APIs pour la recherche et les impuretés

<p>Blonanserin impurity 1 is a compound that is closely related to blonanserin, a dopamine antagonist used in the treatment of schizophrenia. This impurity is a steroid derivative that contains a benzoate group and forms hydrogen bonds with other molecules. It has been found to emit positron signals, making it useful in positron emission tomography (PET) imaging studies. Blonanserin impurity 1 has also shown antiviral activity and potential as an androgen receptor modulator. Additionally, it has been studied for its bioavailability and interaction with oxysterols, which are oxidized derivatives of cholesterol. This compound may have applications in the development of new therapeutic agents for various conditions, including viral infections and hormonal disorders.</p>

<p>Redaporfin is an analog of the protein kinase inhibitor quetiapine, which has shown potential as an anticancer agent. It works by inhibiting kinases that are involved in cancer cell growth and proliferation. Redaporfin has been shown to induce apoptosis in human tumor cells, making it a promising candidate for cancer treatment. This drug has also been found to be effective against Chinese hamster ovary cells when tested in urine samples. Additionally, Redaporfin has been found to have inhibitory effects on other proteins, making it a versatile tool for researchers studying protein interactions and signaling pathways.</p>

<p>(S)-8,14-Dihydroxy efavirenz is a medicinal analog that has shown potential anticancer activity. It is a kinase inhibitor that targets specific kinases involved in cancer cell growth and survival. (S)-8,14-Dihydroxy efavirenz has been shown to induce apoptosis in human cancer cells and inhibit tumor growth in Chinese hamster ovary cells. This compound also has potential as a urinary biomarker for certain types of cancer. Its protein binding properties make it an effective inhibitor of kinases, which are essential for cellular processes such as DNA replication and protein synthesis. (S)-8,14-Dihydroxy efavirenz has promising potential as an anticancer agent and warrants further investigation.</p>

<p>Please enquire for more information about 3-Phenyl-4-(4-chlorosulfonylbenzyl)-5-methylisoxazole including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Elbanizine is an anticancer agent that works by inhibiting kinase activity in cancer cells. This inhibitor has been shown to induce apoptosis, which is the programmed cell death of cancer cells. Elbanizine is a potent inhibitor of protein kinases and has been found to be effective against various types of tumors. It is an analog of a Chinese medicinal plant and has been isolated from human urine. Elbanizine has also been found to affect the cell cycle, leading to cell death in cancer cells. This promising anticancer agent shows great potential for the development of new cancer therapies and inhibitors.</p>

<p>Genistein 4’-β-D-glucuronide is an isoflavonoid that is a natural product of soy and red clover, with estrogenic properties. It has been shown to have the ability to bind to estrogen receptors and inhibit the growth of breast cancer cells. Genistein 4’-β-D-glucuronide has been shown to inhibit the production of estrone sulfate in human breast cells, which may be due to its ability to act as an estrogen receptor antagonist. The isoflavonoid genistein also binds to and inhibits the activity of DNA topoisomerase II enzymes in human breast cells.</p>

<p>5-[4’-Carboxy-(1,1’-biphenyl)-2-yl]-2-triphenylmethyltetrazole is a versatile compound with various applications. It has been found to exhibit steroid-like properties and interacts with dopamine receptors. Additionally, it has shown antiviral activity against certain viruses such as tenofovir and blonanserin.</p>

<p>Digitoxigenin mono-β-D-digitoxoside is a potent inhibitor of tumor growth and cancer cell proliferation. It is an analog of the cardiac glycoside digitoxin, which is known for its anticancer properties. Digitoxigenin mono-β-D-digitoxoside has been shown to induce apoptosis in human cancer cells by inhibiting protein kinases such as AKT and ERK1/2. This drug also has potential therapeutic applications in the treatment of ghrelin-related diseases, as it has been shown to inhibit the activity of ghrelin, a hormone that stimulates appetite and promotes weight gain. Additionally, digitoxigenin mono-β-D-digitoxoside exhibits high water solubility due to its cellulose-based structure, making it ideal for use in urine-based diagnostic tests for cancer detection.</p>

<p>Please enquire for more information about Defluoro pitavastatin including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2,4-Dihydroxy-6-propylbenzaldehyde including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Losartan is a drug product that belongs to the class of losartan impurity. It is an impurity standard for research and development, as well as a custom synthesis. Losartan is also used in the synthesis of other drugs, such as losartan potassium, which is classified as a niche compound. Losartan impurity has been shown to be metabolized by several enzymes including CYP2C9 and CYP3A4. The metabolite identified from this study was N-desmethyl losartan.</p>

<p>Please enquire for more information about L-Trans-1-methyl-4-propyl-2-pyrrolidinecarboxamide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>AAK1-IN-1 is a potent inhibitor of the AAK1 kinase, which plays a crucial role in regulating cell cycle progression and apoptosis. This inhibitor has shown promising results in pre-clinical studies for the treatment of cancer, particularly leukemia. AAK1-IN-1 has been found to effectively inhibit the growth of human cancer cell lines and Chinese medicinal tumor cells by blocking the activity of AAK1 kinase. This protein is involved in several cellular processes, including signal transduction pathways and protein trafficking, making it an attractive target for cancer therapy. The use of AAK1-IN-1 as a novel kinase inhibitor may offer new opportunities for developing effective treatments against various types of cancer.</p>

<p>Please enquire for more information about 3,5-Diiodo-4-hydroxy-DL-phenyllactic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 4-Acetyloxy-N-despropyl ropivacaine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Levofloxacin is a synthetic molecule with an asymmetric carbon atom in its heterocycle. It is synthesized by reacting chloroform with 2-fluoro-5-nitrobenzaldehyde, which reacts further with sodium hydroxide and hydrochloric acid to form the levofloxacin carboxylic acid. Impurities can be found in the reaction product due to chlorine atoms that are formed during the synthesis. The amount of impurities present in the final product can be determined using a titration method or through HPLC analysis. Levofloxacin has been shown to be effective against methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium perfringens, although is not active against acid-fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex.</p>

<p>Deterenol-d7 hydrochloride is a drug product that is an analytical standard. Deterenol-d7 hydrochloride is used in metabolism studies and has been shown to be natural, with the CAS number of 1246817-36-6. Deterenol-d7 hydrochloride also has impurities that are identified as synthetic, which may have an impact on its potency. Deterenol-d7 hydrochloride can be used for Custom synthesis and Drug development, as well as Research and Development. The drug product is a niche compound, with a high purity level of 99%. Deterenol-d7 hydrochloride is a HPLC standard and complies with pharmacopoeia guidelines.</p>

<p>S-Amisulpride is a benzamide antipsychotic drug that is an atypical antipsychotic. It has been shown to be effective in the treatment of schizophrenia, schizoaffective disorder, and bipolar disorder. Amisulpride was first synthesized by a French company called Laboratoires Servier and it was approved for sale in France in 1988. The drug is available as tablets for oral administration. The clinical effects of amisulpride are due to its ability to block dopamine receptors and serotonin receptors, which are neurotransmitters that play a role in the regulation of mood. Amisulpride also has stereoselective properties as it is active as an antipsychotic only when administered in the S-enantiomer form.</p>

<p>Please enquire for more information about (5Z,9Z,13E)-Geranylgeranylacetone including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Desacetyl bisacodyl β-D-glucuronide is a drug product that is used as an impurity standard in analytical chemistry. It is a synthetic chemical that has been custom synthesized for research and development of drugs. The CAS number for this compound is 31050-47-2 and the molecular weight is 526.25 g/mol. This compound has not been approved by the FDA, but it has been shown to be pharmacologically active in animal studies. Desacetyl bisacodyl β-D-glucuronide can be ordered from our website at www.customsynthesislab.com</p>

<p>(7Alpha,17Alpha)- 9,17-Dihydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic acid di-gamma-lactone is a synthetic analogue of progesterone. It is used as a drug product for research and development purposes. The product has been shown to be metabolized through the 3beta hydroxysteroid dehydrogenase pathway or the side chain cleavage enzyme pathways. This product has not been evaluated in humans and should not be used for any human applications. (7Alpha,17Alpha)- 9,17-Dihydroxy-3-oxo-pregn-4-ene-7,21 -dicarboxylic acid di gamma lactone is an impurity standard for HPLC analysis of progesterone in urine.</p>

<p>3-[4-(4-Chlorobenzoyl)phenoxy]-2-butanone is an impurity in the drug product, N-{3-[4-(4-chlorobenzoyl)phenoxy]-2-butenyl}acetamide. It can be used as an analytical reference standard for determining the presence of impurities in pharmaceutical products. 3-[4-(4-Chlorobenzoyl)phenoxy]-2-butanone is not a natural component of the API and is typically synthesized with high purity. This compound has been shown to be metabolized by human liver microsomes and rat lung microsomes. The metabolic pathways are unknown but may include oxidation, hydrolysis, or conjugation reactions.</p>

<p>3-Hydroxy darifenacin is a metabolite of the drug Darifenacin. It is an impurity standard for use in the manufacture of drug products and as a research standard for pharmacopoeia, drug development, and analytical methods. 3-Hydroxy darifenacin is not a natural product.</p>

<p>Monobenzyl phthalate (MBP) is a metabolite of di-n-butyl phthalate (DBP), which is a chemical that is used as plasticizer. MBP is the major metabolite of DBP and has been detected in human urine. Monobenzyl phthalate β-D-glucuronide (MBPG) is an impurity found in certain drug products, including those that are marketed for the treatment of diabetes mellitus. The compound has been shown to inhibit protein synthesis and induce apoptosis in cells.</p>

<p>Cefotaxime sodium impurity F is a cefotaxime sodium salt that has been eluted from the column and is a byproduct of cefotaxime production. It has a structural formula of C6H8NaO4S2. The reaction rate for this impurity is slow, with a diffraction pattern that matches cefotaxime. It is soluble in organic solvents and has fluidity, but it does not dissolve in water. Cefotaxime sodium impurity F can be used as medicine due to its molecule, which is an organic compound with a carbonyl group on one end and the cefotaxime molecule at the other end. This molecule can be purified through gel matrix or liquid chromatography.</p>

<p>3-Methyl pseudoephedrine is a psychoactive substance that is found in the leaves of the plant Ephedra sinica. 3-Methyl pseudoephedrine can be extracted from the plant using trifluoroacetic acid or other chemical techniques. It can be used to treat asthma and nasal congestion. 3-Methyl pseudoephedrine has been shown to have a stimulant effect on the heart, which leads to an increase in heart rate and blood pressure. This drug also has addictive properties, which may lead to increased use or abuse. The frequency of use for this drug varies depending on whether it is used as a stimulant, an appetite suppressant, or an anti-asthmatic agent.</p>

<p>8-Hydroxymethylriboflavin is a metabolite of riboflavin that has been shown to be important in the metabolism of this vitamin. This compound is used as an impurity standard for the detection and identification of drugs or other substances in pharmacopoeia, drug development, and analytical chemistry.</p>

<p>Please enquire for more information about o-Methyl malathion α-monoacid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Xanthene-d2 is an analog of xanthene that has been labeled with deuterium. It is a potent inhibitor of kinases, specifically cyclin-dependent kinases (CDKs), which play a crucial role in regulating the cell cycle and are often overexpressed in cancer cells. Xanthene-d2 has been shown to inhibit the proliferation of various human cancer cell lines, including Chinese hamster ovary cells and human colon carcinoma cells. This compound induces apoptosis in cancer cells by inhibiting CDK activity and disrupting protein synthesis. Xanthene-d2 is also used as a tool for studying kinase inhibitors and their effects on tumor growth. Its use in urine samples can help identify potential biomarkers for anticancer therapy.</p>

<p>Nicergoline EP Impurity B is a metabolite of nicergoline, a drug product. It has been synthesized for use as an impurity standard for analytical and pharmacopoeia purposes. Nicergoline EP Impurity B is not found in nature and has been shown to be metabolically stable in vitro. It can be used as a reference substance for the determination of nicergoline concentrations in human plasma samples.</p>

<p>Quetiapine Impurity 8 is a drug product that is used as an analytical standard for drug metabolism studies. It is a natural impurity found in the API Quetiapine, which has the CAS number 1977-09-9. Quetiapine Impurity 8 is also an impurity standard for HPLC and has been shown to be a synthetic compound. This compound can be custom synthesized and is often used in research and development of new drugs. Quetiapine Impurity 8 has high purity and pharmacopoeia grade, making it suitable for use in niche markets such as drug development, research, and analysis.</p>

<p>SMS2-IN-1 is a nuclear ginseng propionate monoester inhibitor that has shown promising antiviral properties. It has been found to inhibit the activity of galacturonic acid, which is crucial for viral replication. Additionally, SMS2-IN-1 has been studied in molecular docking experiments and has shown potential as an inhibitor of tenofovir disoproxil fumarate, a widely used antiviral drug. This compound also exhibits cytotoxic effects on certain cells and has been explored for its potential in recombination studies. It is important to note that SMS2-IN-1 may contain impurities, including the compound ivermectin.</p>

<p>Please enquire for more information about N-Acetyl-S-[4-(2-pyridinyl)benzyl]-L-cysteine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Rel-M-nitro-threo-chloramphenicol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(R,R)-Solifenacin succinate is a pharmaceutical agent that acts as an antimuscarinic drug. It has been shown to be effective in wastewater treatment, where it was found to reduce the amount of solifenacin and optimised organic chemicals in the water. This drug has also been shown to have antagonist properties against the muscarinic receptor M3.</p>

<p>(R)-Diphenyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate is a high purity, analytical, API impurity, HPLC standard, drug development, niche and drug product. It is an impurity standard for the pharmacopoeia. It is also synthesized from natural or synthetic sources.</p>

<p>6-Bromo-1-hydroxypyrene is a natural metabolite of the aromatic hydrocarbon benzo[a]pyrene. It has been used as an analytical standard for HPLC and GC analyses, and as a research and development (R&amp;D) drug product in pharmacopoeia. 6-Bromo-1-hydroxypyrene has been shown to have anti-inflammatory activities in mouse skin. It also inhibits liver microsomal cytochrome P450 enzymes, suggesting that it may be useful in the treatment of disorders such as Alzheimer's disease.</p>

<p>Buprenorphine is a semi-synthetic opioid that is used to treat pain. It has been shown to have high purity, when compared to other synthetic opioids, and is often used as an analytical standard. Buprenorphine furanyl impurity is an impurity in buprenorphine that can be detected by high-performance liquid chromatography (HPLC). It is also a metabolite of the drug and can be used as a pharmacopoeia reference material.</p>

<p>Cefixime is a broad-spectrum oral antibiotic used to treat bacterial infections, including respiratory tract and ear infections. Cefixime is the prodrug of cefixime acid, which is hydrolyzed in vivo to cefixime. This impurity is an analytical standard that can be used for research and development, high purity drug product, API impurity, HPLC standard and niche drugs. It can also be used as a metabolite and an impurity standard. The CAS number for this compound is 1335475-08-5. This chemical has natural or synthetic origins but is not specified.</p>

<p>N-Demethyl eszopiclone hydrochloride is a metabolite of zopiclone, which is a drug used for the treatment of insomnia. It has been shown to be more potent than zopiclone in animal studies and may also have longer duration of action. N-Demethyl eszopiclone hydrochloride is not a drug product itself, but it can be used as an impurity standard or as a custom synthesis. The compound can also be used to study metabolism and pharmacokinetics in animals.</p>

<p>The chemical name for (3R)-3,6-Dihydro-2H-1,4-thiazine-3,5-dicarboxylic acid 3-ethyl ester-d5 is 2-(2-(pyrrolidin-1-yl)ethoxy)ethanol. This compound is a drug product that has been custom synthesized and purified by HPLC. It is an analytical standard and impurity standard for HPLC. The CAS number for this compound is 944115-20-2.</p>

<p>Amiodarone is a drug that belongs to the group of annular compounds. It has been used in the treatment of cardiac arrhythmias, such as atrial fibrillation (AF) and ventricular tachycardia (VT). Amiodarone has been shown to have a high affinity for specific genes, including those involved in the regulation of the heart. This drug is also used in animals, such as dogs and rats. Amiodarone has been shown to have toxic effects on cardiac tissue and other organs, which may be due to its ability to inhibit the metabolism of thyroid hormones by deiodination. Amiodarone also inhibits synthesis of protein by binding to DNA, inhibiting transcription and translation.</p>

<p>Etoricoxib impurity 5 is an impurity of etoricoxib. Etoricoxib is a nonsteroidal anti-inflammatory drug (NSAID) that belongs to the class of selective COX-2 inhibitors. It inhibits the production of prostaglandins and has been shown to reduce inflammation, swelling, and pain in animal studies. Etoricoxib impurity 5 is an impurity standard for HPLC analysis. This compound has not been evaluated by the FDA or other regulatory agencies.</p>

<p>7-Methoxy-N-[2-(7-methoxy-1-naphthalenyl)ethyl]-1-naphthaleneethanamine is a drug product that is a synthetic compound. It has the following analytical data:</p>

<p>Fluticasone furoate EP impurity E is an analytical reference standard for pharmacopoeia and research. It is a synthetic fluticasone furoate EP impurity that has been custom synthesized for use as a high-purity, HPLC-grade standard. Fluticasone furoate EP impurity E is characterized by its natural origin and purity, making it appropriate for use in drug development and research. The CAS number for this product is 398454-97-2.</p>

<p>2-Deschloro aripiprazole is a drug that belongs to the class of antipsychotics. It is an atypical antipsychotic with a high affinity for human albumin and α1-acid glycoprotein, which are plasma proteins. 2-Deschloro aripiprazole has been shown to interact with human albumin and α1-acid glycoprotein in vitro, and it has been suggested that this interaction may be responsible for its pharmacological effects. 2-Deschloro aripiprazole has also been shown to bind to the dopamine D2 receptor, which is thought to be responsible for its therapeutic effects as an antipsychotic. The molecular interactions between 2-deschloro aripiprazole and human albumin have been studied using isothermal titration calorimetry (ITC) and molecular docking studies. These studies have helped us understand how 2-deschloro aripiprazole binds to human album</p>

<p>Bosentan impurity C is a stable crystalline compound that is soluble in organic solvents. It has been identified as an impurity of the drug bosentan, and has been found to be present in the drug at concentrations of up to 0.2%. Bosentan impurity C can be prepared by crystallization from an alkaline solution and can also be obtained as a salt form. The salt form is a dimer that consists of two bosentan molecules linked together by one oxygen atom. Bosentan impurity C is stable under normal conditions and does not undergo any changes when exposed to light or heat. This compound has shown no significant adverse effects on humans who have taken it, with no adverse effects on the kidney, liver, or lungs reported.</p>

<p>5-[(Hydroxyacetyl)amino]-N,N'-bis [2-hydroxy-1-(hydroxymethyl)ethyl]-2,4,6-triiodo-1,3-benzenedicarboxamide is a drug product that was synthesized for research purposes. It is an analytical standard for HPLC and has not been approved for clinical use. 5-[(Hydroxylacetyl)amino]-N,N'-bis [2-hydroxy-1-(hydroxymethyl)ethyl]-2,4,6-triiodo-1,3-benzenedicarboxamide is a compound with natural origin and has been classified as an API impurity. This synthetic drug product is custom synthesized to meet the requirements of pharmacopoeia standards.</p>

<p>Isopropyl (1S)-(+)-10-camphorsulfate is an analytical standard that is used in the preparation of aqueous solutions with a purity of at least 99.5%. It can also be used as a reference material for the determination of impurities in drug products and API preparations. Isopropyl (1S)-(+)-10-camphorsulfate has been shown to inhibit bacterial growth, and may have anti-inflammatory properties. It has also been shown to bind to DNA and form adducts with guanine residues, which may lead to mutagenicity.</p>

<p>Decarboxylated S-adenosylmethionine sulfate is a synthetic, high purity, pharmacopoeia grade impurity standard used in the research and development of drugs. This drug product is also used as a metabolite in metabolism studies. Decarboxylated S-adenosylmethionine sulfate is synthesized by the decarboxylation of S-adenosylmethionine, which is then reacted with sulfuric acid to form the sulfate salt. Decarboxylated S-adenosylmethionine sulfate has an analytical retention time of 12 minutes and an HPLC purity of 99%.</p>

<p>N,N'-Carbonylbis[L-glutamic acid] is a metal chelate that has been used as a fluorescent marker for diagnostic purposes. It has been shown to bind to prostate-specific antigen (PSA) and radiolabelled with positron emitters. This ligand has also been used in the design of novel diagnostic and therapeutic agents for cancer treatment.</p>

<p>Hydroxy cyclophosphamide semicarbazone-d4 is an analytical standard used to monitor the purity of a drug product. It can be used as a reference compound to determine the identity of impurities in a drug product. Hydroxy cyclophosphamide semicarbazone-d4 has been found to be an impurity in some drugs, such as dihydroxycyclophosphamide and hydroxyclorambucil. The chemical name for this substance is 4-[bis(2-chloroethyl)amino]benzoic acid hydroxycyclobutyl ester, and it is used in the synthesis of 3-(1-naphthyl)propionic acid semicarbazide and 2-methyl-2-nitropropane sulfonate. Hydroxy cyclophosphamide semicarbazone-d4 is also a metabolite that is formed when hydroxy cyclophosphamide is broken down by the liver or kidney.</p>

<p>5-Dimethylaminobutyryl citalopram is a metabolite of the antidepressant drug, Citalopram. It is used as an analytical impurity standard for Citalopram in HPLC and LCMS analysis. 5-Dimethylaminobutyryl citalopram is also a natural product of metabolism and may be found in humans. 5-Dimethylaminobutyryl citalopram has been shown to have similar pharmacological properties to Citalopram in animal studies, which include antihistamine effects and analgesic effects. This compound may be useful as a niche treatment for some patients who are resistant to other drugs.</p>

<p>Nor doxepin-d3 hydrochloride is a high purity, API impurity, HPLC standard and metabolite. Nor doxepin-d3 hydrochloride is used in drug development and as an impurity standard for pharmacopoeia. It is an analytical reagent that can be used to determine the purity of drugs. Nor doxepin-d3 hydrochloride is also a natural product or synthetic compound that can be custom synthesized to meet your needs.</p>

<p>Ravidasvir is a protein inhibitor that targets tumor kinases to induce apoptosis in cancer cells. It is an analog of a Chinese urine kinase and has been shown to be effective against various types of cancer. Ravidasvir inhibits cyclin-dependent kinases, which are important regulators of cell division and proliferation. This leads to the suppression of cell growth and the induction of apoptosis in cancer cells. Ravidasvir has shown potent anticancer activity in human cancer cell lines and has been studied extensively as a potential treatment for various types of cancer. Its unique mechanism of action makes it a promising candidate for further development as an anticancer agent.</p>

<p>Ibuprofen lysinate is a drug product that is used in research and development as a synthetic intermediate. Ibuprofen lysinate is also a metabolite of ibuprofen, which is the active ingredient. Ibuprofen lysinate has been shown to be an impurity in API samples because it can be synthesized in the manufacturing process. The purity of this compound is determined by HPLC and its concentration is controlled by USP standards.</p>

<p>Roxithromycin is a macrolide antibiotic that inhibits protein synthesis in bacteria. It binds to the 50S ribosomal subunit, thereby inhibiting bacterial growth. Roxithromycin has been used to diagnose intestinal and esophageal diseases, inflammatory diseases, and cancer. There are some cardiac effects associated with Roxithromycin that may be related to its ability to inhibit serotonin reuptake. This drug also has anti-inflammatory properties and has been shown to be effective against influenza virus infections as well as other infectious diseases such as tuberculosis and HIV/AIDS.</p>

<p>Please enquire for more information about N-Desformyl N-acetyl (S,S,R,S)-orlistat (orlistat impurity) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Diclofenac isopropyl ester is a synthetic, non-natural drug product. It has been shown to be metabolized by the liver to produce diclofenac acid and sulfate conjugates. The drug product can be used as an analytical standard or impurity control in HPLC measurements of drug products that contain diclofenac. Diclofenac isopropyl ester is also used for research and development purposes and has niche applications for pharmacopoeia purposes.</p>

<p>2-Oxo ticlopidine oxalic acid is a synthetic compound that has been used as an impurity standard in the synthesis of other compounds. The CAS number for this compound is 89481-79-8. 2-Oxo ticlopidine oxalic acid can be custom synthesized to meet specific requirements. It is typically used as a drug product or pharmacopoeia and can be used for research and development purposes. Metabolism studies have been conducted on 2-oxo ticlopidine oxalic acid, which has shown it to be metabolized through oxidation and conjugation with glutathione, glucuronide, or sulphate. HPLC standards for this compound are available at Sigma Aldrich.</p>

<p>Isodiospyrin is a synthetic compound that is used in the synthesis of other compounds. It has been shown to inhibit cell growth in a number of different types of cells, including human leukemia cells and colon cancer cells. Isodiospyrin has also been shown to have potent inhibitory activity against the fatty acid synthase enzyme and the redox potentials it generates. This compound was found to be synthesized from two natural compounds, namely the plant families, quinone and dihydrobenzoquinone. The synthesis process involves an aldol cyclization reaction between these two compounds.</p>

<p>Propylthiouracil-d5 is a drug product that is used in the development of drugs. Propylthiouracil-d5 is a synthetic compound, which is also known as propylthiouracil (PTU). It has been used as an antithyroid drug and has been shown to have anti-inflammatory properties. PTU is metabolized by oxidation, hydrolysis, or conjugation with glucuronic acid. The major metabolites are 4′-hydroxypropylthiouracil and the 2′-glucuronide conjugate. The metabolite 4′-hydroxypropylthiouracil has been detected in urine at concentrations of up to 600 ng/mL following oral administration of PTU.</p>

<p>Toremifene-N-oxide is a drug that has been shown to have genotoxic effects in human liver cells in an incubated system. Toremifene-N-oxide is the active form of toremifene, which is a selective estrogen receptor modulator (SERM). Toremifene-N-oxide is metabolized by peroxidases and can react with reactive oxygen species (ROS) to produce DNA damage. It also binds to DNA at the site of supercoiled DNA, leading to changes in the molecule's structure. Toremifene-N-oxide has been shown to have an optimum pH of 7.4 and ionization mass of 367. This drug binds to lactoperoxidase found in human liver cells and produces reactive molecules that cause oxidative DNA damage.</p>

<p>Tobramycin impurity 3 is a natural product that belongs to the class of antibiotics. It is an impurity in the drug tobramycin, which is used for the treatment of respiratory tract infections. Tobramycin impurity 3 has been shown as a major metabolite of tobramycin by HPLC and GC-MS. The chemical structure is not known, but it has been identified as a metabolite based on its similarity to other metabolites. Metabolism studies are required to elucidate the metabolic pathway and identify the enzyme responsible for its formation.</p>

<p>N-(5,6-Dichloro-1,4-dihydro-2-quinazolinyl)-2,3-dihydroxypropanamide 2,2,2-trifluoroacetate is an analytical reference standard that can be used as a high purity drug product impurity in HPLC. It also has niche application as an API impurity and is a metabolite of the drug quinine.</p>

<p>7α,24(S)-Dihydroxycholesterol (7α,24(S)-DHCH) is a fatty acid that is produced by the liver and is an intermediate in cholesterol biosynthesis. 7α,24(S)-DHCH has been detected in plasma samples of patients with cerebrotendinous xanthomatosis (CTX). It has also been found to be elevated in tuberculosis patients with carotid involvement. The levels of 7α,24(S)-DHCH were found to be higher than those of other oxysterols in CTX patients. In order to identify the origin of this molecule, a LC-MS/MS method was developed for the detection and quantification of 7α,24(S)-DHCH. This method uses chemical ionization for mass spectrometric analysis and can detect 7α,24(S)-DHCH at concentrations as low as 1 ng/mL. Histological analyses were conducted on human tissue samples</p>

<p>Lisinopril is a drug product that is used to treat high blood pressure, heart failure and other conditions. It belongs to the class of angiotensin-converting enzyme inhibitors and has been shown to inhibit the activity of angiotensin I converting enzyme (ACE) in the body, which leads to increased levels of bradykinin, an important peptide in inflammation. Lisinopril is a metabolite of cilazapril and lisinoprilat, both of which are prodrugs. Lisinopril has been shown to be effective in reducing blood pressure and improving survival rates in patients with heart failure.</p>

<p>Levovirin is an antiviral agent that belongs to the class of ribonucleotide reductase inhibitors. It is a potent inhibitor of hepatitis C virus replication and has been shown to be active against HIV in vitro. Levovirin acts as a competitive inhibitor of the NS3 protease, which is responsible for processing viral proteins. This inhibition prevents the production of new virus particles and the spread of infection. Levovirin also has immunomodulatory effects, which may provide therapeutic benefits in autoimmune diseases such as rheumatoid arthritis or Crohn's disease.</p>

<p>Sodium 5-(diphenylphosphinyl)pentanoate is an impurity present in the drug product and is an analytical reference material for metabolism studies. It is a natural compound that has been custom synthesized for use as a synthetic standard. This substance is used in drug development and research, including the study of pharmacokinetics, metabolism, and toxicology. Sodium 5-(diphenylphosphinyl)pentanoate also serves as an impurity standard for HPLC analysis. The purity of this substance is high enough to meet the standards set by the pharmacopoeia.</p>

<p>Levofloxacin is a synthetic fluoroquinolone antibiotic. The diamine impurity of levofloxacin is the major metabolite of levofloxacin and is classified as a pharmacopoeia impurity. Research has shown that the diamine impurity may be formed from levofloxacin through oxidation, hydrolysis, or transamination reactions. Hydrolysis by esterases is the most likely mechanism for the formation of this compound and it has been shown to be excreted in urine. The HPLC standard for the diamine impurity of levofloxacin is available upon request.</p>

<p>Please enquire for more information about Dehydro nicardipine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Anastrozole is an aromatase inhibitor that has been used in the treatment of breast cancer. It binds competitively to the heme moiety of aromatase, blocking its access to substrate and thereby inhibiting estrogen production. Anastrozole dimer impurity is an analytical impurity found in drug products that is not a natural component of the API (active pharmaceutical ingredient). CAS No. 1216898-82-6 refers to this impurity standard as well as other synthetic analogues. This impurity is a custom synthesis with no pharmacopoeia standards for purity. The HPLC standard for this product is high purity (99%).</p>

<p>Aripiprazole impurity is a synthetic impurity that is used as an impurity standard for the pharmaceutical industry. It is used to test the purity of drug products and to assess the quality of raw materials. Aripiprazole impurity is also used in metabolite profiling studies, analytical testing, and pharmacopoeia research and development. This compound has a CAS number of 1797983-65-3.</p>

<p>N-4,5[Acetylamino)methyl]desmopressin is a synthetic drug product that is used as an analytical standard for the identification and quantitation of desmopressin in pharmaceutical preparations. It is also used as an impurity standard for HPLC analysis. This product has been synthesized using a custom synthesis process, and has been shown to be suitable for use in drug development and research and development. N-4,5[Acetylamino)methyl]desmopressin is also available as a high purity HPLC standard that meets pharmacopoeia requirements.</p>

<p>Midostaurin Impurity 1</p>

<p>1,4-Dihydro-1-(5-methoxy-1H-benzimidazol-2-yl)-3,5-dimethyl-4-oxo-2-pyridinecarboxylic acid ammonium salt is a drug product that is custom synthesized to meet the requirements of our customers. It has high purity and analytical properties. Metabolism studies are performed to determine how the drug is broken down in the body and how it may affect other drugs or chemicals. The natural form of this chemical is found in plants and animals. Drug development studies are conducted to find out if this chemical can be used to treat a disease or condition. Pharmacopoeia standards are established for this compound and impurity standards are developed for quality control purposes. CAS No. 2227107-89-1</p>

<p>8-Methyl etodolac is an impurity of etodolac that is used in the drug development and analytical chemistry industry. It is a synthetic metabolite of etodolac, which is an analgesic agent that belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs). 8-Methyl etodolac is primarily excreted unchanged in urine and has been used as an HPLC standard for this purpose. It also serves as a pharmacopoeia reference material for the determination of purity and impurities in drug products.</p>

<p>2-Cyclohexyl-2-(4-methoxyphenyl)-N,N-dimethylethanamine is a synthetic research and development impurity standard. This compound is used as an analytical reference in pharmacopoeia to determine the purity of synthesized drugs. 2-Cyclohexyl-2-(4-methoxyphenyl)-N,N-dimethylethanamine is also a metabolite of other compounds and can be used for metabolism studies.</p>

<p>Nilotinib N-oxide is a bosutinib metabolite that is categorized as a profile 1B inhibitor. It has a chemical structure similar to imatinib and dasatinib. The metabolite of nilotinib N-oxide, which is an active form, focuses on the inhibition of chronic myeloid leukemia (CML) cells by targeting the oncoprotein BCR-ABL. Nilotinib N-oxide has been shown to have cardiac toxicity, which may be due to its ability to inhibit the synthesis of uridine and reduce thrombocytopenia. It also has the potential for toxicities such as pancreatitis and hepatotoxicity.</p>

<p>Capecitabine is a prodrug that is converted to 5-fluorouracil in the body. It has been used for many years in the treatment of breast cancer and colorectal cancer. Capecitabine 2',3'-cyclic carbonate is an analytical standard, research and development tool, high purity drug product, and impurity standard for HPLC analysis. This compound is also used as a pharmacopoeia reference material for quality control testing. Capecitabine 2',3'-cyclic carbonate can be custom synthesized or purified from natural or synthetic sources.</p>

<p>Imazamox methyl ester is a sulphonate herbicide that is used as an intermediate in the synthesis of other herbicides. It inhibits fungal growth by blocking the synthesis of ergosterol, which is essential for the production of fungal cell membranes. Imazamox methyl ester has been shown to be effective against weed species such as Agropyron repens, Alopecurus myosuroides, and Cyperus rotundus. The adjuvant effect increases the performance of other active compounds in controlling weeds such as chlorothalonil. Imazamox methyl ester also has electrolytic properties that are used in combination with other fungicides to control phytopathogenic fungi such as Alternaria alternata and Fusarium culmorum.</p>

<p>Simvastatin hydroxy acid methyl ester is a drug product that belongs to the group of statins. It is an impurity standard for synthetic simvastatin as well as a natural metabolite formed from simvastatin through oxidation and hydroxylation. This impurity is used in analytical and pharmacopoeia testing for simvastatin, and has been shown to inhibit the production of cholesterol by blocking the synthesis of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR).</p>

<p>Haloperidol octanoate is a synthetic, long-acting neuroleptic that is used to treat schizophrenia and other psychotic disorders. It is an antiemetic and has been shown to decrease the incidence of nausea and vomiting associated with cancer chemotherapy. Haloperidol octanoate is metabolized by esterases in the blood, liver, and other tissues. The drug product may contain impurities such as hydrochloride acid or haloperidol free base. Haloperidol octanoate is not manufactured in accordance with the USP or EP pharmacopoeia standards for purity, concentration, or dosage form.</p>

<p>Apixaban impurity 11 is an analytical standard used in research and development, drug development, and the production of API. It has a purity of 99.5% by HPLC and is a metabolite of apixaban. Apixaban impurity 11 has the CAS number 2204368-51-2 and is a Metabolite and Impurity standard for pharmacopoeia with a purity of 99.5% by HPLC. This product can be custom synthesized or natural with a purity of 99.5% by HPLC.</p>

<p>N1.9,N1.9-Dimethyldesmopressin is a synthetic analog of the natural hormone vasopressin. It is used as a drug product in research and development to study drug metabolism, but it has not been approved for use as a drug product by any regulatory agency. Impurities are determined by the USP or EP pharmacopoeia and are present at less than 1% or 2% respectively. The compound is synthesized through high purity chemical synthesis methods with purity greater than 99%.</p>

<p>Adefovir dipivoxil dimer is a synthetic and natural product that is used as an analytical standard for HPLC, as well as in the development of new drug products. It is also used to identify impurities in API. Adefovir dipivoxil dimer has CAS number 323201-05-4 and can be found on the FDA Orange Book.</p>

<p>Levofloxacin hydroxy acid is a high purity, drug product with a HPLC standard. It is used for drug development and research. Levofloxacin hydroxy acid has been developed as an analytical reference standard for the detection of impurities in API manufacturing. The pharmacopoeia includes levofloxacin hydroxy acid as an impurity standard. Levofloxacin hydroxy acid is also used in metabolism studies to investigate the role of levofloxacin's active metabolite, M-2, on the activity of CYP2C8 and CYP3A4 enzymes.</p>

<p>Tobramycin Impurity 4 dihydrochloride (Mixture of Isomers) is an analytical standard that is used in the manufacture of drugs. It is a mixture of two dihydrochloride isomers, which have been separated by high-performance liquid chromatography (HPLC). The impurity's purity is determined by HPLC and it has a retention time of 8.8 minutes. This impurity can be used to create a pharmacopoeia reference standard or as an analyte for the determination of drug product quality.</p>

<p>Please enquire for more information about 2-(2-Chloroethoxy)-N-(2-nitrophenyl)-acetamide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2,3-Dimethylphenyl mefenamic acid is a synthetic drug product. It is used as an impurity standard for the HPLC analysis of N-(2,3-dimethylphenyl)mefenamic acid carboxamide, and is also a custom synthesis intermediate. 2,3-Dimethylphenyl mefenamic acid has been shown to be metabolized by liver microsomes in vitro and to inhibit prostaglandin synthesis. In vivo studies have shown that the primary route of elimination of 2,3-dimethylphenyl mefenamic acid is through the urine.<br>2,3-Dimethylphenyl mefenamic acid has been shown to be effective in inhibiting prostaglandin synthesis in vitro and in vivo studies. It has also been shown to be active against gram positive bacteria such as Bacillus subtilis and Staphylococcus aureus (ATCC 25923).</p>