Acides aminés (AA)

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Angiotensin I/II (3-8) H-Val-Tyr-Ile-His-Pro-Phe-OH is a peptide that has physiological effects and is used as a drug. It is an active analogue of the peptide hormone angiotensin II, which regulates blood pressure and fluid volume. Angiotensin I/II (3-8) H-Val-Tyr-Ile-His-Pro-Phe-OH binds to angiotensin receptors and stimulates the release of calcium ions from cytosolic stores in cells, leading to increased muscle contractions and vasoconstriction. This drug may also have effects on dopamine levels in the brain, locomotor activity, and biochemical properties such as enzyme activity or protein binding.br>
Angiotensin I/II (3-8) H-Val-Tyr-Ile-His Pro Phe OH has been shown to reduce the level of dopamine

Ac-Leu-Glu-His-Asp-AMC trifluoroacetate salt is a synthetic peptide that is derived from the amino acid sequence of caspases. Ac-Leu-Glu-His-Asp-AMC trifluoroacetate salt induces apoptosis in insect and E. coli cells by protease activity, which leads to cell death. The sequence of this peptide is found in Drosophila melanogaster and has been shown to induce apoptosis in insect cells. Caspases are enzymes that regulate apoptosis and play a key role in cell death.

4-Methylsalicylamide is a chemical compound that belongs to the class of isonicotinic amides. It is a potent anti-inflammatory agent with minimal inhibitory concentration (MIC) values of 4 µg/mL for gram-positive bacteria and 8 µg/mL for gram-negative bacteria. This compound has been shown to be effective against methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium perfringens, although is not active against acid-fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex. 4-Methylsalicylamide has been shown to have an inhibitory effect on ring-opening, which may be due to its ability to acetylate mitochondrial membranes, altering the membrane potential. The molecular modeling studies also showed that 4MSAM binds at the same site as antibiotics such as penicillin and erythromycin in bacterial ribos

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Fmoc-Tyr-Ala-OH is a biochemical that is expressed in mammalian cells. It has been shown to activate enzymes and the production of proteins, which are essential for cell growth. Fmoc-Tyr-Ala-OH is also proteolytic and hydrolyzing, meaning it can be used to cleave proteins into smaller pieces. It has been shown to have acidic and neutral properties at different pH levels. This enzyme also has an inhibitory effect on the production of monoclonal antibodies in mcf-7 cells, which are derived from mouse mammary epithelial cells.

H-Ser-Asn-OH is a fatty acid that belongs to the amide group. It has an inhibitory effect on bacterial membranes, which can be seen in the x-ray crystal structures of H-Ser-Asn-OH cocrystallized with lipids from the bacterial membrane. The inhibition of bacterial membranes is due to its ability to bind strongly to the phospholipid head group and reduce the fluidity of the membrane. H-Ser-Asn-OH has also been shown to have a diagnostic effect on tissues and monolayers in vitro.

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Boc-His(Trt)-OH is a chemical compound that has been used in the laboratory to study uptake and binding of compounds. It is stable in complex with albumin, which has led to its use as a model system for studying hepatic steatosis. This chemical can be synthesized by solid-phase synthesis with trifluoroacetic acid and polypeptide synthesis. FT-IR spectroscopy has been used to characterize Boc-His(Trt)-OH, revealing its chemical diversity.

Methyl 6-methylnicotinate is a synthetic compound that has been shown to have cholinergic properties. It is an oxidation catalyst that can be used in the synthesis of methyl nicotinate, which is a drug for the treatment of influenza virus. Methyl 6-methylnicotinate also has been shown to inhibit the replication of influenza virus in vitro and in vivo. Methyl 6-methylnicotinate inhibits viral growth by binding to the antigenic site on hemagglutinin, preventing it from attaching to host cells. This compound also has been shown to inhibit the release of chloride ions in animal models and inhibits neuromuscular transmission. The molecular modeling studies revealed that methyl 6-methylnicotinate binds with high affinity to the active site of acetylcholinesterase enzyme and is able to form a covalent bond with its serine residue, thereby inhibiting its activity.

H-Arg-Arg-Leu-Ile-Glu-Asp-Asn-Glu-Tyr-Thr-Ala-Arg-Gly-OH is a synthetic peptide that has been shown to have a homologous sequence with the amino acid sequence of a primary tumor. This peptide has strong binding affinity to tyrosine kinase, which is an enzyme involved in cellular signal transduction. H-Arg-Arg-Leu-Ile-Glu-Asp-Asn Glu Tyr Thr Ala Arg Gly OH has been shown to inhibit the growth of tumors and can be used as an analytical method for identifying carcinoma cells in vitro. HAAGLTEIGDATASNTTAHARGLTRALAGRGGYOH is also a potential drug for cardiovascular diseases, as it can be taken up intracellularly and may inhibit the proliferation of vascular smooth muscle cells.

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H-Gly-Gly-Pro-OH is a recombinant polypeptide with affinity for amino acids. It is a positionally defined sequence of amino acids that has been shown to bind to Alzheimer's disease (AD) amyloid peptides and inhibit the formation of beta amyloid fibrils. The N-terminal sequence of this polypeptide is immunogenic, which may be useful for generating antibodies against AD.

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Leu-Leu-Leu-OH is a pentapeptide that is used in cancer treatment to inhibit the growth of cancer cells. It prevents the production of proteins and, as a result, cell division. Leu-Leu-Leu-OH has been shown to be effective against tumor cells with an antibody that binds to the surface of cells. The monoclonal antibody is taken up by the cancer cells through receptor mediated endocytosis, which leads to inhibition of protein synthesis and cell death.

Necrostatin-1 is a small molecule inhibitor that blocks the NF-κB signaling pathway. Necrostatin-1 is a potent inducer of apoptosis and has been shown to inhibit necroptosis in cell culture. It also blocks the Toll-like receptor 4 (TLR4), which is an important death receptor that causes inflammation. Necrostatin-1 has been found to be effective in reducing injury and death in low doses, but has not been tested for long periods of time or at high doses.

H-Asp(Leu-OH)-OH is a bioactive molecule that can induce apoptosis in cancer cells. Mechanistically, this compound induces apoptosis by increasing the amount of reactive oxygen species (ROS) and reducing mitochondrial membrane potential in cancer cells. The anti-cancer activity of H-Asp(Leu-OH)-OH has been shown to be dose dependent and it has been observed to cause vacuolization in kidney cells. Chemical compositions show that H-Asp(Leu-OH)-OH is composed of Aspartic acid, Leucine, and Hydroxyl groups.

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Amylin is a hormone that regulates the release of insulin from the pancreas. Amylin is a protein that consists of 39 amino acids, and in its natural form it is not soluble in water. The amyloid fibrils are insoluble aggregates of proteins that can be found in the brain tissue of patients with Alzheimer's disease. Amylin has been shown to have an entrapment efficiency greater than 96% by using polymeric particles with a diameter less than 50 microns. These particles are able to increase water solubility and nutrient metabolism, as well as improve evaporation rates. They also provide an increased surface area for absorption and pharmacological properties. Amylin has been shown to lower postprandial glycemia when used with insulin in type II diabetes mellitus patients, and may also be an anorectic agent.

FA-Ala-Phe-NH2 is a synthetic, hydrophobic peptide that mimics the structure of a spermatozoal regulatory protein. It has been shown to be an irreversible metal chelator and is used as a substrate in assays for metalloendopeptidases. In vitro studies have also shown that this peptide interacts with lectins and can inhibit the binding of spermatozoa to egg zona pellucida.

Boc-Gly-Phe-Gly-Lys-OH is an allergen that belongs to the group of flavonoids. It is a reaction product of cinnamates and methoxycinnamate, which are found in sunscreens. Boc-Gly-Phe-Gly-Lys-OH is used as a model for chemical carcinogens in studies on cancer. Boc-Gly-Phe-Gly-Lys-OH has been shown to be a potent skin cancer and radiation sensitizer. There are no known effects on humans, but it is possible that this compound may react with UV irradiation from sunlight, causing DNA damage and skin cancer.

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Acetyl-Pepstatin is a protein data inhibitor that binds to the active site of enzymes, inhibiting their function. Acetyl-pepstatin has been shown to inhibit cathepsin D, chymotrypsin, and trypsin. It also inhibits the activity of proteases in the stomach and intestinal tract. Acetyl-Pepstatin is used as an anti-inflammatory drug for the treatment of chronic obstructive pulmonary disease (COPD) and congestive heart failure (CHF). The inhibition of these enzymes reduces inflammation by preventing the activation of inflammatory cytokines. It also prevents collagen from being degraded by proteases, which leads to decreased degradation of cartilage by chondrocytes. This drug's mechanism is similar to that of acetylsalicylic acid (aspirin), in that it inhibits prostaglandin synthesis.br>

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5-Amino-2-methoxyisonicotinic acid is a carboxylic acid that is used in the synthesis of aminopyridines. The compound can be synthesized from formamidine acetate and diethyl dicarbonate. This process involves lithiation, followed by addition of an amine and finally conversion to the desired product with formamidine acetate. 5-Amino-2-methoxyisonicotinic acid can also be synthesized from formamide and diethyl ether. 5-Amino-2-methoxyisonicotinic acid is an analog of 2,4,6-trimethylaniline and has been shown to have similar properties to this compound, including strong basicity.

Suc-Ala-His-Pro-Phe-pNA is an amide that binds to the casein kinase II, phosphatase, and inhibits cellular growth. The biochemical and cell specific activity of this drug target has been shown using biochemical and cellular assays. Suc-Ala-His-Pro-Phe-pNA has potent inhibitory activity against the enzyme phosphatase, which is a drug target for many diseases such as cancer. This compound also inhibits fk506 binding to endoplasmic reticulum protein FKBP12, which is a drug target for immunosuppressive therapy in organ transplantation. Suc-Ala-His-Pro-Phe-pNA has been shown to have high protease activity towards peptidyl substrates.

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Pyr-Gly-OH is a metabolite of the amino acid glutamate. It has been shown that this metabolite is formed by a non-enzymatic dehydration of glutamate. This compound has been shown to be effective in treating bowel disease and cancer, as well as stimulating the production of fibrinogen in the blood. Pyr-Gly-OH has also been found to have anti-inflammatory effects and an increased effect on glutamic receptors.

H-Val-Asn-OH is a polyhydroxyamine that is soluble in water and has a low freezing point. It can be used as a coating material, sectioning medium, or to study the thermal expansion of materials. H-Val-Asn-OH has been shown to have no significant effect on the growth rate of bacteria and spores. H-Val-Asn-OH is made up of nitrogen atoms, ferrite, and strain. The microstructure of H-Val-Asn-OH includes a phase equilibrium with ferrite and strain morphology.

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Fluorogenic dye targeting caspase 3

7-Diethylamino-4-methylcoumarin is a fluorescence probe that can be used in applications such as the study of hydrogen bonding interactions. It is excited by laser light and emits a red-shifted fluorescent light. 7-Diethylamino-4-methylcoumarin is a hydroxyl group analogue of coumarin, which has been shown to have physiological effects on the liver cells. The absorption spectrum of 7-Diethylamino-4-methylcoumarin is sensitive to changes in pH and chemical stability. A decrease in pH increases the intensity of the emission while an increase in pH decreases the intensity of the emission. This compound can also be used to label nucleic acids during polymerase chain reactions (PCR) or for sample preparation before analysis using nuclear magnetic resonance spectroscopy (NMR).

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Endogenous heptapetide which causes vasodilation and has anti-hypertensive properties.

Bosentan is a potent inhibitor of the uptake of organic anions. It is used in the treatment of pulmonary arterial hypertension and has been shown to be effective against pravastatin-resistant HIV protease inhibitors, such as saquinavir, quinidine, and rosuvastatin. Bosentan inhibits uptake by binding to the transporter protein at a site that does not overlap with the binding site for organic anion substrates. This leads to a change in kinetic parameters for substrates, such as pravastatin and saquinavir. The binding site on bosentan may also be elucidated through monolayer experiments with efflux transporters.

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8-Phenyltheophylline (8PT) is an adenosine receptor agonist that is used as a bronchodilator for the treatment of asthma. It has been shown to increase the intracellular calcium concentration in hl-60 cells and in rat papillary muscles. 8PT also has locomotor activating effects, which are thought to be due to its ability to block potassium channels in the hippocampal formation. These effects may be related to ATP-sensitive potassium channels, which have been shown to be sensitive to ATP in untreated mice. 8PT also has anti-arrhythmic properties, which may be due to its ability to inhibit sodium channels and its effect on heart rate and contractility.

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(Des-Gly10, tBu-D-Gly6,Pro-NHEt 9)-LHRH acetate salt Pyr-His-Trp-Ser-Tyr-tBu-D-Gly-Leu-Arg-Pro-NHEt acetate salt is a synthetic hormone that belongs to the group of gonadotropin releasing hormones (GnRH). It is used in veterinary medicine to stimulate ovulation and follicular growth in animals. (Des-Gly10, tBu-D-Gly6, Pro -NHEt9)-LHRH acetate salt Pyr -His -Trp -Ser -Tyr -tBu -D -Gly -Leu -Arg -Pro NHEt acetate salt is a prodrug that is hydrolyzed in vivo to buserelin, its active form. This drug has been shown to be effective against estradiol benzoate and sodium salts

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5-[(1-Methylindole-3-yl)carbonyl]-4,5,6,7-tetrahydro-1H-bezimidazole is a reactive heterocyclic compound. It is a carboxylic acid and an amide with a peptic and cephalalgic effect. The symptoms of 5-[(1-methylindole-3-yl)carbonyl]-4,5,6,7-tetrahydro-1H-bezimidazole are hemicrania and amnesia. It has been expressed in the calf thymus DNA.