity standard for HPLC analysis.</p>

<p>Rac-2-cyano-2-phenylbutanamide is a synthetic molecule that is used as a growth regulator. It has been shown to be toxic to the arthropod Mollusca, with an LD50 of 1.6 µg/cm² (milligrams per square centimeter). Rac-2-cyano-2-phenylbutanamide also inhibits the growth of organisms such as Anisopliae and Metarhizium, and has been shown to have an asymmetric effect on tissue culture cells. Rac-2-cyano-2-phenylbutanamide is chemically related to the antibiotic subtilin, which belongs to the class of aminoglycoside antibiotics. Rac-2-cyano-2-phenylbutanamide may inhibit bacterial protein synthesis by binding to ribosomes and blocking the attachment of aminoacyl tRNA molecules during translation. This compound also inhibits DNA replication in bacteria by preventing DNA</p>

<p>2'-Deoxy-2',2'-difluorocytidine 5'-monophosphate (CDFMP) is a potent antitumor agent that has been shown to have a strong anti-angiogenic effect. It inhibits the cancer cell's production of microvessels and interferes with the formation of new blood vessels from pre-existing ones, which can be used to deliver chemotherapy drugs to the tumor. CDFMP is synthesized by reacting 2'-deoxy-2',2'-difluorocytidine with phosphoric acid and then converting it into the monophosphate form using phosphorus oxychloride. This drug is also resistant to platinum-based chemotherapy agents, making it a promising drug for patients who are resistant to other treatments.</p>

<p>Dehydroxy bisoprolol is an impurity of the drug Bisoprolol that is used to make the drug product Metoprolol. It is a metabolite of Bisoprolol, which is produced by the liver after metabolism and excretion. Dehydroxy bisoprolol has been detected in plasma, urine, feces, and breast milk. The pharmacological effects of Dehydroxy bisoprolol have not been studied.</p>

<p>Desfluoro atorvastatin is a crystalline polymorph of atorvastatin that has been shown to have improved flowrate and dissolution profile compared with the conventional form. Desfluoro atorvastatin is synthesized by adding a fluorine atom to a specific position in the molecule. The synthesis procedure includes chromatographic purification and analysis of impurities, which are then eliminated by diode laser irradiation. Impurities may also be eliminated through hydrogenation or recrystallization.</p>

<p>2H,5H-Pyrano[4,3-b]pyranyl mupirocin sodium impurity is an impurity standard that has been custom synthesized for research and development purposes. It has a CAS number of 116182-44-6, which is the same as the parent compound. 2H,5H-Pyrano[4,3-b]pyranyl mupirocin sodium impurity is a metabolite of Mupirocin Sodium (CAS No. 99765-92-8). This impurity has been used in pharmacopoeia drug development and for analytical studies such as HPLC.</p>

<p>Intermediate in the synthesis of ribavirin</p>

<p>4-Desmethoxy omeprazole sulfide is a metabolite of omeprazole, a drug that is used to treat ulcers and gastroesophageal reflux disease. 4-Desmethoxy omeprazole sulfide is not an impurity in the production of omeprazole, but is present as a natural component of omeprazole. This compound has been shown to be an impurity standard for HPLC analysis. The pharmacopoeia defines 4-desmethoxy omeprazole sulfide as an API impurity in drug products. It is also being studied for its potential use in drug development and research and development.</p>

<p>Daunorubicin metabolite</p>

<p>Dideiodo amiodarone is a noncompetitive inhibitor of the enzyme, which is expressed in the human heart. It has been shown to interact with the benzofuran derivatives that are responsible for the antiarrhythmic effects of amiodarone. The inhibitory potency of dideiodo amiodarone is dose-dependent and constant. This drug has shown no competitive inhibition against any other analogs, such as quinidine or digitoxin. Dideiodo amiodarone inhibits the enzyme by binding to an allosteric site on the enzyme molecule. This site does not bind any other analogs, such as quinidine or digitoxin, and therefore it does not compete for this site.</p>