Acides aminés (AA)

<p>Applications 1-Methyl-3-phenylpiperidin-4-one is an intermediate in the synthesis of Setiptiline-d3 (S280802), a labelled version of Setiptiline. Setiptiline is a tetracyclic antidepressant and it acts as a noradrenergic and specific serotonergic antidepressant (NaSSA).<br>References Niho, T. et al.: Yak. Chir., 14, 4625 (1986); Tohda, M. et al.: Eur. J. Pharmacol., 166, 57 (1989); Przegalinski, E. et al.: Pol. J. Pharmacol. Pharm., 38, 377 (1986);<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications 1-Methyl-1,4-dihydronicotinamide (cas# 17750-23-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(2,6-Difluoro-4-methoxyphenyl)-2-oxoacetic Acid is a derivative of 3,5-Difluoroanisole (D445395), which is used in the preparation of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 antagonists. Also used in the preparation of imidazo[1,5-a]pyrido[3,2-e]pyrazines and imidazo[1,5-a]quinoxalines as orally active phosphodiesterase 10A inhibitors.<br>References Procopiou, P.A., et al.: J. Med. Chem., 56, 1946 (2013); Malamas, M.S., et al.: J. Med. Chem., 54, 7621 (2011)<br></p>

<p>Applications 4-(t-Boc-amino)-1-butyl Bromide (cas# 164365-88-2) is a compound useful in organic synthesis.<br>References Bendale, P., et al.: J. Med. Chem., 50, 4585 (2007), Lansdell, M., et al.: Bioorg. Med. Chem. Lett., 18, 4944 (2008), Imaeda, Y., et al.: Bioorg. Med. Chem., 16, 2243 (2008),<br></p>

<p>Applications Ethyl N-(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)-amino-propanoate is used in the preparation of dibenzothiazepines as opioid receptor agonists; Also, it is an intermediate used in the synthesis of N-(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)-β-alanine (C424340), which is a metabolite of Tianeptine (T436800), a tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant.<br>References Kruegel, A., et al.: PCT Int. Appl. (2017) WO 2017049158; Malen, C., et al.: Experientia, 28, 811 (1972), Safa, A., et al.: J. Biol. Chem., 262, 7884 (1987), Ford, J.M., et al.: Pharmacol. Rev., 42, 155, (1990), Pierre, A., et a.: Cancer Res., 51, 2312 (1991), Nair, M. et al.: Analyst, 123, 2267 (1998)<br></p>

<p>Applications 3-(N-Methyl-N-pentyl-amino)propionitrile-d3 (cas# 1185103-36-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Acetyl-1-Boc-pyrrolidine is a boc protected reagent that is used for selective inhibitors of H. influenzae TrmD that mimic tRNA interaction by inducing TrmD lid domain ordering.<br>References Hill, P.J., et al.: J. Med. Chem., 56, 7278 (2013);<br></p>

<p>Applications rac-α-N-Boc-Amino-4-pyridineaceic Acid is a reagent used in the preparation of lactam-containing diaminoalkanes, β/α-amino acids and derivatives of Xa inhibitors.<br></p>

<p>Applications 2-Methylpentane-d14 (CAS# 284487-65-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications It is useful for solid phase synthesis of polyamides containing imidazole.<br></p>

<p>Applications 5-Ethyl-4-hydroxy-2-methyl-3(2H)-furanone, mixture of isomers 96%, FG (cas# 27538-09-6) is a useful research chemical.<br></p>

<p>Applications N-Boc-3-(1-cyano-2-ethoxy-2-oxoethylidene)-1-piperidine is a useful synthetic intermediate.<br></p>

<p>Applications 4,6-Dichloro-2-methoxypyrimidine (cas# 1074-40-4) is a compound useful in organic synthesis.<br></p>

<p>Applications α-Methyl-2-(methylsulfonyl)benzenemethanol is an intermediate used in the synthesis of thiophene inhibitors of polo-like kinase.<br>References Emmitte, K.A., et al.: Bioorg. Med. Chem. Lett., 19, 1018 (2009);<br></p>

<p>Applications 3-O-[(1,1-Dimethylethyl)dimethylsilyl]-1,2-O-(1-methylethylidene)-α-D-xylo-pentodialdo-1,4-furanose is an intermediate used in the synthesis of (5E)-5,6-Dideoxy-3-O-[(1,1-dimethylethyl)dimethylsilyl]-1,2-O-(1-methylethylidene)-6-nitro-α-D-xylo-hex-5-enofuranose (D495405), which can be used in the synthesis of Pancratistatin (P173600), an anti-cancer compound that initiates cell-death in cancer cells.<br>References McLachlan, A. et al.: Apoptosis, 10, 619 (2005);<br></p>

<p>Applications 2’-C-Methyl Cytidine (cas# 20724-73-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Labelled α-Methyl-1-pyrenemethanol is used in the synthesis of colorimetric and fluorescent ratiometric mercury sensors. This is applicable to the quantification of transition metals in the environment as well as biological systems.<br>References Weng, J. et al.: Tetra., 68, 3129 (2012);<br></p>

<p>Applications 3-Amino-2-Methoxydibenzofuran (cas# 5834-17-3) is a useful research chemical.<br></p>