Acides aminés (AA)

<p>Applications 4-Chloro-6-(2-methyl-1H-imidazol-1-yl)pyrimidine is a reagent used in the synthesis of [(aminosulfonylaminoalkyl)piperidinyl]pyrimidines and -quinazolines as PC-1 inhibitors for alleviating hERG interactions through structure based design.<br>References Patel, S. D., et al.: Bioorg. Med. Chem. Lett., 19, 3339 (2009); Patel, S. D., et al.: Bioorg. Med. Chem. Lett., 20, 2685 (2010)<br></p>

<p>Applications 4-(2-methyl-1,3-oxazol-4-yl)benzene-1-sulfonyl chloride (cas# 1086376-81-9) is a useful research chemical.<br></p>

<p>Applications 2-Bromo-6-methoxy-1,3-benzothiazole<br></p>

<p>Applications 5-Hydroxy-6-methyl-3,4-pyridinedicarboxylic Acid is used in studies to identify 4-pyridoxic acid dehydrogenase gene in pyridoxine catabolism of Mesorhizobium loti MAFF303099.<br>References Mukherjee, T., et al.: Bioorg. Chem., 35, 458 (2007)<br></p>

<p>Applications 2-Bromo-2-methylpropionyl-D6 Bromide is an intermediate in the synthesis of Aztreonam-d6 (A965202), which is an isotope labeled Azetreonam (A965200), the first totally synthetic monocyclic β-lactam antibiotic.<br>References Sykes, R.B., et al.: Antimicrob. Agents Chemother., 21, 85 (1982), Florey, K., et al.: Anal. Profiles Drug Subs., 17, 1 (1988),<br></p>

<p>Applications N-(2,6-Dimethylphenyl)-3-methyl-2-butenamide is an intermediate in the synthesis of rac-trans-N-(2,6-Dimethylphenyl)-4-methyl-1-(2-methylphenyl)-5-oxo-3-propylimidazolidine-2-carboxamide (D480822), the trans-isomer of N-(2,6-Dimethylphenyl)-4-methyl-1-(2-methylphenyl)-5-oxo-3-propylimidazolidine-2-carboxamide, an impurity of Prilocaine (Prilocaine Hydrochloride P725000). Prilocaine is a local anesthetic of the amino amide type and is often used in dentistry. Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA) towards the treatment of conditions like paresthesia.<br>References Caliaro, G., et al.: J. Pharm. Biomed. Anal., 26, 427 (2001), Ulmeanu, S., et al.: Pharm. Res., 20, 1317 (2003),<br></p>

<p>Applications Nα-Boc-L-arginine is an N-Boc protected form of L-Arginine (A769505). L-Arginine is an conditionally essential amino acid for humans and adult mammals as it’s requirements exceed production during certain developmental stages in life (such as pregnancy). L-Arginine also prevents blood toxicity from intravenous amino acid administration in humans.<br>References Bronte, V. &amp; Zanovello, P.: Nat. Rev. Immun., 5, 641 (2005); Fahey, J.: J .Clin. Invest., 36, 1647 (1957)<br></p>

<p>Applications 3,3,3-Trifluoroalanine is a useful synthetic intermediate. It is used in the study of β,​β,​β-​trifluoroalanine as suicide substrates for E. coli B alanine racemase.<br>References Wang, E., et al.: Biochem., 20, 7539 (1981);<br></p>

<p>Applications N-Methoxy-N-methylbenzamide is used to prepare orally bioavailable tetrasubstituted imidazoles as inhibitors of p38 mitogen-activated protein kinase. It is used to synthesize benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties.<br>References Liverton, N., et al.: J. Med. Chem., 42, 2180 (1999); Malamas, M., et al.: J. Med. Chem., 43, 1293 (2000)<br></p>

<p>Applications 2-Methyl-1-phenyl-2-propanol is used in the preparation of (hydroisoquinolinylidene)acetic ureides with analgesic and antibacterial activities.<br>References Surikova, O. V., et al.: Pharm. Chem. J., 47, 198 (2013);<br></p>

<p>Applications N-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-carboxamide hydrochloride (cas# 1219957-27-3) is a useful research chemical.<br></p>

<p>Applications 2-(3-Ethoxy-4-methoxy-d3-phenyl)ethyl-1,1,2,2-d4-amine HCl (CAS# 1398065-60-5) is a useful isotopically labeled research compound. This compound can be used as FSH agonist to treat fertility disorders.<br>References Yu, H., et.al., PCT Int. Appl., 68,(2013);<br></p>

<p>Applications methyl 2-methyl-3-sulfanylpropanoate (cas# 4131-76-4) is a useful research chemical.<br></p>

<p>Applications methyl 2-amino-4-fluoro-3-methylbenzoate (cas# 928839-58-1) is a useful research chemical.<br></p>