Acides aminés (AA)

<p>Applications (1S,2S)-Fmoc-acpc is used in preparation of chimeric (α/β + α)-peptide ligands for BH3-recognition cleft of the cancer-associated protein Bcl-xL.<br>References Sadowsky, J., et al.: J. Am. Chem. Soc., 127, 11966 (2005);<br></p>

<p>Applications 4-(1,1-Dimethylethyl)-2-(1-methylpropyl)-6-[2-(2-nitrophenyl)diazenyl]phenol is an intermediate in the synthesis of 2-(2H-Benzotriazol-2-yl)-4-(tert-butyl)-6-(sec-butyl)phenol (B206645), which is often used to increase product stability and to prevent discolouration in various consumer and industrial goods such as plastics. Benzotriazole UV stabilizers, such as 2-(2H-Benzotriazol-2-yl)-4-(tert-butyl)-6-(sec-butyl)pheno, are pollutants for the aquatic environment and have been implicated as a potential stable and toxic ligands for the aryl hydrocarbon receptor in human.<br>References Liu, R., et al.: Talanta 120, 158 (2014); Nagayoshi, H., et al.: Environ Sci Technol. 49, 578 (2015).<br></p>

<p>Applications Methyl 3-amino-2-methylbenzoate (cas# 18583-89-6) is a useful research chemical.<br></p>

<p>Applications 5-Methoxyindole-3-acetonitrile is a versatile reactant used in the preparation of indole-N-acetic acid derivatives as aldose reductase inhibitors for diabetic complications treatment. It is also used in the synthesis of carboline analogs as potent MAPKAP-K2 inhibitors.<br>References Van Zandt, M., et al.: J. Med. Chem., 48, 3141 (2005); Wu, J., et al.: Bioorg. Med. Chem. Lett., 17, 4664 (2007);<br></p>

<p>Applications N-Acetylglycine N-Methylamide-d8 is an isotopic analog of N-Acetylglycine N-Methylamide (7606-79-3).<br></p>

<p>Applications Ethyl 4-bromo-2-methyl-2-(methylsulfonyl)butanoate can be used to synthesize pyridine methylsulfone hydroxamate LpxC inhibitors for treating bacterial infections.<br>References Montgomery, J. I. et al.: J. Med. Chem. 55, 1662 (2012); Brown, M. F., et al.: PCT Int. Appl. WO 2012120397 A1 20120913 (2012)<br></p>

<p>Applications (4-Chloro-3-nitrophenyl)phenyl-methanone is a useful starting material for organic synthesis.<br></p>

<p>Applications 3-Chloro-4-methylbenzoic acid<br></p>

<p>Applications (S)-2-(4-CHLOROPHENYL)-3-METHYLBUTANOIC Acid (cas# 55332-38-2) is a useful research chemical.<br></p>

<p>Applications 2-(2-Methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl Methanesulfonate is a compound useful in organic synthesis.<br></p>

<p>Applications 5,6-Difluoro-2-Hydrazino-1-Methyl-1H-benzimidazole is an intermediate used in the preparation of pentacyclic fluoroquinolines.<br>References Nosova, E. V., et al.: Russian J. Org. Chem., 34, 408 (1998)<br></p>

<p>Applications An intermediate in the synthesis of Metoclopramide.<br>References Murakami, M., et al.: Chem. Pharm. Bull., 19, 1696 (1971),<br></p>

<p>Applications Methyl 3-formyl-5-methylbenzoate<br></p>

<p>Applications 6-(4-Aminophenoxy)-N-methyl-4-pyrimidinamine is an intermediate in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells.<br>References Weisberg, E., et al.: Genes Cancer, 1, 1021-1032 (2010);<br></p>

<p>Applications (±)-Methyl 1,2,3,4-Tetrahydro-β-carboline-3-carboxylate, is an intermediate used for the synthesis of various pharmacutical and biologically active compounds. It is used for the synthesis of the marine indole alkaloid Eudistomin U. It is also an intermediate for the synthesis of Biriperone (B399750).<br>References Panarese, J. D., et al.: Org. Lett., 12 (18), 4086 (2010); Chakrabarty, R., et al.: Bioorg. Med. Chem., 15 (23), 7361 (2007);<br></p>

<p>Applications 4-Bromo-3-fluoro-N-methylbenzamide<br></p>

<p>Applications 1H-1,2,3-Triazole-5-methanamine Dihydrochloride is used in the preparation of optimized 5-membered heterocycle-linked pterins for inhibition of ricin toxin A. Also used in the synthesis of orally bioavailiable human neurokinin-1 (hNK1) antagonists.<br>References Lin, P. et al.: Bioorg. Med. Chem. Lett., 17, 5191 (2007); Pruet, J. et al.: ACS Med. Chem. Lett., 3, 588 (2012);<br></p>

<p>Applications 4-Methylcyclohexanecarboxylic Acid Methyl Ester is the methyl ester derivative of 4-Methyl-cyclohexanecarboxylic Acid (M299530) and is used as a starting material in many organic reactions.<br>References Fedyanin, N. P., et al.: J. Appl. Chem-USSR+, 51, 375 (1978)<br></p>

<p>Applications 1,2-Dinitro-4,5-methylenedioxybenzene (cas# 7748-59-6) is a compound useful in organic synthesis.<br>References Kajihara, Y., et al.: Carb. Res., 331, 455 (2001)<br></p>

<p>Impurity Rivastigmine EP Impurity G<br>Applications 1-(3-Methoxyphenyl)ethanol (Rivastigmine EP Impurity G) is a versatile reactant used in the preparation of 2,3-dihydroimidazo[1,2-a]pyridines as enantioselective acyl transfer catalysts in kinetic resolution of alcohols. Also used in chemoselective preparation of aryl aldehydes/ketones via in situ generated TEMPO-copper(II) diimine catalyzed oxidation of benzylic alcohols in aqueous media.<br>References Birman, V., et al.: J. Am. Chem. Soc., 126, 12226 (2004); Figiel, P., et al.: Adv. Synth. Catal., 349, 1173 (2007);<br></p>

<p>Applications A boc-protected cyclic amine used in the preparation of heterocyclic boronic acid compounds.<br></p>

<p>Applications tert-Butoxycarbonyl-D-valine is used in the preparation of selective CCR1 antagonists in the treatment of rheumatoid arthritis. Also used in the preparation of antileishmanial agents.<br>References Gardner, D. et al.: Bioorg. Med. Chem. Lett., 23, 3833 (2013); Casanova, E. et al.: ChemMedChem., 8, 1161 (2013);<br></p>

<p>Applications 3-(4-Boc-amino-piperidin-1-yl)-2-methyl-propionic Acid Methyl Ester(cas# 886364-51-8) is a useful research chemical.<br></p>

<p>Applications o-Coumaric Acid 4-O-β-D-Glucuronide is a metabolite of either Coumarin (C755380) or o-Hydroxy-cinnamic Acid (614-60-8).<br></p>

<p>Applications 1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine is a guanidinylation reagent for amines and peptides.<br>References Feichtinger, K., et al.: J. Org. Chem., 63, 8432 (1998)<br></p>

<p>Applications Tetrahydro-5-methyl-2-furanmethanol, is shown to be one of the volatile components in grapes, milk, and etc.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mentasti, T., et al.: Milchwissenchaft, 52, 253 (1997);<br></p>

<p>Applications Methyl 3-Amino-4-methylbenzoate-D6 is an intermediate in the synthesis of Nilotinib-d6 (N465303), which is the labeled analogue of Nilotinib (N465300), which might be useful in treatment of chronic myelogenous leukemia.<br>References Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),<br></p>

<p>Applications Isotope labelled Isopropyl 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]phenylcarbamate is an impurity in the synthesis of Sorafenib (S676850), a multiple kinase inhibitor targeting both RAF kinase and receptor tyrosine kinases that promote angiogensis. Antineoplastic.<br>References Richly, H., et al.: Int. J. Clin. Pharmacol. Ther., 41, 620 (2003), Khire, U.R., et al.: Bioorg. Med. Chem. Lett., 14, 783 (2004), Wilhelm, S.M., et al.: Cancer Res., 64, 7099 (2004), Rini, B.I., et al.: Expert Opin. Pharmacother., 7, 453 (2006),<br></p>

<p>Applications 4-Hydroxy-N-methylbutanamide is an intermediate in the synthesis of potential hypotensive agents.<br>References Natarajan, P, N., et al.: Can. J. Pharm. Sci., 8, 61 (1973);<br></p>

<p>Applications 2-Methyl-6-nitroaniline (cas# 570-24-1) is a compound useful in organic synthesis. Dyes and metabolites, Environmental Testing<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications L-Serine (1-13c, 99%) (cas# 81201-84-5) is a useful research chemical.<br></p>

<p>Applications An intermediate in the production of Guanidinoacetic Acid<br>References Kennelly, P., et al.: J. Mol. Biol., 145, 583 (1981),<br></p>

<p>Applications DL-Phenylalanine-2-13C (CAS# 64193-01-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Methoxy-2-pyridinecarboxylic Acid is an intermediate to prepare diacid analogs as glycogen phosphorylase inhibitors. It is also used to prepare allyl phenylethyl ether via ruthenium-pyridinecarboxylic acid-catalyzed allylation.<br>References Lu, Z., et al.: Bioorg. Med. Chem. Lett., 13, 4125 (2003); Tanaka, S., et al.: Chem. Lett., 38, 188 (2009)<br></p>

<p>Applications bis(2-Chloroethoxy)-d8-methane (cas# 93966-78-0) is a useful research chemical.<br></p>

<p>Applications 3-Bromo-2-methylphenol<br></p>

<p>Applications [2R-(2α,3β,6α)]-3-Azido-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]octane-2-carboxylic Acid 5,5-Dioxide Diphenylmethyl Ester is an intermediate in the synthesis of Tazobactam Sodium Salt-13C2,15N1 (T010102), which is a labelled analogue of Tazobactam Sodium Salt (T010100), which is a β-Lactamase inhibitor, used with β-lactam antibiotics to enhance their effect.<br>References Gould, I.M., et al.: Drugs Exp. Clin. Res., 17, 187 (1991); Roland, R.K., et al.: J. Infect. Dis., 4, 226 (2000), Bonomo, R.A., et al.: Biochim. Biophys. Acta, 1547, 196 (2001);<br></p>

<p>Applications 9,9-Dimethyl-N,N'-bis(3-methylphenyl)-N,N'-diphenyl-9H-fluorene-2,7-diamine is used in the preparation of 2,7-bis(diarylamino)-9,9-dimethylfluorenes as hole-transport materials for organic light-emitting diodes.<br>References Hreha, R. D., et al.: Adv. Funct. Mater., 13, 967 (2003)<br></p>

<p>Applications 4-Iodo-2-methyl-1-butene is an reagent used in the synthesis of functionalized cyclic boronates.<br>References Altenhofer, E., et al.: Org. Lett., 16, 3 (2014);<br></p>

<p>Applications 6-{[(4-methoxyphenyl)methyl]amino}-1,2,3,4-tetrahydroquinolin-2-one (cas# 1157411-52-3) is a useful research chemical.<br></p>

<p>Applications (4R)-4,6-Dihydroxy-2-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline-d5 is labelled (4R)-4,6-Dihydroxy-2-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline which is an impurity of (R)-Phenylephrine Hydrochloride (P320640), an α-Adrenergic agonist.<br>References Warren, M.R., et al.: J. Pharmacol. Exp. Ther., 86, 284 (1946), Gaglia, C.A., et al.: Anal. Profiles Drug Subs., 3, 483 (1974)<br></p>

<p>Applications 1-(chloroacetyl)-4-methylpiperazine (cas# 40340-73-6) is a useful research chemical.<br></p>

<p>Applications N-Methylisoamylamine is a reagent used in the synthesis of hepatitis C polymerase inhibitors.<br>References Cheng, C. et al: Bioorg.<br></p>

<p>Applications 4-Bromo-1-methanesulfonyl-2-methylbenzene is a useful research chemical for organic synthesis and other pharmacological processes.<br>References Wacker, D. A., et al.: J. Med. Chem., 57, 7499 (2014); Groebel, W.: Chemische Berichte, 92, 2887 (1959)<br></p>

<p>Applications 2-(2-CHLORO-6-METHYLPHENOXY)ACETIC ACID (cas# 19094-75-8) is a useful research chemical.<br></p>

<p>Applications A reagent for high performance polymer research.<br>References Fouassier, J., et al.: Polymer, 36, 5005 (1995),<br></p>

<p>Applications Methyl2-(4-methylphenylsulfonamido)acetate (cas# 2645-02-5) is a useful research chemical.<br></p>

<p>Stability Air Sensitive<br>Applications 2-Methyl-1-[4-(methylsulfanyl)phenyl]-1-propanone is a useful research chemical for organic synthesis and other chemical processes.<br>References Aslam, M., et al.: J. Org. Chem., 56, 5955 (1991), Swyka, R. A., et al.: J. Am. Chem. Soc., 141, 6864 (2019)<br></p>

<p>Applications 2'-Deoxy-N3-methyluridine (cas# 24514-32-7) is a useful research chemical.<br></p>

<p>Applications 4-[N-Ethyl-(4-methoxyphenyl)methylamino]-2-butynyl-1-ol (cas# 181647-06-3) is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications 5-(4-methylpiperazin-1-yl)pyridin-2-amine (cas# 571189-49-6) is a useful research chemical.<br></p>

<p>Applications Boc-Glu(OBzl)-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.<br></p>

<p>Applications (Z)-2-Methoxyimino-2-furanacetic Acid-D3 is an intermediate used in the synthesis of Cefuroxime-d3 (C248052), which is a labeled Cefuroxime (C248050), an anti-bacterial.<br>References O’Callaghan, C.H., et al.: Antimicrob. Agents Chemother., 9, 511 (1976), Norrby, R., et al.: J. Antimicrob. Chemother., 3, 355 (1977), Brogden, R.N., et al.: Drugs, 17, 233 (1979), Wozniak, J.R., et al.: Anal. Profiles Drug Subs., 20, 209 (1991)<br></p>

<p>Applications 4-Methylumbelliferyl Butyrate is suitable to use as a fluorogenic substrate for esterases/lipases, such as butyrate esterase.<br>References M. Vaneechoutte et al. J. Clin. Microbiol. 26, 1227, (1988)<br></p>

<p>Stability Moisture Sensitive<br>Applications A synthetic intermediate<br></p>

<p>Applications 6-methylthieno[2,3-b]quinoline-2-carboxylic acid (cas# 333312-07-5) is a useful research chemical.<br></p>

<p>Applications Isotope labelled 2-Bromo-4-methoxy-6-methylpyrimidine is a chemical reagent used in the preparation and synthesis of novel thiadiazoles and their derivatives for their growth stimulant activity.<br>References Knyazyan, A. et al.: J. Hetero. Chem., 50, 1281 (2013);<br></p>

<p>Applications 2-(tert-butyl) 3a-methyl tetrahydropyrrolo[3,4-c]pyrrole-2,3a(1H,3H)-dicarboxylate (cas# 1823265-38-8) is a useful research chemical.<br></p>

<p>Applications Sodium 2-Keto-4(R,S)-methyl-d3-pentanoate (CAS# 93523-67-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications L-Alanine-2-d1-N-t-BOC (CAS# 88181-11-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications N,N-Dimethyl-d3-chloroacetamide (N-methyl-d3) (CAS# 1219802-19-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,2,3,4-Tetra-O-acetyl-β-D-glucopyranose has been used in the study of substrates for inositol synthase, and for the preparation of anionic surfactants.<br>References Graham, B., et al.: Tetrahedron, 47, 3895 (1991); Alain, M., et al.: Carbohydrate Res., 229, 323 (1992)<br></p>